Nancy Yuk-Yu IP, Professor and Department Head; Associate Dean of Science; Director, BRI and Co-Director, Molecular Neuroscience Center
Robert K M KO, Professor
Randy Yat Choi POON, Professor
Yung Hou WONG, Professor and Associate Director of Biotechnology Research Institute Mingjie ZHANG, Professor
Jeffrey Tze-Fei WONG, Adjunct Professor Yifan HAN, Associate Professor
Chun LIANG, Associate Professor Zilong WEN, Associate Professor
Wan-Keung R WONG, Associate Professor Zhenguo WU, Associate Professor
Hong XUE, Associate Professor and Director, Hong Kong Bioinformatics Center Guang ZHU, Associate Professor
Raymond S C WONG, Adjunct Associate Professor and Director, Animal and Plant Care Facility
Kenny K K CHUNG, Assistant Professor Robert Zhong QI, Assistant Professor
Shui Ying TSANG, Visiting Assistant Professor Jun XIA, Assistant Professor
Anthony S L CHAN, Research Assistant Professor Zelda H Y CHEUNG, Research Assistant Professor
Wei FENG, Research Assistant Professor Kit Yu FU, Research Assistant Professor
Christina J MORRIS, Research Assistant Professor Jun WAN, Research Assistant Professor
Nancy Yuk-Yu IP
Professor and Department Head; Associate Dean of Science; Director, BRI and Co-Director, Molecular Neuroscience Center
(2358 7289 ; [email protected])
PhD (1983) and Postdoctoral Fellow (1983-84), Harvard Medical School Laboratory Head, Medical Genetics, Lifecodes Corporation (1987-89) Senior Staff Scientist, Regeneron Pharmaceuticals (1989-93)
Academician, CAS (2001- )
Current Research Activities:
The functional roles of trophic factors in neuronal differentiation and synapse formation, and their potential applications in the treatment of neurodegenerative diseases.
Active Projects as Principal Investigator:
Molecular neuroscience: basic research and drug discovery
UGC - Areas of Excellence HK$8,000,00001 Sep 2007
Croucher forum on molecular neuroscience
Croucher Foundation HK$190,000 01 Jun 2005
Symposium on "The Role of Cdk5 in Neuronal Plasticity"
Croucher Foundation HK$85,000 09 Jan 2007
Molecular neuroscience: Basic research and drug discovery
Office of the Dean of Science, HKUST HK$2,250,00012 Jul 2005
Modernization of chinese medicine: from clinical efficacy to drug production - two innovative formulae for comprehensive research (GHP/037/05)
Innovation and Technology Commission & Industries HK$1,219,00001 May 2006 Molecular medicine
UGC - High Impact Area HK$1,000,00001 Dec 2005
Understanding the postsynaptic signaling mechanisms of Eph receptor in muscle RGC - Competitive Earmarked Research Grant HK$1,089,95701 Nov 2005
Representative Research Publications:
Ip, Nancy Y. (2007) "Biotech News on Hong Kong", Asia Pacific Biotech News, 11(4): 218-220.
Cheung, Zelda H. Y., Chin, Wing Hong, Chen, Yu, Ng, Yu Pong, Ip, Nancy Y. (2007) "Cdk5 is involved in BDNF-stimulated dendritic growth in hippocampal neurons", PLoS Biol., 5(4) e63: 1-13.
Fu, Ada W. Y., Chen, Yu, Sahin, Mustafa, Zhao, Xiao Su, Shi, Lei, Bikoff, Jay B., Lai, Kwok On, Yung, Wing Ho, Fu, Amy K. Y., Greenberg, Michael E., Ip, Nancy Y. (2007) "Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism", Nat.
Neurosci., 10:67-76.
Lok, Ka Chun, Fu, Amy K. Y., Ip, Fanny C. F., Wong, Yung Hou, Ip, Nancy Y. (2007)
"Expression of G protein Beta subunits in rat skeletal muscle after nerve injury: Implication in the regulation of neuregulin signaling", Neurosci., 146: 594-603.
