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Physiological and pathophysiological regulation of cytochrome P450.

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Physiological and pathophysiological regulation of

cytochrome P450.

陳玉華

Mogran ET;Sewer MB;Iber H;Gonzalez FJ;Lee YH;Tukey RH;Okino S;Vu T;Chen

YH;Sidhu JS and Omiecinski CJ

Abstract

This article is a report on a symposium sponsored by the American Society for Pharmacology and Experimental Therapeutics and held at the April 1998 Experimental Biology '98 meeting in San Francisco. The presentations focused on the mechanisms of regulation of cytochrome P450 gene expression by developmental factors and by hormones and cytokines, as well as on the interplay between physiological and chemical regulation. Approaches and systems used to address these questions included conditional gene knockouts in mice, primary hepatocyte cultures, immunofluorescence imaging of cells, and cell lines stably expressing reporter gene constructs.

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