H Benjamin PENG, Head of Department and Professor Donald C CHANG, Professor
Maria LI LUNG, Professor and Director, Cooperative Nasopharyngeal Carcinoma Research Center
Peiyuan QIAN, Professor and Assoc Director, Atmospheric, Marine and Coastal Environment Program; Director, Coastal Marine Laboratory
Madeline C S WU, Professor
Shain Dow KUNG, Adjunct Professor and Professor Emeritus Shang-fa YANG, Adjunct Professor
David K BANFIELD, Associate Professor King Lau CHOW, Associate Professor
Michael HORNER, Visiting Associate Professor and Program Advisor, German Center, Representative of the DAAD (German Acad. Exchange Service)
Kevin A W LEE, Associate Professor Ning LI, Associate Professor
Andrew L MILLER, Associate Professor Karl W K TSIM, Associate Professor Wenxiong WANG, Associate Professor Joseph T Y WONG, Associate Professor Yong XIE, Associate Professor
Pingbo HUANG, Assistant Professor Peng LI, Assistant Professor
H Benjamin PENG
Head of Department and Professor (2358 7302 ; [email protected])
PhD (1976) and Postdoctoral Fellow (1976-78) Purdue University
Assistant Professor to Associate Professor, University of Illinois College of Medicine (1978-85)
Associate Professor to Full Professor, School of Medicine, University of North Carolina at Chapel Hill (1985-2000)
Current Research Activities:
Molecular and cellular neuroscience; cell biology; developmental biology.
Active Projects as Principal Investigator:
The role of cadherin junctional complexes in the formation of acetylcholine receptor clusters RGC - Competitive Earmarked Research Grant HK$954,000 01 Nov 2002 Signal transduction mechanisims in presynaptic development at the neuromuscular junction RGC - Competitive Earmarked Research Grant HK$1,986,000 01 Oct 2001 The function of a tyrosine phosphatase in synaptic induction
RGC - Competitive Earmarked Research Grant HK$1,335,000 01 Dec 2003
Representative Research Publications:
Peng, H. Benjamin, Madhavan, Raghavan (2004) "A synaptic balancing act: local and global signaling in the clustering of ACh receptors at vertebrate neuromuscular junctions", Symposium on Neural Plasticity, Development and Repair, The Hong Kong Society of Neurosciences, HK, 015, April 22-23, 2004.
Lee, Chi Wai, Peng, H. Benjamin (2004) "Co-clustering of mitochondria and synaptic vesicles during presynaptic differentiation at the neuromuscular junction", J. Neurochem., Supplement 1, P7-7.
Zhao, Xiaotao, Madhavan, Raghavan, Peng, H. Benjamin (2004) "Tyrosine phosphatase regulation of MuSK-dependent ACh receptor clustering", J. Neurochem, Supplement 1, P33-13.
Madhavan, Raghavan, Peng, H. Benjamin (2003) "A synaptic balancing act: Local and global signaling in the clustering of ACh receptors at vertebrate neuromuscular junctions", Journal of Neurocytology, 32, 685-696.
Lee, Chi Wai, Peng, H. Benjamin (2003) "Co-clustering of mitochondria and synaptic vesicles during presynaptic differentiation at the neuromuscular junction", The 23rd Annual Scientific Meeting,
The Hong Kong Society of Neurosciences, HK, PP1, December 9-10, 2003.
Xie, Qunhui, Genin, Alexis, Choi, Roy C.Y., Peng, H. Benjamin, Massoulie, Jean, Tsim, Karl W.K.
(2003) "PRiMA, the membrane anchor of acetylcholinesterase in the brain: searching for its proteic partners using the yeast-two hybrid system", The 23rd Annual Scientifc Meeting, The Hong Kong Society of Neurosciences, HK, PP4, 9-10 December, 2003.
Madhavan, Raghavan, Peng, H. Benjamin (2003) "The role of p120 catenin in nerve-muscle interaction and agrin-induced myopodial assembly", 33rd Annual Meeting, Society for Neuroscience, New Orleans, USA, Program No. 782.9, 8-12 November 2003.
Zhao, Xiaotao, Madhavan, Raghavan, Luo, Xiaoyan, Peng, H. Benjamin (2003) "Tyrosine phosphatase regulation of MuSK-dependent ACh receptor clustering", The 23rd Annual Scientific Meeting, The Hong Kong Society f Neurosciences, HK, PP5, Deember 9-10, 2004.
