內 寸 且 改3 向 改 水
寸 TAPES 功 改 且 (Wu 2016, Chuang
2017) ， 改 佐 另 改 CA1
CA3 小件 CA1 勻 日(Apical dendritic spine)
CA3 毛 成 件 否民 (nissl
stain) 水 H&E 好 功
母A# 但 八 (congo red stain)
內 寸 且 3 向 改 另 ，
寸 他 向 TAPES 功 改 且 (Wu
2016, Chuang 2017)
住 佐 另 功 改 且 小 改 內 H&E
行 安
(Saldiva, Clarke et al. 2002) Saldiva 4 改佐 另 包佐
262.21 µg/m3 且 改佐
水 內 寸且
5.11. 另 改向
努 才 方 (Gloor
and Guberman 1997) 妄序 小
才 妄
抑 另
才 否
且 改 另 p-Tau
打乙 另 改向 百
住 內 母 件 小 尼 元由
五 元 化了 乎
(olfactory epithelium) 每 (olfactory receptor neurons,
ORN) 外乙 功 (Halász 1990) AD
ORN 小由 Tau 主(Tabaton, Cammarata et al. 1991)
71% AD 小 Aβ 但
22%(Arnold, Lee et al. 2010) 寸 式 AD
西 互 E(Apolipoprotein E, ApoE) 五 小
ApoE ； 否 ORN 包 AD 平 3.5
(Yamagishi, Takami et al. 1998)
小 改 另 安 八
小 由 安 ORN 3-
(3-nitrotyrosine)； 否 安 平 右 ；
否 行 AD 安 八 成
doi:10.6342/NTU201901973
69
互 AD 安 八 (Chuah and Getchell
1999)
冰13 (CMD = 36nm; GSD = 1.66) 改6 H
改1,3,5 7 H 由
氏 冰13 佐 向 平(干 0 ) 冰 13 支 改 7
佐 人1.39 g/ g (干 1 ) 0.59 g/ g 干1 千
冰13 佐 他 安 0.35 g/ g 干7 安 0.43 g/ g
UFP 但 他 (Oberdorster,
Sharp et al. 2004)
印 且 小 改 另 向
才
5.12.
TAPES 功 3 改 才
功 改 改佐 否
另 功 每 包 功 伊 另
否 好 改 安 改 包 否
外
由 改另 功 Aβ 但
每 妄序 行 妄序 化中 努 功 母
伊 另 努 攻 努
功 Aβ 每
寸 右 H&E
西
H 八 又 H
每 改另 件 攻 克成 (selection
bias) 努 H (3xTg-AD mice)功
改 H 外判他 估 互 扮且
向 努 H
H 功 改 他
doi:10.6342/NTU201901973
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干 且百
伊 亦 另 攻 6
3xTg-AD TAPES 改 另 3 且 休 佐
仍 另 改 外 向p-Tau 互 安
他 p-Tau 互 他
百 另 生 火 3 另
改 3×Tg-AD 西 串 生 件 他 攻
改 另 攻 ， 伊
向 住 且
H 改方 功 叉 另
攻
干
1. 心 (2007). " / 字 否向 否 用." Chemistry 65(2):
151-155.
2. Ajmani, G. S., H. H. Suh and J. M. Pinto (2016). "Effects of ambient air pollution exposure on olfaction: a review." Environmental health perspectives 124(11):
1683-1693.
3. Ajmani, G. S., H. H. Suh and J. M. Pinto (2016). "Effects of Ambient Air Pollution Exposure on Olfaction: A Review." Environ Health Perspect 124(11): 1683-1693.
4. Alonso Adel, C., A. Mederlyova, M. Novak, I. Grundke-Iqbal and K. Iqbal (2004).
"Promotion of hyperphosphorylation by frontotemporal dementia tau mutations." J Biol Chem 279(33): 34873-34881.
5. Arnold, S. E., E. B. Lee, P. J. Moberg, L. Stutzbach, H. Kazi, L. Y. Han, V. M. Lee and J. Q. Trojanowski (2010). "Olfactory epithelium amyloid-β and paired helical filament-tau pathology in Alzheimer disease." Annals of neurology 67(4): 462-469.
6. Asami-Odaka, A., Y. Ishibashi, T. Kikuchi, C. Kitada and N. Suzuki (1995). "Long amyloid. beta.-protein secreted from wild-type human neuroblastoma IMR-32 cells." Biochemistry 34(32): 10272-10278.