Ng, Yu Pong, Lo, Kin Yip, Cheung, Zelda H. Y., Ip, Nancy Y. (2006) "Signaling through the neurotrophin receptors in the nervous system", Handbook of Neurochemistry, 2:12-32.
Liu, Yu Xin, Cheng, Kai, Gong, Ke, Fu, Amy K. Y., Ip, Nancy Y. (2006) "Pctaire1
phosphorylates N-Ethylmaleimide-sensitive fusion protein: implications in the regulation of its hexamerization and exocytosis", J. Biol. Chem., 281: 9852-9858.
Ng, Yu Pong, Cheung, Zelda H. Y., Ip, Nancy Y. (2006) "STAT3 as a downstream mediator of Trk signaling and functions", J. Biol. Chem., 281: 15636-15644.
Cheung, Zelda H. Y., Fu, Amy K. Y., Ip, Nancy Y. (2006) "Synaptic roles of Cdk5:
implications in higher cognitive functions and neurodegenerative diseases", Neuron, 50: 13-18.
Robert K M KO Professor
(2358 7298 ; [email protected])
PhD, University of British Columbia (1990)
Current Research Activities:
Myocardial ischemia/reperfusion injury and carbon tetrachloride-induced hepatotoxicity;
protection against such injuries by antioxidants; antioxidant properties of traditional Chinese medicine.
Active Projects as Principal Investigator:
Cellular signaling triggered by schisandrin B in the protection against oxidant injury
RGC - Competitive Earmarked Research Grant HK$655,496 01 Sep 2007
Representative Research Publications:
CHIU, P.Y., LEUNG, H.Y., Siu, A.H.Y., Poon, M.K.T., Dong, T.T.X., Tsim, K.W.K., Ko, K.M.
(2007) "Dang-Gui Buxue Tang protects against oxidant injury by enhancing cellular glutathione in H9c2 cells: Role of glutathione synthesis and regeneration", Planta Med., 73: 134-141.
Ko, K.M., LEUNG, H.Y. (2007) "Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities of Chinese Yang and Yin tonifying herbs", Chinese Medicine, 2:3 doi:10.1186/1749-8546-2-3.
CHIU, P.Y., LEUNG, H.Y., Siu, A.H.Y., Poon, M.K.T., Ko, K.M. (2007) "Schisandrin B decreases the sensitivity of mitochondria to calcium ion-induced permeability transition and protects against carbon tetrachloride toxicity in mouse livers", Biol. Pharm. Bull., 30: 1108-1112.
Ko, K.M., LEON, T.Y.Y., Mak, D.H.F, CHIU, P.Y., DU, Y., Poon, M.K.T. (2006) "A characteristic pharmacological action of 'Yang-invigorating' Chinese tonifying herbs:
Enhancement of myocardial ATP generation capacity", Phytomedicine, 13:636-642.
CHIU, P.Y., LEUNG, H.Y., Poon, M.K.T., Ko, K.M. (2006) "Chronic schisandrin B treatment improves mitochondrial antioxidant status and tissue heat shock protein production in various tissues of young adult and middle-aged rats", Biogerontology, 7: 199-210.
DU, Y., Ko, K.M. (2006) "Effects of pharmacological preconditioning by emodin/oleanolic acid treatment and/or ischemic preconditioning on mitochondrial antioxidant components as well as the susceptibility to ischemia-reperfusion injury in rat hearts", Mol. Cell. Biochem., 288: 135-142.
CHIU, P.Y., LEUNG, H.Y., Poon, M.K.T., Mak, D.H.F., Ko, K.M. (2006) "Schisandrin B is more potent than its enantiomer in enhancing cellular glutathione and heat shock protein production as well as protecting against oxidant injury in H9c2 cardiomyocytes", Mol. Cell.
Biochem., 289: 185-191.
CHIU, P.Y., Ko, K.M. (2006) "Schisandrin B-induced increase in cellular glutathione level and protection against oxidant injury are mediated by the enhancement of glutathione synthesis and regeneration in AML12 and H9c2 cells", Biofactors, 26:221-230.
