In addition to ODI, other variable such as heart rate variability (HRV) for quantizing sympathetic tone was also suggested as a useful parameter in the evaluation of OSA. Future work will test this parameter to verify if it is a valuable parameter. It will be accompanied with ODI for constructing a predictive model for OSA diagnosis if it has been verified as an effective parameter.
In previous section, we have demonstrated that the variables, such as age, ODI, and AHI, obtained from subjects without enough sleeping time is significantly different from those whose sleeping time is more than 4 hours. The former group tends to be more severe than the latter group.
More PSG tests are needed to confirm if the test with sleeping less than 4 hours is valid for OSA diagnosis.
Based on the cost-benefit analysis, we suggest that home-styled oximetry alone can be used for sifting severe patients which will be followed by PSG to discriminate normal, mild, and moderate subjects with a total cost down of 35.72%. More large scale experiment and rigorous analysis are needed to see the proportion of normal subjects will be incorrectly diagnosed as severe.
Bibliographies
Al-Delaimy, W.K., Manson, J.E., Willette, W.C., Stampfer, M.J., Hu, F.B. Snoring as a risk factor for type II diabetes mellitus: a prospective study. Am J Epidemiol 2002;155:387-393.
Arias, M.A., Garcia-Rio, F., Alonso-Fernandez, A., Mediano, I., Martinez, O., Villamor, J. Obstructive sleep apnea syndrome affects left ventricular diastolic function: effect of nasal continuous positive airway pressure in men. Circulation 2005;112:375-383.
Atwood, C.W., McCroy, D., Garcia, J.G.N., Abman, S.H., Aheam, G.S. Pulmonary artery hypertension and sleep-disordered breathing: ACCP evidence-based clinical practice guidelines. Chest 2004;126:72-77.
Baltzan, M.A., Verschelden, P., Al-Jahdali, H., et al. Accuracy of oximetry with thermistor (OxiFlow) for diagnosis of obstructive sleep apnea and hypopnea.
Sleep 2000;23:61–69.
Barnes, M., Houston, D., Worsnop, C.J., et al. A randomized controlled trial of continuous positive airway pressure in mild obstructive sleep apnea. Am J Respir Crit Med 2002; 165: 773-780.
Basner, R.C. Continuous positive airway pressure for obstructive sleep apnea. N Engl J Med 2007;356:1751-1758.
Bloch, K.E. Alternatives to CPAP in the treatment of the obstructive sleep apnoea syndrome. Swiss Med Wkly 2006;136:261-267.
Bradley, T.D., Floras, J.S. Sleep apnea and heart failure: Part I: obstructive sleep apnea. Circulation 2003;107:1671-1678.
Brouillette, R.T., Morielli, A., Leimanis, A., Waters, K.A., Luciano, R., Ducharme, F.M. Nocturnal pulse oximetry as an abbreviated testing modality for pediatric obstructive sleep apnea. Pediatrics 2000;105:405-412.
Brown, M. P. S., Grundy, W. N., Lin, D., Cristianini, N., Sugnet, C., Furey, T. S., Ares, J. M., et al. (2000). Knowledge-based analysis of microarray gene expression data using support vector machines. PNAS, 97(1), 262–267.
Caples, S.M., Gami, A.S., Somers, V.K. Obstructive sleep apnea. Ann Intern Med 2005;142:187-197.
Castronovo, V., Zucconi, M., Nosetti, L., et al. Prevalence of habitual snoring and sleep disordered breathing in pre-school-aged children in an Italian community. J Pediatr 2003;142: 377-382.
Chervin, R.D., Aldrich., M.S. The Epworth Sleepiness Scale may not reflect objective measurements of sleepiness or sleep apnea. Neurology 1999;52:125–131.
Chesson, A.L., Berry, R.B., Pack, A. Practice parameters for the use of portable monitoring devices in the investigation of suspected obstructive sleep apnea in adults. Sleep 2003;26:907-913.
Choi, S., Bennett, L.S., Mullins, R., et al. Which derivative from overnight oximetry best predicts symptomatic response to nasal continuous positive airway pressure in patients with obstructive sleep apnea? Respir Med 2000;94:895-899.
Coffee, J.C. Is chronic hyperventilation syndrome a risk factor for sleep apnea? Part 1, Journal of Bodywork and Movement Therapies 2006; 10: 134-146.
