CrispianScully ,MarcoCarrozzo Oralmucosaldisease:Lichenplanus

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British Journal of Oral and Maxillofacial Surgery 46 (2008) 15–21

Oral mucosal disease: Lichen planus

Crispian Scully a,∗ , Marco Carrozzo b

aUniversity College London, Eastman Dental Institute, UK

bUniversity of Newcastle, UK

Accepted 19 July 2007

Available online 5 September 2007

Abstract

Lichen planus (LP) is a common disorder in which auto-cytotoxic T lymphocytes trigger apoptosis of epithelial cells leading to chronic inflammation. Oral LP (OLP) can be a source of severe morbidity and has a small potential to be malignant.

The diagnosis of OLP can be made from the clinical features if they are sufficiently characteristic, particularly if typical skin or other lesions are present, but biopsy is recommended to confirm the diagnosis and to exclude dysplasia and malignancy.

OLP is treated with anti-inflammatory agents, mainly the topical corticosteroids, but newer agents and techniques are becoming available.

© 2007 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

Keywords: Lichen planus; Oral; Skin

Introduction

Oral lichen planus (OLP) is a common disorder that affects stratified squamous epithelium virtually exclusively. It is seen worldwide, mostly in the fifth to sixth decades of life, and is twice as common in women than in men.

1–3

Aetiology and pathogenesis

OLP is a T cell-mediated autoimmune disease but its cause is unknown in most cases.

4

The increased production of TH1 cytokines is a key and early event in LP, it is geneti- cally induced, and genetic polymorphism of cytokines seems to govern whether lesions develop in the mouth alone (interferon-gamma (IFN-␥) associated) or in the mouth and skin (tumour necrosis factor-alpha (TNF-␣) associated).

5

Activated T cells are then attracted and migrate towards the oral epithelium, further attracted by intercellular adhesion

Corresponding author at: Eastman Dental Institute, University College London, 256 Gray’s Inn Road, London WC1X 8LD, UK.

Tel.: +44 20 7915 1038; fax: +44 20 7915 1039.

E-mail address:cscully@eastman.ucl.ac.uk(C. Scully).

molecules (ICAM-1 and VCAM), upregulation of epithelial basement membrane extracellular matrix proteins, including collagen types IV and VII, laminin and integrins,

6

and pos- sibly by CXCR3 and CCR5 signalling pathways.

7

Cytokines secreted by keratinocytes such as TNF-␣ and interleukins (IL)-1,IL-8, IL-10, and IL-12 are also chemotactic for lym- phocytes. The T cells then bind to keratinocytes and IFN-␥, and subsequent upregulation of p53, matrix metallopro- teinase 1 (MMP1) and MMP3

8

leads to programmed death of cells (apoptosis),

6,9

which destroys the epithelial basal cells.

The chronic course of OLP may result from the activation of the inflammatory mediator nuclear factor kappa B (NF-

␬B),

10

and the inhibition of the transforming growth factor control pathway (TGF-beta/smad) may cause keratinocyte hyperproliferation that leads to the white lesions.

11

Associations with systemic disease

LP may be associated with many systemic diseases; few have been confirmed, but infection with hepatitis C virus (HCV) can produce extrahepatic signs of which LP is one.

12

HCV- specific T cells may have a role in the pathogenesis of some cases of OLP.

13,14

In a recent systematic review that included

0266-4356/$ – see front matter © 2007 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

doi:10.1016/j.bjoms.2007.07.199

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Fig. 1. Reticular lichen planus in the most common site, the buccal mucosa.

controlled studies, the proportion of people infected with HCV was higher in the LP group than in controls in 20 of the 25 studies, and patients with LP had about a five-fold greater risk of being infected with HCV than controls.

15

However, this appears not to be the case in the UK or northern Europe.

HCV-related OLP seems to be associated with the HLA class II allele HLA-DR6 in Italian patients but not in British patients, which could partly explain the peculiar geographical heterogeneity of the association.