Randy Yat Choi POON Professor
(2358 8703 ; [email protected])
PhD, University of Cambridge (1994)
Current Research Activities:
Molecular basis of cell cycle control in normal and cancer cells.
Active Projects as Principal Investigator:
The molecular basis of immortalization and transformation of serum-free mouse embryonic fibroblasts
RGC - Competitive Earmarked Research Grant HK$1,858,01401 Sep 2005
The molecular basis of mitotic catastrophe and adaptation associated with the G2DNA damage checkpoint and the spindle-assembly checkpoint
RGC - Competitive Earmarked Research Grant HK$998,500 01 Sep 2006
Representative Research Publications:
Fung, Tsz Kan, Ma, Hoi Tang, Poon, Randy Y.C. (2007) "Specialized roles of the two mitotic cyclins in somatic cells: cyclin A as an activator of M phase-promoting factor", Molecular Biology of the Cell, 18: 1861-73.
Ho, C.C., Siu, W.Y., Lau, Anita, Chan, W.M., Arooz, Talha, Poon, Randy Y.C. (2006)
"Stalled replication induces p53 accumulation through distinct mechanisms from DNA damage checkpoint pathways", Cancer Res., 66: 2233-41.
Woo, Richard Aleston, Poon, Randy Yat Choi (2003-2004) "Activated oncogenes promote and cooperate with chromosomal instability for neoplastic transformation", Genes and
Development, 18: 1317-1330.
Chow, Jeremy Pak Hong, Siu, Wai Yee, Fung, Tsz Kan, Chan, Wan Mui, Lau, Anita,
Arooz, Talha, Ng, Chuen-Pei, Yamashita, Katsumi, Poon, Randy Yat Choi (2003-2004) "DNA damage during the spindle-assembly checkpoint degrades CDC25A, inhibits cyclin-CDC2 complexes, and reverses cells to interphase", Molecular Biology of the Cell, 14: 3189-4002.
Chow, Jeremy Pak Hong, Siu, Wai Yee, Ho, Horace Tsun-Bond, Ma, Ken Hoi Tang, Ho, Chiu Chiu, Poon, Randy Yat Choi (2003-2004) "Differential contribution of inhibitory
phosphorylation of CDC2 and CDK2 for unperturbed cell cycle control and DNA integrity checkpoints", Journal of Biological Chemistry, 278: 40815-40828.
Ng, Chuen-Pei, Lee, Hung Chiu, Ho, Chung Wai, Arooz, Talha, Siu, Wai Yee, Lau, Anita, Poon, Randy Yat Choi (2003-2004) "Differential mode of regulation of the checkpoint kinases CHK1 and CHK2 by their regulatory domains", Journal of Biological Chemistry, 279: 8808-8819.
Chan, Wan Mui, Siu, Wai Yee, Lau, Anita, Poon, Randy Yat Choi (2003-2004) "How many mutant p53 molecules are needed to inactivate a tetramer?", Molecular and Cellular Biology, 24:
3536-3551.
Yung Hou WONG
Professor and Associate Director of Biotechnology Research Institute (2358 7328 ; [email protected])
PhD, University of Cambridge (1988)
Current Research Activities:
The role of G-proteins in cell proliferation, differentiation and the development of drug tolerance;
cell-based high throughput drug screening.
Active Projects as Principal Investigator:
Deciphering the role of Gaz in cell differentiation
RGC - Competitive Earmarked Research Grant HK$1,928,10001 Nov 2005 Elucidating the role of G£\ interacting protein (RGS-GAIP/RGS19) in cell growth and proliferation RGC - Competitive Earmarked Research Grant HK$1,936,50001 Dec 2006
Representative Research Publications:
Chan, A.S.L., Ng, L.W.C., Poon, L.S.W., Chan, W.W.Y., Wong, Y.H. (2007) "Dopaminergic and adrenergic toxicities on SK-N-MC human neuroblastoma cells are mediated through G protein signaling and oxidative stress", Apoptosis, 12: 167-179.
