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Appendix
Appendix A
There are our test model’s parameters of positive. The parameter in are the probability of start in our model that are start to α-helix, β-sheet and Coil. The parameters G are probability of amino acid Glycine in our test model. The first { } are probability of nine block in α-helix. Second { } are probability of nine block in β-sheet. Third { } are probability of nine block in Coil. AA is every line of probability of α-helix to α-helix in our Model. AB is α-helix to β-sheet. AC is α-helix to Coil.
in
{-1.0777484790871408, -1.41793359126078, -0.8736504077353311}
G
{-3.1472099796503588, -3.176290472458474, -3.132314282148041, -3.1271823434115507, -3.2674273229628823, -3.1966431861736067, -3.191360861582931, -3.1405311497865993, -3.1704568492847907}
{-3.0265814305739434, -2.9168862794395998, -2.893277584798866, -2.812688108111485, -3.0427160035491525, -2.841998173611949, -3.0399703917915564, -2.940463884492605, -2.983449354200421}
{-2.096009620981201, -2.064385422239733, -2.05657944445429, -2.082847989410555, -2.119986681270305, -2.055625172856532, -2.0552605041272054, -2.086381997532866, -2.0962277155624154}
A
{-2.1455519319871406, -2.1477286968354514, -2.171977549526432, -2.1521312750481134, -2.2412306130592263, -2.137561736262132, -2.1686246078935123, -2.172829020263138, -2.144980591112694}
{-2.768752321271844, -2.724105591855508, -2.7452681729936903, -2.631495856914682, -2.919441111091819, -2.7316501164430833, -2.783850572235712, -2.800046705662858, -2.7003230982845006}
{-2.7255797122714434, -2.7423509786322, -2.8078202060431514, -2.781021709456435, -2.845962132143586, -2.7047217187282295, -2.7660877032233233, -2.7628381431244042, -2.7573675086213933}
V
{-2.735603603520112, -2.7060226075129585, -2.679960426837384, -2.748114707154411, -2.8152351384467487, -2.74235435628598, -2.7700169248514097, -2.733754566080624, -2.835982615326251}
{-2.0161437154904993, -2.0563256251739856, -2.0267775174277265, -2.0414101001857605, -2.218591710169781, -2.0910314221631774, -2.042659217843056, -2.086369360488356, -2.0656013938776594}
{-3.109090041732639, -3.091401997460273, -3.084337581194451, -3.063862960688206, -3.113584534920831, -3.042440838304006, -3.0897108485780294, -3.030926521675784, -3.1158441072936385}
L
-2.1942289803824573, -2.1729883635946896, -2.1650142718742873, -2.1551592864457545, -2.1779684162812596, -2.210542439668368, -2.126002432869109, -2.1803365630328737, -2.196386916037448}
{-2.3019653222893606, -2.357270491504177, -2.404113457814055, -2.393027767244314, -2.3821643012386584, -2.2384631517416906, -2.409436803959598, -2.3630603632449154, -2.328692063192118}
{-2.773316047895526, -2.8371032783662673, -2.8242140158188276,
I
{-2.8724446458122785, -2.878616205378244, -2.854313813982162, -2.8369983932474456, -2.9077954793376133, -2.7918830481334123, -2.7949835475818707, -2.834320999773776, -2.9224746466796945}
{-2.332156294568506, -2.430659814686977, -2.3982910250626217, -2.4653113375237004, -2.48852933732249, -2.399145533432164, -2.4359387447051044, -2.3701375336190007, -2.379914332330163}
{-3.4287660178597172, -3.387558696903026, -3.276199139561885, -3.278498970398999, -3.373615076042102, -3.3286683650447926, -3.3851269116295466, -3.2843754224853225, -3.3723240788754403}
F
{-3.24416422065525, -3.2486111340381005, -3.1716161344956544, -3.259855244067479, -3.1636626129554637, -3.141130476243348, -3.180976552277215, -3.184803973464587, -3.262379559475451}
{-2.917646747210275, -2.855712056070446, -2.9222651216721185, -2.8707764456318645, -2.768979111212414, -2.8636596703931283, -2.848538246927143, -2.8701318765484185, -2.8521932754130335}
{-3.5202717844371865, -3.387558696903026, -3.3613569479021916, -3.3710505277642437, -3.4339872044851463, -3.384459724673208, -3.5225107315997377, -3.4201070360194477, -3.552952155163062}
Y
{-3.3315870356264092, -3.309519887125093, -3.3514092449362507, -3.368526599372607, -3.2449038482957993, -3.332290981704507, -3.3347829387631482, -3.335531164840325, -3.3491920304475182}
{-3.0265814305739434, -2.947730954790698, -2.8814431271518632, -2.897444692714026, -2.8143383606113446, -2.9368322762827876, -2.9024728861620903, -2.9480301248759213, -2.9731133448697586}
{-3.503218996054467, -3.509606131345867, -3.4700901480386572, -3.599257381035, -3.371596911885865, -3.4880004036140484, -3.5060203697003223, -3.566942394270333, -3.505855471499963}
W
{-4.136977071467123, -4.115030035872082, -4.128816769113936, -4.066788880599322, -3.90950902551626, -4.168352768824785, -4.148125701384861, -4.217721002867302, -3.997991220553155}
{-4.060815057428617, -3.919763669673088, -4.043183167854527, -4.062070791698029, -3.762452638298337, -3.9334929945111945, -3.823814133822314, -3.9162805956807873, -3.812728709084946}
{-4.692803062928303, -4.598648968997826, -4.484510345486419, -4.538655687919305, -4.442374401560531, -4.37627809926053, -4.489969750048292, -4.625549348324744, -4.587660641851691}
H
{-3.744487122222092, -3.7369639019520324, -3.803394368679308, -3.7907123542678494, -3.7243056223474165, -3.798910512966002, -3.7035792432342256, -3.704585909252649, -3.7310711395498033}
