DNA 分子對於生物科技以及奈米科技上的應用，一直以來都是許多研究團隊 注意的焦點。然而不管是在 DNA 生物感測器或是電子元件上，都存在許多的問題等 著我們去克服，DNA 的電傳導性質就是其中之一。在本研究中，我們以二價的鎳離 子於鹼性 (pH ≧ 8.5) 的環境下，參雜入 DNA 分子的鹼基對中以形成 Ni-DNA。藉 由電性的量測以及電化學的分析，證實了鎳離子的參雜，確實可以有效的改善 DNA 的電導特性。由電化學分析的結果，我們可以得知 DNA 電性的改善，主要是由於鎳 離子參雜入具有良好鹼基對堆疊的 DNA 分子後，鎳離子就扮演著電荷傳輸介質的角 色。電荷可以藉由電子跳躍 (Electron hopping) 的方式於 Ni-DNA 中做傳輸，並且由 實驗可知，鹼基對的堆疊對於電荷的傳輸有著顯著的影響。當 Ni-DNA 序列中有鹼基 對錯誤配對時，其電阻將會有明顯增加的現象。利用此特性，我們將 Ni-DNA 導入至 生物感測器上的應用，配合電化學的分析技術，可以有效的對 DNA 序列中，是否有 鹼基對的錯誤配對做檢測，並對於單一核苷酸多型性(single nucleotide polymorphisms;
SNPs) 的檢測提供了一個新的方向。
Ni-DNA 除了可以應用於生物感測器外，在分子元件上的應用也有著的表現。
在 實 驗 中 ， 我 們 將 Ni-DNA 架於兩個金電極之間，形成 Metal-Molecules-Metal (M-M-M) 接合結構，並量測其電性。由電性上可以發現 Ni-DNA 分子元件在室溫、
常壓下，就具有可再現性且穩定的 NDR 特性。而造成 NDR 特性的原因，主要是由 於參雜在 Ni-DNA 中之鎳離子的氧化還原反應所誘發的。此獨特的電子特性，將使得 Ni-DNA 於奈米電子元件上更具發展潛力。
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