16,17

Oral lesions

OLP can present as small, raised, white, lacy lesions (Figs. 1 and 2), papules (Fig. 3), or plaques, and can resem- ble keratotic diseases such as leukoplakia. Atrophic lesions (Fig. 4) and erosions (Fig. 5) are the forms most likely to cause pain.

The most common sites affected are the buccal mucosae, tongue (mainly the dorsum), gingiva, labial mucosa, and ver- milion of the lower lip.

18,2

About 10% of patients with OLP have the disease confined to the gingiva (Fig. 6).

19

Erythe- matous lesions that affect the gingiva cause desquamative gingivitis, the most common type of gingival LP,

20

which can also present as small, raised, white, lacy papules or plaques,

Fig. 2. Reticular lichen planus.

Fig. 3. Papular lichen planus.

Fig. 4. Atrophic lichen planus.

Fig. 5. Erosive lichen planus.

Fig. 6. Gingival lichen planus.

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and may resemble keratotic diseases such as frictional ker- atosis or leukoplakia.

Lesions on the palate, floor of the mouth, and upper lip are uncommon. LP isolated to a single oral site other than the gingiva is also uncommon, but occasional patients with isolated lesions on the lip

21

or tongue

22

have been described.

Lichenoid lesions may be isolated (see below).

OLP can be clinically distinctive, though many cases are not. The plaque-like forms of LP may resemble leukoplakia, particularly proliferative verrucous leukoplakia. Striated white lesions, with or without erosions can mimic lupus ery- thematosus. In rare cases where white lesions cannot be seen in erosive or ulcerated forms, they can be difficult to differ- entiate clinically from other vesiculoerosive diseases such as pemphigus and pemphigoid. Occasionally lesions may mimic carcinoma.

Malignant potential of OLP

At least three studies using strict diagnostic criteria have shown a significant risk of malignant transformation of OLP to squamous cell carcinoma (SCC).

24–26

Accumulation of inducible nitric oxide synthase (iNOS) with 8-nitroguanine and 8-oxo-7, 8-dihydro-2



-deoxyguanosine (8-oxodG) in oral epithelium in OLP may reflect nitrative and oxidative damage to DNA that could be the basis of malignancy.

27

The risk of malignant transformation varies between 0.4 and 5% over periods of observation from 0.5 to 20 years,

28

and seems to be independent of the clinical type of OLP or the treatment used.

25

However, there remains some con- cern about treatment with immunosuppressive agents that could theoretically impair defences (see below under Man- agement).

Extraoral lesions

Patients with OLP may develop lesions that affect the skin, skin appendages, or other mucosa.

Skin

About 15% of patients with OLP have or develop cutaneous lesions.

29

Typically, these lesions are seen on the flexor sur- faces of the forearms and are erythematous to violaceous, flat-topped, pruritic, polygonal papules that have a network of fine lines (Wickham’s striae) on the surface, and develop within several months of the appearance of OLP.

29

(Fig. 7) Skin appendages

LP on the scalp can cause scarring alopecia, lichen planopi- laris. LP may also affect the nails where it produces thinning and ridging of the nail plate, and splitting of the distal free edge of the nail.

Fig. 7. Cutaneous lichen planus.

Extraoral mucosa

Genital lesions called vulvovaginal-gingival syndrome develop in 20% of women with OLP

30,31

and present with burning, pain, discharge, and dyspareunia. These lesions may become malignant.

32,33

The penogingival syndrome is the male equivalent and may also become malignant.

34

Oesophageal LP has been well-documented

35–37

and is relatively common in patients with oral LP,

38

but ocular, uri- nary, nasal, laryngeal, otic, gastric, and anal mucosa are rarely involved.

Oral lichenoid reactions

Lichenoid reaction is a term used for lesions that resemble OLP clinically and histologically, but have an identifiable aetiology. Precipitants include chronic graft-versus-host dis- ease (cGVHD), some dental materials, and a range of drugs.

There may be a tendency for lichenoid lesions to be unilateral

39

and erosive,

40

and histological examination may show a more diffuse lymphocytic infiltrate with eosinophils and plasma cells, and with more colloid bodies than in classic LP.