7. Ashford, T. P. and K. R. Porter (1962). "Cytoplasmic components in hepatic cell lysosomes." The Journal of Cell Biology 12(1): 198.
8. Atkinson, R. W., G. W. Fuller, H. R. Anderson, R. M. Harrison and B. Armstrong (2010). "Urban ambient particle metrics and health: a time-series analysis."
Epidemiology 21: 501-511.
9. Attems, J., L. Walker and K. A. Jellinger (2014). "Olfactory bulb involvement in neurodegenerative diseases." Acta Neuropathol 127(4): 459-475.
10. Ayala, A., M. F. Muñoz and S. Argüelles (2014). "Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal." Oxidative Medicine and Cellular Longevity 2014: 31.
11. Becker, S., L. A. Dailey, J. M. Soukup, S. C. Grambow, R. B. Devlin and Y.-C. T.
Huang (2005). "Seasonal variations in air pollution particle-induced inflammatory mediator release and oxidative stress." Environmental health perspectives 113(8):
1032-1038.
12. Benedetti, A., M. Comporti and H. Esterbauer (1980). "Identification of 4-hydroxynonenal as a cytotoxic product originating from the peroxidation of liver
doi:10.6342/NTU201901973
73
microsomal lipids." Biochimica et Biophysica Acta 620(2): 281-296.
13. Bhatt, D. P., K. L. Puig, M. W. Gorr, L. E. Wold and C. K. Combs (2015). "A pilot study to assess effects of long-term inhalation of airborne particulate matter on early Alzheimer-like changes in the mouse brain." PLOS ONE 10(5): e0127102.
14. Biederbick, A., H. F. Kern and H. Elsässer (1995). "Monodansylcadaverine (MDC) is a specific in vivo marker for autophagic vacuoles." European journal of cell biology 66(1): 3-14.
15. Billings, L. M., S. Oddo, K. N. Green, J. L. McGaugh and F. M. LaFerla (2005).
"Intraneuronal Aβ Causes the Onset of Early Alzheimer’s Disease-Related Cognitive Deficits in Transgenic Mice." Neuron 45(5): 675-688.
16. Blennow, K. and H. Hampel (2003). "CSF markers for incipient Alzheimer's disease." Lancet Neurol 2(10): 605-613.
17. Block, M. L. and L. Calderón-Garcidueñas (2009). "Air pollution: mechanisms of neuroinflammation and CNS disease." Trends in neurosciences 32(9): 506-516.
18. Block, M. L., L. Zecca and J.-S. Hong (2007). "Microglia-mediated neurotoxicity:
uncovering the molecular mechanisms." Nature Reviews Neuroscience 8(1): 57.
19. Bolton, J. L., S. H. Smith, N. C. Huff, M. I. Gilmour, W. M. Foster, R. L. Auten and S. D. Bilbo (2012). "Prenatal air pollution exposure induces
neuroinflammation and predisposes offspring to weight gain in adulthood in a sex-specific manner." The FASEB Journal 26(11): 4743-4754.
20. Bos, I., P. De Boever, J. Emmerechts, J. Buekers, J. Vanoirbeek, R. Meeusen, M.
Van Poppel, B. Nemery, T. Nawrot and L. I. Panis (2012). "Changed gene
expression in brains of mice exposed to traffic in a highway tunnel." Inhal Toxicol 24(10): 676-686.
21. Brown, J. S., T. Gordon, O. Price and B. Asgharian (2013). "Thoracic and
respirable particle definitions for human health risk assessment." Particle and Fibre Toxicology 10(1): 12.
22. Caceres, A. and K. S. Kosik (1990). "Inhibition of neurite polarity by tau antisense oligonucleotides in primary cerebellar neurons." Nature 343(6257): 461.
23. Calderon-Garciduenas, L., B. Azzarelli, H. Acuna, R. Garcia, T. M. Gambling, N.
Osnaya, S. Monroy, M. Del Rosario Tizapantzi, J. L. Carson and A. Villarreal-Calderon (2002). "Air pollution and brain damage." Toxicologic pathology 30(3):
373-389.
24. Calderon-Garciduenas, L., B. Azzarelli, H. Acuna, R. Garcia, T. M. Gambling, N.
Osnaya, S. Monroy, D. E. L. T. MR, J. L. Carson, A. Villarreal-Calderon and B.