{-3.6529547385944983, -3.628901944303928, -3.5769460214042677, -3.653984450109991, -3.5191542850056674, -3.740589328386703, -3.6393850946887945, -3.6488012305465256, -3.8067939735651315}
{-3.6402070115469005, -3.6458885573422792, -3.602335366852436,
D
{-2.9915936686066176, -2.967198674599915, -3.071331771869689, -3.149473033309922, -3.031158441787471, -3.0278017909363446, -3.097760246256137, -2.979095483972479, -2.9365925282254794}
{-3.527228849424178, -3.573332093149117, -3.2602090289047876, -3.56392362619181, -3.5381121987502815, -3.502355531348903, -3.461459149367878, -3.5108154875726227, -3.4856542349225044}
{-2.5763563252549133, -2.5991013365387556, -2.600834364869476, -2.6086411517189507, -2.5906825916098013, -2.61537661839238, -2.641514937143692, -2.601861498226746, -2.5949058545324375}
N
{-3.354059891478468, -3.2832966920259903, -3.419320450552461, -3.3019175192409316, -3.3236482158073555, -3.3469253892229447, -3.3741000421039833, -3.4766097631002304, -3.3420576363336436}
{-3.66257019729394, -3.6053714468937335, -3.6402274713517877, -3.6179908474620857, -3.602331791484575, -3.7464544478391013, -3.603205438111292, -3.6642257008721573, -3.771906714564691}
{-2.8432240228114223, -2.820071236471835, -2.825395350864659, -2.82919616175956, -2.758156473936662, -2.7982681381541723, -2.78408593934594, -2.8313418974580484, -2.7735341424767403}
E
{-2.4885309631475687, -2.5577392673152906, -2.543851713198561, -2.5132432156064755, -2.5007418085443107, -2.56227244208553, -2.5865544666216636, -2.5051215224816428, -0.48591311589854097}
{-3.103644778733538, -3.1678669850409524, -3.177790082489368, -3.2058143047659344, -3.105894905170684, -3.1851593983839583, -3.2062365578322134, -3.1461723739847134, -0.625110339102301}
{-2.9143593696760206, -2.9162261638072366, -2.9498495253380645, -2.938350259048477, -2.916318098065481, -2.9844740823296694, -2.9265757761155986, -2.9022576783741494, -0.5945049416605906}
Q
{-3.1700562485015285, -3.034600066287163, -3.1023420086122493, -3.0898131969035862, -3.0980979244625804, -3.1019097630900667, -3.152461381969194, -3.126845696701345, -3.123664687778032}
{-3.477836094094602, -3.495370551679405, -3.5174318938718603, -3.4297943262251103, -3.3629935542503846, -3.422667370745204, -3.5633991877108726, -3.542420826987954, -3.468632547353074}
{-3.4888302586023676, -3.387558696903026, -3.4346882209877414, -3.4335708847455777, -3.335949573155627, -3.3601670321041635, -3.3955328327906633, -3.3417601062662747, -3.349286410808423}
K
{-2.8237287730882206, -2.889666041564829, -2.7975821851770726, -2.8340043790348406, -2.795148379880011, -2.7932944809718196, -2.7879856183942264, -2.834320999773776, -2.9271584959921206}
{-3.031709646940863, -3.1324650579900366, -3.1714809132961035, -3.14735610427934, -3.0027106689354532, -3.1456805874101708, -3.0284760123658216, -3.0862742324036447, -3.1467325175909515}
{-2.915700751500222, -2.9892110565637253, -2.983889571578056,
R
{-2.814852975174252, -2.7687134311471664, -2.848188220555479, -2.819167311604373, -2.624495011187198, -2.84548023414239, -2.879954107536648, -2.784840942510406, -2.814780407675648}
{-3.1931706151822463, -3.233006287211914, -3.1497071137465427, -3.2226781108179394, -2.8569988577540597, -3.0681223530642963, -3.175982149474411, -3.074713410002569, -3.113646793005186}
{-3.11072003394357, -3.045025835670122, -3.04088505262742, -3.050578632489472, -2.960769860636315, -3.081021290674669, -3.018358154521595, -3.0861552796235694, -3.0131099884180315}
S
{-2.9951147990051963, -3.003884011056716, -2.9128285280435886, -2.924691479991474, -3.1038838615296243, -2.962147820714908, -2.9812454415877485, -2.960837715398914, -2.9851457536424704}
{-2.836193602067376, -2.921570128752026, -2.9173751363779266, -2.912296450850052, -2.849761190453829, -2.873439699446768, -2.8087669235002464, -2.804423080262657, -3.0097666625177943}
{-2.615347619220097, -2.5923543229921613, -2.6452432062221987, -2.6431603987604255, -2.714369447157838, -2.6902884784835726, -2.6172064966671504, -2.6486129257063293, -2.6458404780479032}
T
{-3.029198815784933, -3.093162595495242, -3.0524276172305362, -3.097565173707904, -3.077164714796115, -3.049463287717524, -3.0714923194355266, -3.0665637949431, -3.0292206838615563}
{-2.6219692009822966, -2.625123758306657, -2.607382822921181, -2.639057329615259, -2.6246964089617255, -2.7488548418927143, -2.574674357696366, -2.583035455650712, -2.513445724954685}
{-2.6832050946157318, -2.7268467920962345, -2.7657446421686824, -2.725482124187433, -2.8005262449756754, -2.771269872918017, -2.7506006680221606, -2.797684874454572, -2.720263758418016}
M
{-3.554730586940619, -3.595592948771173, -3.5707720734105544, -3.593585248622916, -3.54378424605761, -3.578086251442883, -3.3969147198701544, -3.5933602741424244, -3.46548453072584}
{-3.6481814598418407, -3.6147173093119713, -3.6970903332463307, -3.6230541494186324, -3.7928501154827083, -3.6352288127288768, -3.6660533417709558, -3.674642461730413, -3.7381956572223793}
{-3.8153521643704122, -4.034959855674767, -3.9975702067097854, -4.00345425815517, -4.002223735464476, -4.025699045631136, -3.98164725650042, -4.045142790720247, -3.9533539613146793}
C
