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Study on the effects of scutellarein decrease the proliferation through the EGFR inhibition of human lung cancer line A549

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Study on the effects of scutellarein decrease the proliferation through the EGFR inhibition of human lung cancer line A549

Wei-Jen Ting

1,#

Jin-Ming Hwang

2,*

Chih-Yang Huang

1,*

1. Graduate Institute of Basic Medical Science, China Medical University 2. School of Apply Chemical, Chung Shan Medical University

Human lung cancer cell line A549 has a strong ability in proliferation.

Cyclooxygenase-2, which can induce hyperplasia in the cells, highly expression is one of the major reasons. Scutellarein is a compound, as flavonoids, with anti-oxidant and anti-inflammatory activity. In this work, we screened the various concentrations (0, 5, 25, 50μM) of scutellarein in medium and cultured with A549 cell line for 48h. After the incubation with 50μM scutellarein for 48h, A549 cell line proliferation ability decreased more than 50%. Further, the protein analysis discovered that the growth inhibition of A549 was administrated by epidermal growth factor receptor (EGFR) pathway. Scutellarein treatment can decrease extracellular regulated protein kinases (ERK) activation，and decreased the expression of nuclear factor κB (NFκB). Finally, scutellarein treatment inhibited the COX2, which is the down stream target of EGFR pathway, and inhibited the proliferation of A549 cell line.

Keywords: A549 cell line; scutellarein; cyclooxygenase-2

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