4,39

Chronic graft-versus-host disease (cGVHD)

Haematopoietic stem cell transplantation is widely used in the treatment of malignant and non-malignant haema- tological diseases, but is associated with a range of complications, including graft-versus-host disease. Oral lichenoid reactions are often seen in chronic graft-versus-host disease.

41–43

Patients who have allogeneic transplantation and are at

high risk of developing secondary neoplasms, particularly

leukaemias and lymphomas, are also at risk of squamous

cell carcinomas, and a number of oral carcinomas have been

reported.

44

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Dental restorative materials

Dental restorative materials thought to be causes of oral lichenoid reactions include amalgams, composite resins, cobalt, and gold.

45

These reactions may be suspected when OLP lesions are confined to the mucosa in close contact with, or in proximity to, the restoration. They are sometimes unilateral. Some authors have suggested that sensitisation to mercury is an important cause,

46

but others have found few who are sensitised to mercury, with no beneficial effects from removing amalgam restorations,

47

which suggests that other factors may be involved.

48

Unfortunately, skin patch testing and biopsy specimens cannot reliably predict the response to the removal of amalgam,

49,50

but a reaction to a patch test for more than one mercurial allergen can increase the likelihood of an accurate diagnosis.

51

There have also been reports of malignant transformation of restoration-related lichenoid lesions.

52,53

Drugs

Drug-induced oral lichenoid reactions are mostly caused by non-steroidal anti-inflammatory agents and angiotensin- converting enzyme inhibitors.

40,54

Other drugs have also been linked to oral lichenoid reactions, but many of these reports have been based on single cases only.

The most reliable method of diagnosing lichenoid drug reactions is to see if the reaction resolves after the drug has been withdrawn, and if it returns when the drug is taken again. However, this is often not practical and can be potentially dangerous; it may be months before the lichenoid reaction resolves so that empirical withdrawal of the drug in question, and its substitution with another, may be warranted.

Diagnosis of OLP

OLP that presents with classic white lesions may be diagnosed correctly if there are classic skin or other extrao- ral lesions. However, an oral biopsy with histopathological examination is recommended both to confirm the clinical diagnosis and particularly to exclude dysplasia and malig- nancy.

Nevertheless, the histopathological assessment of OLP can be subjective

55

and, in about half the cases, there is poor clinicopathological correlation.

56

In these instances it may help to use direct immunofluorescence, which shows a linear pattern of fibrin and shaggy fibrinogen deposits at the epithe- lial basement membrane or cytoid bodies (Russell bodies), or both, in the absence of deposition of fibrinogen.

57

Management of OLP

Treatment of LP depends on symptoms, the extent of oral and extra-oral clinical involvement, medical history, and

other factors. In the case of patients with lichenoid lesions, the suspected precipitant should be eliminated.

Patients with reticular and other asymptomatic OLP lesions usually require no active treatment. Mechanical injury or irritants such as rough restoration margins or badly fitting dentures should be given attention, and an optimal pro- gramme of oral hygiene instituted, particularly in patients with gingival LP.

Patients with symptomatic lesions may also need treat- ment, usually with drugs, but occasionally surgery has a role.

Drug treatment

Drug treatment with topical agents is preferred as it has fewer adverse effects. However, systemic agents may be required if lesions are widespread, or there is recalcitrant disease. Drugs for OLP are fundamentally immunosuppressive and few were developed or intended for oral diseases; consequently, we lack adequate studies of their efficacy.

4

Patients should be warned about the need to follow instructions, particularly when drug instructions state for “external use only”.

Topical corticosteroids

Midpotency topical corticosteroids such as triamcinolone, potent fluorinated steroids such as fluocinolone acetonide and fluocinonide, and superpotent halogenated steroids such as clobetasol, are effective in most patients.

58–61

Elixirs such as dexamethasone, triamcinolone, and clobetasol can be used as oral rinses for patients with diffuse oral involvement or for those who find it difficult to apply medication to various sites. There are no definitive data to prove that topical steroids in adhesive bases are more effective than other preparations, though they are widely used.

