Reciprocal regulation of microRNA-99a and insulin-like growth factor I receptor signaling in oral squamous cell carcinoma cells.

1. Page 3, “Introduction” part, paragraph 2, line 10, insert a “dot”. 2. Page 6, Figure 3, line 7, Alex Fluro488 change to Alex Fluro 488.

3. Page 7, “”MiR-99a negatively regulate IGF1R protein levels and reduces IGF1R signaling” part, line 11, (Atdditional file 3: Figure S2A) change to “(Additional file 3: Figure S2A).

4. Page 7, “”MiR-99a negatively regulates IGF1R protein levels and reduces IGF1R signaling” part, line 21, level change to “levels”.

5. Page 9, Figure 6, line 3, Delete “Expression of miR-99a was normalized against an endogenous control U6. The relative expression of miR-99a was determined by normalizing the expression of miR-99a in OEC-M1 cells in different conditions to that in cells in complete medium (CM). Bar, SE; * p < 0.05; ** p < 0.01.

6. Page 8, Figure 5, line 8, delete “cultured cells”.

7. Page 9, Figure 6, line 12, delete “Bar, SE; * p < 0.05; *** p < 0.001.”

8. Page 9, Figure 6, line 18, “Bar, SE; * p < 0.05; ** p < 0.01.” change to “Bar, SE; * p < 0.05; ** p < 0.01; *** p <0.001.”

9. Page 10, Discussion part, paragraph 2, line 6, even thought change to “even though”.

10. Page 12, “Materials and methods/Quantification of miRNA” part, line 9, change to “U6”.

11. Page 14, “Materials and methods/Lentiviral infection of miR-99a” part, line 4, “After 48 h incubation” change to “After 48-hour incubation”.

12. Page 15, “Authors’ contributions” part, line 4, add “and helped to draft the manuscript”.

13. Page 19, “Reference 47”, Oncogene 2013 change to “Oncogene, in press.”.

14. Page 21, “Additional files” part, Additional files 1: Table S1 change “Additional file 1: Table S1”.

15. Page 21, “Additional file 1: Table S1” part, line 2, change to Table S2 (in Bold). 16. Page 21, “Additional file 3: Figure S2” part, line 4," if OSCC tissues” change to “of OSCC tissues”.

17. Page 21, “Additional file 3: Figure S2” part, line 6, -actin change to -actin. 18. Page 21, “Additional file 4: Figure S3” part, line 5, -actin change to -actin. 19. Page 22, “Additional file 5: Figure S5 Figure S4” change to “Additional file 5: Figure S4”.

20. Page 22, “Additional file 5: Figure S4” part, line 3,”OEC-M1 (OEC-M1 miR-99a)” change to “OEC-M1 (OEC-M1 miR-99a) cells”.