建立一個世界級之巨量生醫資料(Big Biodata)合作研究平台-成大、日本京都大學、美國系統生物學研究院共構老藥新用篩選平台建置計畫

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國立成功大學「邁向頂尖大學計畫」

延攬優秀人才工作報告表

NCKU’s “Aim for the Top University Project” Work Report Form for Distinguished Scholars □續聘continuation of employment █離職resignation

100 年 7 月 13 日更新 受聘者姓名

Name of the Employee

鄭婉淑 男 ▌女 Male Female 聘 期 Period of Employment from 103 年(y)09 月(m) 01 日(d) to 103 年(y) 12 月(m)31 日(d) 研究或教學或科技研發與 管理計畫名稱

The project title of research, teaching, technology development and management

建立一個世界級之巨量生醫資 料(Big Biodata)合作研究平台 -成大、日本京都大學、美國 系統生物學研究院共構老藥新 用篩選平台建置計畫 計畫主持人 (申請單位主管) Project Investigator (Head of Department/Center) 蔣榮先 補助延聘編號

Grant Number HUA - - -

一、 研究、教學、科技研發與管理工作全程經過概述。(由受聘人填寫)

Please summarize the entire research, teaching, or science and technology R&D and management work process (To be

completed by the employee)

Achieving early detection at the onset of cancer is a major goal of cancer research. The early presence of aberrant DNA methylation makes the use of DNA methylation biomarkers an attractive candidate for early detection. Altered DNA methylation is ubiquitous in human cancers and specific methylation changes are often correlated with clinical features. DNA methylation biomarkers provide a range of opportunities for early detection, diagnosis, prognosis, therapeutic stratification and post-therapeutic monitoring. Moreover, aging is one of the primary risk factors associated with cancer development. Through aging correlated features, epigenetic age-dependent marker panel on high-grade serous ovarian cancer was conducted. The refined prognostic marker panels are strongly connected with literature with the potential for considering into clinical assay for patients’ stratification and future personalized medicine interventions.

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Figure 1. KM survival curve for (a) distinct HGSOC phenotypes clustered by the age-dependent features, and (b) the extracted age-dependent marker panel that can differentiate the two specific phenotypes.

二、研究或教學或科技研發與管理成效評估(由計畫主持人或單位主管填寫)

Please evaluate the performance of research, teaching or science and technology R&D and management Work: (To be completed

by Project Investigator or Head of Department/Center) (1)是否達到延攬預期目標?

Has the expected goal of recruitment been achieved?

已達當時延攬博士後研究員參與計畫之目標,惟發表論文未盡理想。 (2)研究或教學或科技研發與管理的方法、專業知識及進度如何?

What are the methods, professional knowledge, and progress of the research, teaching, or R&D and management work?

鄭博士於延攬期間積極充實其專業知識並順利協助計畫執行。

(3)受延攬人之研究或教學或科技研發與管理成果對該計畫(或貴單位)助益如何?

How have the research, teaching, or R&D and management results of the employed person given benefit to the project (or your unit)?

鄭博士在參與計畫期間協助計畫之執行,也積極參與實驗室的研究報告會議,對實驗室研究生的專業 訓練頗有助益。

(4)受延攬人於補助期間對貴單位或國內相關學術科技領域助益如何?

How has the employed person, during his or her term of employment, benefited your unit or the relevant domestic academic field?

目前所參與計畫已初步完成,達到計畫預期目標。 (5)具體工作績效或研究或教學或科技研發與管理成果:

Please describe the specific work performance, or the results of research, teaching, or R&D and management work:

老藥的好處在藥物臨床前的數據都比未知的化學合成物完整。成功發現老藥新用不但比研發全新藥物 容易,且可加快開發速度,同時也能降低上市成本及失敗風險。老藥新用已經有許多成功的例子,如 最有名的阿斯匹靈。 至於癌症,早期發現早期治療是癌症研究的主要目標。而 DNA 甲基化的異常可在癌症早期發現使得 DNA 甲基化生物標誌深具潛力。人類癌症的 DNA 甲基化變異及特定甲基化的改變通常與臨床特徵具 相關性。DNA 甲基化的生物標誌為早期發現、診斷、預後、分層治療及治療後療效監測提供了很大的 潛力。然而,老化是癌症發展的主要風險因子。鄭博士於任職間透過老化的特徵,於卵巢癌找出可信 且具潛力的甲基化與老化相關的生物標誌。期望未來之研究能依據此關鍵之生物標誌找出潛在的老藥 進行新疾病或癌症治療之運用。 鄭博士依剛入職時所訂之工作計畫, 於九到十月間,每月月底依進度繳交工作報告-十月底前完成文 獻探勘;十一月底前完成實驗設計、實驗實作、實驗結果資料分析、及最後之期刊初稿撰寫;於十二月 前完成文章之編修後進行投稿。同時於任職期間,鄭博士亦用心引導指派之碩班學生入門生物資訊之 學門,及引導潛在有興趣該學門之學生。

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※ 此報告表篇幅以三~四頁為原則。This report form should be limited to 3-4 pages in principle.

※ 此表格可上延攬優秀人才成果報告繳交說明網頁下載。

數據

Figure 1. KM survival curve for (a) distinct HGSOC phenotypes clustered by the age-dependent  features, and (b) the extracted age-dependent marker panel that can differentiate the two specific  phenotypes.

Figure 1.

KM survival curve for (a) distinct HGSOC phenotypes clustered by the age-dependent features, and (b) the extracted age-dependent marker panel that can differentiate the two specific phenotypes. p.2

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