Donald C CHANG
Professor
(2358 7326 ; [email protected])
PhD, Rice University (1970)
Summer Investigator, Marine Biological Laboratory at Woods Hole (1976-94) Associate Professor, Baylor College of Medicine (1985-91)
Current Research Activities:
Molecular biophysics; calcium signaling; cellular structure and function by laser microscopy;
mechanisms of cell division and apoptosis; gene transfer and cell fusion using an electric field.
Active Projects as Principal Investigator:
Calcium signaling in programmed cell death
RGC - Competitive Earmarked Research Grant HK$876,000 01 Dec 2002 Calcium signaling in regulation of cell division
RGC - Competitive Earmarked Research Grant HK$1,542,000 01 Oct 2001
Representative Research Publications:
Chang, Donald C. (2004) "Electroporation and electrofusion", Encyclopedia of Molecular Cell Biology and Molecular Medicine, Vol. 4, pp.135-157.
Luo, Kathy Q., Chang, Donald C. (2004) "The gene-silencing efficiency of siRNA is strongly dependent on the local structure of mRNA at the targeted region", Biochem Biophys Res Comm, 318:303-310.
Chang, Donald C., Xu, Naihan, Luo, Kathy Q. (2003) "Degradation of cyclin B is required for the onset of anaphase in mammalian cells", J. Biol. Chem, 278:37865-37873.
Luo, Kathy Q., Yu, Vivian C., Pu, Yongmei, Chang, Donald C. (2003) "Measuring dynamics of caspase-8 activation in a single living HeLa cell during TNFa-induced apoptosis", Biochem. Biophys.
Res. Comm., 304: 217-222.
Pu, Yongmei, Luo, Kathy Q., Chang, Donald C. (2002) "A Ca2+ signal is found upstream of cytochrome c release during apoptosis in HeLa cells", Biochem. Biophys. Res. Comm., 299: 762-769.
Gao, Wenhua, Pu, Yongmei, Luo, Kathy Qian, Chang, Donald C. (2001) "Temporal relationship between cytochrome c release and mitochondrial swelling during UV-induced apoptosis in living HeLa cells", Journal of Cell Science, 114: 2855-2862.
Li, C. J., Heim, R., Lu, P., Pu, Y. M., Tsien, R. Y., Chang, D. C. (1999) "Dynamic redistribution of calmodulin in HeLa cells during cell division as revealed by a GFP-calmodulin fusion protein
technique", J. Cell Sci, 112(10): 1567-1577.
Chang, D. C., Meng, C. (1995) "A localized elevation of cytosolic free calcium is associated with cytokinesis in zebrafish embryo", J. Cell Biol, 131:1539-1545.
Maria LI LUNG
Professor and Director, Cooperative Nasopharyngeal Carcinoma Research Center (2358 7307 ; [email protected])
PhD, Stanford University (1978)
Lecturer, University of Hong Kong (1980-91)
Current Research Activities:
Molecular oncology; cancer genomics; epidemiology of cancer.
Active Projects as Principal Investigator:
Cooperative nasopharyngeal carcinoma research center
RGC - Central Allocation Vote HK$2,400,00001 Apr 2004
Identification of key tumor suppressor genes mapping to 3p21.3 and global gene expression changes resulting from their critical loss in NPC
RGC - Competitive Earmarked Research Grant HK$1,806,00001 Aug 2004
Identification of tumor suppressor genes on chromosome 11q in nasopharyngeal and esophageal carcinomas
RGC - Competitive Earmarked Research Grant HK$1,296,00001 Sep 2001
Representative Research Publications:
Cheng, Y, Lung, HL, Wong, PS, Hao, DC, Chim, SM, Stanbridge, EJ, Lung, ML (2004)
"Chromosome 13q12 region critical for the viability and growth of nasopharyngeal carcinoma hybrids", Int J Cancer, 019: 357-362.
Yang, LC, Tang, CMC, Lau, KW, Lung, ML (2003) "Frequent loss of heterozygosity on chromosome 9 in Chinese esophageal squamous cell carcinomas", Cancer Letters, 203: 71-77.
Lung, Maria (2003) "Functional approaches to localize and identify tumor suppressive regions required for development of nasopharyngeal carcinoma", Cancer Reviews: Asia Pacific, 1: 21-30.
