Studies on the Stability and Formulation of Alkannin / shikonin Enantiomers
Abstract
Preparation Ziyun Lithospermum ointment is the main raw herb ingredients, its role in the treatment of wounds, skin diseases and burns the main. Purple
Principal component Grass shikonin for light-sensitive compounds, in the outdoor light down the optical solution is mainly generated by the photo-oxidation
Nai Kun a new product category (-) -5,8-dihydroxy-2-(1-hydroxy-3-oxo-4- methyl-4-
pentenyl) -1,4-naphthoquinone. The study found that the photolysis of shikonin is to be a dynamic degradation.
Light stability of shikonin by the light source, solvent polarity, Kong fluid oxygen content, container type and quality of the film pH
Ring, but it has nothing to do with the ionic strength. Kinetic studies have shown that the photolysis of shikonin may be the involvement of free radicals. In addition,
, Shikonin base by means of propane with OH - β - cyclodextrin complexing compound and the formation of packets received can increase the dissolution of shikonin
Solutions degrees, light stability and in vitro permeability of drug.
Shikonin - hydroxy propyl - β - cyclodextrin compound of the deposit received
Can help in the infrared spectrum, thermal analysis and powder X- ray diffraction confirmed.
English Abstract
