[PDF] Top 20 Variations of Phospholipases A2 in the Geographic Venom Samples of Pitvipers

... locality. The variations could be attributed to their distinct specificities towards the platelets of different prey, and to possible adaptation for playing other functional ...roles. ... See full document

... Department of Biochemistry, Colorado State University, Fort Collins, Colorado 80523, USA Received 6 December 2002, and in revised form 26 December 2002 Abstract Geographic venom samples ... See full document

... investigate the geographic variations in venoms of two medically important pitvipers, we have purified and characterized the phospholipases A 2 (PLA ... See full document

... *Institute of Biological Chemistry, Academia Sinica, Institute of Biochemical Sciences, National Taiwan University, ...†Department of Biology, National Normal University, Taipei 107, Taiwan ... See full document

... Eight phospholipases A 2 (PLAs) and four three-finger-toxins (3FTx) from the pooled venom of Bungarus fasciatus (Bf) were previously studied and sequenced, but their expression ... See full document

... geographic samples. However, possibilities that we did not obtain all the transcripts of PLA from DsM venom glands, or that some of purified PLAs have undergone ... See full document

... Mechanisms of PLA Inactivation Normal reactions of PLAs include three ...First, the enzyme binds to the interface and conveys a phospholipid molecule to the active site slot; ... See full document

... explore the venom diversity and systematics of pit vipers under the genus Protobothrops, the venom phospholipases A 2 (PLA 2 s) of ...for ... See full document

... explore the venom diversity of Asian pit vipers, we investigated the structure and function of venom phospholipase A 2 (PLA 2 ) derived from two primitive ... See full document

... relationship The 3D model of CRV-W6D49 PLA 2 is shown in ...atoms in 122 amino-acid residues, showing excellent geometry with rmsd of ...0.003 AÊ in bond lengths ... See full document

... PLA2 family has been the subject of many comprehensive reviews [2, 51, I will focus on recent findings about molecular and mechanistic analysis related with the PLA2s from Asian s[r] ... See full document

... It has been reported that the histidine and aspartic acid residues at positions 47 and 48 in the amino acid sequence of snake venom phospholipases A Z are involved in the active.. FYG.[r] ... See full document

... striking geographic variations and a distinct spatial patterning for pesticide suicide in Taiwan, with higher rates in Central and East Taiwan and lower rates in major ...cities. ... See full document

... detoxification in the human body. These effects might be attributed to the hepatocellular concentration of zinc as a primary influence on ...concentration of serum copper ... See full document

... Discussions The present study presents the information of geographic differences in disability prevalence and its overtime change in ...that the average prevalence ... See full document

... presence of phospholipase A 2 (PLA 2 ) in the venom of Malayan krait (Bungarus candidus ) and its structure were ...studied. The PLA 2 cDNAs from ... See full document

... the specific activity of FXXII-2 decreased when further purified by G-75 gel-filtration or by HPLC (Fig.. Amino acid .cquence of TMV-K49 deduced from pept,de fragments. th[r] ... See full document

... is a 10% difference between nucleotide se- quences from Tanzania and ...Madagascar. The reason for this rather distinct sequence difference from 2 rela- tively close areas is not ...characteristic ... See full document

... at National Taiwan University on June 11, 2009.. www.jbc.org.[r] ... See full document

... *Institute of Biochemical Sciences, College of Science, National Taiwan University, Taiwan; and †Institute of Biological Chemistry, ...2000 In order to circumvent the difficulty ... See full document