第六章 結論與建議
第二節 後續建議
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第二節 後續建議
後續建議將分為對臺灣廠商之建議與對後續研究之建議：
一、對臺灣廠商之建議：
因臺灣內需市場較小，總體消費不及人口眾多的市場，所以企業不論在進行 策略規劃、商業活動或專利佈局都應放眼國際，多了解國外的市場與制度，尤其 不同國家的專利制度都有差別及特色，應仔細研究自身產品的主要市場後，再對 於主要市場的專利制度及佈局方法多加研究，並可仿效國際知名藥廠的專利佈局 模式，避免自身產品品質優良卻淪為專利侵權的受害者，甚至是被控侵權而須付 出大筆權利金。
再者，企業內部應做好專利檢索與分析，除了可了解競爭者的研發方向外，
也可以搶先研發特定的技術或醫藥組合物，甚至還可避免往後在專利侵權訴訟中 處於弱勢地位。另外，由於生醫及化學類的專利經常在說明書或請求項當中以圖 片的形式呈現其內容，而目前的專利檢索系統仍無法以圖片進行檢索，即使可以 使用圖片來檢索，以圖片描述主要化學骨架並加上部分文字補充的撰寫方式仍需 要以人工閱讀後才能判斷其專利範圍，而且以圖片直接繪出完整化學結構也有許 多不同的呈現方式，這些或許都不是使用具圖片檢索功能的檢索系統可以解決的 問題，因此現階段在進行專利檢索時應多嘗試不同的關鍵字，甚至是做專利申請 人、專利權人或主要發明人全部的公告專利檢索，盡量避免有掛一漏萬的現象發 生。此外，本研究發現在進行專利資料庫檢索時發現，單純的專利檢索有時只會 找到一部份的專利，若是可配合檢索橘皮書中登錄的專利資料再進行交叉比對，
可能可以在橘皮書發現尚未在專利資料庫搜索到的專利，因此本研究認為對於生
技醫藥領域來說，檢索專利資料庫與橘皮書都可以作為檢索專利資料的方法，而
且兩者不同衝突，可以同時進行檢索。
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臺灣企業若是到美國或是專利制度與美國類似的國家申請專利時，可以仿效 吉利德公司使用臨時申請案加上延續案、部分延續案或分割案並用的方式進行專 利申請與佈局，一方面可提早取得有效的專利優先權日，避免申請的請求項內容 因對手公開相關資訊而喪失新穎性，另一方面也可將被核駁的請求項以延續案的 型式處理，使沒有被核駁的請求項得以保留在母案當中盡早獲准專利，此舉亦可 避免同一專利申請案的在答辯過程中有過多限縮專利請求項的紀錄，降低未來若 發生專利訴訟時違反禁反言原則而敗訴的可能性。
最後，臺灣藥廠進行專利佈局時可以考慮採用與吉利德公司類似的佈局方法，
例如在申請專利時以物質專利為主，或是申請物質專利作為主要的核心專利，後 續再申請組合物、適應症、製備方法、固定劑量組合等專利圍繞在核心專利周遭。
甚至是不同商品有共通技術或類似成分時，可以將共同的部分作為專利保護的核 心，周圍再佈局不同商品各自的專利，因此核心專利可以同時涵蓋多個不同的商 品，藉此達到最佳的專利保護效果。
二、對後續研究之建議：
本研究僅進行吉利德公司在美國被授予而公告之專利研究，而沒有包含吉利 德公司在美國所有因申請而公開的專利申請案，亦沒有包含吉利德公司在其他國 家的申請公開案及核准公告案，因此建議未來可研究並比較吉利德公司在其他國 家的專利佈局狀況，也可透過研究吉利德公司之 PCT (Patent Cooperation Treaty) 專利案件來追蹤該公司在不同國家的佈局情況。
吉利德公司有許多的專利訴訟案件截至本研究探討之最後時間區間的 2017
年底仍在進行當中，且因為該些專利訴訟尚未塵埃落定，因此本研究對於吉利德
公司專利的訴訟結果及相關法律狀態均著墨不多，建議未來的研究可針對此項進
行吉利德公司專利之法律狀態分析，研究並評析法院對於該些專利訴訟之見解，
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或者亦可研究吉利德公司專利的繳費及維持情況，分析吉利德公司是否有專利尚
未到期就因未繳費而喪失其專利權，並探討其背後的原因及專利策略。
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1 RE046762 1'-substituted carba-nucleoside analogs for antiviral treatment 2018/03/27 2016/10/07 Thomas Butler, Aesop Cho, Choung U. Kim, Jay P. Parrish, Oliver L. A01N 43/04, A61K 31/70, C07H 5/04, C07H 7/06, C07H 19/23,
