題名: Magnetic Properties of Gd-Doped Iron Oxide Nanoparticles and the Application to Magnetic Resonance Imaging
作者: 卓慧如;施勝銘;林玉娟
貢獻者: 工研院 生物醫學工程中心醫療工程技術組 生物奈米技術部 Dept. of Biomedical Nanotechnology, Medical Engineering Technology Division, Biomedical Engineering Center, Industrial Technology Research Institute
日期: 2003-09-13
上傳時間: 2009-12-09T05:24:55Z 出版者: 臺中健康暨管理學院
摘要: Superparamagnetic iron oxide nanoparticles have played an important role as contrast agents of magnetic resonance imaging (MRI). In this report, a novel research in Gd-doped iron oxide nanoparticles prepared by coprecipitation has been carried out. Particle sizes, elemental composition, magnetic properties, and relaxation times of these iron oxide based nanoparticles were investigated by TEM, XRD, ICP-AES, SQUID, and MRI individually. Particle sizes of uncoated iron oxide
nanoparticles could be controlled well by doping different concentration of Gd. As the concentration of doped Gd increasing, particle sizes increase from 8.4?2.7 nm to 56.2?5.9 nm. From the investigation of ICP- AES, the purity of iron oxide nanoparticles was very high. No matter how many percentages of Gd were added before reacting, the maximum content of Gd/(Gd+Fe) analyzed by ICP-AES were about 3%. SQUID analysis demonstrated the magnetic characteristics of these nanomaterials. Hysteretic feature was observed at 10K and this phenomenon disappeared at room temperature (300K). On the T2- weighted imaging, 2.46 mol% Gd-doped iron oxide could significantly enhance the contrast (~18%). For the purpose of delivering iron oxide nanoparticles to tissue, we modified iron oxide nanoparticle with
dextran. In the future, we would further modify iron oxide nanoparticles with bio-molecules, such as glucose, protein, etc to develop
functionalized MRI contrast agents.