{-4.445124974511194, -4.3725412306905, -4.3155436193758065, -4.495601352704478, -4.492114331676381, -4.219940137615278, -4.428587525863155, -4.473172797414169, -4.445420527760351}
{-3.998076716795194, -3.7030099164576495, -4.020877410340228, -3.824853513172158, -4.028416186795475, -4.053939147587061, -3.9811343884108514, -4.051718566575891, -4.053890765901834}
{-4.429218542055583, -4.325355633998145, -4.318890638310396,
P
{-3.7042623209115826, -3.8505889274597522, -3.835655230897529, -3.6227607377568476, -3.6381939305286846, -3.8066624897703196, -3.639476357041466, -3.6976893301935885, -3.660215202782459}
{-4.075308064731185, -3.697894815790879, -3.8772864907279723, -3.831084062922794, -3.681949419449267, -3.8783065789439037, -3.7273538676347515, -3.84551152479258, -3.7002507256582557}
{-2.4806985611578987, -2.525477040331585, -2.4951906032106055, -2.4479145909855355, -2.483937992686037, -2.4888736661607442, -2.4246905221809607, -2.4185685960431593, -2.4791805441919363}
AA
{-0.11054072845386553, -0.11706635967900694, -0.11332514642978274, -0.11092076257300289, -0.1166986485540919, -0.11973045594077908, -0.1108016260987283, -0.10249766133782619}
AB
{-5.346490056168674, -5.328140917500478, -5.46162244528284, -5.728870526518845, -5.480725725130163, -5.12163207006828, -5.4919462813120505, -5.24387821231999}
AC
{-2.3037328439698204, -2.247900397174975, -2.274065303672067, -2.2853387810301284, -2.244501261927349, -2.2361029366479035, -2.2949752918318995, -2.3844461379586543}
BA
{-4.836405907199637, -4.422132583420855, -4.369184104608444, -4.54954905146703, -4.437795194224776, -4.463412277092765, -4.420501048194697, -4.438279520044903}
BB
{-0.2621782929206016, -0.2877242087627532, -0.2967798696024034, -0.2829044909119928, -0.2748761486814421, -0.27357500335094714, -0.2528561743168481, -0.25958003993108614}
BC
{-1.5019717416971643, -1.435387946364244, -1.4100509835027826, -1.4446174859480463, -1.4761673326778244, -1.479191793799272, -1.5540399609202185, -1.528741796806578}
CA
{-2.5167040880021165, -2.5232766610609687, -2.4907521779154362, -2.448765055398181, -2.4746753348370905, -2.407647399054195, -2.4635584113721913, -2.421491994868105}
CB
{-2.129830220003835, -2.1765893157505847, -2.140378452053433, -2.2110780925162765, -2.153560061411043, -2.1543810882848766, -2.04379771254138, -2.090196646426426}
CC
{-0.2226220670503171, -0.21520531415033786, -0.2237161548539694, -0.2181344489957895, -0.22346925908864798, -0.23067407154660857, -0.24164784745068255, -0.2388307817197822}
Appendix B
There are our test model’s parameters of negative. The parameter nin are the probability of start in our model that are start to α-helix, β-sheet and Coil. The parameters NG are probability of amino acid Glycine in our test model. The first { } are probability of nine block in α-helix. Second { } are probability of nine block in β-sheet. Third { } are probability of nine block in Coil. NAA is every line of probability of α-helix to α-helix in our Model. NAB is α-helix to β-sheet. NAC is α-helix to Coil.
in {-2.1343466431956153, -0.8006154179037511, -0.8378825800382865}
NG
{-3.7680764957751296, -3.8365632757841213, -3.7475413667625226, -3.855301470932434, -3.4678994023300698, -3.477004589568837, -3.7213185843154126, -3.9077280811452653, -3.7292307496375035}
{-3.6490878839653975, -3.3375011327273745, -3.5036691134140905, -3.2416976747520474, -3.120620134834119, -3.245611981359237, -3.4764152394471757, -3.2147185887130454, -3.1174141988127175}
{-1.892917618914803, -1.9593774214036348, -1.879944679494974, -1.8998086748098095, -1.8355803103900716, -1.9991771782368006, -1.8320666253594147, -1.8503667830759811, -1.8438220272972863}
NA
{-2.7029868991456634, -2.725829626583667, -2.6176765345903084, -2.6231577896398015, -2.5899584758307808, -2.4349045111640697, -2.6621202641881796, -2.387902327400852, -2.515016451259371}
{-2.731255923941309, -3.3264104460332162, -2.774841337834309,
-2.9150395075435083, -2.711596304108961, -2.9771755066226895, -3.063937032783139, -3.19479455799314, -3.0532359731213066}
{-2.512351902061136, -2.4448234496725725, -2.5529630926243057, -2.436609784979061, -2.339732887468214, -2.6837357002189006, -2.6400141618378195, -2.5626639587729825, -2.6092043664655775}
NV
{-3.644207014062344, -3.259675901340038, -3.2085448660298352, -3.518829234311221, -3.0267741138230213, -3.2003723533036412, -3.119143181961194, -3.4112911948313744, -2.854988254006848}
{-2.2231032739062084, -2.1072955116560808, -2.349640985604412, -2.23807765140458, -2.0610859669905164, -2.2205062967142695, -2.0786703715392894, -2.1150748404382735, -2.096685566961451}
{-3.578947976830287, -3.4448450744571955, -3.5732063141769084, -3.7347968785886847, -3.5303354572309784, -3.646112160766017, -3.585065045887237, -3.762448901758444, -3.248671397561899}
NL
{-2.2198128067101828, -2.18649850981975, -2.6100136618447394, -2.007972150549568, -1.8369131536897667, -2.3008887397458673, -2.5527477070403926, -2.0249968337114836, -2.282311766701178}
{-1.9846361006535087, -2.1700612072058685, -2.2333565265809434, -2.0809344506408682, -2.0052155823865756, -2.4010409186762898, -2.0024299498154914, -2.2067832669277725, -2.1055513355937743}
