Of endometriosis patients, the incidence of chlamydia infection and the molecular mechanisms of cell adhesion
Chlamydia trachomatis Infection and Cell Adhesion in Patient with Endometriosis
Abstract
Endometriosis (Endometriosis) is a common chronic gynecological disease occurs in women of reproductive age, defined as the peritoneal or uterine cavity in the pelvis was found outside the endometrial glands (Gland)and stromal cells (Stroma cell ), the most common clinical symptoms as pelvic pain and infertility.
To date, its pathogenesis remains unclear, the most widely accepted theory of reflux menstruation theory (Retrograde menstruation), which is retrograde menstruation into the abdominal cavity. Chlamydia trachomatis (Chlamydia trachomatis) is a common bacterial sexually transmitted diseases, often result in women's pelvic pain and uterine, tubal adhesions, endometriosis and some symptoms similar to the first part of this thesis to explore the uterus
Endometriosis prevalence in patients with chlamydia infection to patients with peritoneal fluid samples for ELISA and PCR testing for chlamydia, chlamydia was found in patients showing the percentage of positive responses than the control group. Both endometriosis peritoneal fluid testing for chlamydia infection, the percentage of positive detection of the more traditional way of using the vagina more high, suggesting that endometriosis may be associated with Chlamydia infection up.
Although endometriosis is a benign disease, there are adhesions, invasion and metastasis of cancer and similar pathological characteristics, and cell adhesion and movement has with the extracellular matrix (Extracellular matrix, ECM) and cell adhesion molecules (Cell adhesion molecules, CAM), and therefore the second part of this research study in patients with endometriosis and ectopic endometrial tissue in situ, and normal endometrial tissue of women in the extracellular matrix and cell adhesion molecules whether the difference in performance using the ECM and CAM microarray (Microarray) analysis of gene expression experiments and endometrial tissue, and further to do with Western blot analysis of protein
expression revealed a number of extracellular matrix and cell adhesion molecule expression are indeed different place in situ and endometrial tissue and normal endometrial tissue of women compared are different. In addition, a presence in
the extracellular matrix glycoprotein SPARC (Secreted protein acidic and rich in cysteine), in patients with ectopic expression of endometrial tissue compared with normal endometrial tissue of women obviously, was not previously related
literature SPARC in endometrial tissues of patients with ectopic expression, therefore, this study will focus on SPARC in the formation of endometriosis may play a role in the process of further study.
English Abstract