Cheng, Yue, Ko, Josephine M.Y., Lung, Hong Lok, Lo, Paulisally H.Y., Stanbridge, Eric J., Lung, Maria L. (2003) "Monochromosome transfer provides functional evidence for
growth-suppressive genes on chromosome 14 in nasopharyngeal carcinoma", Genes, Chromosomes and Cancer, 37: 359-368.
Cheng, Yue, Chakrabarti, Rita, Garcia-Barcelo, Merce, Ha, Thomas J., Srivatasan, Eri, Stanbridge, Eric J., Lung, Maria Li (2002) "Mapping of nasopharyngeal carcinoma tumor-suppressive activity to a 1.8 megabase region of chromosome band 11q13", Genes, Chromosomes & Cancer, 34: 97-103.
Lung, Maria Li, Choi, Carolyn, Kong, Heidi, Yuen, Po Yuen, Kwong, Dora, Sham, Jonathan, Wei, William (2001) "Microsatellite allelotyping of Chinese nasopharyngeal carcinomas", Anticancer
Research, 21: 3081-4.
Cheng, Y., Stanbridge, E. J., Kong, H., Bengtsson, U., Lerman, M. I., Lung, M. L. (2000) "A functional investigation of tumor suppressor gene activities in a nasopharyngeal carcinoma cell line HONE1 using a monochromosome transfer approach", Genes, Chromosomes, and Cancer, 28: 82-91.
Cheng, Y., Poulos, N., Lung, M. L., Hampton, G., Ou, B., Lerman, M., Stanbridge, Ej. (1998)
"Functional evidence for a nasopharyngeal carcinoma tumor suppressor gene that maps at chromosome 3p21.3", Proc. Natl. Acad. Sci, 95: 3042-3047.
Peiyuan QIAN
Professor and Assoc Director, Atmospheric, Marine and Coastal Environment Program; Director, Coastal Marine Laboratory
(2358 7331 ; [email protected])
PhD, University of Alberta (1991)
Current Research Activities:
Larval ecology; anti-fouling; marine aquaculture; benthic ecology; marine natural products.
Active Projects as Principal Investigator:
Centre for marine environmental research and innovative technology (MERIT)
UGC - Areas of Excellence HK$1,406,00001 Apr 2004
The 6th International Larval Biology Conference
Croucher Foundation HK$99,840 21 Feb 2004
Detection and quantification of human enteric viruses in Victoria Harbor and Hong Kong coastal waters
RGC - Direct Allocation Grant HK$160,000 01 Jan 2004
Comparative study on the bacterial communities on the surface of the soft corals from Hong Kong waters and Mediterranean Sea, using Genescan and DGGE methods
France / Hong Kong Joint Research Scheme HK$30,600 01 Jan 2004
Comparative study of microbial associations in sponges of the South China Sea and the North Sea Germany / Hong Kong Joint Research Scheme HK$29,200 01 Jan 2004
Biomaterials and genomics of extremophile organisms
UGC - High Impact Area HK$755,000 13 Nov 2002
ESCE 500 introductory environmental chemistry and microbiology
Teaching Development Grants HK$200,000 01 Aug 2002
Partial purification of bioactive bacterial metabolites as larval settlement inducers/inhibitors of biofouling organisms
RGC - Competitive Earmarked Research Grant HK$816,000 01 Dec 2002
Antifouling mechanisms of soft-bodied marine invertebrates in Hong Kong waters
RGC - Competitive Earmarked Research Grant HK$1,182,00001 Dec 2001
Relationship between bacterial community structure and dynamics of biofilm and larval settlement induction/inhibition of marine invertebrates
RGC - Competitive Earmarked Research Grant HK$1,153,00001 Jul 2003
Cloning and application of an important anti-pathogenic functional gene for marine farming shellfishes
National 863 Project HK$373,800 01 Oct 2002
Representative Research Publications:
Tilmann, Harder, Lau, Stanley Chun Kwan, Tam, Wai Yee, Qian, Pei-Yuan (2003-2004) "A bacterial culture-independent method to investigate chemically-mediated control of bacterial epibiosis in marine invertebrates by using TRFLP analysis and natural bacterial populations.", FEMS Microbial Ecology., 47:93-99.