{-3.210649308597397, -3.2746049386374447, -3.4570997248477773, -3.439612895485109, -3.326119915802287, -3.364418130158859,
{-3.59680477516776, -3.4896923319420097, -3.4870102833766925, -3.1270629705612185, -3.155766234014125, -3.0250194658257796, -3.0137826663033676, -3.0502778492940434, -2.999978564435442}
{-2.8047322838839177, -2.7367872333237955, -3.3012516926169977, -3.1191565016492473, -2.802652666793486, -3.218133752168109, -2.7813505127579585, -3.0911046327458687, -3.1260973213861782}
{-3.95138255926197, -4.484117923338996, -4.56922573268261, -4.277241658600288, -4.197774281080717, -4.324444255540822, -4.259814861307467, -4.156044434311225, -3.977283287694127}
NF
{-3.7250591106914386, -3.8244419152517763, -3.7475413667625226, -3.649449416728285, -3.561231342122289, -3.5335167998321793, -3.466788719180532, -3.4112911948313744, -3.3043475556722375}
{-2.903362887325545, -3.074279357845754, -3.2256489518740468, -3.1578710138299377, -3.465146106262429, -2.911026735548497, -3.221906940677393, -2.8343331650019046, -3.178309030043091}
{-4.209424050427457, -3.9157224477515276, -3.721927872295406, -3.9831037858056355, -4.26062218474038, -3.753132427842208, -3.968234148440028, -4.023619848661893, -3.966511190712216}
NY
{-4.20139855838626, -3.515894704336034, -3.771638918341583, -3.929409443086156, -3.676300671907076, -3.828981012726015, -3.3403045720714126, -3.1881476435171647, -3.8543938925915096}
{-2.3361108248651337, -2.4234433753575315, -2.3523400425735765, -2.4487699053277505, -2.5496103763116427, -2.101146388195005, -2.381007054769849, -2.321604591089828, -2.447591690819181}
{-3.1440689835158295, -3.265438971623365, -3.3350998901859863, -3.2465125686586918, -3.6940806284519976, -3.405803346321713, -3.3603312477496923, -3.2924452725127082, -3.3571338932177293}
NW
{-4.517735886598417, -4.63236461040415, -4.246532532881511, -4.520277774525683, -4.586512357704849, -4.4615035714695255, -3.6927452118713564, -3.805945386835323, -4.142075965043291}
{-2.7139526932538556, -3.693114505441148, -2.669274657862795, -3.1920750916008016, -3.188372370574786, -3.3441531817450083, -3.3352356259843963, -3.917197096701875, -3.6709247424296585}
{-4.47553363762511, -4.182642528754879, -4.647003433725294, -4.598289424895869, -4.8758078238306135, -4.664452146994343, -4.20410425429346, -4.205941405455848, -4.359553778821823}
NH
{-4.695417063835869, -4.947445657044045, -4.712622262806109, -4.968302497052643, -4.419458273041683, -4.655659585910484, -4.521437884427526, -4.349560833424304, -4.45223089334713}
{-3.9088847529276425, -3.733715481063388, -4.196816293974036, -3.9206378286676435, -4.501581149978647, -4.265310103270336, -4.522679128359122, -4.648565490082018, -4.959405793527106}
{-4.141678061895068, -4.515468453223073, -4.654383541022916, -4.649582719283419, -4.532218119440537, -3.8918981888299866, -4.199190239491031, -4.004425401405745, -4.4028037626156395}
ND
-2.617887009211354, -2.8210919835238712, -2.8861434217866435}
{-4.543763025363612, -4.4324028419989485, -4.5769635940979105, -3.9428257436430054, -4.4857496847619664, -4.294178087271188, -4.329487899328263, -4.278346321035529, -4.275391096530433}
{-2.9526637414994683, -2.8359342443290534, -2.723399042184279, -2.833069510902426, -2.7692376147625253, -2.7619746384756705, -2.885308455939618, -3.007098013169214, -2.9191921964316565}
NN
{-3.261656165477055, -3.777374404393791, -3.103184350372009, -3.1693227798511012, -3.185180119220418, -2.900267760853303, -3.0281714037554672, -3.170905837082658, -3.1447174100803537}
{-3.902240210208974, -3.5500136618004747, -3.7772066784797067, -3.4494593412487835, -4.1967595676501706, -3.383762319840054, -3.5115751111008033, -3.47894216577072, -3.4373098912481534}
{-3.2764508185933656, -3.250945964320798, -3.068934784958839, -3.187302451185607, -3.0774038118838902, -3.073363373228439, -3.242548212093309, -3.148474160898914, -3.2093836804888634}
NE
{-2.0117354537506174, -1.7928121009041982, -1.9617520645209712, -2.021577802605347, -2.1996975306830504, -2.213312550541279, -2.2583316024072677, -2.006153745910004, -0.48625711166978053}
{-3.9256918712440236, -3.4790304352202615, -3.351351614668493, -4.243411220930694, -3.7770177731853227, -3.8304703864822676, -4.069204801064597, -3.659652118670333, -0.6714534367149234}
{-3.4773257832830677, -3.4826693831245343, -3.7605656650008203, -3.7684907243751575, -3.703325686596049, -3.608040212816609,
-3.472304919299236, -3.5081538453394, -0.6660624724046332}
NQ
{-2.548836219318405, -3.273469223472374, -2.4712479008569606, -2.310783104597649, -2.9355254423578763, -2.91269028085186, -2.5572623873949194, -2.864175569660183, -2.372789351667294}
{-3.15589757201168, -2.8580165676237668, -2.8756304169595546, -2.8789995710603113, -3.2549157613513975, -2.944096415646105, -3.18825343563575, -2.9320801738978677, -3.10027092182628}
{-2.913545324903997, -3.0321283029537107, -3.13155304677675, -3.244665846065527, -3.4148699197149575, -3.1430780058437997, -3.421485670903023, -3.0663210930603606, -3.627491182012204}
NK
{-2.9176438365825543, -3.1074840859981125, -2.9208627935780545, -2.9220131626897077, -3.0460673167577, -2.8879976682614887, -2.8616748881059095, -2.670389582975529, -2.275415187642118}
