2.4 GFOGER Cit12 C E11 D
6.1.2 GLOGER&GAOGER
GLOGER R12B 0
GFOGER Glu Ser GLOGER R12B 0
GFOGER R12C 1
GFOGER R12C GFOGER R218
0 R219 E11D Phe Leu
GLOGER F8B 0 GFOGER
GFOGER L F
S284 N286 0
GFOGER L287 Y157
Y286 GFOGER
GLOGER R12B R12C E11D
F8B GFOGER
GLOGER
GFOGER GLOGER GAOGER R12B R12C E11D
8B PI-stacking
GFOGER GLOGER GAOGER
GLOGER GAOGER
6.1.3 GFOGER
GFOGER Cit12B Cit12C E11D
R218
GFOGER (1.4 0.5
Cit12C
6.1.4 GLOGER&GAOGER
GLOGER Cit12C
E220 E11D
Cit12C
Cit12B E298 E255
Cit12C D259 E11D R218
E11D R219
6.2
GPO Beta
(R12B R12C E11D F8B
kd ( cluster
[1] Wegner, N., Lundberg, K., Kinloch, A., Fisher, B., Malmström, V., Feldmann, M., &
Venables, P. J.
to the etiology of rheumatoid arthritis. Immunological reviews, 233 –54.
[2] McInnes, I. B., & Schett, G. The
New England journal of medicine, 365 –2219.
[3] Sipilä, K. H., Ranga, V., Rappu, P., Mali, M., Pirilä, L., Heino, I., Jokinen, J., Käpylä, inflammation related citrullination of functional arginines in extracellular proteins. Scientific reports, 7
[4]
may ignite the fire in rheumatoid arthritis. Arthritis research & therapy, 6 –111.
[5] Sipilä, K., Haag, S., Denessiouk, K., Käpylä, J., Peters, E. C., Denesyuk, A., Hansen,
collagen II affects integrin-mediated cell adhesion in a receptor-specific manner. FASEB journal: official publication of the Federation of American Societies for Experimental Biology, 28 –3768.
[6] Di Lullo, G. A., Sweeney, S. M., Korkko, J., Ala-Kokko, L., & San Antonio, J. D.
-binding sites and disease-associated mutations on the most
abundant protein in the human, type I collagen. The Journal of biological chemistry,
277 –4231.
[7] Kim, J. K., Xu, Y., Xu, X., Keene, D. R., Gurusiddappa, S., Liang, X., Wary, K. K., e in collagen type III for integrins alpha1beta1and alpha2beta1. The Journal of biological chemistry, 280 –32520.
[8] Park, K. S., Park, M. J., Cho, M. L., Kwok, S. K., Ju, J. H., Ko, H. J., Park, S. H., &
ype II collagen oral tolerance; mechanism and role in collagen-induced arthritis and rheumatoid arthritis. Modern rheumatology, 19 –589.
[9] in
structure, tissue distribution, and associated diseases. Gene, 707, 151–171 [10]
the rheumatoid arthritis cycle. Arthritis research & therapy, 10
[11] in
articular cartilage and bone with emerging roles as an extracellular signaling molecule and metabolic regulator. Frontiersin endocrinology, 3, 153.
[12] in the
progression and complications of atherosclerosis. Vascular medicine (London, England),
14 –89.
[13] integrins: versatility, modulation, and signaling in cell adhesion.
Cell, 69 –25.
[14] integrin-collagen connection--a glue for tissue
repair? Journal of cell science, 129 –664.
[15] Lundgren- integrin
critical in skeletal development. Advances in experimental medicine and biology, 819, 61–71.
[16] Kaltz, N., Ringe, J., Holzwarth, C., Charbord, P., Niemeyer, M., Jacobs, V. R.,
cells defined by genome-wide gene expression analysis of stromal cells from different sources. Experimental cell research, 316 –2617.
[17] Zemmyo, M., Meharra, E. J., Kühn, K., Creighton-Achermann, L., & Lotz, M.
-dependent development of osteoarthritis in alpha1integrin-deficient mice. Arthritis and rheumatism, 48 –2880.
[18] Ekholm, E., Hankenson, K. D., Uusitalo, H., Hiltunen, A., Gardner, H., Heino, J., &
in alpha1beta1 integrin-deficient mice during bone fracture healing. The American journal of pathology,
160 –1785.
[19] Peters, M. A., Wendholt, D., Strietholt, S., Frank, S., Pundt, N., Korb-Pap, A.,
1 integrin suppresses joint inflammation and cartilage destruction in mouse models of rheumatoid arthritis. Arthritis and rheumatism, 64 –1368.
[20] Fireste in Nature, 423
356–361.
[21] Bengtsson, T., Aszodi, A., Nicolae, C., Hunziker, E. B., Lundgren-Akerlund, E., &
Fässler, 1 integrin expression leads to moderate dysfunction of growth plate chondrocytes. Journal of cell science, 118 29–936.
[22] Schulz, J. N., Zeltz, C., Sørensen, I. W., Barczyk, M., Carracedo, S., Hallinger, R.,
strength in 1integrin. The Journal of in vestigative dermatology,
135 –1444.
[23] Chin, Y. K., Headey, S. J., Mohanty, B., Patil, R., McEwan, P. A., Swarbrick, J. D.,
integrin in complex with a collagen-mimetic peptide. The Journal of biological chemistry, 288 –36809.