Harder, Tilmann, Lau, Stanley Chun Kwan, Dobretsov, Serguei, Qian, Pei-Yuan (2003-2004) "A distinctive epibiotic bacterial community on the soft coral Dendronephthya sp. and antibacterial activity of coral tissue extracts suggest a chemical mechanism against bacterial epibiosis.", FEMS
Microbiology Ecology., 43(3):337-347.
Dobretsov, Serguei, Dahms, Hans-Uwe, Qian, Pei-Yuan (2003-2004) "Antilarval and antimicrobial activity of waterborne metabolites of the sponge Callyspongia (Euplacella) pulvinata: evidence of
allelopathy.", Mar. Ecol. Prog. Ser., 271:133-146.
Jin, Tao, Qian, Pei-Yuan (2003-2004) "Effect of mono-amino acids on larval metamorphosis of the polychaete Hydroides elegans.", Mar. Ecol. Prog. Ser., 267:223-232.
Thiyagarajan, Vengatesen, Harder, Tilmann, Qiu, Jianwen, Qian, Pei-Yuan (2003-2004) "Energy content at metamorphosis and growth rate of the early juvenile barnacle Balanus amphitrite Drawin.", Mar. Biol., 143:543-554.
Lam, Ka Sin, Harder, Tilmann, Qian, Pei-Yuan (2003-2004) "Induction of larval settlement in the polychaete Hydroides elegans by surface-associated settlement cues of marine benthic diatoms.", Mar. Ecol. Prog. Ser., 263:83-92.
Lee, On On, Qian, Pei-Yuan (2003-2004) "Potential control of bacterial epibiosis on the surface of the sponge Mycale adhaerens.", Aquatic Microbial. Ecology., 34:11-21.
Qian, Pei-Yuan, Thiyagarajan, Vengatesen, Lau, Stanley Chun Kwan, Cheung, Sam Chi Kin (2003-2004) "Relationship between microbial community and the attachment of acorn barnacle Balanus amphitrite Darwin.", Aquatic Microbial. Ecology., 33:225-237.
Madeline C S WU
Professor
(2358 7301 ; [email protected])
PhD, University of Texas, Austin (1966)
Professor, Department of Biological Sciences, University of Maryland (1987-93)
Current Research Activities:
Algal and bacterial biotechnology; genetic variation of stress response genes.
Active Projects as Principal Investigator:
CAS-HKUST Tropical Marine Ecological Joint Station in Sanya
UGC - Collaboration with Mainland Institutions HK$250,000 19 Nov 2003 Molecular mechanism of phosphate acquisition and xenobiotic resistance in Chlamydomonas reinhardtii
RGC - Competitive Earmarked Research Grant HK$699,600 01 Nov 2001
Pharmacogenomic/pharmacogenetic-guided and related development of therapeutics for cancers and lupus erythematosus
Innovation and Technology Commission & Industries HK$6,480,00001 Dec 2003
Representative Research Publications:
Zheng, Zhengui, Wu, Madeline (2004) "Cadmium treatment enhances the production of alkaloid secondary metabolites in Catharanthus roseus.", Plant Science, 166, 507-514.
Vladimirov, Vladimir, Wu, Madeline, Pedley, Tim, Denissenko, Peter, Zakhidova, Samuel (2004)
"T.J., ,P.V., and S.G. , Measurement of cell velocity distributions in populations of motile algae. The (2004).", J of Exptl Biol, 207, 1203-1216.
Wu, Shuangxiu, Zu, Yuangang, Wu, Madeline (2003) "High yield production of salidroside in the suspension culture of Rhodiola sachalinesis.", J. Biotechnology, 106, 33-43.
Wu, Madeline, Mak, Sally, Zhang, Xiujun, Qian, Pei-Yuan (2003) "The effect of co-cultivation on the pearl yield of Pinctada martensi (Dumker).", Aquaculture, 221, 347-356.Wu, M., Mak, S.K.K., ,X., and Qian, P.Y.
Wu, Shuangxiu, Zu, Yuangang, Wu, Madeline (2001) "Cadmium response of the hairy root culture of the endangered species, Adenophora lobophylla", Plant Science, 160, 551-562.
Hu, Shengxi, Lau, Ken, Wu, Madeline (2001) "Cadmium sequestration in Chlamydomonas reinhardtii", Plant Science, 161, 987-996.
