Case report
Primary bone lymphoma of the mandible and thyroid incidentaloma identified by
18FDG PET/CT: a case report
Joaquim Bosch-Barrera
1*, Leire Arbea
1, Maria J García-Velloso
2, Ignacio Gil-Bazo
1, Jesús García-Foncillas
1and Carlos Panizo
3Addresses:1Department of Oncology, Clínica Universidad de Navarra, Pamplona, Spain,2Department of Nuclear Medicine, Clínica Universidad de Navarra, Pamplona, Spain and3Department of Hematology, Clínica Universidad de Navarra, Pamplona, Spain
Email: JBB* - jbosch@unav.es; LA - larbea@unav.es; MJGV - mjgarciave@unav.es; IGB - igbazo@unav.es; JGF - jgfoncillas@unav.es;
CP - cpanizo@unav.es
* Corresponding author
Received: 4 March 2009 Accepted: 12 June 2009 Published: 26 June 2009 Cases Journal 2009, 2:6384 doi: 10.4076/1757-1626-2-6384
This article is available from: http://casesjournal.com/casesjournal/article/view/6384
© 2009 Bosch-Barrera et al; licensee Cases Network Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
The mandible is a rare site for the occurrence of primary bone lymphoma (PBL), a non-Hodgkin lymphoma. We report herein a case of an incidentally diagnosed thyroid incidentaloma by
18Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in a patient with a previous diagnosis of PBL. Therapeutic options are reviewed and discussed.
Introduction
Primary bone lymphoma (PBL) represents approximately 3% of all malignant bone tumors [1] and 5% of all non- Hodgkin lymphomas. Most occurrences present similar characteristics such as a slightly greater frequency in men, early-stage disease presentation and a median age of appearance in the fifth or sixth decade. PBL can appear in any part of the skeleton. The most common tumor sites are the long bones (50% extremities), followed by the axial skeleton (44%). The mandible is a rare location, compris- ing approximately only 2-4% of all PBLs [2,3].
Establishment of useful diagnostic and therapeutic guide- lines is problematic because of the infrequency of PBLs.
PBL therapy has evolved from radiotherapy as a stand- alone strategy (since the 1960s) to combined modality therapy (chemotherapy and radiotherapy) [4]. There have
also been a few reports of patients treated with chemother- apy alone [2,3]. Surgery is currently limited to diagnostic procedures and repair of pathological fractures of the bone.
Diffuse large B-cell lymphoma (DLBCL) is the most frequent histopathological subtype of PBL. Standard chemotherapy for patients with DLBCL consists of administration of CHOP (cyclophosphamide, doxorubi- cin, vincristine, and prednisone) in conjunction with the monoclonal antiCD20 rituximab [5-7]. Treatment options differ for patients with localized (Ann Arbor stage I-II) or advanced (Ann Arbor stage III-IV) disease. We present the case of a PBL that affected the mandible. Therapeutic options are reviewed and discussed.
Case presentation
A 47-year-old Caucasian Spanish man presented with a history of eight months of dental pain. Despite extraction of
two teeth (numbers 37 and 38), improvement of symptoms was not achieved. A computed tomography (CT) scan of the head revealed an osteolytic lesion on the left mandible of 3.8¥ 1 cm (Figure 1). A CT-guided biopsy was performed.
Histopathological examination of the biopsy revealed a DLBCL; immunohistochemistry analysis tested positive for cytoplasmic CD20, Bcl-2 and nuclear Bcl-6.
The disease was staged using a bone marrow biopsy, CT body scan and fluorodeoxyglucose positron emission
tomography (FDG PET). CT scan revealed a lesion on the left mandible as well as the presence of a cyst on the right thyroid.18FDG PET/CT showed high uptake of tracer in the left mandible lesion with a standard uptake value (SUV) of 5.5 (Figure 1) and a higher focal uptake in the right thyroid, with an SUV of 8 (Figure 2). The bone marrow biopsy and hematological and chemical analysis were normal. A fine-needle aspiration (FNA) guided by echography of the thyroid lesion revealed a papillary thyroid carcinoma.
Figure 1.18FDG PET/CT showing the left mandible lesion in sagital (a), coronal (b) and axial (d) view. Image (c) shows an osteolytic lesion in the left mandible in an axial view of the CT scan.
Cases Journal 2009, 2:6384 http://casesjournal.com/casesjournal/article/view/6384
The final diagnosis was DLBCL stage I EA with a low IPI score and a synchronic papillary thyroid carcinoma.
