題名: Biological Data Warehousing System for Identifying Transcriptional Regulatory Sites From Gene Expressions of Microarray Data
作者: Ann-Ping Tsou;Yi-Ming Sun;Chia-Lin Liu;Hsien-Da Huang;Jorng-Tzong Horng;Meng-Feng Tsai;Baw-Juine Liu
貢獻者: Department of Bioinformatics
關鍵詞: Index Terms—Databases;data warehouse;gene expression;gene
regulation;microarray;regulatory sites;synexpression group;transcription factor.
日期: 2006-07
上傳時間: 2010-03-19T08:24:36Z 出版者: Asia University
摘要: Identification of transcriptional regulatory sites plays an important role in the investigation of gene regulation. For this propose, we designed and implemented a data warehouse to integrate multiple heterogeneous biological data sources with data types such as text-file, XML, image, MySQL database model, and Oracle database model. The utility of the biological data warehouse in predicting transcriptional regulatory sites of coregulated genes was explored using a synexpression group derived from a microarray study. Both of the binding sites of known transcription factors and predicted over-represented (OR) oligonucleotides were demonstrated for the gene group. The potential biological roles of both known nucleotides and oneORnucleotide were demonstrated using bioassays. Therefore, the results from the wet-lab experiments reinforce the power and utility of the data warehouse as an approach to the genome-wide search for important transcription regulatory elements that are the key to many complex biological systems.