Cristianini, N., Shawe-Taylor, J. An Introduction to Support Vector Machines and Other Kernel-Based Methods. Cambridge University Press, Cambridge UK (2000).
De La Eva, R.C.,. Baur, L.A., Donaghue, K.C., Waters, K.A. Metabolic correlates with obstructive sleep apnea in obese subjects. J Pediatr 2002;140:654-659.
DeCoste, D., & Schuolkopf, B. (2002). Training invariant support vector machines. .
Machine Learning, 46, 161-190.
Devouassoux, G., Levy, P., Rossini, E., Pin, I., Fior-Gozlan, M., Henry, M., Seigneurin, D., Pepin, J-L. Sleep apnea is associated with bronchial imflammation and continuous positive airway pressure-induced airway hyperresponsiveness, J Allergy Clin Immunol 2007; 119: 597-603.
Dixon, J.B. , Schachter, L.M., O’Brien., P.E. Predicting sleep apnea and excessive day sleepness in the severely obese: Indicators for polysomnography. Chest 2003;
123:1134-1141.
El Solh, A.A., Aldik, Z., Alnabhan, M., Grant, B. Predicting effective continuous positive airway pressure in sleep apnea using an artificial neural network. Sleep Med 2007;8:471-477.
Eom, J. H., Kim, S. C., & Zhang, B. T. (2008). AptaCDSS-E: A classifier ensemble-based clinical decision support system for cardiovascular disease level prediction. Expert Systems with Applications, 34(4), 2465-2479.
Fleisher, K.E., Krieger., A.C. Current trends in the treatment of obstructive sleep apnea. J Oral Maxillofac Surg 2007;65:2056-2068.
Flemons, W.W., Littner, M. R. , Rowley, J. A., Gay, P. , Anderson, W. M. , Hudgel, D.W., McEvoy, R. D., and Loube, D. I., Home diagnosis of sleep apnea: A systematic review of the literature, Chest 2003; 124:1543-1579.
Flemons, W.W., Douglas, N.J., Kuna, S.T., Rodenstein, D.O., Wheatley, J. Access to diagnosis and treatment of patients with suspected sleep apnea. Am J Respir Crit Care Med 2004;169:668-672.
Flemons, W.W. Obstructive sleep apnea. N Engl J Med 2002;347:498-504.
Flint, J., Kothare, S.V., Zihlif, M., Suarez, E., Adams, R., Legido, A., De Luca., F.
Association between inadequate sleep and insulin resistance in obese children. J Pediatr 2007;150:364-369.
Freire, A.O., Sugai, G.C., Chrispin, F.S. , Togeiro, S.M. , Yamamura, Y., Mello, L.E. , Tufik., S. Treatment of moderate obstructive sleep apnea syndrome withacupuncture: A randomised, placebo-controlled pilot trial. Sleep Med 2007;8:43-50.
Gami, A.S., Pressman, G., Caples, S.M., Kanagala, R., Gard, J.J., Davison, D.E.
Association of atrial fibrillation and obstructive sleep apnea. Circulation 2004;110:364-367.
Gami, A.S., Howard, D.E., Olson, E.J., Somers, V.K. Day-night pattern of sudden death in obstructive sleep apnea. N Engl J Med 2005;352:1206-1214.
Gjorup, P.H., Sadauskiene, L. J., Wessels, O. Nyvad, B. Strunge, E.B. Pedersen.
Abnormally increased endothelin-1 in plasma during the night in obstructive sleep apnea: relation to blood pressure and severity of disease. Am J Hypertension 2007; 20:44-52.
Goncalves, M.A., Paiva, T., Ramos, E. and Guilleminault, C. Obstructive Sleep Apnea Syndrome, Sleepiness, and Quality of Life, Chest 2004;125:2091-2096.
Gosselin, N., Mathieu, A., Mazza, S., Petit, D., Malo, J., Montplaisir, J. Attentional deficits in patients with obstructive sleep apnea syndrome: An event-related potential study, Clinical Neurophysiology 2006; 117:2228–2235.
Grebe, M., Eisele, H.J., Weissmann, N., Schaefer, C., Tillmanna, H., Seeger, W., et al.
Antioxidant vitamin C improves endothelial function in obstructive sleep apnea.
Am J. Respir Crit Care Med 2006; 173:897-901.
