Author(s): Chen, SY (Chen, Shih-Yin); Wan, L (Wan, Lei); Huang, YC (Huang, Yu-Chuen);
Sheu, JJC (Sheu, Jim Jinn-Chyuan); Lan, YC (Lan, Yu-Ching); Lai, CH (Lai, Chih-Ho); Lin, CW (Lin, Cheng-Wen); Chang, JS (Chang, Jeng Sheng); Tsai, Y (Tsai, Yuhsin); Liu, SP (Liu, Shih-Ping); Lin, YJ (Lin, Ying-Ju); Tsai, FJ (Tsai, Fuu-Jen)
Title: Interleukin-18 Gene 105A/C Genetic Polymorphism is Associated With the Susceptibility of Kawasaki Disease
Source: JOURNAL OF CLINICAL LABORATORY ANALYSIS, 23 (2): 71-76 2009 Language: English
Document Type: Article
Author Keywords: Kawasaki disease (KD); interleukin 18 (IL-18); polymorphism
KeyWords Plus: TUMOR-NECROSIS-FACTOR; SYSTEMIC-LUPUS-ERYTHEMATOSUS;
ORAL LICHEN-PLANUS; IFN-GAMMA; PROMOTER POLYMORPHISMS; RHEUMATOID- ARTHRITIS; CORONARY ANEURYSMS; FACTOR-ALPHA; IL-18; EXPRESSION
Abstract: Interleukin-18 (IL-18)-656T/G, -607A/C, and -137C/G promoter polymorphisms had been reported associated with Kawasaki disease (KD). An IL-18 genetic A/C polymorphism at coding position 105 (rs549908) has been linked with asthma, rheumatoid, and systemic lupus erythematosus. We tested a hypothesis that the IL-18 105A/C genetic polymorphism confers KD susceptibility. Study participants were Taiwanese KD patients and a healthy control group.
Our data indicated that the frequency of C allele was significantly higher in the patient group (13.9%) than in the control group (2.7%; P<0.0001, odds ratio [OR] = 5.93; 95% confidence interval [CI] = 2.57-13.73). Therefore, persons with the C allele may have higher risk of deve loping KD. In addition, compared with the haplotype frequencies between case and control groups, the KD patients with TACC haplotype appeared to be a significant "at-risk" haplotype compared with other haplotypes (OR: 4.62, 95% CI: 1.71-12.43; P = 0.001). KD patient with the TAGA haplotype appeared to be a significant "protective" haplotype compared with other haplotypes (OR: 0.51, 95% CI:0.29-0.89; P = 0.017). Our results suggest that 105A/C polymorphism and the haplotypes in IL-18 gene are associated with the risk of KD in Taiwanese population. Clin. Lab. Anal. 23:71-76, 2009. (C) 2009 Wiley-Liss, Inc.
Addresses: [Tsai, Fuu-Jen] China Med Univ Hosp, Dept Med Res, Dept Med Genet, Dept Pediat, Taichung, Taiwan; [Chen, Shih-Yin; Wan, Lei; Sheu, Jim Jinn-Chyuan; Tsai, Yuhsin]
China Med Univ, Grad Inst Chinese Med Sci, Taichung, Taiwan; [Wan, Lei; Sheu, Jim Jinn- Chyuan; Tsai, Yuhsin; Lin, Ying-Ju; Tsai, Fuu-Jen] Asia Univ, Dept Biotechnol & Bioinformat, Taichung, Taiwan; [Lin, Ying-Ju; Tsai, Fuu-Jen] China Med Univ, Grad Inst Acupuncture Sci, Taichung, Taiwan; [Liu, Shih-Ping] China Med Univ & Hosp, Ctr Neuropsychiat, Taichung, Taiwan; [Huang, Yu-Chuen] Acad Sinica, Inst Phys, Taipei, Taiwan; [Huang, Yu-Chuen]
Mackay Mem Hosp, Dept Med Res, Taipei, Taiwan; [Lin, Cheng-Wen] China Med Univ, Dept Med Lab Sci & Biotechnol, Taichung, Taiwan; [Lai, Chih-Ho] China Med Univ, Sch Med, Dept
Microbiol, Taichung, Taiwan; [Lan, Yu-Ching] China Med Univ, Dept Hlth Risk Management, Taichung, Taiwan
Reprint Address: Tsai, FJ, China Med Univ Hosp, Dept Med Res, Dept Med Genet, Dept Pediat, 2 Yuh Der Rd, Taichung, Taiwan.
E-mail Address: [email protected] Funding Acknowledgement:
Funding Agency Grant Number
China Medical University CMU95-061 CMU95-062 China Medical University Hospital DMR-97-124
National Science Council in Taiwan NSC94-2320-B-039-042
Grant sponsor China Medical University: Grant numbers: CMU95-061; CMU95-062; Grant sponsor: China Medical University Hospital; Grant number: DMR-97-124; Grant sponsor:
National Science Council in Taiwan: Grant number: NSC94-2320-B-039-042.
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Publisher: WILEY-LISS
Publisher Address: DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
ISSN: 0887-8013 DOI: 10.1002/jcla.20292
29-char Source Abbrev.: J CLIN LAB ANAL ISO Source Abbrev.: J. Clin. Lab. Anal.
Source Item Page Count: 6
Subject Category: Medical Laboratory Technology ISI Document Delivery No.: 425VG
