Author(s): Ho, YT (Ho, Yung-Tsuan); Yang, JS (Yang, Jai-Sing); Lu, CC (Lu, Chi-Cheng);
Chiang, JH (Chiang, Jo-Hua); Li, TC (Li, Tsai-Chung); Lin, JJ (Lin, Jen-Jyh); Lai, KC (Lai, Kuang-Chi); Liao, CL (Liao, Ching-Lung); Lin, JG (Lin, Jaung-Geng); Chung, JG (Chung, Jing- Gung)
Title: Berberine inhibits human tongue squamous carcinoma cancer tumor growth in a murine xenograft model
Source: PHYTOMEDICINE, 16 (9): 887-890 SEP 2009 Language: English
Document Type: Article
Author Keywords: Berberine; Human tongue SCC-4 cancer cells; Xenograft transplantation;
In vivo
KeyWords Plus: CELLS; APOPTOSIS; PATHWAY
Abstract: Our primary studies showed that berberine induced apoptosis in human tongue cancer SCC-4 cells in vitro. But there is no report to show berberine inhibited SCC-4 cancer cells in vivo on a murine xenograft animal model. SCC-4 tumor cells were implanted into mice and groups of mice were treated with vehicle, berberine (10 mg/kg of body weight) and doxorubicin (4 mg/kg of body weight). The tested agents were injected once per four days intraperitoneally (i.p.), with treatment starting 4 weeks prior to cells inoculation. Treatment with 4 mg/kg of doxorubicin or with 10 mg/kg of berberine resulted in a reduction in tumor
incidence. Tumor size in xenograft mice treated with 10 mg/kg berberine was significantly smaller than that in the control group. Our findings indicated that berbeirne inhibits tumor growth in a xenograft animal model. Therefore, berberine may represent a tongue cancer preventive agent and can be used in clinic. (c) 2009 Elsevier GmbH. All rights reserved.
Addresses: [Chung, Jing-Gung] China Med Univ, Dept Biol Sci & Technol, Taichung 404, Taiwan; [Ho, Yung-Tsuan; Li, Tsai-Chung; Liao, Ching-Lung; Lin, Jaung-Geng] China Med Univ, Grad Inst Chinese Med Sci, Taichung 404, Taiwan; [Yang, Jai-Sing] China Med Univ, Dept Pharmacol, Taichung 404, Taiwan; [Lu, Chi-Cheng; Chiang, Jo-Hua] Natl Chung Hsing Univ, Dept Life Sci, Taichung 402, Taiwan; [Lin, Jen-Jyh] China Med Univ Hosp, Div Cardiol, Taichung 404, Taiwan; [Lai, Kuang-Chi] China Med Univ, Sch Med, Taichung 404, Taiwan;
[Lai, Kuang-Chi] China Med Univ, Beigang Hosp, Dept Surg, Yunlin 651, Taiwan; [Chung, Jing-Gung] Asia Univ, Dept Biotechnol, Wufeng 413, Taichung County, Taiwan
Reprint Address: Chung, JG, China Med Univ, Dept Biol Sci & Technol, 91 Hsueh Shih Rd, Taichung 404, Taiwan.
E-mail Address: jgchung@mail.cmu.edu.tw Funding Acknowledgement:
Funding Agency Grant Number
China Medical University of Taiwan CMU96-086 CMU97-086
This work was supported by grants CMU96-086 and CMU97-086 from China Medical University of Taiwan.
Cited References: BINKIM J, 2008, PLANTA MED, V74, P39, DOI 10.1055/s-2007-993779.
CHOI BH, 2006, EXP MOL MED, V38, P599.
CRAIG WJ, 1999, AM J CLIN NUTR S, V70, S491.
HO YT, 2008, CANC SCI UNPUB.
KUO PL, 2006, MOL CANCER THER, V5, P3209, DOI 10.1158/1535-7163.MCT-06-0478.
LIN CC, 2007, ANTICANCER RES, V27, P3371.
LIN TH, 2008, BMC CANCER, V8, ARTN 58.
NISHINO H, 1986, ONCOLOGY, V43, P131.
PARKIN DM, 1990, INT J CANCER, V80, P827.
PENG PL, 2006, TOXICOL APPL PHARM, V214, P8, DOI 10.1016/j.taap.2005.11.010.
SACK RB, 1982, INFECT IMMUN, V35, P471.
YANG SF, 2008, J DENT RES, V87, P401.
YOUNT G, 2004, J EXP THER ONCOL, V4, P137.
Cited Reference Count: 13 Times Cited: 2
Publisher: ELSEVIER GMBH, URBAN & FISCHER VERLAG
Publisher Address: OFFICE JENA, P O BOX 100537, 07705 JENA, GERMANY ISSN: 0944-7113
DOI: 10.1016/j.phymed.2009.02.015
29-char Source Abbrev.: PHYTOMEDICINE ISO Source Abbrev.: Phytomedicine
Source Item Page Count: 4
Subject Category: Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy ISI Document Delivery No.: 488HU