Guilleminault, C., Lee, J.H., Chan, A. Pediatric obstructive sleep apnean syndrome.
Arch Pediatr Adolesc Med 2005; 159: 775-785.
Hartenbaum, N., Collop, N., Rosen, I.M., Phillips, B., George, C.F. P., et al. Sleep Apnea and Commercial Motor Vehicle Operators: Statement from the joint task force of the American College of Chest Physicians, American College of Occupational and Environmental Medicine, and the National Sleep Foundation, JOEM 2006; 48: S4-S37.
Hunsaker, H., Riffenburgh, R.H. Snoring significance in patients undergoing home sleep studies, Otolary Head Neck Surg 2006; 134:756-760.
Huupponen, E., Saastamoinen, A., Eskelinen, V. Apnea patients show a frontopolar inter-hemispheric spindle frequency difference. Neuros Letter 2006;403:186-189.
Jankel, W.R., Niedermeyer, E. Sleep spindles. J Clin Neurophysiol 1985; 2:1-35.
Johns, M.W. A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep 1991; 14: 540-545.
Juan-Carlos, V., Willis, H.T., Flemons, W.W., et al. Automated analysis of digital oximetry in the diagnosis of obstructive sleep apnea. Thorax 2000;55:302-307.
Kao, Y.H., Shnayder, Y. K., Lee. The efficacy of anatomically based multilevel surgery for obstructive sleep apnea. Otolaryngol Head Neck Surg 2003;129:327-335.
Khoo, S.M., Tan, W.C., Ng, T.P., Ho, C.H. Risk factors associated with habitual snoring and sleep-disordered breathing in a multi-ethnic Asian population: a population-based study. Resp Med 2004;98: 557-566.
Kirby, S.D., Danter, W., George, C.F.P., Francovic, T., Ruby, R.R.F., Ferguson, K.A.
Neural network prediction of obstructive sleep apnea from clinical criteria. Chest 1999; 116:409-415.
Kirk, V.G., Bohn, S.G., Flemons, W.W., Remmers, J.E. Comparison of home oximetry monitoring with laboratory polysomnography in children. Chest 2003;
124:1702-1708.
Lam, J.C.M., Lam, B., Lam, C.L., Fong, D., Wang, J.K.L., Tse, H.F., Lam, K.S.L., Ip, M.S.M. Obstructive sleep apnea and the metabolic syndrome in community-based Chinese adults in Hong Kong, Respiratory Medicine 2006;
100: 980-987.
Lavie-Nevo, K. and Pillar, G.. Evening-morning differences in blood pressure in sleep apnea syndrome: effect of gender. Am J Hypertension 2006;19:1064-1069.
Lewis, C.A., Eaton, T.E., Fergusson, W., Whyte, K.F., Garrett, J.E., Kolbe, J. Home overnight pulse oximetry in patients with COPD: More than one recording may be needed. Chest 2003; 123:1127-1133.
Lin, C.C., Hsieh, W.Y., Chou, C.S., Liaw, S.F.. Cardiopulmonary exercise testing in obstructive sleep apnea syndrome, Respiratory Physiology & Neurobiology 2006;
150: 27-34.
Lindman, R., Stal, P.S. Abnormal palatopharyngeal muscle morphology in sleep-disordered breathing. J Neurol Sci. 2002;195:11–23.
Lu, L.R., Peat, J.K. Sullivan, C.E. Snoring in preschool children: prevalence and association with nocturnal cough and asthma. Chest 2003;124:587-593.
Lecun, Y., Jackel, L., Bottou, L., Brunot, A., Cortes, C., Denker, J., et al. (1995).
Comparison of learning algorithms for handwritten digit recognition. Paper
presented at the International Conference on Artificial Neural Networks.Luthje, L. and Andreas, S. Obstructive sleep apnea and coronary artery disease. Sleep Med Rev 2008; 12:19-31
Masa, J.F., Jimenez, A., Duran, J., et al. Alternative methods of titrating continuous positive airway pressure: A large multicenter study. Am J Resp Crit Care Med 2004;170:1218-1224.
Monasterio, C. Vidal, S. Duran, J., et al. Effectiveness of continuous positive airway pressure in mild sleep apnea-hypopnea syndrome. Am J Respir Crit Med 2001;164:939-943.
