• 沒有找到結果。

Studies on the Inhibition of Bovine Liver Dihydrofolate Reductase by Pyrimidine Compounds

N/A
N/A
Protected

Academic year: 2021

Share "Studies on the Inhibition of Bovine Liver Dihydrofolate Reductase by Pyrimidine Compounds"

Copied!
1
0
0

加載中.... (立即查看全文)

全文

(1)

Studies on the Inhibition of Bovine Liver Dihydrofolate

Reductase by Pyrimidine Compounds

王惠珀

Cheng CY;Wang HP

Abstract

A series of 6-slky1-2,4-diaminopyrimidines (compounds 1- 5) and 6- methylamino-2,4-diaminopyimidines (copounds 6-12), prepared as nonclassical folate antimetabolites, were subjected to inhibition study on bovine liver dihydrofolate reductase. The 2,4-diaminopyrimidine compounds showed IC50's at 10-7-10-9M, with compound 5 as the most acitve showing comparable activity to that of methotrexate. The triaminopyrimidine analogues 6-12 were much less active, with IC50's ranged between 10-4-10-6 M.

參考文獻

相關文件

It also follows the general direction set out in the Personal, Social and Humanities Education Key Learning Area Curriculum Guide (Primary 1 – Secondary 3) (CDC, 2002) and extends

It also follows the general direction set out in the Personal, Social and Humanities Education Key Learning Area Curriculum Guide (Primary 1 – Secondary 3) (CDC, 2002) and extends

Consequently, Technology Education is characterized by learning activities which provide students with authentic experiences in various technological areas such as

年青的學生如能把體育活動融入日常生活,便可提高自己的體育活動能

常識科的長遠目標是幫助學生成為終身學習者,勇於面對未來的新挑 戰。學校和教師將會繼續推展上述短期與中期發展階段的工作

[r]

地址:香港灣仔皇后大道東 213 號 胡忠大廈 13 樓 1329 室 課程發展議會秘書處 傳真:2573 5299 或 2575 4318

教育統籌委員會的教育改革建議指出