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固態栽培樟芝亦顯示具有降血脂的功能

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• 系統編號 RG9503-3117

• 計畫中文名稱 人工栽培樟芝產品成分之比較及對生理疾病保健預防功能之評估

• 計畫英文名稱 Compositional and Functional Caparisms between Cultivated and Natural Taiwanofungal Camaphoratus on the Prevention of Cardiovascular-Hepatic Diseases

• 主管機關 行政院農業委員會 • 計畫編號 94 農科-12.1.3-糧-Z1(15)

• 執行機構 台北醫學大學生物醫學材料所

• 本期期間 9401 ~ 9412

• 報告頁數 0 頁 • 使用語言 中文

• 研究人員 林時宜;侯文琪;蘇慶華;林哲堂;梁有志 Shyr-Yi.Lin;Wen-Chi.Hou;Ching Hua.Su;Che Tong.Lin;Yu-Chih.Liang

• 中文關鍵字 血液黏度;紅血球變形;高血脂;高血壓;高血壓鼠;樟芝;膽固醇

• 英文關鍵字 Blood Viscosity;Erythrocyte Deformability;Hyperlipidemic;Hypertension;Spontaneously Hypertensive Rat;Taiwanofungus camphorates (Antrodia ampphorata);Cholesterol

• 中文摘要

本研究自固態栽培樟芝中分離出F6 具有基質金屬型蛋白水解酶及 COX-2 之抑制 顯示對發炎反應具有抑制作用。利用自然老化動物實驗 樟芝對血液黏度下降之功能開無論是天然樟芝或人工培養樟芝對自然老化老鼠之異常血液流變參數都有明顯之改善效果。樟芝預防肝纖維化的 功能評估中固態培養樟芝有明顯減緩之現象。固態栽培樟芝亦顯示具有降血脂的功能。對調節血壓的活性發現固態栽培樟芝或其萃取物在 10mg/kg 劑量下對先天性高血壓小鼠具有降低 20 毫米汞柱之功效而對正常小鼠不造成影響,在時間尚可持續 48 小時。整體而言人工栽培樟芝極 具開發為保健食品之本土素材。

• 英文摘要

The present project is to study the prevention function of C. camphorata on cardiovascular-hepatic diseases. The results indicated C. canpohorata improved the condition of blood rheology, hypolipidemic conditon and hypertension in animal models. In addition, function of anti-hepatofibrosis was also abserved in solid-state cultivated samples.The solid-state cultivated samples were fond to be comparable to the fruiting body collected from nature and the

possibility to replace wild collected C. camphoratus by cultivated ones is suggested.

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