60,62

Patients should be instructed to apply the steroid (oint- ment, spray, rinse, or other form) several times daily, to maintain the drug in contact with the mucosa for a few min- utes, and they should refrain from eating and drinking for 1 hour afterwards.

Most studies have shown that topical corticosteroids are safe when applied to mucous membranes for short intervals,

63,64

and even up to 6 months,

65

but the poten- tial for adrenal suppression with prolonged use, particularly for a disease that is chronic, necessitates careful and fre- quent follow-up. Adrenal suppression seems to be more common when steroids are used as mouthwashes.

66

Few seri- ous adverse effects arise with topical corticosteroids, but up to a third of patients with OLP develop secondary candidiasis, so some clinicians institute antifungal drugs.

58,59

Other topical agents

More potent immunosuppressants or immunomodulatory

agents such as calcineurin inhibitors (ciclosporin, tacrolimus,

or pimecrolimus) or retinoids (tretinoin) can help.

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Ciclosporin has been used as a mouth rinse

67

but is expensive, not particularly effective,

68

and less effective than topical clobetasol in inducing clinical improvement in OLP, though the two drugs have comparable effects on symptoms.

68

Tacrolimus, which is up to 100 times more potent than ciclosporin, has been shown to be effective without notable adverse clinical effects in several uncontrolled studies,

69–74

but accelerates skin carcinogenesis in mice

75

and so the US Food and Drug Administration (FDA) has restricted its use.

Recently an oral cancer has been reported that arose in OLP treated with tacrolimus.

76

Topical retinoids such as tretinoin or isotretinoin have been used to treat OLP,

77

particularly atrophic-erosive forms, with considerable improvement,

78

but retinoids often cause adverse effects and are less effective than topical corticosteroids.

79

Systemic drug treatment

Some consider systemic corticosteroids to be the most effec- tive treatment for OLP, but a recent comparative study did not find differences in response between systemic pred- nisone (1 mg/kg/day) with topical clobetasol in an adhesive base and topical clobetasol alone.

65

Systemic corticosteroids are, therefore, usually reserved for cases where topical approaches have failed, where there is recalcitrant, erosive, or erythematous OLP, or for widespread OLP when skin, gen- itals, oesophagus, or scalp are also involved. Prednisolone 40 to 80 mg daily is usually sufficient to achieve a response:

its toxicity requires that it should be used only when neces- sary, at the lowest dose, and for the shortest time, possible.

It should be taken either for brief periods of time, (5–7 days) and then withdrawn abruptly, or the dose should be reduced by 5–10 mg/day gradually over 2–4 weeks. Adverse effects may be minimised if patients can tolerate the same total dose on alternate days.

Several other systemic immunosuppressive agents have been used in the treatment of OLP, but there has been little evaluation of their efficacy. They include acitretin;

80

azathioprine;

81

basiliximab;

82

cyclosporin;

83

dapsone;

84

eiconol;

85

enoxaparin;

86

glycyrrhizin;

87

hydroxychloroquine;

23

interferon alpha;

88

levamisole;

89

mycophenolate mofetil;

90

and thalidomide

91,92

.

Surgery

Resection has been recommended for isolated plaques or non-healing erosions, because it provides excellent tissue specimens for histopathological confirmation of diagno- sis, and is said to cure localised lesions – but there are few data.

93

Free soft-tissue grafts have also been used for localised areas of erosive OLP,

94

and symp- tomatic OLP disappeared completely after treatment with a free gingival graft after 3.5 years follow-up.

95

How-

ever, periodontal surgery has also been reported to provoke OLP.

96

Cryosurgery

97

has been used particularly in erosive drug- resistant OLP, but lesions may develop in the healing wounds and recur in scars.

Lasers have also been used to treat OLP; carbon dioxide lasers have been used to treat multicentric lesions or diffi- cult areas

98–100

; and low-dose excimer 308-nm laser seems promising from the results of three small trials,

101,102

but much more evidence is required to show its efficacy in OLP, as is the case for photodynamic therapy.

103

Cancer surveillance

In the light of the above, it seems prudent to monitor patients with OLP in the long term.

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