Rewcastle (2002). "Air pollution and brain damage." Toxicol Pathol 30(3): 373-389.
25. Calderon-Garciduenas, L., A. C. Solt, C. Henriquez-Roldan, R. Torres-Jardon, B.
Nuse, L. Herritt, R. Villarreal-Calderon, N. Osnaya, I. Stone, R. Garcia, D. M.
Brooks, A. Gonzalez-Maciel, R. Reynoso-Robles, R. Delgado-Chavez and W.
Reed (2008). "Long-term air pollution exposure is associated with
neuroinflammation, an altered innate immune response, disruption of the blood-brain barrier, ultrafine particulate deposition, and accumulation of amyloid beta-42 and alpha-synuclein in children and young adults." Toxicol Pathol 36(2): 289-310.
26. Campbell, A., M. Oldham, A. Becaria, S. C. Bondy, D. Meacher, C. Sioutas, C.
Misra, L. B. Mendez and M. Kleinman (2005). "Particulate matter in polluted air may increase biomarkers of inflammation in mouse brain." Neurotoxicology 26(1):
133-140.
27. Ceconi, C., A. Cargnoni, E. Pasini, E. Condorelli, S. Curello and R. Ferrari (1991).
"Evaluation of phospholipid peroxidation as malondialdehyde during myocardial ischemia and reperfusion injury." Am J Physiol 260(4 Pt 2): H1057-1061.
28. Chan, Y., R. Simpson, G. McTainsh, P. Vowles, D. Cohen and G. Bailey (1997).
"Characterisation of chemical species in PM2. 5 and PM10 aerosols in Brisbane, Australia." Atmospheric Environment 31(22): 3773-3785.
29. Chang, C.-C., J.-S. Hwang, C.-C. Chan and T.-J. Cheng (2007). "Interaction effects of ultrafine carbon black with iron and nickel on heart rate variability in
spontaneously hypertensive rats." Environmental health perspectives 115(7): 1012-1017.
30. Chang, C.-C., J.-S. Hwang, C.-C. Chan, P.-Y. Wang, T.-H. Hu and T.-J. Cheng (2005). "Effects of concentrated ambient particles on heart rate variability in spontaneously hypertensive rats." Journal of occupational health 47(6): 471-480.
31. Chen, L., H. M. Lee, G. H. Greeley, Jr. and E. W. Englander (2007).
"Accumulation of oxidatively generated DNA damage in the brain: a mechanism of neurotoxicity." Free Radic Biol Med 42(3): 385-393.
32. Cheng, H., A. Saffari, C. Sioutas, H. J. Forman, T. E. Morgan and C. E. Finch (2016). "Nanoscale particulate matter from urban traffic rapidly induces oxidative stress and inflammation in olfactory epithelium with concomitant effects on brain."
Environmental health perspectives 124(10): 1537-1546.
doi:10.6342/NTU201901973
75
33. Cheng, T.-J., J.-S. Hwang, P.-Y. Wang, C.-F. Tsai, C.-Y. Chen, S.-H. Lin and C.-C.
Chan (2003). "Effects of concentrated ambient particles on heart rate and blood pressure in pulmonary hypertensive rats." Environmental health perspectives 111(2): 147-150.
34. Chuah, M. I. and M. L. Getchell (1999). "Metallothionein in olfactory mucosa of Alzheimer's disease patients and apoE-deficient mice." Neuroreport 10(9): 1919-1924.
35. Chuang, C. (2017). "Ambient particles exposure and progress of Alzheimer's disease in 3xTg-AD mice: a pilot study."
36. Chuang, K.-J., Y.-H. Yan, S.-Y. Chiu and T.-J. Cheng (2011). "Long-term air
pollution exposure and risk factors for cardiovascular diseases among the elderly in Taiwan." Occupational environmental medicine 68(1): 64-68.
37. Clinton, L. K., L. M. Billings, K. N. Green, A. Caccamo, J. Ngo, S. Oddo, J. L.
McGaugh and F. M. LaFerla (2007). "Age-dependent sexual dimorphism in cognition and stress response in the 3xTg-AD mice." Neurobiology of disease 28(1): 76-82.