2 09925184 Spray-dry formulations 2018/03/27 2014/10/10 Lawrence S Zisman A61K 31/497, A61K 31/4965, A61K 31/506, A61K 9/00, A61K 9/16
3 09920018 Fused heterocyclic compounds as ion channel modulators 2018/03/20 2016/12/07 Michael Graupe, Yafan Lu, Jeff Zablocki C07D 261/20, C07D 413/12, C07D 413/14, C07D 471/04, C07D
4 09918939 Formulation of Syk inhibitors 2018/03/20 2014/07/29 Melissa Jean Casteel, Bei Li, Rowchanak Pakdaman, Diana Sperger, Dimitrios Stefanidis
A61K 31/537, A61K 9/20, C07C 309/66, C07D 487/04,, A61K 31/5377, A61K 47/10, A61K 47/38, B29B 9/10,, B29C 43/00, B29C 43/02, A61K 9/28
5 09908875 Apoptosis signal-regulating kinase inhibitors 2018/03/06 2014/12/15 Gregory Notte A61K 31/444, C07D 401/14, C07D 417/14, A61K 31/4439, A61K
31/4545, A61K 31/496, A61K 31/5377, A61K 31/553, C07D 487/04,
6 09907790 Solid forms of an ASK1 inhibitor 2018/03/06 2017/04/06 Gregory Notte C07D 249/08, A61K 31/4439, A61K 31/422, A61K 31/541
7 09890134 Processes for preparing antiviral compounds 2018/02/13 2017/04/28
Kevin M. Allan, Shinji Fujimori, Lars V. Heumann, Grace May Huynh, Katie Ann Keaton, Chrisopher M. Levins, Ganapati Reddy Pamulapati, Benjamin James Roberts, Keshab Sarma, Martin Gerald Teresk, Xiang Wang, Scott Alan Wolckenhauer
C07D 311/78, C07C 49/755
8 09891239 Modulators of pharmacokinetic properties of therapeutics 2018/02/13 2008/02/22 Manoj C. Desai, Hongtao Liu, Lianhong Xu G01N 33/94, A61K 31/427, A61K 31/496, A61K 31/5377, A61K 45/06, C07D 277/28, C07D 277/30, C07D 417/14, G01N 33/58 9 09884873 Solid forms of an antiviral compound 2018/02/06 2017/03/15 Olga Viktorovna Lapina, Bing Shi, Fang Wang, Scott Alan Wolckenhauer C07D 491/052
10 09878995 Cot modulators and methods of use thereof 2018/01/30 2017/02/09
Elizabeth M. Bacon, Gayatri Balan, Chien-Hung Chou, Christopher T. Clark, Jeromy J. Cottell, Musong Kim, Thorsten A. Kirschberg, John O. Link, Gary Phillips, Scott D. Schroeder, Neil H. Squires, Kirk L. Stevens, James G.