Montplaisir, J., Bedard, M.A., Richer, F., Rouleau,I. Neurobehavioral manifestations in obstructive sleep apnea syndrome before and after treatment with continuous positive airway pressure. Sleep 1992; 15: 517-519.
Mortimore, I. Douglas, N. Palatal muscle EMG response to negative pressure in awake sleep apneic and control subjects. Am J Respir Crit Care Med 1997;156:867-873.
Mulgrew, A.T., Fox, N., Ayas, N.T., Ryan, C.F. Diagnosis and initial management of obstructive sleep apnea without polysomnography-A randomized validation study. Ann Intern Med 2007;146:157-166.
Netzer, N., Eliasson, A.H., Netzer, C., Krisco, D.A. Overnight Pulse Oximetry for Sleep-Disordered Breathing in Adults-A Review. Chest 2001; 120:625-633.
Nieto, F.J., Herrington, D.M., Redline, S., Benjamin, E.J., Robbins, J.A. Sleep apnea and markers of vascular endothelial function in a large community sample of older adults. Am J. Respir Crit Care Med 2004;169:354-360.
Nuber, R., Varvrina, J., Karrer, W. Predictive value of nocturnal pulse oximetry in sleep apnea screening. Schweiz Med Wochenschr Suppl 2000;116:120S–122S.
Orth, M., Kotterba, S., Walther, J.W., Rasche, K., Schultze-Weringhaus, G., Duchna, H.W. Lomg-term compliance of CPAP therapy-update, predictor and interventions. Pneumologie 2006;60:480-484.
Pang, K.P., Terris, D.J., Podolsky, R. Severity of obstructive sleep apnea: Correlation with clinical examination and patient perception. Otolaryngology-Heah and Neck Surgery 2006;135:555-560.
Pang, K.P., Terris, D.J., Podolsky. R., Screening for obstructive sleep apnea: an evidence-based analysis. Am J Otolaryngology 2006;27:112-118.
Patel, S.R., White, D.P., Malhortra, A. et al. Continuous positive airway pressure therapy for treating sleepiness in a diverse population with obstructive sleep apnea 2003;163:565-571.
Peppard, P.E., Young, T., Palta, M. et al. Prospective study of the association between sleep-disordered breathing and hypertension. N Engl J Med 2000;342:1378-1384.
Phillips, B.G., Narkiewicz, K., Pesek, C.A., Haynes, W.G., Dyken, M.E., Somers, V.K.
Effects of obstructive sleep apnea on endothelin-1 and blood pressure. J Hypertens 1999;17:61-66.
Polat, K., & Gunes, S. (2007). Breast cancer diagnosis using least square support vector machine. Digital Signal Processing, 17(4), 694-701.
Rosen, C., Larkin, E., Kirchner, H. et al. Prevalence and risk factors for aleep-disordered breathing in 8-11-year-old children: association with race and prematurity. J Pediatr 2003;142: 383-389.
Russo, M.B. Normal Sleep, Sleep Physiology, and Sleep Deprivation: General Principles. Retrieved from http://www.emedicine.com/neuro/topic444.htm 2005.
Last Updated: April 6, 2005
Sangal, R.B., Sangal, J.M., Thorp, K. Atomoxetine improves sleepiness and global severity of illness but not the respiratory disturbance index in mild to moderate obstructive sleep apnea with sleepiness. Sleep Med 2008; 9:506-510
Schellenberg, J.B., Maislin, G., Schwab, R.J. Physical findings and the risk for obstructive sleep apnea: the importance of oropharyngeal structure. Am J Respir Crit Care Med 2000;162:740-748.
Schultz, R., Eisele, H.J., Weissmann, N., Seeger. W. Pulmonary hypertension and sleep-related breathing disorders. Pneumologie 2005;59:270-274.
Schulz, R., The vascular micromilieu in obstructive sleep apnea. Eur Respir J 2005;25:780-782.
Schulz, R., Schmidt, D., Blum, A., Lopes-Ribeiro, X., Lucke, C., Mayer, K. et al.
Decreased plasma levels of nitride oxide derivatives in obstructive sleep apnoea:
response to CPAP therapy. Thorax 2000;55:1046-1051.
Schwab, R., Pack, A., Gupta, K. et al. Upper airway and soft tissue structure changes induced by CPAP in normal subjects. Am J Respir Crit Care Med 1996;154:1106-1116.