{-3.4141885110915355, -2.9545933720432846, -2.877913522974123, -3.1038037925596615, -3.4427571113689504, -3.2753760832656904, -3.148756059041778, -3.268785809983321, -3.1275518670971727}
{-3.109255341211689, -2.8182763399736004, -2.979019182176397, -3.053771058561084, -2.987224169967019, -2.669021229864898, -2.6693049587588846, -2.6049108288577205, -2.9030327397660525}
NR
{-3.896909367618098, -3.345442723097463, -3.3661738102334184, -3.3675982645872975, -3.8635122139952225, -3.1756797407132695,
-3.9557291484789134, -3.6155303032942103, -3.5926975251520985, -3.4295463054556374, -3.8477876453297073, -3.69373942019583}
{-3.261852019172213, -3.4041977676830393, -3.392141828573005, -3.3434877197106525, -3.532943020638059, -3.49923735296781, -3.465221064410831, -3.2905813390746457, -3.1382713369607953}
NS
{-2.1967170919155334, -2.2926399704606477, -2.4131670628209916, -2.332355589851777, -2.469891812783259, -2.470411199620979, -2.0555277353301804, -2.691332756820772, -2.4393501181856334}
{-2.8757002695819884, -2.3854271015686894, -2.7463841330202734, -2.4430310086587324, -2.625695668097685, -2.5590849058888976, -2.5066838084182477, -2.427105941900341, -2.4085411759473083}
{-1.8316968072755546, -1.9153770921411974, -1.8744147114855128, -1.8400894401081873, -1.933476327003738, -1.7749990846152504, -1.9525532204295188, -1.977678976712101, -1.885731259361257}
NT
{-2.5751535276357784, -2.6522955425375176, -2.6370946204474097, -2.8997900259049976, -2.760009940032921, -2.4157100639079223, -2.779275356338843, -3.0888926854218233, -3.0142645216829185}
{-2.4769798805556995, -2.3028492588917646, -2.4368974306016398, -2.139910780243165, -2.3659050844708096, -1.9647595989740778, -2.38357775027295, -2.1486209629294772, -2.322298415780926}
{-2.576890423198707, -2.5497378354992204, -2.5529630926243057, -2.5405093799972125, -2.5149538227125925, -2.6952037158105417, -2.6799774186496568, -2.7797557153086547, -2.644755350729896}
NM
{-4.695417063835869, -4.746774961581894, -4.3941685316875745, -4.440235066852146, -4.394140465057393, -3.9103266521799678, -4.554227707250517, -3.9818360532989874, -4.45223089334713}
{-3.5145929454176037, -4.3023497137507505, -3.6556853207127165, -4.184570720907761, -3.8031289171890084, -4.377014092850337, -4.347670218411453, -4.291890546143286, -4.4341394856063205}
{-5.370707446058343, -4.871233892778964, -4.669309191239592, -4.695744761046582, -5.3065907399230685, -5.065793537918645, -5.474258965500698, -5.402192163687873, -5.523763349975746}
NC
{-4.877738620629824, -4.9851859850268925, -4.811062335619362, -4.736500882995319, -4.3694478524670215, -4.729767558064205, -4.371906150456562, -4.219507705176107, -4.3933903933241965}
{-3.382185780005362, -3.969367882069306, -2.854196996356807, -3.603610021076042, -2.7560884356522077, -3.9446415318222487, -3.0613989603546683, -3.331148051698297, -2.9942024415371136}
{-4.921439715291785, -4.9970032800679975, -4.974690840790775, -5.13321260024092, -5.124269183129114, -5.47125864602681, -5.110590986070995, -5.465705569410199, -5.426913523985828}
NP
{-3.8722167550277264, -3.939217429844205, -3.583238315471246, -3.899104093590827, -4.039968651336779, -4.159222699596592, -3.7965420055530004, -3.9077280811452653, -3.805603728422078}
{-4.649822597323936, -4.405003867810834, -4.8238236720294365,
{-2.414554158785009, -2.323921676803534, -2.2110707885337533, -2.1320075249455743, -2.0864849025996675, -2.2153011462540766, -2.059124075994761, -2.169261723114093, -2.2317000733550563}
NAA
{-0.23591511699369727, -0.2436039435489243, -0.22679883445058427, -0.1761116673660147, -0.23603893703254122, -0.21890805154735504, -0.16804306242797137, -0.18074460857812283}
NAB
{-5.388564244395814, -5.065228692700429, -5.539300835990577, -4.669809508496646, -4.750815408996125, -4.9433416583622645, -5.652839995918626, -5.294022442265156}
NAC
{-1.581901754625495, -1.5611739255985657, -1.6145026390737085, -1.8832065428820537, -1.6014427898948982, -1.663505133704376, -1.8893169988089242, -1.8305211772668457}
NBA
{-5.407974608192878, -5.23091053821672, -5.644804224099267, -5.437333689403129, -5.627149248635285, -5.5659490198117325, -5.469485404159227, -4.251796088941408}
NBB
{-0.2131952068851571, -0.22316005963853275, -0.20057783931411463, -0.17775715117152283, -0.18324233456202382, -0.21288909056696878, -0.23928101462870244, -0.229803120363933}
NBC
{-1.673864979429363, -1.6364774395799315, -1.7248130490219435, -1.8419802933000162, -1.8088966255017969, -1.671694890259359,
-1.567370476955777, -1.6551085303651627}
NCA
{-3.1408535466618552, -3.353114138879651, -3.53863497011182, -3.5585176362506927, -3.6942331953910377, -3.4249948958292373, -3.7907567115684886, -3.9565251763062794}
NCB
{-1.5544723464677317, -1.4354887036629198, -1.4441374379145768, -1.39351252440717, -1.3578692576359994, -1.5683979071058747, -1.5773766940099843, -1.6110333069389011}
NCC
{-0.2937628115910918, -0.31879343906007923, -0.3078881377220238, -0.32390765906069285, -0.3313898269104925, -0.27565891360889677, -0.2601896797935745, -0.24693770778135096}
Appendix C
We use NetsurfP to judge the interaction sites are exposed on interface.
