題名:The cadmium-induced death of mesangial cells results in nephrotoxicity.
作者:吳冠勳
Yang LY; Wu KH; Chiu WT; Wang SH; Shih CM 貢獻者:小兒學科
上傳時間:2009-08-10T03:33:57Z
摘要:This study summarizes our most recent findings on the mechanisms underlying the cadmium-induced death of
mesangial cells, which leads to nephrotoxicity. Multiple pathways participate in cadmium-induced nephrotoxicity. In the ROS-GSK-3beta autophagy pathway, cadmium induces ROS most likely from the mitochondria, and the ROS
consequently activate GSK-3beta leading to autophagic cell death. In the calcium-ERK autophagy and apoptosis pathway, cadmium stimulates calcium release from the endoplasmic reticulum, which activates ERK leading to predominantly autophagic cell death and a minor level of apoptotic cell death. In the
calcium-mitochondria-caspase apoptosis pathway, cadmium-induced elevation of calcium depolarizes the mitochondrial membrane potential and then activates caspase signaling leading to
apoptosis. A proposed model for cadmium-induced
autophagy and apoptosis leading to nephrotoxicity is summarized in Figure 1.
