*A C S does not ow n copyrights to the individual abstracts. For perm ission, please contact the author(s) of the abstract.
AGFD Lauren Jackson Tuesday, August 21, 2012
133 - Pharmacokinetics and tissue distribution of resveratrol and emodin in rats after intake of Polygonum cuspidatum Yu-Chi Hou1, hou5133@gmail.com, Shiuan-Pey Lin1, Meng-Hao Wu2, Shang-Yuan Tsai1, Pei-Dawn Lee Chao1. (1) School of Pharmacy, China Medical University, Taichung, Taiwan Republic of China, (2) School of Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung, Taiwan Republic of China
The rhizom e of Polygonum cuspidatum (PC) contains polyphenols such as resveratrol and em odin. In order to understand the pharm acokinetics and tissue distribution of polyphenols in PC , rats w ere given w ater extracts of PC . A t predeterm ined tim e points, blood sam ples w ere w ithdraw n via cardiopuncture. In addition, after 7 doses of PC (2 g/kg), the brain, liver, lung, kidney, and heart w ere collected. The concentrations of resveratrol and em odin as w ell as their m etabolites in plasm a and tissues w ere assayed by using H PLC . The results show ed that the m ajor form s in plasm a w ere glucuronides/sulfates of resveratrol and glucuronides of em odin, w hereas no free form s w ere detected. In the studied organs, the conjugated m etabolites of resveratrol and em odin w ere the m ajor m olecules, except em odin present m ainly as free form in liver. In conclusion, conjugated m etabolites of resveratrol and em odin are predom inant in the circulation and m ost organs after intake of PC .
Tuesday, August 21, 2012 02:00 PM G eneral Posters (02:00 PM - 04:00 PM ) Location: Pennsylvania Convention Center Room: Hall D
C lose W indow