Qian, Pei-Yuan, Wu, Madeline, Ni, I-Hsun (2001) "Comparison of nutrient release among fish feed, fish, scallops, mussels and abalone", Aquaculture, 200: 305-316.
Yin, Kedong, Qian, Pei-Yuan, Wu, Madeline, Chen, Jay, Huang, Liangmin, Song, Xiuxian, Jian, Weijun (2001) "Shift from P to N limitation of phytoplankton biomass across the Pearl River Estuarine plume during summer", Mar. Ecol. Prog. Ser., Vol 221, P. 17-28.
Shain Dow KUNG
Adjunct Professor and Professor Emeritus (2358 7527 ; [email protected])
PhD, University of Toronto (1968).Research Cell Biologist/ Biochemist, University of California, Los Angeles (1971-74).
Acting Provost, Maryland Biotechnology Institute, University of Maryland (1989-91) Vice-President for Academic Affairs, Hong Kong University of Science and
Technology (1992-98)
Current Research Activities:
Molecular evolution of chloroplast genomes; structure and function of Rubisco; molecular mechanism of genetic tumors.
Shang-fa YANG
Adjunct Professor (2358 7310 ; )
Current Research Activities:
David K BANFIELD
Associate Professor
(2358 8633 ; [email protected])
PhD, University of British Columbia (1991)
Current Research Activities:
Intracellular protein trafficking and secretory organelle maintenance.
Active Projects as Principal Investigator:
Systematic analysis of genetic interactions among non-essential genes involved in membrane and protein trafficking in yeast
RGC - Direct Allocation Grant HK$80,000 01 Nov 2003
Investigations into the molecular basis of the regulation of intra-cellular vesicle mediated transport RGC - Competitive Earmarked Research Grant HK$1,677,50001 Aug 2002
Representative Research Publications:
Tai, William, Banfield, David Karl (2002) "Genes that allow cells to grow in the absence of the Golgi SNARE Sft1p: Identification of new components of the vesicle budding machinery.", European Science Foundation meeting 'EXOCYTOSIS: Membrane structure and dynamics.'.
Banfield, David Karl, Tochio, Hidehito, Tsui, Marco, Zhang, Mingjie (2001) "An Auto-Inhibitory Mechanism for Non-Syntaxin SNARE Proteins Revealed by the Structure of Ykt6p.", the Cold Spring Harbor Yeast Cell Biology Meeting.
Tochio, Hidehito, Tsui, Marco Man Kin, Banfield, David Karl, Zhang, Mingjie (2001) "An Auto-Inhibitory Mechanism for Nonsyntaxin SNARE Proteins Revealed by the Structure of Ykt6p", Science, 293, 698-702.
Tai, William, Banfield, David Karl (2001) "AtBS14a and AtBS14b two Bet1 / Sft1-like SNAREs from Arabidopsis thaliana that Complement Mutations in the Yeast SFT1 Gene", FEBS Letters, 500, 177-182.
King Lau CHOW
Associate Professor
(2358 7342 ; [email protected])
PhD, Baylor College of Medicine (1990)
Research Associate, Molecular Genetics, Albert Einstein College of Medicine
Current Research Activities:
Pattern formation and differentiation of sensory organ in animal; tissue remodeling and
morphogenesis; genetic diseases associated with sensory function; functional genomics in model organism.
Active Projects as Principal Investigator:
Developmental genomics & skeletal research
UGC - Areas of Excellence HK$680,000 21 Apr 2004
Genomic approaches to uncover functionally relevant signalling pathways in craniofacial development
RGC - Central Allocation Vote HK$329,088 01 Jun 2002
Development of a rapid and sensitive bioassay of heavy metal toxicity by coupling a transgenic reporter gene in a mutant nematode strain
Environment and Conservation Fund / Woo Wheelock Green Fund
HK$149,920 15 Mar 2004
Molecular genetic analysis of ram genes orchestrating sensory ray morphogenesis in C. elegans RGC - Competitive Earmarked Research Grant HK$876,000 15 Dec 2002 Molecular genetic analysis of ray cell assembly in C. elegans male tail
RGC - Competitive Earmarked Research Grant HK$1,730,00015 Dec 2001
Characterizationof sin3-like as a mab-21-dependent dbl/sma signal transducer for C. elegans sensory organ differentiation
RGC - Competitive Earmarked Research Grant HK$1,523,00015 Dec 2003
Representative Research Publications:
Ko, F.C.F., Chow, K.L. (2003) "A mutation at the start codon defines the differential requirement of dpy-11 in C. elegans body hypodermis and male tail.", Biochem. Biophy. Res. Comm., 309:201-208.
