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Vitexin Triggers Apoptosis via Mitochondrial Signaling Pathway in Human
U937 Leukemia Cells
Chao-Ying Lee1*, Yung-Shin Chien2, Tai-Hui Chiu1, Wen-Wen Huang3, Shu-Fen Peng3, Jai-Sing Yang2
1
School of Pharmacy, China Medical University., 2Department of Pharmacology, School of Medicine, China Medical University., 3Department of Biological Science and Technology, China Medical University.
Vitexin has been shown to induce apoptotic cell death in human breast cancer cell lines. However, there is no report addressing that vitexin induced cell death in human U937 leukemia cells. The purpose of this study was investigated the mechanisms of vitexin-induced cell death in human U937 leukemia cells. The results indicated that vitexin significantly decreased the
percentage of viability, triggered apoptosis in U937 cells. The down-regulation of the protein levels for Bcl-2 with the simultaneous up-regulation of the cytochrome c, Apaf-1, AIF, caspase-3, -7, -9 and Bax protein expressions by western blotting in U937 cells after vitexin treatment. On the other hand, the exhibition of the caspase-3, -9 activities were observed in U937 cells after vitexin treatment. Our results suggested that vitexin might be used as a therapeutic agent for the treatment of human leukemia in the future.
Vitexin Triggers Apoptosis via Mitochondrial Signaling Pathway in Human
U937 Leukemia Cells
1中國醫藥大學 藥學系, 2中國醫藥大學 醫學系 藥理學科, 3中國醫藥大學 生物科 技系 李昭瑩1*, 錢永炘2, 邱泰惠1, 黃雯雯3, 彭淑芬3, 楊家欣2
