低劑量 AVLE 10 μg/ml 有長效性舒張血管和抗氧化、清除超氧陰 離子之效應; 但高劑量 AVLE 30、90 μg/ml 反而會降低此功效。本實 驗結果推測，此逆轉舒張，恢復收縮之作用為組織中超氧陰離子之產 生與 NO 競爭之失衡，導致血管平滑肌恢復前置收縮劑之收縮狀態。
因此本實驗結論中，建議使用 AVLE，當「適量」即可，「過量」反 而降低良好之功效，並且會有血管組織損傷之現象。
第二節、對未來研究方向的建議
1、 AVLE 之長效效應 ( Long-lastng effect )，缺乏對於整體性動物之 研究，建議未來整體性之動物研究中可作長效之作用。AVLE 之 長效效應俱有臨床效應，表示長效效應對未臨床藥物之使用，只 需少量、適量極可達到效應，不需高劑量之使用。
2、 高劑量之 AVLE，缺乏整體性動物之血管組織損傷研究，建議未 來可作整體性動物和細胞損傷之研究。探討整體性動物之損傷研 究是否與離體動物實驗吻合。
3、 有效成分：本實驗使用之 AVLE 萃取物為，Venetron：含有金絲 桃苷 ( hyperoside ) 和異榭皮苷 ( isoquercitin)，經前學者之研究，
兩項植物化合物互相結合，在生物體內會有最佳之代謝吸收時間。
但單項之藥物研究仍究缺乏，建議未來可作單項藥物之整體性動 物與細胞之研究。單項成份之研究，具有藥理上和經濟上之價值。
參考文獻
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