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Louisianin A was produced from the fermentation broth of

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Louisianin A was produced from the fermentation broth of Streptomyces sp.WK-4028 which was isolated from a soil sample collected in the state of Louisiana(USA). The louisianin A remarkably inhibited the growth of testosterone-resposive

Shionogi carcinoma SC 115 cells in the presence of 10-7 M testosterone with an IC50value of 0.6 μg/ml.

Recently, louisianin C and D were reported which potently

supressed the tubeformation of cultured vascular endothelical cell in vitro, although louisianin C and Dshowed only slight inhibitory activity on the growth of testosterone-resposive Shionogi carcinoma SC 115 cells.

Up to date, we have designed two strategies for the synthesis of louisianin A, andwe are not only interested in the synthesis of

louisianin A, but also can develop thederivatives of louisianins.

Key words: Louisianin A、testosterone-responsive、SC 115 cell、IC50、vascular endothelical cell

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