38. Cole, T. B., J. Coburn, K. Dao, P. Roqué, Y.-C. Chang, V. Kalia, T. R. Guilarte, J.
Dziedzic and L. G. Costa (2016). "Sex and genetic differences in the effects of acute diesel exhaust exposure on inflammation and oxidative stress in mouse brain." Toxicology 374: 1-9.
39. Cole, T. B., J. Coburn, K. Dao, P. Roque, Y. C. Chang, V. Kalia, T. R. Guilarte, J.
Dziedzic and L. G. Costa (2016). "Sex and genetic differences in the effects of acute diesel exhaust exposure on inflammation and oxidative stress in mouse brain." Toxicology 374: 1-9.
40. Colton, C. A. (2009). "Heterogeneity of microglial activation in the innate immune response in the brain." Journal of neuroimmune pharmacology 4(4): 399-418.
41. Colton, C. A. and D. M. Wilcock (2010). "Assessing activation states in microglia." CNS Neurological Disorders-Drug Targets 9(2): 174-191.
42. Colton, C. A. and D. M. Wilcock (2010). "Assessing activation states in microglia." CNS Neurological Disorders-Drug Targets 9(2): 174-191.
43. Cordis, G. A., D. K. Das and W. Riedel (1998). "High-performance liquid
chromatographic peak identification of 2,4-dinitrophenylhydrazine derivatives of lipid peroxidation aldehydes by photodiode array detection." J Chromatogr A 798(1-2): 117-123.
44. Costa, L. G., T. B. Cole, J. Coburn, Y. C. Chang, K. Dao and P. Roque (2014).
"Neurotoxicants are in the air: convergence of human, animal, and in vitro studies on the effects of air pollution on the brain." Biomed Res Int 2014: 736385.
45. Costa, L. G., T. B. Cole, J. Coburn, Y. C. Chang, K. Dao and P. J. Roque (2017).
"Neurotoxicity of traffic-related air pollution." Neurotoxicology 59: 133-139.
46. Craig, L., J. R. Brook, Q. Chiotti, B. Croes, S. Gower, A. Hedley, D. Krewski, A.
Krupnick, M. Krzyzanowski and M. D. Moran (2008). "Air pollution and public health: a guidance document for risk managers." Journal of Toxicology and Environmental Health, Part A 71(9-10): 588-698.
47. De Kok, T. M., H. A. Driece, J. G. Hogervorst and J. J. Briedé (2006).
"Toxicological assessment of ambient and traffic-related particulate matter: a review of recent studies." Mutation Research/Reviews in Mutation Research 613(2-3): 103-122.
48. Drubin, D. G. and M. W. Kirschner (1986). "Tau protein function in living cells."
The Journal of Cell Biology 103(6): 2739-2746.
49. Dunn Jr, W. A. (1994). "Autophagy and related mechanisms of lysosome-mediated protein degradation." Trends in cell biology 4(4): 139-143.
50. Dunn, W. (1990). "Studies on the mechanisms of autophagy: formation of the autophagic vacuole." The Journal of Cell Biology 110(6): 1923-1933.
51. Ebneth, A., R. Godemann, K. Stamer, S. Illenberger, B. Trinczek and E.
Mandelkow (1998). "Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implications for Alzheimer's disease." J Cell Biol 143(3): 777-794.
52. Elder, A., R. Gelein, V. Silva, T. Feikert, L. Opanashuk, J. Carter, R. Potter, A.
Maynard, Y. Ito, J. Finkelstein and G. Oberdorster (2006). "Translocation of inhaled ultrafine manganese oxide particles to the central nervous system."
Environ Health Perspect 114(8): 1172-1178.
53. Esterbauer, H., K. Cheeseman, M. Dianzani, G. Poli and T. Slater (1982).
"Separation and characterization of the aldehydic products of lipid peroxidation stimulated by ADP-Fe2+ in rat liver microsomes." Biochemical Journal 208(1):
129-140.
54. Esterbauer, H., P. Eckl and A. Ortner (1990). "Possible mutagens derived from lipids and lipid precursors." Mutation Research/Reviews in Genetic Toxicology 238(3): 223-233.
doi:10.6342/NTU201901973
77
55. Fagundes, L. S., S. Fleck Ada, A. C. Zanchi, P. H. Saldiva and C. R. Rhoden (2015). "Direct contact with particulate matter increases oxidative stress in different brain structures." Inhal Toxicol 27(10): 462-467.
