高雄醫學大學 100 學年度研究所招生考試試卷
系所: 醫藥暨應用化學系碩士班
科目: 分析化學
可使用電子計算機
單選題(共 30%)
1. Consider the equilibrium reaction: H2(g) + Br2(g) 2HBr(g). Which of the following
correctly describes the relationship between Kc and Kp for the reaction?
A. Kp = Kc
B. Kp = (RT)Kc
C. Kp = (RT)2Kc
D. Kp = Kc/RT
2. Which measurement is expressed to 4 significant figures? A. 0.423 kg
B. 62.40 g C. 82,306 m D. 1300 K
3. Which of the following has an effect on the magnitude of the equilibrium constant? A. removing products as they are formed
B. adding more of a reactant C. change in temperature D. adding a catalyst
4. Select the correct relationship among the concentrations of species present in a 1.0 M aqueous solution of the weak acid represented by HA.
A. [H2O] > [A¯] ~ [H3O+] > [HA] > [OH¯]
B. [H2O] > [HA] > [A¯] > [H3O+] > [OH¯]
C. [HA] > [H2O] > [A¯] > [H3O+] > [OH¯]
D. [H2O] > [HA] > [A¯] ~ [H3O+] > [OH¯]
5. The hydrated Al3+ ion, Al(H2O)63+, is a weak acid in water. What are the products of its reaction
with H2O? (Al(H2O)63+(aq) + H2O(l) ?)
A. Al(H2O)5OH2+(aq) + H3O+(aq)
B. Al(H2O)6H4+(aq) + OH¯(aq)
C. Al(H2O)53+(aq) + 2H2O(l)
D. Al(H2O)6OH2+(aq) + H3O+( aq)
6. When a weak acid is titrated with a strong base, the pH at the equivalence point A. is equal to 7.0.
C. 0.12 V
D. 0.15 V
9. Examine the following half-reactions and select the strongest oxidizing agent among the species listed.
A. Cr2+(aq) B. Co2+(aq) C. Sr2+(aq) D. Fe(s)
10. The difference between a student's experimental measurement of the density of sodium chloride and the known density of this compound reflects the ___________ of the student's result.
A. accuracy B. precision C. random error D. systematic error
問答及申論題(共 70%)
Molecular Mass Spectrometry (20%)
1. How do the spectra for electron-impact, field ionization, and chemical ionization sources differ from one another?
2. What mass differences can just be resolved at m values of 100, and 500 if the mass spectrometer has a resolution of (a) 500, and (b) 1000?
Electroanalytical Chemistry (30%)
1. Calculate the electrode potential of the following half-cell at 298 K. HCl(1.76 M)|H2(0.98 atm),Pt (R=8.314 J· K-1·mol-1)
2. Define junction potential. Explain how junction potential occurs and how junction potential influences with a potentiometric measurement.
3. Define faradaic current and nonfaradaic current. Separation Methods (20%)
1. You are asked to use column chromatography to separate two compounds from their mixtures and both GC and HPLC are available. If only one of the two methods is suitable for the separation, please explain the reason based on the properties of the two compounds. If both methods are suitable for the separation, which one should be chosen and why.
高雄醫學大學 100 學年度研究所招生考試試卷
系所: 醫藥暨應用化學系碩士班
科目: 有機化學
1. (60%) Give the major product of each of the following reactions.
(1) (2) (3) (4) (5) (6) (7) (8) (9) O OH 1. Br2, PBr3 2. H2O OH O O2N 1. BH3, THF 2. H3O+ CH3 CH3 O Cl Et2CuLi, ether O NH2 SOCl2, C6H6 O CH2-SMe2, DMSO CHO CHO 1. NaOH 2. H3O+ O H3C CH3 CH3 TFA N Cl Me2NH CO2 N2 furan, heat (11) O O CO2Et EtO2C heat (12) (13) (14) (15) (16) (17) (18) (19) O N2 hv, H2O O CH3 H3C CH3 heat H3C CH3 OH CH3 H H2SO4 O ClCH2CO2Et, NaOEt O H3C CH3 H3C H3C 1. (CH2SH)2, BF3 2. Raney Ni O 1. NaOH 2. H3O+ Br O CH2N2, ether N CH3 H3C heat
3. (20%) Propose a reasonable mechanism for the following reactions.
(1) H3C CH3 O NH2 NaOH, Br2 H2O H3C CH3 NH2 CO2
+
(2) CH4+
Cl2 light CH3Cl+
HCl (3) CH Li / NH3 3 H3C H3C CH3 (4) CHO O2N+
CN O2N OH CN Me3N, H2O H H4. (10%) Design a synthesis for the target molecule from the indicated starting material.
(1) CH3 H3C CH3 H3C CH3 CO2H (2) O CO2H
高雄醫學大學 100 學年度研究所招生考試試卷
系所: 醫藥暨應用化學系碩士班
科目: 生物化學
一，解釋名詞: 每題 3 分，共 30 分。 1. Induced fit model
2. Hairpin
3. FRET(fluorescence resonance energy transfer) 4. De novo pathway 5. Ketone bodies 6. Chemiosmotic coupling 7. Leucine zipper 8. miRNA 9. Telomerase 10. Transamination reaction 二，簡答題: 每題 5 分，共 30 分。
1. Steroid hormones 如何影響 gene expression?
2. 說明 E. coli 在 protein synthesis 中的 polypeptide chain elongation 過程。 3. 解釋 the fluid mosaic model: 其如何來描述 biological membranes 的組成結構? 4. 說明在休息及激烈運動中有關 pyruvate metabolism。
5. 說明 the Sanger method: 如何定 DNA sequence?
6. 說明 mitochondria 中的 the electron transport process。.
三，問答題: 共 40 分。
1. 抗生素 Penicillin 會破壞細菌細胞壁中之 peptidoglycan 的合成，但過度使用抗生素會造成 細菌的抗藥性，此時會給 clavulanic acid 來治療。已知 penicillin 及 clavulanic acid 的結構如 下: N S H N R O N O CH 2OH
(a) reversible inhibitor (b) irreversible inhibitor (c) competitive inhibitor (d) noncompetitive inhibitor (e) uncompetitive inhibitor (f) mix inhibitor (g) suicide inhibitor (3 分)
2. Myoglobin 及hemoglobin 與O2 結合，以提供生理上對O2的需求。
請回答下列相關問題: (共 15 分)
(A) Myoglobin 及 hemoglobin 結構上的差異? (2 分) (B) 活化位置上之何物質參與O2 結合? (2 分)
(C) 與O2 結合後, 對myoglobin 及 hemoglobin結構上, 有何影響? (3 分)
(D) 劃出myoglobin 及 hemoglobin之θ(the fraction of ligand binding sites) 與O2 結合之關係圖 (θ vs. pO2)，並解釋其生理上功能。(5 分)
(E) 何謂 Bohr Effect? (3 分)