1AQD_G
# Column 1: Class assignment - B for buried or E for Exposed - Threshold: 25%
exposure, but not based on RSA
# Column 2: Amino acid
# Column 3: Sequence name
# Column 4: Amino acid number
# Column 5: Relative Surface Accessibility - RSA
# Column 6: Absolute Surface Accessibility
# Column 7: Z-fit score
E I 1AQD_G_PDBID_CHAIN_SEQUENCE 1 0.568 105.098 -0.926 E K 1AQD_G_PDBID_CHAIN_SEQUENCE 2 0.561 115.398 0.691 E E 1AQD_G_PDBID_CHAIN_SEQUENCE 3 0.404 70.596 -0.524 E E 1AQD_G_PDBID_CHAIN_SEQUENCE 4 0.498 87.018 -0.492 B H 1AQD_G_PDBID_CHAIN_SEQUENCE 5 0.190 34.616 0.483 E V 1AQD_G_PDBID_CHAIN_SEQUENCE 6 0.267 41.038 0.406 B I 1AQD_G_PDBID_CHAIN_SEQUENCE 7 0.122 22.589 1.154 B I 1AQD_G_PDBID_CHAIN_SEQUENCE 8 0.153 28.286 0.235 B Q 1AQD_G_PDBID_CHAIN_SEQUENCE 9 0.174 31.130 0.110 B A 1AQD_G_PDBID_CHAIN_SEQUENCE 10 0.037 4.110 -0.211 B E 1AQD_G_PDBID_CHAIN_SEQUENCE 11 0.055 9.626 0.326 B F 1AQD_G_PDBID_CHAIN_SEQUENCE 12 0.027 5.519 -0.436 B Y 1AQD_G_PDBID_CHAIN_SEQUENCE 13 0.031 6.689 -0.352 B L 1AQD_G_PDBID_CHAIN_SEQUENCE 14 0.049 8.990 -1.792
B N 1AQD_G_PDBID_CHAIN_SEQUENCE 15 0.191 27.933 -1.104 E P 1AQD_G_PDBID_CHAIN_SEQUENCE 16 0.391 55.455 -1.495 E D 1AQD_G_PDBID_CHAIN_SEQUENCE 17 0.324 46.674 -0.616 E Q 1AQD_G_PDBID_CHAIN_SEQUENCE 18 0.544 97.087 -2.241 E S 1AQD_G_PDBID_CHAIN_SEQUENCE 19 0.599 70.215 -0.314 B G 1AQD_G_PDBID_CHAIN_SEQUENCE 20 0.166 13.048 -0.763 B E 1AQD_G_PDBID_CHAIN_SEQUENCE 21 0.178 31.149 0.284 B F 1AQD_G_PDBID_CHAIN_SEQUENCE 22 0.218 43.733 -0.125 B M 1AQD_G_PDBID_CHAIN_SEQUENCE 23 0.148 29.555 0.941 B F 1AQD_G_PDBID_CHAIN_SEQUENCE 24 0.098 19.608 0.594 B D 1AQD_G_PDBID_CHAIN_SEQUENCE 25 0.070 10.130 -0.914 B F 1AQD_G_PDBID_CHAIN_SEQUENCE 26 0.118 23.642 0.239 E D 1AQD_G_PDBID_CHAIN_SEQUENCE 27 0.292 42.048 0.424 E G 1AQD_G_PDBID_CHAIN_SEQUENCE 28 0.376 29.623 -0.857 E D 1AQD_G_PDBID_CHAIN_SEQUENCE 29 0.427 61.531 0.222 B E 1AQD_G_PDBID_CHAIN_SEQUENCE 30 0.126 22.047 0.353 B I 1AQD_G_PDBID_CHAIN_SEQUENCE 31 0.060 11.100 1.170 B F 1AQD_G_PDBID_CHAIN_SEQUENCE 32 0.037 7.346 0.359 B H 1AQD_G_PDBID_CHAIN_SEQUENCE 33 0.094 17.153 0.940 B V 1AQD_G_PDBID_CHAIN_SEQUENCE 34 0.045 6.993 0.725 B D 1AQD_G_PDBID_CHAIN_SEQUENCE 35 0.197 28.359 0.357 E M 1AQD_G_PDBID_CHAIN_SEQUENCE 36 0.287 57.429 -0.485 E A 1AQD_G_PDBID_CHAIN_SEQUENCE 37 0.626 68.974 0.088 E K 1AQD_G_PDBID_CHAIN_SEQUENCE 38 0.520 107.046 0.274
B T 1AQD_G_PDBID_CHAIN_SEQUENCE 41 0.145 20.139 0.060 B V 1AQD_G_PDBID_CHAIN_SEQUENCE 42 0.175 26.836 -0.453 B W 1AQD_G_PDBID_CHAIN_SEQUENCE 43 0.156 37.494 -0.476 E R 1AQD_G_PDBID_CHAIN_SEQUENCE 44 0.306 70.074 -0.660 B L 1AQD_G_PDBID_CHAIN_SEQUENCE 45 0.178 32.537 -0.067 E E 1AQD_G_PDBID_CHAIN_SEQUENCE 46 0.456 79.733 -0.441 E E 1AQD_G_PDBID_CHAIN_SEQUENCE 47 0.490 85.551 -0.109 B F 1AQD_G_PDBID_CHAIN_SEQUENCE 48 0.279 56.056 -0.714 B G 1AQD_G_PDBID_CHAIN_SEQUENCE 49 0.279 21.973 -0.697 E R 1AQD_G_PDBID_CHAIN_SEQUENCE 50 0.532 121.736 0.178 E F 1AQD_G_PDBID_CHAIN_SEQUENCE 51 0.286 57.320 0.114 E A 1AQD_G_PDBID_CHAIN_SEQUENCE 52 0.306 33.677 -0.990 E S 1AQD_G_PDBID_CHAIN_SEQUENCE 53 0.480 56.256 -0.712 B F 1AQD_G_PDBID_CHAIN_SEQUENCE 