Chow, K.L. (2003) "Speech and language ¡V a human trait defined by molecular genetics.", Language Acquisition, Change and Emergence: Essays in evolutionary linguistics. City University Press., p. 122-128.
Wong, Yau Ming, Chow, King L. (2002) "Expression of Mab21 genes marks the differentiating eye, midbrain and neural tube in developing Danio rerio", Mechanism of Development, 113: 149-152.
Chu, Ka Wah, Chow, King L. (2002) "Synergistic toxicity of multiple heavy metals is revealed by a biological assay using nematode and its transgenic derivatives", Aquatic Toxicology, 61: 53-64.
Ko, Frankie C.F., Chow, King L. (2002) "A novel thioredoxin-like protein encoded by dpy-11 is required for body and sensory organ morphogenesis in C. elegans.", Development, 129:1185-1194.
Wong, Y. Ming, Chow, King L. (2001-2002) "Expression of Mab21 genes marks the differentiating eye, midbrain and neural tube in developing Danio rerio", Mechanism of Development, 113: 149-152.
Chasnov, J.R., Chow, K.L. (2001-2002) "Why are there males in the hermaphroditic species Caenorhabditis elegans?", Genetics, 160:983-994.
Ho, Stephen Siu Hong, So, Gloria Ming Kit, Chow, King L. (2001) "Postembryonic expression of C. elegans mab-21 and its requirement in sensory ray differentiation.", Developmental Dynamics, 221:422-430.
Michael HORNER
Visiting Associate Professor and Program Advisor, German Center, Representative of the DAAD (German Acad. Exchange Service) (2358 8390 ; [email protected])
PhD, University of Gottingen (1989)
Assistant Professor (1990-97) and Associate Professor (1997- ), Institute of Zoology, University of Gottingen
Humboldt Research Scholar, Harvard Medical School, (1994-95) Research Fellow, Marine Biological Laboratory, Woods Hole (1992, 97)
Current Research Activities:
Transmitter function and neuromodulatory role of biogenic amines; electrophysiology and
immunocytochemistry of amine-containing neurons; neuroethology. Recent publications: HEINRICH, R., CROMARTY, S. I., HOERNER, M., EDWARDS, D.H., KRAVITZ, E.A. (1999) Autoinhibition of serotonin cells: An intrinsic regulatory mechanism sensitive to the pattern of usage of the cells. Proc.
Natl. Acad. Sci. USA 96:2473-2478 FERBER, M., HOERNER, M., CEPOK, S., GNATZY, W. (2001) Digger wasp versus cricket: Mechanisms underlying the total paralysis caused by the predators venom. J. Neurobiol. 47:207-222 HOERNER, M. (2002) Fight or flight? How aminergic
neuromodulation influences cricket escape and fighting behavior. 22nd Annual Conference of the Hong Kong Society of Neurosciences, Hong Kong, Neuroscience Letters in print ROSE, T., HOERNER, M.
(2003) Activity-Dependent Suppression of Spontaneous Spike Generation in the Retzius Neurons of the Leech, Hirudo medicinalis. Proc. 29th Goettingen Neurobiol. Conf., Thieme, Stuttgart, New York, 765, pp 798-799
Kevin A W LEE
Associate Professor
(2358 8636 ; [email protected])
PhD, McGill University (1985)
Research Scientist, Imperial Cancer Research Fund, UK (1988-95)
Current Research Activities:
Mammalian transcription factors; nucleic acid¡Vprotein interactions; Ewings sarcoma oncogene; cancer therapeutics.
Active Projects as Principal Investigator:
Molecular characterisation of the EWS oncogene and evaluation of potential peptide inhibitors Association for International Cancer Research HK$1,120,031 01 Apr 2003 Functional analysis of the EWS/ATF1 oncogene using RNA interference (RNAi)
RGC - Direct Allocation Grant HK$80,000 16 Nov 2003
Representative Research Publications:
Li, Kim, Goodall, Jane, Goding, Colin, Liao, Sk, Wang, Ch, Lin, Yc, Hiraga, H, Nojima, T, Nagashima, K, Schaefer, Kl, Lee, Kevin (2003) "The melanocyte inducing factor MITF is stably expressed in cell lines from clear cell sarcoma", ¢Ð¢à¢×¢â¢×¢á¢Ö ¢Ø¢ÝURNAL OF CANCER, Volume89pages1072to1078.