56. Filali, M., R. Lalonde, P. Theriault, C. Julien, F. Calon and E. Planel (2012).
"Cognitive and non-cognitive behaviors in the triple transgenic mouse model of Alzheimer's disease expressing mutated APP, PS1, and Mapt (3xTg-AD)."
Behavioural brain research 234(2): 334-342.
57. Fonken, L. K., X. Xu, Z. M. Weil, G. Chen, Q. Sun, S. Rajagopalan and R. J.
Nelson (2011). "Air pollution impairs cognition, provokes depressive-like behaviors and alters hippocampal cytokine expression and morphology." Mol Psychiatry 16(10): 987-995, 973.
58. García-Mesa, Y., H. Pareja-Galeano, V. Bonet-Costa, S. Revilla, M. C. Gómez-Cabrera, J. Gambini, L. Giménez-Llort, R. Cristòfol, J. Viña and C. Sanfeliu (2014). "Physical exercise neuroprotects ovariectomized 3xTg-AD mice through BDNF mechanisms." Psychoneuroendocrinology 45: 154-166.
59. Giera, M., H. Lingeman and W. M. Niessen (2012). "Recent advancements in the LC-and GC-based analysis of malondialdehyde (MDA): a brief overview."
Chromatographia 75(9-10): 433-440.
60. Giménez-Llort, L., L. Arranz, I. Maté and M. De la Fuente (2008). "Gender-specific neuroimmunoendocrine aging in a triple-transgenic 3× Tg-AD mouse model for Alzheimer’s disease and its relation with longevity."
Neuroimmunomodulation 15(4-6): 331-343.
61. Giménez-Llort, L., I. Maté, R. Manassra, C. Vida and M. De la Fuente (2012).
"Peripheral immune system and neuroimmune communication impairment in a mouse model of Alzheimer's disease." Annals of the New York Academy of Sciences 1262(1): 74-84.
62. Glenner, G. G. and C. W. Wong (1984). "Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein."
Biochemical biophysical research communications 120(3): 885-890.
63. Gloor, P. and A. H. Guberman (1997). "The temporal lobe & limbic system."
Canadian Medical Association. Journal 157(11): 1597.
64. Grundke-Iqbal, I., K. Iqbal, M. Quinlan, Y.-C. Tung, M. S. Zaidi and H. M.
Wisniewski (1986). "Microtubule-associated protein tau. A component of Alzheimer paired helical filaments." Journal of Biological Chemistry 261(13):
6084-6089.
65. Guaita, R., M. Pichiule, T. Maté, C. Linares and J. Díaz (2011). "Short-term impact of particulate matter (PM2. 5) on respiratory mortality in Madrid." International journal of environmental health research 21(4): 260-274.
66. Guerra, R., E. Vera-Aguilar, M. Uribe-Ramirez, G. Gookin, J. Camacho, A.
Osornio-Vargas, V. Mugica-Alvarez, R. Angulo-Olais, A. Campbell, J. Froines, T.
Kleinman and A. De Vizcaya-Ruiz (2013). "Exposure to inhaled particulate matter activates early markers of oxidative stress, inflammation and unfolded protein response in rat striatum." Toxicol Lett 222(2): 146-154.
67. Halász, N. (1990). Vertebrate olfactory system, Akadémiai Kiadó.
68. Halonen, J. I., T. Lanki, T. Yli-Tuomi, P. Tiittanen, M. Kulmala and J. Pekkanen (2009). "Particulate air pollution and acute cardiorespiratory hospital admissions and mortality among the elderly." Epidemiology: 143-153.
69. Hamano, T., T. F. Gendron, E. Causevic, S. H. Yen, W. L. Lin, C. Isidoro, M.
Deture and L. W. Ko (2008). "Autophagic-lysosomal perturbation enhances tau aggregation in transfectants with induced wild-type tau expression." Eur J Neurosci 27(5): 1119-1130.
70. Hampel, H., K. Blennow, L. M. Shaw, Y. C. Hoessler, H. Zetterberg and J. Q.
Trojanowski (2010). "Total and Phosphorylated Tau Protein as Biological Markers of Alzheimer's Disease." Exp Gerontol 45(1): 30.
71. Hanger, D. P., B. H. Anderton and W. Noble (2009). "Tau phosphorylation: the therapeutic challenge for neurodegenerative disease." Trends Mol Med 15(3): 112-119.
