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[PDF] Top 20 Genome-wide association studies in pharmacogenomics of antidepressants

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Genome-wide association studies in pharmacogenomics of antidepressants

Genome-wide association studies in pharmacogenomics of antidepressants

... Conclusions In this study, we reviewed several recent GWAS findings and relevant studies for the drug efficacy of antidepressants in MDD ...power of large-scale genetic ... See full document

1

Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians

Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians

... understanding of the genetic basis of T2D, its heritability has not been fully explained 12 .... In addition, most of the T2D loci were detected initially in population samples ... See full document

7

A simple Bayesian mixture model with a hybrid procedure for genome-wide association studies

A simple Bayesian mixture model with a hybrid procedure for genome-wide association studies

... difference in allele frequencies between case and control groups, and is drawn from a distribution with a mean On i g i and variance 1, where n i is the sample size and the index i ranges from 1 to M ...use ... See full document

6

Genome-wide Association study of bipolar I disorder in the Han Chinese population.

Genome-wide Association study of bipolar I disorder in the Han Chinese population.

... results of the first large-scale GWA study of bipolar I disorder conducted in a non- Caucasian population, the Han ...GWA studies of bipolar disorder in the Caucasian population, ... See full document

9

A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2

A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2

... adiponectin association in populations of East Asian ancestry to ...evidence of a novel adiponectin-associated locus near ...threshold of GWA significance. In addition to ... See full document

12

Identification of Novel Susceptibility Loci for Kawasaki Disease in Han Chinese Population by a Genome-Wide Association Study

Identification of Novel Susceptibility Loci for Kawasaki Disease in Han Chinese Population by a Genome-Wide Association Study

... some of the SNPs in the GWAS. Many of the significantly associated SNPs in the discovery phase were either insignificant or of marginal significance in the replication phase ... See full document

31

A new method for post Genome-Wide Association Study (GWAS) analysis of colorectal cancer in Taiwan

A new method for post Genome-Wide Association Study (GWAS) analysis of colorectal cancer in Taiwan

... located in specific loci or genes have been identified associated with susceptibility to colorectal cancer (CRC) in Genome-Wide Association Studies ...However, in different ... See full document

7

Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis

Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis

... role in immune activ- ity have been a focus of candidate gene studies of Kawasaki disease susceptibility and disease outcome 10 ...A genome-wide linkage ana- lysis conducted ... See full document

5

Genome-wide microarray analysis of gene expression profiling in major depression and antidepressant therapy

Genome-wide microarray analysis of gene expression profiling in major depression and antidepressant therapy

... effectiveness of any particular antidepressant in an individual ...prescribe antidepressants based on educated guesses. With the recent advent of scientific research, genome-wide ... See full document

1

The role of non-homologous end-joining in oral cancer and personalized pharmacogenomics

The role of non-homologous end-joining in oral cancer and personalized pharmacogenomics

... Abstract In the past years, the incidence of cancer keeps its rapid increasing step all over the world and the war against cancer is not yet ...series of genetic alterations leading to progressive ... See full document

1

Functional variants at the 21q22.3 locus involved in breast cancer progression identified by screening of genome-wide estrogen response elements.

Functional variants at the 21q22.3 locus involved in breast cancer progression identified by screening of genome-wide estrogen response elements.

... polymorphism in determining breast cancer progression. This issue is certainly of more translational relevance, and may add significant prognostic value to the currently used indicators for outcome ... See full document

34

Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height

Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height

... Discussion In a meta-analysis of genecentric association studies of height, including 114,223 individuals from 47 studies and six ethnicities, significant association was ... See full document

13

Genome-wide association study for diabetic retinopathy in a Taiwanese population

Genome-wide association study for diabetic retinopathy in a Taiwanese population

... ratios of the diabetic retinopathy (DR) susceptibility SNPs in non-proliferative DR and proliferative DR Chr, chromosome; dbSNP ID, SNP database identification; T2D, type 2 diabetes; DR, diabetic ... See full document

40

Genome-wide detection of hybrid genes with multiple components in human

Genome-wide detection of hybrid genes with multiple components in human

... Previous studies showed that gene hybrid is one of the principal processes for generating new ...detection of the events with multiple components. Hence in this study, we focus on building up ... See full document

1

A genome-wide association study on chronic HBV infection and its clinical progression in male Han-Taiwanese.

A genome-wide association study on chronic HBV infection and its clinical progression in male Han-Taiwanese.

... the association between the clinical characteristics and the SNPs, the three clinical groups (PNALT, CHB and HCC) were investigated in the case-only ...Each of the three groups was coded as a binary ... See full document

32

Genome wide analysis of oral squamous cell carcinoma.

Genome wide analysis of oral squamous cell carcinoma.

... Targeting of oncogenes has proven clinically useful in treating patients with HER2/neu gene amplification and BCR/Abl oncogene ...amplification of specific oncogenes could be linked with disease ... See full document

1

Genome-wide structural modelling of TCR-pMHC interactions

Genome-wide structural modelling of TCR-pMHC interactions

... number of potential antigens, we evaluate our methods on experi- mental free energy data and 389 complete pathogen ...correlation of the binding interface energies. In addition, the homologous ... See full document

13

Comparison of Genome-wide DNA Methylation in Urothelial Carcinomas of Patients with and without Arsenic Exposure

Comparison of Genome-wide DNA Methylation in Urothelial Carcinomas of Patients with and without Arsenic Exposure

... Enrollment of Patients affected with AsUC and non-AsUC In total, 28 urothelial carcinomas were obtained from 14 matched pairs of patients with and without exposure to arsenic through drinking ... See full document

30

Genome-wide LOH map and its

Genome-wide LOH map and its

... characterization of patients The study group consisted of 71 patients diagnosed with primary NSCLC, who were admitted to Veterans General Hospital, Taichung, Taiwan, between 1993 and ...characteristics ... See full document

29

An integrated approach for genome-wide gene expression analysis

An integrated approach for genome-wide gene expression analysis

... received in revised form 23 May 2000; accepted 21 June 2000 Abstract Since efficient and relatively cheap methods were developed for determining biosequences, a lot of biosequence data has been ...problem ... See full document

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