A Novel Promoter Polymorphism on Interleukin-10 was Associated with Taiwan Lung Cancer Risk, especially among Males and Smokers

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第三十屆生物醫學聯合學術年會

投稿摘要表格（正本）

A Novel Promoter Polymorphism on Interleukin-10 was Associated with Taiwan Lung Cancer Risk, especially among Males and Smokers

王守正1

, 繆佳恩3, 夏德椿2,3,4, 梁信杰2, 陳偉峻2,3,4, 涂智彥2,3, 陳鴻仁4, 林良怡3, 莊志亮1, 蔡長海3

, 包大靝3,5

Shou-Cheng Wang1, Chia-En Miao3, Te-Chun Hsia2,3,4, Shinn-Jye Liang2, Wei-Chun Chen2,3,4, Chih-Yen Tu2,3, Hung-Jen Chen4, Liang-Yi Lin3, Chin-Liang Chuang1, Chang-Hai Tsai3 and Da-Tian Bau3,5

1

Taichung Armed Forced General Hospital,

2

Department of Internal Medicine, China Medical University Hospital,

3

Terry Fox Cancer Research Laboratory, China Medical University Hospital,

4

Department of Respiratory Therapy, China Medical University Hospital,

5

Graduate Institute of Clinical Medical Science, China Medical University

Backgrounds: Interleukin-10 (IL-10) is an immunosuppressive cytokine which involved in carcinogenesis via immune escape. The study aimed at evaluating the contribution of IL-10 promoter A-1082G (rs1800896), T-819C (rs3021097), A-592C (rs1800872) genetic polymorphisms to the risk of lung cancer in Taiwan. Materials and Methods: Associations of three IL-10 polymorphic genotypes with lung cancer risk were investigated among 358 lung cancer patients and 716 age- and gender matched healthy controls. In addition, the genetic-lifestyle interaction was also examined. Results: The results showed that the percentages of TT, TC and CC for IL-10 T-819C genotypes were differentially represented as 59.2%, 35.8% and 5.0% in the lung cancer patient group and 52.0%, 37.0% and 11.0% in the non-cancer control group, respectively (p for trend=0.0025). The CC genotype carriers were of lower risk for lung cancer (odds ratio=0.4, 95% confidence interval=0.23-0.69, p=0.0005). We have further stratified the populations by genders and smoking behaviors and the results showed that the IL-10 T-819C genotype conducted a protective effect on lung cancer susceptibility which was obvious among males and smokers (p=0.0003 and 0.0004, respectively). Conclusion: The CC and TC genotypes of IL-10 T-819C compared to the TT genotype may have a protective effect on lung cancer risk in Taiwan, particularly among males and smokers.

第一作者中文姓名：王守正 傳真：

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地址：台中市北區育德路 2 號中國醫藥大學附設醫院癌症大樓 5 樓泰瑞法克斯癌症研究室