First, firing rate of the retina is consistent with Weber’s law. Second, the retina can extract information form the hidden variable in the stimulus and make prediction. In the future, stimuli with higher order hidden variables will be tested on the retina to see the influence of the hidden variables on the retina’s prediction. We are also curious about the limit of the prediction power in the retina.
Third, the 2-peak in the mutual information seems to come from the ON/OFF pathways which indicate the differentiating and cooperating encoding strategy. In the future, differ-ent cell types need to be classified by the ON/OFF test and STA (mdiffer-entioned in Appendix A) or spike triggered covariance (STC) [42], pharmacological test and so on.
Finally, the results from periodic stimuli shows that the neuronal latency changes with different stimulation which means that the latency is also an encoding method. As a result, different encoding strategies (e.g. latency, spike time and so on) will be considered in the future and the encoding information will be compared. The final goal is to understand the strategies for a retina to encode light intensity.
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Appendix A
Pretest Response
Before the experiments, three pretest experiments were done to test activities of the retina. First, the spontaneous firing baseline of the retina was recorded under dark envi-ronment. Next, to test the ON/OFF types of the ganglion cells, a square wave stimulus was given (Fig. A.1a). Finally, a uniformly random intensity stimuli was given to test the intensity spike trigger average (iSTA) and each intensity last for 50ms (Fig. A.1b). Each pretest was done once lasting for 3 minutes.
Figure A.1: The stimulation for the pretest. (a)The ON/OFF stimulus. (b)The random stimulus.