Severely Depressed Young Patients Have
Over Five Times Increased Risk for
Stroke: A 5-Year Follow-Up Study
李信謙;蔡尚穎
Lee HC;Lin HC;Tsai SY
摘要
Abstract
Background: This study aims to estimate the risk of developing stroke within 5 years of discharge among young patients ages 18 to approximately 44 who were hospitalized for depressive disorders. Methods: Our study design features a study cohort and a comparison cohort. The study cohort included patients ages 18 to approximately 44 who were
hospitalized with a principal diagnosis of depressive disorder (n = 827), whereas the comparison cohort consisted of 4,135 patients selected randomly (five for every depressed patient) and matched with the study group in terms of gender, age, and date of discharge. Each patient was tracked for 5 years after their discharge in 1998. Cox proportional hazard regressions were performed to compute the 5-year stroke-free survival rates after adjusting for possible confounding factors. Results: During the 5-year follow-up period, 50
depressed patients (6.05% of the study cohort) and 48 non-depressed subjects (1.16% of the comparison cohort) developed strokes. The adjusted hazard of stroke was 5.43 (95% confidence interval = 3.47- 8.51, p <.001) times greater for depressed patients than for non-depressed subjects. Conclusions: Our findings show young patients ages 18 to approximately 44 who were hospitalized for depressive disorders were at over five times greater risk of developing stroke within 5 years of discharge compared with non-depressed age- and gender-matched subjects.