An, H., Ip, F.C.F., Hu, Y.Q., Ho, M.K.C., Chin, A.C., Harley, C.B., Wong, Y.H., Ip, N.Y. (2007)
"Drug development candidate TAT2 activates telomerase in primary neuronal cultures", MGH-HKU-Nature Forum. Molecular Medicine and Biopharma Opportunities, Hong Kong., 5-6 March 2007. Abstract P052.
Lok, K.C., Fu, A.K.Y., Ip, F.C.F., Wong, Y.H., Ip, N.Y. (2007) "Expression of G protein Beta subunits in rat skeletal muscle after nerve injury: implication in the regulation of neuregulin signaling", Neurosci., 146: 594-603.
Ho, M.K.C., New, D.C., Hu, Y.Q., Pang, H., Wong, Y.H. (2007) "Identification of subtype-selective melatonin receptor ligands from traditional Chinese medicine", MGH-HKU-Nature
Forum. Molecular Medicine and Biopharma Opportunities, Hong Kong., 5-6 March 2007. Abstract P042.
Pang, H., Hu, Y.Q., Ho, M.K.C., Ip, F.C.F., An, H., Ip, N.Y., Wong, Y.H. (2007) "Knowledge-based drug discovery: identification of novel leads from traditional Chinese medicine", MGH-HKU-Nature Forum. Molecular Medicine and Biopharma Opportunities, Hong Kong., 5-6 March 2007.
Abstract P050.
New, D.C., Wong, Y.H. (2007) "Molecular mechanisms mediating the G protein-coupled receptor regulation of cell cycle progression", J. Mol. Signal., 2: 2.
Wu, E.H.T., Wu, K.K.H., Wong, Y.H. (2007) "Tuberin: a stimulus-regulated tumor suppressor protein controlled by a diverse array of receptor tyrosine kinases and G protein-coupled
receptors", NeuroSignals, 15: 217-227.
Yung, H.S., Wong, Y.H., Wise, H. (2006) "A time-dependent loss of prostaglandin EP3 receptors in PC12 cells during neuroal differentiation", The 4th Congress of Federation of Asian-Oceanian Neuroscience Societies (FAONS) & Annual Scientific Meeting of Hong Kong Society of Neurosciences, Hong Kong., November 30 - December 2, 2006. Abstract.
Mingjie ZHANG Professor
(2358 8709 ; [email protected] ; http://bcz102.ust.hk)
PhD, University of Calgary (1993)
Current Research Activities:
High resolution nuclear magnetic resonance (NMR) and biochemical studies of regulatory proteins in neuronal signal transductions.
Active Projects as Principal Investigator:
Protein-lipid interactions in neuronal signaling complex organization
RGC - Central Allocation Vote - Matching Grant HK$250,000 25 Jun 2007 Solution structure and biological functions of the novel N-terminal multimerization domain of Par-3
RGC - Competitive Earmarked Research Grant HK$1,915,51401 Nov 2005 Structural basis of split PH domain assembly and biochemical functions of split PH domains RGC - Competitive Earmarked Research Grant HK$1,960,50001 Sep 2006 Systematic analysis of lipid and PDZ interactions
UGC - Research Infrastructure Grant HK$600,000 30 Jun 2007
Representative Research Publications:
Feng, Wei, Wu, Hao, Chan, Ling-Nga, Zhang, Mingjie (2007) "The Par-3 NTD adopts a PB1-like structure required for Par-3 oligomerization and apical membrane localization", EMBO J., 26,2786-2796.
Long, Jia-fu, Feng, Wei, Wang, Rui, Chan, Ling-Nga, Ip, Fanny, Xia, Jun, Ip, Nancy, Zhang, Mingjie (2005) "Autoinhibition of X11s/Mints Scaffold Proteins Revealed by the Closed Conformation of the PDZ Tandem", Nat. Struct. & Mol. Biol., 12, 722-728.
