5-1 結論
本實驗研究如何調動 FET 元件的臨界電壓(threshold voltage),提出了兩種方法:汲極 源極控制法(VDS control method)、反向器控制法(inverter control method)。兩種方法都可以 簡單且精準地調動臨界電壓到達我們想要的位置,並且能夠不傷害元件的特性。
在 pH 緩衝溶液即時量測實驗中,使用了 VDS control method 後,電流訊號的穩定度 優於在溶液中施加一個不為零的參考電極電壓(Vref),此外表面修飾也對於溶液對元件表 面的穩定度有幫助。
在 Streptavidin 即時量測實驗中,可以藉由汲極電流的改變換算回表面電位的變化,
分辨不同濃度的 Streptavidin,並且偵測極限(LOD)為 42 pM。
根據這些實驗的結果,相信這個技術可以應用到未來的生醫感測裝置上。
5-2 未來展望
目前本實驗能夠做到以市售 FET 電晶體完成延伸式閘極場效電晶體,並且以 VDS
control method 進行 pH 緩衝溶液即時量測實驗改善時漂效應以及遲滯效應並且擁有良好 的靈敏度,以及 Streptavidin 感測實驗亦能對濃度有辨別效果。希望對於電極大小以及流 道大小作量測效果的比較,並做出最佳化。希望能降低流道的大小,以達到微小化以及 提高反應的效率。另外,最後未來希望能夠利用表面修飾,對不同的目標分析物有選擇 性的感測,增加 EGFET 感測器的專一性。
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