• 沒有找到結果。

Sequential up-regulation of the c-fos, c-jun and bax genes in the cortex, striatum and cerebellum induced by a single injection of low dose of 1-methyl-4 phenyl-1,2,3,6-tetrahydropyridine (MPTP) in C57BL/6 mice

N/A
N/A
Protected

Academic year: 2021

Share "Sequential up-regulation of the c-fos, c-jun and bax genes in the cortex, striatum and cerebellum induced by a single injection of low dose of 1-methyl-4 phenyl-1,2,3,6-tetrahydropyridine (MPTP) in C57BL/6 mice"

Copied!
1
0
0

加載中.... (立即查看全文)

全文

(1)

Sequential up-regulation of the c-fos, c-jun and bax

genes in the cortex, striatum and cerebellum induced

by a single injection of low dose of 1-methyl-4

phenyl-1,2,3,6-tetrahydropyridine (MPTP) in C57BL/6

mice

葉健全

Julia Yi-Ru Chen;Ping-Ching Hsu;Lee-Lin Hsu;Geng-Chang Yeh

摘要 Abstract

We investigated whether single injection of 1-methyl-4-phenyl-1,2,3,6-

tetrahydropyridine (MPTP) (20 mg/kg) will alter the expression of pro-apoptotic genes, namely, the c-fos, c-jun, and bax, in the striatum, cortex, and cerebellum of adult male C57BL/6 mice using reverse transcription-polymerase chain reaction assay. Injection of MPTP induced a transient decrease in the content of tyrosine hydroxylase estimated by the immunoreactivity in the striatum, which completely recovered 14 day after injection. A rapid but transient up-regulation of c-fos and c-jun genes occurred an hour after MPTP-injection, and a delayed but persistent up-regulation of bax gene expression occurred 3 day after injection. The up-regulation of these genes was present in all the examined brain regions. This result suggests that MPTP, at a low dose causing transient degeneration in the striatum, is capable of triggering two genetic pathways related to the generation of apoptosis in both dopaminergic and non-dopaminergic systems in the mouse brain.

參考文獻

相關文件

Yesterday he was absent from school because he had a coldD. Yesterday the weather was

Although Taiwan stipulates explicit regulations governing the requirements for organic production process, certification management, and the penalties for organic agricultural

(c) Draw the graph of as a function of and draw the secant lines whose slopes are the average velocities in part (a) and the tangent line whose slope is the instantaneous velocity

In stating Green’s Theorem we use the convention that the positive orientation of a simple closed curve C refers to a single counterclockwise traversal of C...

[This function is named after the electrical engineer Oliver Heaviside (1850–1925) and can be used to describe an electric current that is switched on at time t = 0.] Its graph

Consistent with the negative price of systematic volatility risk found by the option pricing studies, we see lower average raw returns, CAPM alphas, and FF-3 alphas with higher

21 Article 6(x): Where the financial sector is unduly protected from normal commercial and financial risks, serious prejudice in the sense of paragraph (c) of Article 5 shall

6 《中論·觀因緣品》,《佛藏要籍選刊》第 9 冊,上海古籍出版社 1994 年版,第 1