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Fisher information metric for the Langevin equation and least informative models of continuous stochastic dynamics

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FIG. 1. The reference potential of mean force and the corresponding equi- equi-librium probability density for illustrating the calculations of the Fisher  in-formation of trajectories
FIG. 2. The contours of ln ρ(xt, x 0 ) at t = 0.025 s for the reference PMF
FIG. 4. LID (least informative dynamics) distributions. (Top) For the bounded domain constraint of x ∈ [0.7, 1.3]
FIG. 5. Least informative dynamic models for using the mean first passage times as constrains
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