54 0.289 58.022 -0.062 E E 1AQD_G_PDBID_CHAIN_SEQUENCE 55 0.458 79.943 0.522 E A 1AQD_G_PDBID_CHAIN_SEQUENCE 56 0.442 48.763 -0.151 B Q 1AQD_G_PDBID_CHAIN_SEQUENCE 57 0.249 44.489 -0.699 E G 1AQD_G_PDBID_CHAIN_SEQUENCE 58 0.345 27.120 -0.492 E A 1AQD_G_PDBID_CHAIN_SEQUENCE 59 0.513 56.500 -0.108 B L 1AQD_G_PDBID_CHAIN_SEQUENCE 60 0.252 46.141 -0.601 E A 1AQD_G_PDBID_CHAIN_SEQUENCE 61 0.327 36.079 -0.061 E N 1AQD_G_PDBID_CHAIN_SEQUENCE 62 0.412 60.361 0.415 E I 1AQD_G_PDBID_CHAIN_SEQUENCE 63 0.300 55.463 0.332 B A 1AQD_G_PDBID_CHAIN_SEQUENCE 64 0.277 30.514 -0.012 B V 1AQD_G_PDBID_CHAIN_SEQUENCE 65 0.248 38.148 0.529 B D 1AQD_G_PDBID_CHAIN_SEQUENCE 66 0.148 21.298 0.300
E K 1AQD_G_PDBID_CHAIN_SEQUENCE 67 0.455 93.511 0.300 E A 1AQD_G_PDBID_CHAIN_SEQUENCE 68 0.345 38.019 -0.330 B N 1AQD_G_PDBID_CHAIN_SEQUENCE 69 0.151 22.048 -0.088 B L 1AQD_G_PDBID_CHAIN_SEQUENCE 70 0.165 30.175 -0.526 E E 1AQD_G_PDBID_CHAIN_SEQUENCE 71 0.374 65.390 -0.637 E I 1AQD_G_PDBID_CHAIN_SEQUENCE 72 0.302 55.851 -0.489 B M 1AQD_G_PDBID_CHAIN_SEQUENCE 73 0.210 42.101 -0.541 E T 1AQD_G_PDBID_CHAIN_SEQUENCE 74 0.346 48.046 -1.328 E K 1AQD_G_PDBID_CHAIN_SEQUENCE 75 0.329 67.675 -1.216 E R 1AQD_G_PDBID_CHAIN_SEQUENCE 76 0.331 75.707 -1.115 E S 1AQD_G_PDBID_CHAIN_SEQUENCE 77 0.339 39.743 -1.116 E N 1AQD_G_PDBID_CHAIN_SEQUENCE 78 0.565 82.657 -1.349 E Y 1AQD_G_PDBID_CHAIN_SEQUENCE 79 0.462 98.623 -1.128 E T 1AQD_G_PDBID_CHAIN_SEQUENCE 80 0.368 51.028 -0.681 E P 1AQD_G_PDBID_CHAIN_SEQUENCE 81 0.316 44.840 -1.182 E I 1AQD_G_PDBID_CHAIN_SEQUENCE 82 0.540 99.900 -1.110 E T 1AQD_G_PDBID_CHAIN_SEQUENCE 83 0.494 68.559 -0.764 E N 1AQD_G_PDBID_CHAIN_SEQUENCE 84 0.417 61.078 -1.245 E V 1AQD_G_PDBID_CHAIN_SEQUENCE 85 0.352 54.179 -1.225 E P 1AQD_G_PDBID_CHAIN_SEQUENCE 86 0.351 49.878 0.182 B P 1AQD_G_PDBID_CHAIN_SEQUENCE 87 0.064 9.039 -1.751 E E 1AQD_G_PDBID_CHAIN_SEQUENCE 88 0.371 64.814 0.566 B V 1AQD_G_PDBID_CHAIN_SEQUENCE 89 0.041 6.302 -1.119 E T 1AQD_G_PDBID_CHAIN_SEQUENCE 90 0.240 33.302 0.686
B T 1AQD_G_PDBID_CHAIN_SEQUENCE 93 0.165 22.886 -1.707 B N 1AQD_G_PDBID_CHAIN_SEQUENCE 94 0.279 40.904 -0.282 E S 1AQD_G_PDBID_CHAIN_SEQUENCE 95 0.490 57.416 -1.351 E P 1AQD_G_PDBID_CHAIN_SEQUENCE 96 0.440 62.393 -1.737 E V 1AQD_G_PDBID_CHAIN_SEQUENCE 97 0.397 60.973 -2.075 E E 1AQD_G_PDBID_CHAIN_SEQUENCE 98 0.479 83.699 -1.730 E L 1AQD_G_PDBID_CHAIN_SEQUENCE 99 0.478 87.522 -2.367 E R 1AQD_G_PDBID_CHAIN_SEQUENCE 100 0.665 152.239 -1.934 E E 1AQD_G_PDBID_CHAIN_SEQUENCE 101 0.438 76.466 -0.756 E P 1AQD_G_PDBID_CHAIN_SEQUENCE 102 0.381 54.106 0.615 B N 1AQD_G_PDBID_CHAIN_SEQUENCE 103 0.052 7.613 -0.337 B V 1AQD_G_PDBID_CHAIN_SEQUENCE 104 0.126 19.366 0.703 B L 1AQD_G_PDBID_CHAIN_SEQUENCE 105 0.017 3.076 1.348 B I 1AQD_G_PDBID_CHAIN_SEQUENCE 106 0.050 9.158 1.027 B C 1AQD_G_PDBID_CHAIN_SEQUENCE 107 0.015 2.148 1.384 B F 1AQD_G_PDBID_CHAIN_SEQUENCE 108 0.092 18.545 0.521 B I 1AQD_G_PDBID_CHAIN_SEQUENCE 109 0.023 4.274 0.166 B D 1AQD_G_PDBID_CHAIN_SEQUENCE 110 0.230 33.143 -0.284 E K 1AQD_G_PDBID_CHAIN_SEQUENCE 111 0.444 91.310 -0.934 B F 1AQD_G_PDBID_CHAIN_SEQUENCE 112 0.148 29.643 -1.724 E T 1AQD_G_PDBID_CHAIN_SEQUENCE 113 0.281 39.002 -0.083 B P 1AQD_G_PDBID_CHAIN_SEQUENCE 114 0.154 21.909 -0.587 E P 1AQD_G_PDBID_CHAIN_SEQUENCE 115 0.455 64.550 -0.774 E V 1AQD_G_PDBID_CHAIN_SEQUENCE 116 0.416 64.001 -0.323 B V 1AQD_G_PDBID_CHAIN_SEQUENCE 117 0.029 4.488 0.071 B N 1AQD_G_PDBID_CHAIN_SEQUENCE 118 0.248 36.307 0.809