Yan, Jing, Wen, Wenyu, Xu, Weiguang, Long, Jia-fu, Adams, Marvin E, Froehner, Stanely C, Zhang, Mingjie (2005) "Structure of the Split PH domain and Distinct Lipid Binding Properties of the PH-PDZ Supramodule of alpha-Syntrophin", EMBO J., 24, 3985-3995.
Feng, Wei, Long, Jiafu, Zhang, Mingjie (2005) "A unified assembly mode revealed by the
structures of tetrameric L27 domain complexes formed by mLin-2/mLin-7 and Patj/Pals1 scaffold proteins", Proc. Natl. Acad. Sci. USA, 102, 6861-6866.
Feng, Wei, Long, Jiafu, Fan, Jing-Song, Tetsuya, Suetake, Zhang, Mingjie (2004) "Hetero-tetrameric L27 (Lin-2, Lin-7) domain complexes as organization platforms for supra-molecular assemblies", Nat. Struct. & Mol. Biol., 11, 475-480.
Zhang, Mingjie, Wang, Wenning (2003) "Organization of Signaling Complexes by PDZ-Domain Scaffold Proteins", Acc. Chem. Res., 36, 530-538.
Feng, Wei, Shi, Yawei, Li, Ming, Zhang, Mingjie (2003) "Tandem PDZ repeats in glutamate receptor interacting proteins have a novel mode of PDZ domain-mediated target binding", Nat.
Struct. Biol., 10, 972-978.
Tochio, H, Tsui, Marco M. K., Banfiel, David K., Zhang, Mingjie (2001) "An Auto-Inhibitory Mechanism for Non-Syntaxin SNARE Proteins Revealed by the Structure of Ykt6p", Science, 293, 698-702.
Jeffrey Tze-Fei WONG Adjunct Professor
(2358 7288 ; [email protected])
PhD, University of Toronto (1963)
Professor of Biochemistry, University of Toronto (1976-90)
Current Research Activities:
Origin of genetic coding; evolution of codon usages; identity elements of transfer RNA.
Representative Research Publications:
Wong, J.T. (2007) "Coevolution theory of the genetic code: a proven theory", Orig. Life Evol.
Biosph., PMID: 17611816.
Wong, J.T. (2005) "Coevolution theory of the genetic code at age thirty", BioEssays, 27, 416-425.
Tong, K.L., Wong, J.T. (2004) "Anticodon and wobble evolution", Gene, 333,169-177.
Tong, Ka-Lok, Wong, J. T.-F. (2004) "Anticodon and wobble evolution", Gene, 333: 169-177.
Xue, Hong, Ka-lok, Tong, Marck, Christian, Grosjean, Henri, Wong, J. Tze-Fei (2003)
"Transfer RNA Paralogs: Evidence for Genetic Code-Amino Acid Biosynthesis Coevolution and an Archaeal Root of Life.", Gene, 310, 59-66.
Wong, J. Tze-Fei (2002) "Mutation and Expansion of the Genetic Code", Engineering Enzymes for Biocatalysis by Using Directed Evolution, Pasteur Institute, Paris, France.
Xue, Hong, Tong, Ka-Lok, Wong, J. Tze-Fei (2002) "Sequence Identities Between Extremely Slow-Evolving Aminoacyl-tRNA Synthetase and Transfer RNA Paralogs: Evidence for Genetic Code-Amino Acid Biosynthesis Coevolution and an Archaeal Root of Life", The 4th International Congress on Extremophiles 2002, Complesso Universitario, Monte Sant'Angelo, University Federico II of Naples, Naples, Italy, L54, p. 84.
Gong, Qingguo, Guo, Qing, Tong, Ka-Lok, Zhu, Guang, Wong, Tze-Fei Jeffrey, Xue, Hong (2001-2002) "NMR analysis of bovine tRNATrp. Conformation dependence of Mg2+
binding.", J. Biol. Chem., 277, 20694-20701.
