Comparison of Han Chinese and aborigines in Taiwan chemokine Eotaxin, MCP-1, RANTES and chemokine
receptors CCR5, CCR3 and CCR2 expression were Expression level of Eotaxin, MCP-1, RANTES, CCR5, CCR3 and CCR2 of Taiwanese and Aboriginal Taiwanese
Abstract
Chemokines are a group of 10 ~ 17 kd molecular weight small molecule protein, N terminal cysteine according to the difference between the mixture of amino acids can be divided into four
different family: CXC, CC, C, CX3C, these small molecule protein can activate G protein receptor binding protein (G protein-coupled receptor) and then started to move to a special part of white blood cells, such as lymphoid tissue, location of injury, site of infection, inflammation of the area ... and so on, also enables T cells, B cells move to the antigen presenting cell surface antigen sites, the most well-known chemokine and HIV research than the relationship, in addition, the role of chemokines are also associated with inflammation and some diseases such as rheumatoid arthritis, atopic dermatitis , I diabetes, multiple sclerosis tissue inflammation (Muliple Sclerosis) ... and other diseases are related.
Chemokine and its receptor, another feature is between different ethnic groups (such as Hispanic Americans and African American world, Latin and Asian human) gene and the expression is different, this phenomenon has led to diseases (such as HIV), the difference
between whether or not susceptible to infection.
The main point of this research is preliminary understanding of Taiwanese Han Chinese and indigenous areas of China chemokine Eotaxin, MCP-1, RANTES and its receptor CCR5, CCR3 and CCR2
expression patterns and preliminary results of this and ankylosing spondylitis patients compared with Han Chinese and aborigines in Taiwan chemokine receptors CCR3 in monocytes may speculate on the performance of different indigenous groups and environmental factors. Also found in normal subjects and patients with ankylosing spondylitis in between CCR2 expression on monocytes significantly
different CCR2 may be speculated that perhaps the cause of ankylosing spondylitis associated.
English Abstract