72. Hanisch, U.-K. and H. Kettenmann (2007). "Microglia: active sensor and versatile effector cells in the normal and pathologic brain." Nature neuroscience 10(11):
1387.
73. He, C. and D. J. Klionsky (2009). "Regulation mechanisms and signaling pathways of autophagy." Annual review of genetics 43.
74. Hensley, K., J. Carney, M. Mattson, M. Aksenova, M. Harris, J. Wu, R. Floyd and D. Butterfield (1994). "A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease."
Proceedings of the National Academy of Sciences 91(8): 3270-3274.
75. Hesterberg, T. W., C. M. Long, W. B. Bunn, C. A. Lapin, R. O. McClellan and P. A.
Valberg (2012). "Health effects research and regulation of diesel exhaust: an
doi:10.6342/NTU201901973
79
historical overview focused on lung cancer risk." Inhalation toxicology 24(sup1):
1-45.
76. Hjortenkrans, D., B. Bergbäck and A. Häggerud (2006). "New metal emission patterns in road traffic environments." Environmental Monitoring Assessment 117(1-3): 85-98.
77. Ho, Y. S., X. Yang, S. C. Yeung, K. Chiu, C. F. Lau, A. W. Tsang, J. C. Mak and R.
C. Chang (2012). "Cigarette smoking accelerated brain aging and induced pre-Alzheimer-like neuropathology in rats." PLOS ONE 7(5): e36752.
78. Holcomb, L., M. N. Gordon, E. McGowan, X. Yu, S. Benkovic, P. Jantzen, K.
Wright, I. Saad, R. Mueller and D. Morgan (1998). "Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes." Nature medicine 4(1): 97.
79. Hu, W., F. Wu, Y. Zhang, C. X. Gong, K. Iqbal and F. Liu (2017). "Expression of Tau Pathology-Related Proteins in Different Brain Regions: A Molecular Basis of Tau Pathogenesis." Front Aging Neurosci 9.
80. Hu, Y. Y., S. S. He, X. Wang, Q. H. Duan, I. Grundke-Iqbal, K. Iqbal and J. Wang (2002). "Levels of Nonphosphorylated and Phosphorylated Tau in Cerebrospinal Fluid of Alzheimer’s Disease Patients : An Ultrasensitive Bienzyme-Substrate-Recycle Enzyme-Linked Immunosorbent Assay." Am J Pathol 160(4): 1269-1278.
81. Ito, D., Y. Imai, K. Ohsawa, K. Nakajima, Y. Fukuuchi and S. Kohsaka (1998).
"Microglia-specific localisation of a novel calcium binding protein, Iba1."
Molecular brain research 57(1): 1-9.
82. J., C. M. A. (1932). "Cytology and Cellular Pathology of the Nervous System."
Canadian Medical Association Journal 27(5): 576-576.
83. Johnson, G. V. and W. H. Stoothoff (2004). "Tau phosphorylation in neuronal cell function and dysfunction." Journal of cell science 117(24): 5721-5729.
84. Juda-Rezler, K., M. Reizer and J.-P. Oudinet (2011). "Determination and analysis of PM10 source apportionment during episodes of air pollution in Central Eastern European urban areas: The case of wintertime 2006." Atmospheric Environment 45(36): 6557-6566.
85. Jung, C.-R., Y.-T. Lin and B.-F. Hwang (2015). "Ozone, particulate matter, and newly diagnosed Alzheimer's disease: a population-based cohort study in Taiwan."
Journal of Alzheimer's Disease 44(2): 573-584.
86. Kabeya, Y., N. Mizushima, T. Ueno, A. Yamamoto, T. Kirisako, T. Noda, E.
Kominami, Y. Ohsumi and T. Yoshimori (2000). "LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing." The EMBO journal 19(21): 5720-5728.
87. Kabeya, Y., N. Mizushima, A. Yamamoto, S. Oshitani-Okamoto, Y. Ohsumi and T.
Yoshimori (2004). "LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation." Journal of cell science 117(13): 2805-2812.
88. Katsuragi, Y., Y. Ichimura and M. Komatsu (2015). "p62/SQSTM 1 functions as a signaling hub and an autophagy adaptor." The FEBS journal 282(24): 4672-4678.
89. Kim, S. H., E. M. Knight, E. L. Saunders, A. K. Cuevas, M. Popovech, L.-C. Chen and S. Gandy (2012). "Rapid doubling of Alzheimer’s amyloid-β40 and 42 levels in brains of mice exposed to a nickel nanoparticle model of air pollution."