Yifan HAN
Associate Professor
(2358 7293 ; [email protected])
PhD, Medical College of Ohio (1991) Visiting Scientist, Hoechst AG (1985-86)
Current Research Activities:
Molecular mechanisms of learning and memory; neuropsychopharmacologic research and development of anti-Alzheimer's agents, including those from Chinese medicinal herbs.
Active Projects as Principal Investigator:
Novel dimeric AChE inhibitors: Cellular and molecular characterization of one-compound-multi-targets at soluble amyloid cascade associated with Alzheimer's Disease
RGC - Competitive Earmarked Research Grant HK$1,049,20001 Sep 2007
Novel dimeric AChE inhibitors: Signaling mechanisms of neuroprotections against excitotoxins associated with Alzheimer's disease
RGC - Competitive Earmarked Research Grant HK$1,530,50001 Oct 2006
Representative Research Publications:
NIE, H., YU, W.J., LI, X.Y., YUAN, C.H., PANG, Y.P., LI, C.Y., Han, Y.F., LI, Z.W. (2007)
"Inhibition by bis(7)-tacrine of native delayed rectifier and KV1.2 encoded potassium channels", Neurosci Lett, 412(2):108-13.
WANG, W., YANG, Y., YING, C., Li, W., RUAN, H., ZHU, X., YOU, Y., Han, Y.F., CHEN, R., WANG, Y., LI, M. (2007) "Inhibition of glycogen synthase kinase-3beta protects dopaminergic neurons from MPTP toxicity", Neuropharmacology, 52(8):1678-84.
Fu, H., LI, W., LIU, Y., LAO, Y., LIU, W., CHEN, C., Yu, H., Lee, N.T., Chang, D.C., PANG, Y., Tsim, K.W., LI, P., LI, M., Han, Y.F. (2007) "Mitochondrial Proteomic Analysis and
Characterization of the Intracellular Mechanisms of Bis(7)-tacrine in Protecting against Glutamate-Induced Excitotoxicity in Primary Cultured Neurons", J Proteome Res, 6(7):2435-2446.
Li, W., Xue, J., Niu, C., Fu, H., Lam, C.S., Luo, J., Chan, H.H., Xue, H., Kan, K.K., Lee, N.T., LI, C., PANG, Y., LI, M., Tsim, K.W., JIANG, H., CHEN, K., LI, X., Han, Y.F. (2007) "Synergistic Neuroprotection by Bis(7)-tacrine via Concurrent Blockade of N-Methyl-D- aspartate Receptors and Neuronal Nitric-Oxide Synthase", Mol Pharmacol, 71(5):1258-67.
LI, C.Y., Carlier, P.C., Ren, H., Kan, K.K., HUI, K.M., WANG, H., LI, W.M., LI, Z.W., XIONG, K.M., CLEMENT, E.C., Lee, N.T.K., Tsang, H.W., Xue, H., LIU, X.G., LI, M.T., PANG, Y.P., Han, Y.F. (2007) "Tether length dependent GABAA receptor competitive antagonism by alkylend-linked tacrine dimers: bis(2)-tacrine is ten times more potent than (+)-bicuculine",
NeuroPharmacol, 52(2):436-43.
DENG, R., LI, W.M., ZHOU, J.M., MEI, Y.P., LI, M.T., FENG, G.K., HUANG, W.L., LIU, Z.C., Han, Y.F., ZENG, Y.X., ZHU, X.F. (2006) "Acetylcholinesterase expression mediated by c-Jun-NH2-terminal kinase pathway during apoptosis", Oncogene, 25(53):7070-7.
Fu, H.J., LI, W.M., Lao, Y.Z., Luo, J.L., Lee, N.T.K., Kan, K.K.W., Tsang, H.W., Tsim,
K.W.K., PANG, Y.P., LI, Z.W., Chang, D.C., LI, M.T., Han, Y.F. (2006) "Bis(7)-tacrine attenuates Beta amyloid-induced apoptosis by regulating L-typecalcium channels", J Neurochem, 98, 1400-1410.