Schwab, R., Pasirstein, M., Pierson, R. et al. Identification of upper airway anatomical risk factors for obstructive sleep apnea with volumetric magnetic resonance imaging. Am J Respir Crit Care Med 2003; 168:522-530.
Series, F., Mare, I. Nasal pressure recording in the diagnosis of sleep apnea- hypopnea syndrome. Thorax 1999; 54:506–510.
Shahar, E., Whitney, C.W., Redline, S. et al. Sleep-disordered breathing and cardiovascular disease: cross-sectional results of he sleep heart study. Am J Respir Crit Care Med 2001;163:19-25.
Shin, C., Joo, S., Kim, J., Kim, T. Prevalence and correlates of habitual snoring in high school students. Chest 2003;124:1709-1715.
Shinji, T., Takeshi, M., Yoshinosuke, F. Clinical significance of nocturnal oximeter monitoring for detection of sleep apnea syndrome in the elderly. Sleep Med 2002;3:67-71.
Shinohara, E., Kihara, S., Yamashita, S., Nishida, M., Arai, T. et al. Viseral fat accumulation as an important risk factor for obstructive sleep apnea syndrome in obese subjects, J Intern Med 1997;241:11-18.
Shivalkar, B., Van De Heyning, C., Kerremans, M., Rinkevich, D., Verbraecken, J., De Backer, W., Vrints. C. Obstructive sleep apnea syndrome-more insights on structural and functional cardiac aletrations, and the effects of treament with continuous positive airway pressure. J Am Coll Cardiol 2006;47:1433-1439.
Steriade. M., Basic mechanisms of sleep generation. Neurology 1992;42:9-18.
Taman, R. and Gozal, D. Obesity and obstructive sleep apnea in children. Pediatr Respir Review 2006;7:247-259.
Taman, R., Gulliver, T.E., Krishna, J., Montgomery-Downs, H.E., O’Brien, L.M., A.
Ivanenko, D. Gozal. Persistence of obstructive sleep apnea syndrome in children after adenotonsillectomy. J Pediatr 2006;149:803-808.
Teloken, P.E., Smith, E. B., Lodowsky, C., Freedom, T., and Mulhall, J. P. Defining association between sleep apnea syndrome and erectile dysfunction, Urology 2006; 67: 1033-1037.
Theodoridis, S., Koutroumbas, K. Pattern Recognition. 2nd edn. Academic Press, San Dieago (2003).
Thomas, R.J., Mietus, J.E., Peng, C.K. A.L. Goldberger. An electrocardiogram-based technique to assess cardiopulmonary coupling during sleep, Sleep 2005; 28:
1151-1161.
Tong, J., Jiang, P., & Lu, Z. (2008). RISP: A web-based server for prediction of RNA-binding sites in proteins. Computer Methods and Programs in Biomedicine,
90(2), 148-153.
Vagiakis, E., Kapsimalis, F., Lagogianni, I., Perraki, H., Minaritzoglou, A., Alexandropoulou, K., Roussos, C. Kryger, M. Gender differences on ploysomnographic findings in Greek subjects with obstructive sleep apnea syndrome. Sleep Med 2006;7:424-430.
Whitelaw, W.A., Brant, R.F., Flemons. W.W. Clinical usefuleness of home oximetry compared with polysomnography for assessment of sleep apnea. Am J Respir Crit Care Med 2005;171:188-193.
Yaggi, H.K., Concato, J., Kernan, W.N., Lichtman, J.H., Brass, L.M., Mohsenin, V.
Obstructive sleep apnea as a risk factor for stroke and death. N Engl J Med 2005;353:2034-2041.
Young, T., Palta, M., Dempsey, J. et al. The occurrence of SDB among middle-aged adults. N Engl J Med 1993; 328: 1230-1235.
Young, T., Even, L., Finn, L. et al. Estimation of the clinically diagnosed proportion of sleep apnea syndrome in middle aged men and women. Sleep 1997; 20:
705-706.
Zhang, J., Wang, Y., Dong, Y., & Wang, Y. (2008). Computer-aided diagnosis of cervical lymph nodes on ultrasonography. Computers in Biology and Medicine,
38(2), 234-243.
Zhi, L., Zhang, D., Yan, J., Li, Q., & Tang, Q. (2007). Classification of hyperspectral medical tongue images for tongue diagnosis. Computerized Medical Imaging and