F1000Research 1: 70.
90. Kim, S. Y., J. K. Kim, S. H. Park, B. G. Kim, A. S. Jang, S. H. Oh, J. H. Lee, M.
W. Suh and M. K. Park (2018). "Effects of inhaled particulate matter on the central nervous system in mice." Neurotoxicology 67: 169-177.
91. Kim, Y. C. and K.-L. Guan (2015). "mTOR: a pharmacologic target for autophagy regulation." The Journal of clinical investigation 125(1): 25-32.
92. Kimura, T., T. Ono, J. Takamatsu, H. Yamamoto, K. Ikegami, A. Kondo, M.
Hasegawa, Y. Ihara, E. Miyamoto and T. Miyakawa (1996). "Sequential changes of tau-site-specific phosphorylation during development of paired helical filaments."
Dementia 7(4): 177-181.
93. Koukourakis, M. I., D. Kalamida, A. Giatromanolaki, C. E. Zois, E. Sivridis, S.
Pouliliou, A. Mitrakas, K. C. Gatter and A. L. Harris (2015). "Autophagosome proteins LC3A, LC3B and LC3C have distinct subcellular distribution kinetics and expression in cancer cell lines." PLOS ONE 10(9): e0137675.
94. Kreutzberg, G. W. (1996). "Microglia: a sensor for pathological events in the CNS." Trends in neurosciences 19(8): 312-318.
95. Lachen-Montes, M., A. Gonzalez-Morales, X. M. de Morentin, E. Perez-Valderrama, K. Ausin, M. V. Zelaya, A. Serna, E. Aso, I. Ferrer, J. Fernandez-Irigoyen and E. Santamaria (2016). "An early dysregulation of FAK and MEK/ERK signaling pathways precedes the beta-amyloid deposition in the olfactory bulb of APP/PS1 mouse model of Alzheimer's disease." J Proteomics 148: 149-158.
doi:10.6342/NTU201901973
81
96. Lambert, M. P., A. Barlow, B. A. Chromy, C. Edwards, R. Freed, M. Liosatos, T.
Morgan, I. Rozovsky, B. Trommer and K. L. Viola (1998). "Diffusible, nonfibrillar ligands derived from Aβ1–42 are potent central nervous system neurotoxins."
Proceedings of the National Academy of Sciences 95(11): 6448-6453.
97. Larsen, K. E. and D. Sulzer (2002). "Autophagy in neurons a review." Histology and histopathology.
98. Le, W.-d., D. Rowe, W. Xie, I. Ortiz, Y. He and S. H. Appel (2001). "Microglial activation and dopaminergic cell injury: an in vitro model relevant to Parkinson's disease." Journal of Neuroscience 21(21): 8447-8455.
99. Lee, J., S. Giordano and J. Zhang (2012). "Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling." Biochemical Journal 441(2): 523-540.
100. Lee, Y.-K. and J.-A. Lee (2016). "Role of the mammalian ATG8/LC3 family in autophagy: differential and compensatory roles in the spatiotemporal regulation of autophagy." BMB reports 49(8): 424.
101. Lei, Y.-C., M.-C. Chen, C.-C. Chan, P.-Y. Wang, C.-T. Lee and T.-J. Cheng (2004).
"Effects of concentrated ambient particles on airway responsiveness and
pulmonary inflammation in pulmonary hypertensive rats." Inhalation toxicology 16(11-12): 785-792.
102. Levesque, S., M. J. Surace, J. McDonald and M. L. Block (2011). "Air pollution &
the brain: Subchronic diesel exhaust exposure causes neuroinflammation and elevates early markers of neurodegenerative disease." J Neuroinflammation 8: 105.
103. Levesque, S., T. Taetzsch, M. E. Lull, U. Kodavanti, K. Stadler, A. Wagner, J. A.
Johnson, L. Duke, P. Kodavanti, M. J. Surace and M. L. Block (2011). "Diesel exhaust activates and primes microglia: air pollution, neuroinflammation, and regulation of dopaminergic neurotoxicity." Environ Health Perspect 119(8): 1149-1155.
104. Li, R., Y. G. Huang, D. Fang and W. D. Le (2004). "(−)-Epigallocatechin gallate inhibits lipopolysaccharide-induced microglial activation and protects against inflammation-mediated dopaminergic neuronal injury." Journal of neuroscience research 78(5): 723-731.