[24]
integrins in mediating cardiac fibroblast-cardiomyocyte cross talk: a dynamic relationship in cardiac biology and pathophysiology. Basic research in cardiology, 112
[25] BioEssays :
news and reviews in molecular, cellular and developmental biology, 29 –1010.
[26] Xu, Y., Gurusiddappa, S., Rich, R. L., Owens, R. T., Keene, D. R., Mayne, R., Höök, in collagen type I for the integrins alpha1beta1 and alpha2beta1. The Journal of biological chemistry, 275 – 38989
[27] Knight, C. G., Morton, L. F., Onley, D. J., Peachey, A. R., Messent, A. J., Smethurst, P. A., Tuckwell, D. S., Farndale, R. W., & B in collagen type I of an integrin alpha2beta1-binding site containing an essential GER sequence. The Journal of biological chemistry, 273 –33294.
[28] Ramshaw, J. A., Werkmeister, J. A., &
collagens: emerging directions for biomedical materials. Bioengineered, 5 –233.
[29]
An activating mutation reveals a second binding mode of the integrin 2I domain to the GFOGER motif in collagens. PloS one, 8
[30] Raynal, N., Hamaia, S. W., Siljander, P. R., Maddox, B., Peachey, A. R., Fernandez, R., Foley, L. J., Slatter, D. A.,
peptides to locate novel integrin alpha2beta1-binding motifs in human collagen III. The Journal of biological chemistry, 281 –3831.
[31] Davidenko, N., Hamaia, S., Bax, D. V., Malcor, J. D., Schuster, C. F., Gullberg, D.,
model for assessing of the biological response of collagen-based biomaterials. Acta biomaterialia, 65, 88–101.
[32]
deiminases: physiological function, interaction with chemokines and role in pathology.
Drug discovery today. Technologies, 9 4, e227-314.
[33] -translational modifications of integrin ligands
as pathogenic mechanisms in disease. Matrix biology: journal of the international Society for Matrix Biology, 40, 5–9.
[34] de Fougerolles, A. R., Sprague, A. G., Nickerson-Nutter, C. L., Chi-Rosso, G.,
Regulation of inflammation by collagen-binding integrins alpha1beta1 and alpha2beta1 in models of hypersensitivity and arthritis. The Journal of clinical investigation, 105 721–729.
[35] Suzuki, A., Yamada, R., Ohtake-Yamanaka, M., Okazaki, Y., Sawada, T., -citrullinated collagen type I antibody is a target of autoimmunity in rheumatoid arthritis. Biochemical and biophysical research communications, 333 –426.
[36] Haag, S., Schneider, N., Mason, D. E., Tuncel, J., Andersson, I. E., Peters, E. C., Identification of new citrulline-specific autoantibodies, which bind to human arthritic cartilage, by mass spectrometric analysis of citrullinated type II collagen. Arthritis & rheumatology (Hoboken, N.J.), 66 – 1449.
[37] Herr, in sights into the interactions
between platelet receptors and fibrillar collagen. The Journal of biological chemistry,
284 –19785.
[38] in 2017. RMD open, 3
[39] Zhang, W. M., Kapyla, J., Puranen, J. S., Knight, C. G., Tiger, C. F., Pentikainen, O.
1 integrin recognizes the GFOGER sequence in interstitial collagens. The Journal of biological chemistry, 278 –7277.
[40] Efficient molecular dynamics and hybrid Monte Carlo algorithms for path integrals. The Journal of Chemical Physics, 99 -2808.
[41] Molecular Dynamics Simulation - Michel Cuendet - EMBL 2008 [42]
polarizable force fields for biophysics and computer-aided drug design. Biochimica et biophysica acta, 1850 –871.
[43]
structural database of non-natural sidechains. Nucleic acids research, 41 D327–D332.
[44]
Structural basis of collagen recognition byintegrin alpha2beta1. Cell, 101 –56.
[45] H.M. Berman, J. Westbrook, Z. Feng, G. Gilliland, T.N. Bhat, H. Weissig, I.N.
Shindyalov, P.E. Bourne. in Data Bank. Nucleic Acids Research, 28: 235-242.
[46] https://www.uniprot.org [47] https://www.ks.uiuc.edu/
[48] https://sybyl.com/
[49] https://ctlee.github.io/BioChemCoRe-2018/distance-analysis/
[50] analysis of atomic protein-ligand interactionsinthe PDB. MedChemComm, 8 –1981.
[51]
character of a protein. Journal of molecular biology, 157 –132.
[52] PI-stacking interactions.
Alive and well in proteins. The Journal of biological chemistry, 273 –15463.
[53] Lehtonen, J. V., Still, D. J., Rantanen, V. V., Ekholm, J., Björklund, D., Iftikhar, Z., Huhtala, M., Repo, S., Jussila, A., Jaakkola, J., Pentikäinen, O., Nyrönen, T., Salminen,
for structure-function analysis and drug design. Journal of computer-aided molecular design, 18 –419.
[54] Griffiths, David J., Introduction to Elementary Particles 2nd revised, WIleY-VCH, 2008, ISBN 978-3-527-40601-2
[55] Hamaia SW Luff D Hunter EJ Malcor JD Bihan D Gullberg D Farndale RW. Unique charge-dependent constraint on collagen recognition by integrin
Matrix Biol. 2017 May; 59:80-94. doi: 10.1016/j.matbio.2016.08.010. Epub 2016 Aug 25. PMID: 27569273; PMCID: PMC5380659.