我們的研究係以明膠為基本材料，加入葛根濃縮粉末，並以戊二醛 來進行化學交聯，製成長度12 mm，內徑約為 1.7 mm，外徑約為 2.5 mm 的可降解性實驗組葛根明膠神經導管。對照組則製備不含葛根的明膠神 經導管。兩組各採用10 隻雌性 SD 大鼠，截斷坐骨神經 10 mm，將導管 植入後飼養八週，然後將大鼠犧牲收成，以解剖目測觀察、電生理、組 織學方法評估神經再生情形。結果顯示，兩組皆可以肉眼觀察到橫跨斷 面的成功神經再生，而且導管降解情況良好。在電生理評估上，實驗組 在潛期及神經傳導速率上，比對組組有良好的表現，而且已達到統計上 的顯著差異。在組織學評估上，可以觀察到實驗組的再生神經比對照組 更為緻密，有髓鞘的軸突較多，軸突形狀也較大而圓。因此，我們的結 論是，葛根明膠神經導管，比未加葛根的導管，更能促進神經的再生與 神經功能的恢復。本研究尚有許多改善空間，葛根對神經再生的作用與 機轉，仍需後續的研究來進一步加以探討。
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