其變化與心臟輸出的總量有關，可以代表循環系統的整體功能指標。如
（Hepatic Venous Pressure Gradient, HVPG）相當期盼，過去雖有研究指 出超音波與核磁共振攝影可監測此壓力梯度，但此法目前尚未有明確定 論 52。本研究的實驗結果顯示，藉由脈波的分析，可以發現門靜脈高壓
大鼠的訊號變化，若能更進一步將這些變化與 HVPG 的關係定量，應可 為 HVPG 的非侵入式監測提供一可行方案。
Dr. Pessin 曾說：「CAM can provide medical professionals with new medical information. This new information can improve the success rate of diagnosis, preventive medical care and treatment. 53」我們相信，中國傳統 醫學，可以彌補現代醫學的不足。兩者合一的醫學，能對每個人有更好 的治療與照顧。
第六章 結論
由本研究的結果顯示，當大鼠產生門靜脈高壓後，靜脈循環產生變 異，而動脈壓力波中確實可以測得變化的出現，這證明動脈血壓波不僅 能偵測出動脈循環的變異，當靜脈循環發生變化時，如本研究門靜脈高 壓的出現，脈波同樣可以偵測出不同，為中醫脈診提供更多的客觀證據。
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Analyses of Pulse Waves in Portal Hypertensive Rats
Henry Cherng-han Lin Major Professor: Yi Chang Su
Institute of Chinese Medical Science, China Medical University
Chronic liver disease or cirrhosis has been one of most common causes of death in Taiwan. Cirrhosis is the end stage of any chronic liver disease.
Portal hypertension is the main consequence of cirrhosis, and is responsible for most of its complications. Pulse diagnosis is a widely used technique in Chinese Medicine to assess patients. According to its related theories, hemodynamic changes can be obtained through finger sensations. Recent researches had more and more revealed its scientific foundations. In this study, we tried to investigate arterial wave changes in portal hypertension using PPVL rats.
Twelve rats were separated into PPVL and Sham group. Rats form PPVL group were ligated by PPVL method. After 30 days, the 12 rats received femoral artery and ileocolic vein catheterization. The arterial and venous pressures were then recorded for 15 minutes long for analyses. The arterial pressure wave was transformed into frequency domain (Cn) by Fourier transformation, and then calculated the phases (Pn). Arterial pressure variability (APV) will be calculated by fast Fourier transformation (FFT) of arterial pressure wave. Heart rate variability (HRV) will be calculated by FFT of heart rate.
Results showed a decrease in C0, but increase in C2, C3, and C4, while P4, P5, and P6 decreased. These indicated the accumulation of blood in middle and lower part of the body. AP-LF decreased and AP-HF increased indicated increased activity of sympathetic tone. Increases of HR-VLF, HR-LF, and the decrease of HR-HF suggested that vagal tone has less effect to the heart.
Furthermore, this study suggested that the differences from arterial signals could be detected from arterial pressure wave in portal hypertensive rats. This could provide a feasible application of using pulse diagnosis to detect portal hypertension.
Keywords: portal hypertension; pulse diagnosis; harmonic spectrum analysis;
arterial pressure variability; heart rate variability
謝 辭
首先誠摯的感謝指導 蘇奕彰老師，老師悉心的教導使我得以瞭解 進行研究的方法與態度，並不時的討論並指點我正確的方向，使我在這 些年中獲益匪淺。老師對學問的嚴謹更是我輩學習的典範。
感謝張鈺鑫學長、林睿珊學姐不厭其煩的指出我研究中的缺失，且 總能在我迷惘時為我解惑，也感謝同學的幫忙，恭喜我們順利走過這兩 年。實驗室的諸位當然也不能忘記，大家的幫忙我銘感在心。
老婆玉鳳在背後的默默支持更是我前進的動力，沒有玉鳳的體諒、
包容，相信這兩年的生活將是很不一樣的光景。
最後，謹以此文獻給我摯愛的雙親。