PAN, S.Y., Han, Y.F., YU, Z.L., YANG, R., DONG, H., Ko, K.M. (2006) "Evaluation of acute tacrine treatment on passive-avoidance response, open-field behavior, and toxicity in 17- and 30-day-old mice", Pharmacol Biochem Behav., 85: 50-56.
Chun LIANG
Associate Professor
(2358 7296 ; [email protected])
PhD, Brown University (1993)
Current Research Activities:
Mechanism and cell cycle control of DNA replication in the budding yeast Saccharomyces cerevisiae; regulation of DNA replication in normal and cancer cells; molecular cancer detection and anticancer agents.
Active Projects as Principal Investigator:
Characterization of a novel class of proteins involved in both ribosome biogenesis and initiation of DNA replication
RGC - Competitive Earmarked Research Grant HK$1,489,50001 Sep 2006
Representative Research Publications:
Liang, Chun (2007) "DNA REPLICATION-INITIATION PROTEINS AND THEIR POTENTIAL APPLICATION AS ANTICANCER TARGETS", Croucher Foundation Advanced Study Institute on Molecular Genetics and Cell Signaling in Cancer and Cancer Metatasis, Hong Kong, 1.2007.
Liang, Chun (2007) "Study on DNA replication initiation proteins and their applications in cancer", Shenzhen-Hong Kong Joint Symposium on Biomedical Research, Shenzhen, China, 6.2007.
Liang, Chun (2006) "DNA replication-initiation proteins: identification, characterization and potential application as anticancer targets (Invited talk)", Croucher Foundation Advanced Study Institute on Signaling in Cell Growth and Differentiation, 1.2006.
Huo, Lin, Yu, Zhiling, Chan, Tsz Choi, Lu, Yongjun, Zhang, Yuan, Wong, Bonnie, Labib, Karim, Liang, Chun (2006) "Ipi3p is an essential DNA replication-initiation protein required for and directly involved in pre-replication complex assembly and maintenance (Talk)", The Cell Cycle Meeting, Cold Spring Harbor Laboratory, N.Y., USA, 9.2006.
Liang, Chun (2005) "DNA replication-initiation proteins and their potential applications in cancer. (Invited talk)", The 1st eIMBL (electronic International Molecular Biology Lab) Workshop, eIMBL, Seoul, Korea, 7.2005.
Liang, Chun (2005) "DNA replication-initiation proteins as novel anticancer targets. (Invited talk)", Hong Kong University Symposium on Frontiers in Biomedical Research, 12.2005.
Liang, Chun (2005) "Identification of effective anticancer drug candidates with low toxicity from Chinese medicinal herbs targeted to DNA replication-initiation proteins. (Invited talk)", Hong Kong Baptist University Conference on Traditional Chinese Medicine., 11.2005.
Zhai, Yuanliang, Chan, Tsz Choi, Feng, Daorong, Fu, Xinrong, Lo, Alice, Chen, Yanhong, Ma, Lijuan, Lu, Yongjun, Liang, Chun (2005) "Identification of novel initiation proteins for yeast DNA replication by using the IDR (Initiation of DNA Replication) screen", Eukaryotic DNA Replication Meeting, Cold Spring Harbor Laboratory, N.Y., USA, 9.2005.
Zilong WEN
Associate Professor
(2358 7294 ; [email protected])
PhD, Rockefeller University (1997)
Current Research Activities:
Hematopoietic Cell Development in Vertebrates
Active Projects as Principal Investigator:
Characterization and initial mapping of zebrafish mutant mac230
RGC - Direct Allocation Grant HK$100,000 29 Jun 2007
Representative Research Publications:
Qian, F., Zhen, F.H., Xu, J., Huang, M., Li, W.Y., Wen, Z.L. (2007) "Distinct functions for different scl isoforms in zebrafish primitive and definitive hematopoiesis", PLoS Biology, in press.
Jin, H., Xu, J., Wen, Z.L. (2007) "Migratory path of definitive hematopoietic stem/progenitor cells during zebrafish development", Blood, in press.
