WTH* and KRT* are the first authors and contributed equally to the work. WTH helped designing the study and provided specific domain knowledge on cancer biology. KRT carried out data retrieval,data analysesandprogram coding. JSC helped performing simulation studies and conducted the enrichment analysis. JJPT oversee the work and proofread the article. NK helped setting up the web site and provide guidence on database management. CHH§ and KLN§ are the corresponding authors of the article, they designed the study, provided insight for all discussions and drafted the manuscript. CHH also providedinstructions on designing the algorithms. All authors read andapproved the manuscript.
Acknowledgements
The works of Wen-Tsong Hsieh and Ka-Lok Ngare supported by the Asia University and China Medical University grant of ASIA101-CMU-1. The works of Ka-Lok Ng, Ke-Rung Tzeng, and Jin-Shuei Ciou are supported by the Ministry of Science and Technology of Taiwan, under the grant of NSC 102-2221-E-468-024, NSC 102-2632-E-468-001-MY3. The work of Chien-Hung Huang is supported by the grant NSC 101-2221-E-150-088-MY2. The work of Jeffrey J. P. Tsai is supported by the grant
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