B V 1AQD_G_PDBID_CHAIN_SEQUENCE 119 0.027 4.211 0.625 B T 1AQD_G_PDBID_CHAIN_SEQUENCE 120 0.177 24.522 1.637 B W 1AQD_G_PDBID_CHAIN_SEQUENCE 121 0.064 15.392 0.758 B L 1AQD_G_PDBID_CHAIN_SEQUENCE 122 0.245 44.805 0.756 B R 1AQD_G_PDBID_CHAIN_SEQUENCE 123 0.210 48.067 0.172 E N 1AQD_G_PDBID_CHAIN_SEQUENCE 124 0.578 84.634 -0.721 E G 1AQD_G_PDBID_CHAIN_SEQUENCE 125 0.665 52.359 -1.685 E K 1AQD_G_PDBID_CHAIN_SEQUENCE 126 0.572 117.578 0.314 E P 1AQD_G_PDBID_CHAIN_SEQUENCE 127 0.590 83.749 0.112 B V 1AQD_G_PDBID_CHAIN_SEQUENCE 128 0.173 26.544 0.841 E T 1AQD_G_PDBID_CHAIN_SEQUENCE 129 0.486 67.408 -0.202 E T 1AQD_G_PDBID_CHAIN_SEQUENCE 130 0.647 89.767 -0.242 E G 1AQD_G_PDBID_CHAIN_SEQUENCE 131 0.676 53.162 -1.606 E V 1AQD_G_PDBID_CHAIN_SEQUENCE 132 0.294 45.188 -0.344 E S 1AQD_G_PDBID_CHAIN_SEQUENCE 133 0.502 58.834 -0.761 E E 1AQD_G_PDBID_CHAIN_SEQUENCE 134 0.433 75.610 -0.873 E T 1AQD_G_PDBID_CHAIN_SEQUENCE 135 0.343 47.616 -1.846 E V 1AQD_G_PDBID_CHAIN_SEQUENCE 136 0.526 80.908 -1.370 E F 1AQD_G_PDBID_CHAIN_SEQUENCE 137 0.446 89.452 -0.495 E L 1AQD_G_PDBID_CHAIN_SEQUENCE 138 0.321 58.738 -0.201 E P 1AQD_G_PDBID_CHAIN_SEQUENCE 139 0.438 62.209 -1.022 E R 1AQD_G_PDBID_CHAIN_SEQUENCE 140 0.512 117.362 -1.107 E E 1AQD_G_PDBID_CHAIN_SEQUENCE 141 0.648 113.241 -1.892 E D 1AQD_G_PDBID_CHAIN_SEQUENCE 142 0.654 94.184 -1.518
B F 1AQD_G_PDBID_CHAIN_SEQUENCE 145 0.052 10.336 0.488 B R 1AQD_G_PDBID_CHAIN_SEQUENCE 146 0.080 18.343 0.388 B K 1AQD_G_PDBID_CHAIN_SEQUENCE 147 0.045 9.236 -0.007 B F 1AQD_G_PDBID_CHAIN_SEQUENCE 148 0.097 19.528 0.180 B H 1AQD_G_PDBID_CHAIN_SEQUENCE 149 0.030 5.512 -0.457 B Y 1AQD_G_PDBID_CHAIN_SEQUENCE 150 0.112 23.999 0.231 B L 1AQD_G_PDBID_CHAIN_SEQUENCE 151 0.031 5.658 0.005 E P 1AQD_G_PDBID_CHAIN_SEQUENCE 152 0.307 43.606 0.628 B F 1AQD_G_PDBID_CHAIN_SEQUENCE 153 0.069 13.888 0.524 E L 1AQD_G_PDBID_CHAIN_SEQUENCE 154 0.323 59.123 0.494 E P 1AQD_G_PDBID_CHAIN_SEQUENCE 155 0.380 53.936 -0.491 E S 1AQD_G_PDBID_CHAIN_SEQUENCE 156 0.676 79.192 -0.487 E T 1AQD_G_PDBID_CHAIN_SEQUENCE 157 0.612 84.857 -0.349 E E 1AQD_G_PDBID_CHAIN_SEQUENCE 158 0.629 109.799 -0.804 E D 1AQD_G_PDBID_CHAIN_SEQUENCE 159 0.371 53.476 -0.041 E V 1AQD_G_PDBID_CHAIN_SEQUENCE 160 0.437 67.152 1.564 B Y 1AQD_G_PDBID_CHAIN_SEQUENCE 161 0.055 11.668 1.012 B D 1AQD_G_PDBID_CHAIN_SEQUENCE 162 0.208 29.915 1.183 B C 1AQD_G_PDBID_CHAIN_SEQUENCE 163 0.013 1.881 1.454 B R 1AQD_G_PDBID_CHAIN_SEQUENCE 164 0.190 43.487 1.410 B V 1AQD_G_PDBID_CHAIN_SEQUENCE 165 0.026 4.042 0.713 E E 1AQD_G_PDBID_CHAIN_SEQUENCE 166 0.343 59.887 0.827 B H 1AQD_G_PDBID_CHAIN_SEQUENCE 167 0.071 12.860 -0.089 E W 1AQD_G_PDBID_CHAIN_SEQUENCE 168 0.485 116.594 -0.152 E G 1AQD_G_PDBID_CHAIN_SEQUENCE 169 0.424 33.337 -1.154 B L 1AQD_G_PDBID_CHAIN_SEQUENCE 170 0.233 42.571 -0.073