105. Lindbom, J., M. Gustafsson, G. Blomqvist, A. Dahl, A. Gudmundsson, E.
Swietlicki and A. G. Ljungman (2006). "Exposure to wear particles generated from studded tires and pavement induces inflammatory cytokine release from human macrophages." Chemical research in toxicology 19(4): 521-530.
106. Lindsay, J., D. Laurin, R. Verreault, R. Hébert, B. Helliwell, G. B. Hill and I.
McDowell (2002). "Risk factors for Alzheimer’s disease: a prospective analysis from the Canadian Study of Health and Aging." American journal of epidemiology 156(5): 445-453.
107. Lippa, C., L. Nee, H. Mori and P. George-Hyslop (1998). "Aβ− 42 deposition precedes other changes in PS-1 Alzheimer's disease." The Lancet 352(9134): 1117-1118.
108. Liu, B. and J.-S. Hong (2003). "Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic
intervention." Journal of Pharmacology and Experimental Therapeutics 304(1): 1-7.
109. Liu, Z., T. Li, P. Li, N. Wei, Z. Zhao, H. Liang, X. Ji, W. Chen, M. Xue and J. Wei (2015). "The Ambiguous Relationship of Oxidative Stress, Tau
Hyperphosphorylation, and Autophagy Dysfunction in Alzheimer's Disease." Oxid Med Cell Longev 2015: 352723.
110. Löndahl, J., J. Pagels, E. Swietlicki, J. Zhou, M. Ketzel, A. Massling and M.
Bohgard (2006). "A set-up for field studies of respiratory tract deposition of fine and ultrafine particles in humans." Journal of Aerosol Science 37(9): 1152-1163.
111. Madl, P. (2012). Exposure to Nano-Sized Particles and the Emergence of Contemporary Diseases with a Focus on Epigenetics. Air Pollution-Monitoring, Modelling and Health, IntechOpen.
112. Malm, W. C., J. F. Sisler, D. Huffman, R. A. Eldred and T. A. Cahill (1994).
"Spatial and seasonal trends in particle concentration and optical extinction in the United States." ournal of Geophysical Research: Atmospheres 99(D1): 1347-1370.
113. Masters, C. L., G. Simms, N. A. Weinman, G. Multhaup, B. L. McDonald and K.
Beyreuther (1985). "Amyloid plaque core protein in Alzheimer disease and Down syndrome." Proceedings of the National Academy of Sciences 82(12): 4245-4249.
114. Maurage, C. A., N. Sergeant, M. M. Ruchoux, J. J. Hauw and A. Delacourte (2003). "Phosphorylated serine 199 of microtubule-associated protein tau is a neuronal epitope abundantly expressed in youth and an early marker of tau pathology." Acta Neuropathol 105(2): 89-97.
115. McGeer, P. L., S. Itagaki, H. Tago and E. G. McGeer (1987). "Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the
histocompatibility glycoprotein HLA-DR." Neuroscience letters 79(1-2): 195-200.
doi:10.6342/NTU201901973
83
116. Metcalfe, M. J. and M. E. Figueiredo-Pereira (2010). "Relationship between tau pathology and neuroinflammation in Alzheimer's disease." Mt Sinai J Med 77(1):
50-58.
117. Misra, C., M. D. Geller, P. Shah, C. Sioutas and P. A. Solomon (2001).
"Development and Evaluation of a Continuous Coarse (PM10–PM25) Particle Monitor." Journal of the Air Waste Management Association 51(9): 1309-1317.
118. Mizushima, N. and M. Komatsu (2011). "Autophagy: renovation of cells and tissues." Cell 147(4): 728-741.
119. Morgan, D., S. Munireddy, J. Alamed, J. DeLeon, D. M. Diamond, P. Bickford, M.
Hutton, J. Lewis, E. McGowan and M. N. Gordon (2008). "Apparent behavioral benefits of tau overexpression in P301L tau transgenic mice." Journal of
Alzheimer's Disease 15(4): 605-614.
120. Mumaw, C. L., S. Levesque, C. McGraw, S. Robertson, S. Lucas, J. E. Stafflinger,
120. Mumaw, C. L., S. Levesque, C. McGraw, S. Robertson, S. Lucas, J. E. Stafflinger,