• 沒有找到結果。

Increase of cardiac M2-muscarinic receptor gene expression in type-1 but not in type-2 diabetic rats

N/A
N/A
Protected

Academic year: 2021

Share "Increase of cardiac M2-muscarinic receptor gene expression in type-1 but not in type-2 diabetic rats"

Copied!
1
0
0

加載中.... (立即查看全文)

全文

(1)

Increase of cardiac M2-muscarinic receptor

gene expression in type-1 but not in type-2

diabetic rats

李良明

LM Lee;CK Chang;KC Cheng;DH Kou;IM Liu;JT

Cheng*

摘要

Abstract

Changes of cardiac M2-muscarinic receptor (M2-mAChR) gene expression was

investigated in type-1 like diabetic rats induced by intravenous injection of streptozotocin (STZ) and type-2 like diabetic rats induced by fed with fructose-rich chow. Systolic blood pressure (SBP) in STZ-diabetic rats was significantly lower than that in age-matched non-diabetic rats, while the SBP in type-2 like diabetic rats was higher than in non-diabetic rats. Also, the mRNA or protein level of cardiac M2-mAChR in STZ-diabetic rats was markedly higher than non-diabetic rats, but it was not observed in type-2 like diabetic rats as compared to age-matched non-diabetic rats. Arecaidine propargyl ester (APE), the agonist of M2-mAChR, produced a marked reduction of heart rate in STZ-diabetic rats but made less influence on heart rate in fructose-fed rats or non-diabetic rats. The results suggest that cardiac M2-mAChR gene expression is raised in type-1 like diabetic rats but not in type-2 like diabetic rats, this difference mainly due to hyperglycemia, for the production of hypotension in diabetic disorders.

參考文獻

相關文件

In this paper, we would like to characterize non-radiating volume and surface (faulting) sources for the elastic waves in anisotropic inhomogeneous media.. Each type of the source

The main tool in our reconstruction method is the complex geometri- cal optics (CGO) solutions with polynomial-type phase functions for the Helmholtz equation.. This type of

From these results, we study fixed point problems for nonlinear mappings, contractive type mappings, Caritsti type mappings, graph contractive type mappings with the Bregman distance

Diagonal elements in bosonic environments protected by (fermion) parity so that the qubit state decohere completely but does not thermalize for sub-Ohmic environment.. This is not

Abstract In this paper, we consider the smoothing Newton method for solving a type of absolute value equations associated with second order cone (SOCAVE for short), which.. 1

That is to say, while the building with the Chinese character ‘工’ shaped architectural plan is the common building type in the northern part of Vietnam, building layout in

• But, If the representation of the data type is changed, the program needs to be verified, revised, or completely re- written... Abstract

Microphone and 600 ohm line conduits shall be mechanically and electrically connected to receptacle boxes and electrically grounded to the audio system ground point.. Lines in