Liu, Y.M., Du, L.S., Osato, M., Teo, E.H., Qian, F., Jin, H., Zhen, F.H., Xu, J., Guo, L., Huang, H.H., Chen, J., Geisler, R., Jiang, Y.J., Peng, J.R., Wen, Z.L. (2007) "The zebrafish udu gene encodes a novel nuclear factor and is essential for primitive erythroid cell development", Blood, in press.
Jin, H., Xu, J., Qian, F., Du, L.S., Tan, C.Y., Lin, Z.X., Peng, J.R., Wen, Z.L. (2006) "The 5' zebrafish scl promoter targets transcription to the brain, spinal cord, hematopoietic and
endothelial progenitors", Developmental Dynamics, 235:60-67.
Chen, J., Ruan, H., Ng, S.M., Gao, C., Soo, H.M., Wu, W., Zhang, Z.H., Wen, Z.L., Lane, D.P., Peng, J.R. (2005) "Loss of function of def selectively up-regulates 113p53 expression to arrest expansion growth of digestive organs in zebrafish", Genes & Development, 19:2900-2911.
Qian, F., Zhen, F.H., Ong, C.T., Jin, S-W., Soo, H. M., Stainier, D.Y.R., Lin, S., Peng, J.R., Wen, Z.L. (2005) "Microarray analysis of zebrafish cloche mutant using amplified cDNA and the identification of potential hematopoietic-endothelial target genes", Developmental Dynamics, 233:1163-1172.
Lo, J., Lee, S., Xu, M., Liu, F., Ruan, H., Eun, A., He, Y., Wang, W., Wen, Z.L., Peng, J.R.
(2003) "15,000 unique zebrafish EST clusters and their use in microarray for profiling gene expression patterns during embryogenesis", Genome Research, 13:455-466.
Huang, M., Qian, F., Hu, Y., Ang, C, Li, Z., Wen, Z.L. (2002) "The chromatin-remodelling factor BRG1 selectively activates a subset of interferon a-inducible genes", Nature Cell Biology, 4:774-781.
Wan-Keung R WONG Associate Professor
(2358 7299 ; [email protected])
PhD, University of British Columbia (1986)
Project Leader, Allelix Biopharmaceuticals Inc (1988-90)
Current Research Activities:
Development of microbial host systems for extracellular production of valuable proteins;
production and reconstitution of recombinant cellulases.
Representative Research Publications:
Wong, W.K.R. (2007) "An E. coli excretion system for efficient production of extracellular recombinant proteins", Macau Institute for Applied Research in Medicine and Health, Macau, China, May 2007.
Wong, W.K.R. (2007) "An E. coli excretion system for efficient production of extracellular recombinant proteins", Macau Institute for Applied Research in Medicine and Health, Macau China, May.
Wong, W.K.R. (2007) "Application of human growth factors to skin care", Lee Kum Kee's Xinhui Production Plant, Xinhui China, April.
Wong, W.K.R. (2007) "Production of recombinant human growth factor for cosmetic applications", 999 Cogem Group Co., Limited, Guangzhou China, March.
Wong, W.K.R. (2007) "Production of recombinant human growth factors for cosmetic applications", 999 Cogem Group Co Limited, Guangzhou, China, March 2007.
Fu, Z. B., Ng, K. L., Lam, C. C., Leung, K. C., Yip, W. H., Wong, W. K. R. (2006) "A
two-stage refinement approach for the enhancement of excretory production of an exoglucanase from Eshcerichia coli.", Protein Expression and Purification, 48: 205-214.
Wong, W.K.R. (2006) "Application of recombinant human epidermal growth factor to the treatment of chronic wound ulcers", Guangzhou Institute of Lazer Application, Guangzhou China, August.
Wong, W.K.R. (2006) "Employment of recombinant cellulases for the production of biofuel", Technology Transfer Center, HKUST, Hong Kong, August.
Wong, W.K.R. (2006) "Employment of recombinant cellulases for the production of biofuel", Technology Transfer Center, HKUST, Hong Kong, August.