Feng, L., Lee, K. A. W. (2001) "A Repetitive Element Containing a Critical Tyrosine Residue is Required for Transcriptional Activation by the Ewings Sarcoma Oncogene", Oncogene, 20: 4161-4168.
Huiqing, Z., Lee, K. A. W. (2001) "An hsRPB4/7-dependent yeast assay for trans-activation by the EWS oncogene", Oncogene, 20: 1519-1524.
Lung, R., Lee, K. A. W. (2000) "The cellular Oncogene EWS/ATF1 does not activate adenovirus borne promoters: Implications for cytotoxic pro-drug therapy of MMSP", Cancer Gene Therapy, 7: 396-406.
Li, K. K. C., Lee, K. A. W. (2000) "Transcriptional activation by the EWS oncogene can be cis-repressed by the EWS RNA-binding-domain", J. Biol. Chem, 275: 23053-23058.
Li, K. K. C., Lee, K. A. W. (1998) "MMSP tumor cells expressing the EWS/ATF1 oncogene do not support cAMP-inducible transcription", Oncogene, 16: 1325-1331.
Pan, S., Koh, Y. M., Dunn, T., Li, K. K. C., Lee, K. A. W. (1998) "The EWS/ATF1 fusion protein contains a dispersed activation domain that functions directly", Oncogene, 16: 1625-1631.
Ning LI
Associate Professor
(2358 7335 ; [email protected])
PhD, University of Washington (1989)
Research Associate, USDA/ARS/PSI Plant Molecular Biology Laboratory (1989-93)
Current Research Activities:
Plant hormone signal transduction; plant functional genomics; genetic engineering.
Active Projects as Principal Investigator:
Investigation of the role of tyrosine152 in 1-aminocyclopropane-1-carboxylate synthase catalysis RGC - Competitive Earmarked Research Grant HK$876,00001 Sep 2002 Elucidation of the biological function of cis-cinnamic acid in higher plants through multidisciplinary approaches
RGC - Competitive Earmarked Research Grant HK$986,00015 Jul 2003
Representative Research Publications:
Yong, Wd, Xu, Yy, Xu, Wz, Wang, X, Li, N, Wu, Js, Liang, Tb, Chong, K, Xu, Zh, Tan, Kh, Zhu, Zq (2003-2004) "Vernalization-induced flowering in wheat is mediated by a lectin-like gene VER2.", Planta, 217, 261-270.
Wu, Lg, Fan, Jh, Jiang, Lb, Wang, H, Song, Rt, Zhang, Qq, Zhu, Hh, Li, N, Liu, Zx, Xu, Zk (2003)
"A specific cis-hairpin ribozyme facilitates infection of a TMV-based DNA vector in tobacco protoplasts", Journal Of Virological Methods, 111, 101-109.
Yi, Zhiqi, Wong, W.S., Ye, W.C., Li, Ning (2003) "Biologically active cis-cinnamic acid occurs naturally in Brassica parachinensis", Chinese Science Bulletin, 48: 555-558.
Lu, Bingwen, Yu, Ho Yan, Pei, Lai Kwan, Wong, Man Yu, Li, Ning (2002) "Prolonged exposure to ethylene stimulates the negative gravitropic responses of Arabidopsis inflorescence stems and
hypocotyls", Functional Plant Biology, 29(8): 989-999.
Mehta, R.A., Cassol, T., Li, Ning, Ali, N., Handa, A.K., Mattoo, A.K. (2002) "Engineered polyamine accumulation in tomato enhances phytonutrient content, juice quality and vine life", Nature
Biotechnology, 20, 613-618.
Huai, Q., Xia, Y.H., Chen, Y.Q., Callahan, B., Li, Ning, Ke, H.M. (2001) "Crystal structures of ACC synthase in complex with AVG and PLP provide new insight into catalytic mechanism", J. Biol. Chem.,
Huai, Q., Xia, Y.H., Chen, Y.Q., Callahan, B., Li, Ning, Ke, H.M. (2001) "Crystal structures of ACC synthase in complex with AVG and PLP provide new insight into catalytic mechanism", J. Biol. Chem.,