The papillary thyroid carcinoma was treated first with a total thyroidectomy. Anatomopathological examination revealed a follicular variant of papillary carcinoma of the thyroid of 1.5 cm with pT1pN1aM0 stage (stage III). The patient began treatment with levothyroxine.
The lymphoma was treated with six cycles of chemother- apy (R-CHOP) with good tolerance. An 18FDG PET/CT was performed at the end of the treatment with no pathological signal.
After chemotherapy the patient was irradiated with 3D conformational radiotherapy. The left mandible branch received 30 Gy in 20 fractions of 2.0 Gy followed by 6 Gy as a boost to the initial tumor volume.
One month later, the patient received adjuvant radio- iodine ablation with I131 for the thyroid carcinoma. The patient has been completely tumor-free of the two tumors for 28 months, with the last follow-up in January 2009.
Discussion
Presentation symptoms of PBL include localized bone pain and sometimes the presence of a palpable mass. In Figure 2.18FDG PET/CT showing the thyroid incidentaloma in sagital (a), coronal (b) and axial (d) view. Image (c) shows the right thyroid cyst on the CT scan.
the mandible, the main symptoms of PBL are pain, swelling, numbness, tooth mobility and cervical lympha- denopathy. In this case, the patient had what appeared to be dental caries, which were previously evaluated by a dentist. Initial diagnosis is often wrong; Limb et al.
suggested that the mean time to achieve a correct diagnosis of PBL is 8 months [1].
The role of FDG-PET in the management of patients with lymphoma is clear. It has the potential to influence both the initial choice of chemotherapy and alterations to the management of the disease based on the response to therapy [8]. In our case, the 18FDG PET/CT provided staging information of the lymphoma and revealed the presence of a hypermetabolic lesion on the thyroid that was finally diagnosed as papillary carcinoma.
Thyroid incidentalomas are defined as newly identified thyroid lesions encountered during imaging studies. As
18FDG PET/CT is becoming a more common imaging modality, the incidence of thyroid incidentalomas is also increasing. A few retrospective studies have shown the prevalence of this finding to be approximately 2.3% [9].
Kang et al. studied the possibility of differentiating a malignant from a benign lesion with SUV. While a SUV > 9 suggested a higher likelihood of cancer, the authors concluded that a pathological confirmation is required.
The value of FDG-PET in patients with differentiated thyroid cancer is under review. FDG-PET has a clear role in I131-negative thyroid cancer and follow-up, but it should not be performed in patients with a stimulated Tg < 10μgr/L because of its low sensitivity [10,11].
The treatment and optimal management of patients with PBL are unclear because of the low incidence of this pathology. Few retrospective studies have examined the clinical characteristics, treatment and outcome of these patients. The published studies span many years, during which time staging techniques and treatment modalities have changed. Despite the heterogeneity of the treatment in the literature, it seems clear that a combined modality therapy of chemotherapy with radiotherapy leads to better results than a single modality of treatment [2,12]. Someya et al. reviewed the literature regarding the treatment of PBL of the mandible and concluded that radiotherapy alone was not enough for tumor control for stage I + II disease and that combination chemotherapy might be needed [13]. This conclusion is consistent with the results of studies on patients with early-stage non-Hodgkin lymphoma [14,15].
Rituximab added to six cycles of CHOP is an effective treatment for young patients with good-prognosis DLBCL [7] and is currently the gold standard treatment for these
patients. This regimen results in improvement of both event-free survival and survival. The excellent results achieved in patients with stage I without bulky disease suggest that the addition of rituximab may lead to a reduction in chemotherapy cycles and may therefore be an option for the future treatment of these patients.
Abbreviations
PBL, Primary bone lymphoma; DLBCL, Diffuse large B-cell lymphoma; CT, Computed tomography; FDG PET, fluorodeoxyglucose positron emission tomography; SUV, Standard uptake value; FNA, Fine needle aspiration.
Consent
Written informed consent was obtained from the patient for publication of this case report and accompanying images. A copy of the written consent is available for review by the journal’s Editor-in-Chief.
Competing interests
The authors declare that they have no competing interests.
Authors’ contributions
JB-B and LA developed the concept and wrote the draft. CP reviewed PBL treatment. MJ.G-V revised the CT and PET images. All the authors contributed to the final manuscript version and have given final approval of this version.
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