• 沒有找到結果。

Distinguishing angioimmunoblastic T-cell lymphoma from peripheral T-cell lymphoma; unspecified; using morphology; immunophenotype and molecular genetics.

N/A
N/A
Protected

Academic year: 2021

Share "Distinguishing angioimmunoblastic T-cell lymphoma from peripheral T-cell lymphoma; unspecified; using morphology; immunophenotype and molecular genetics."

Copied!
1
0
0

加載中.... (立即查看全文)

全文

(1)

Distinguishing angioimmunoblastic T-cell

lymphoma from peripheral T-cell

lymphoma;unspecified;using

morphology;immunophenotype and molecular

genetics.

莊世松

Attygalle AD;Chuang SS;Diss TC;Du MQ;Isaacson

PG;Dogan A

摘要

Abstract

Aims: To identify distinguishing histological, immunophenotypic and molecular genetic features between angioimmunoblastic T-cell lymphoma (AITL) and peripheral T-cell lymphoma (PTL). Methods: Nodal T-cell lymphomas examined (n = 137), included AITL (n = 89), PTL (n = 22), anaplastic large cell lymphoma (n = 16) and 'AITL/PTL

indeterminate' (n = 10) with overlapping features between AITL and PTL, showing morphology typical of AITL but lacking follicular dendritic cell expansion.

Immunohistochemistry for CD3, CD20, CD21 and CD10, in situ hybridization for Epstein-Barr virus encoded RNA (EBER) and polymerase chain reaction for T-cell and B-cell clonality analysis were performed. Results: Of the AITLs, 74/89 showed typical morphology, whereas 15/89 showed hyperplastic follicles. AITL and 'AITL/PTL

indeterminate' showed a polymorphous infiltrate and prominent vascularity in all cases. In both groups, CD10 was present in the majority and clear cells and EBER positivity were specific (but not universal) features lacking in PTL. Detection of T-cell clonality was significantly higher in AITL (90%) compared with PTLu (59%). Conclusion: Clear cells and EBV infection (when present) are useful distinguishing features and CD10 a sensitive and specific marker of AITL. Hyperplastic follicles are present in a significant minority of AITL. AITL/PTL indeterminate probably falls within the spectrum of AITL rather than PTL

參考文獻

相關文件

The aim is to present a case of rare giant granular cell ameloblastoma and to review the pertinent literature highlighting the molecular aspects of its pathogenesis by analyzing

Extranodal natural killer/T cell (NK/T cell) lymphoma, nasal type, is a rare non-Hodgkin lymphoma originating in the nasal cavity or in the paranasal sinuses.. It is strongly

The authors report a case of a 71-year-old woman in which the numb chin syndrome was the first symptom of the diffuse large B-cell lymphoma, which caused infiltration and

Persons with a phenotype mediated by one of these MC1R genetic variants are at greater risk of UV-induced skin cancers, because pheomelanin not only provides less effective

One of these enlargements is peripheral giant cell granuloma (PGCG), a lesion unique to the oral cavity, occurring only on the gingiva.. It is distinguishable from similar lesion

For those cases of primary splenic lymphoma with leukemic change (confirmed by flow cyto- metric immunophenotyping) but devoid of surgical or bi- opsy specimens, “splenic

Plasmacytoid lymphocyte, plasma cell 的 Flow cytometric immunophenotyping ,與 Mature B-cell lymphoma 不同.. Mediastinal lymphoblastic lymphoma(2)

1 In 2005 the World Health Organization defined BCAC as ‘‘an epithelial neoplasm that has cytological characteristics of basal cell adenoma (BCA), but a morphologic growth