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C07D 401/14
11 09879023 Therapeutic compounds 2018/01/30 2016/09/06 Kerim Babaoglu, Michael L. Mitchell, Ryan McFadden, Paul A. Roethle, Lianhong Xu, Hong Yang
C07D 491/06, C07D 277/64, C07D 417/10, A61K 9/12, A61K 9/20, A61K 9/48, A61K 31/428, A61K 31/4741, A61K 45/06, A61K 9/00
12 09873716 Macrocyclic inhibitors of flaviviridae viruses 2018/01/23 2015/06/16
Caroline Aciro, David Kenneth Dean, Neil Andrew Dunbar, Adrian John Highton, Petr Jansa, Kapil Kumar Karki, Andrew J. Keats, Linos Lazarides, Richard L. Mackman, Simon N. Pettit, Karine G. Poullennec, Adam James Schrier, Dustin Siegel, Victoria Alexandra Steadman
A61K 38/21, C07K 5/062, C07D 487/08, C07D 498/08, C07D 498/18, A61K 38/12, A61K 39/29, A61K 45/06, C07K 5/02, C07D 471/18, C07D 498/22, A61K 38/55, A61K 31/403, A61K 31/497, A61K 31/504, A61K 31/7056, A61K 31/7072, C07K 5/078, C07K 5/065, A61K 38/15, A61K 38/00
13 09873682 Apoptosis signal-regulating kinase inhibitor 2018/01/23 2017/04/19 Gregory Notte A61K 31/44, C07D 213/56, C07D 401/14
14 09873680 Therapeutic compounds 2018/01/23 2015/08/26
Gediminas Brizgys, Eda Canales, Randall L. Halcomb, Yunfeng Eric Hu, Darryl Kato, John O. Link, Qi Liu, Roland D. Saito, Winston C. Tse, Jennifer R. Zhang
C07D 401/14, C07D 403/14, C07D 405/14, C07D 413/14, C07D 471/04, C07D 493/04, C07D 498/04, A61K 31/4439, A61K 31/444, A61K 31/4709, A61K 31/496, A61K 31/506, A61K 31/5377, A61K 45/06, C07D 519/00
15 09868745 Antiviral compounds 2018/01/16 2014/11/13
Elizabeth M. Bacon, Jeromy J. Cottell, Ashley Anne Katana, Darryl Kato, Evan S. Krygowski, John O. Link, James G. Taylor, Chinh Viet Tran, Teresa Alejandra Trejo Martin, Zheng-Yu Yang, Sheila Zipfel
A61K 31/4188, C07D 491/052, A61K 45/06, A61K 31/7056, A61K 38/21, C07F 5/02, A61K 31/7064, A61K 31/7072, A61K 38/06, A61K 38/07, C07D 405/12, A61K 47/60
16 09862728 Crystalline forms of an antiviral compound 2018/01/09 2016/12/21 Dustin Bringley, Johann Chan, Peter Fung, Katie Keaton, Olga Lapina,
Henry Morrison, Dominika Pcion C07D 498/16, C07K 5/083, A61K 45/06, A61K 31/4985 17 09845299 Process for the preparation of a fluorolacton derivative 2017/12/19 2017/03/09 Rongmin Chen, Yuanqiang Li, Jianqiang Zhao, Jianbing Zheng, Guoliang C07D 263/26
18 09828388 Thieno[3,2-d]pyrimidine, furo[3,2-d]pyrimidine, and
pyrrolo[3,2-D]pyrimidines useful for treating respiratory syncitial virus infections 2017/11/28 2015/07/22 Michael O'Neil Hanrahan Clarke, Richard L. Mackman, Dustin Siegel C07H 7/06, C07H 11/04, C07D 495/04 19 09820979 FXR (NR1H4) binding and activity modulating compounds 2017/11/21 2016/12/05 Olaf Kinzel, Christoph Steeneck, Claus Kremoser A61K 31/42, A61K 31/422, A61K 31/4439
20 09815815 Non-selective kinase inhibitors 2017/11/14 2014/01/09 Lawrence S Zisman C07D 401/12, C07D 241/20, C07D 403/12, A61K 31/4965
21 09815818 Cot modulators and methods of use thereof 2017/11/14 2016/06/30
Elizabeth M. Bacon, Gayatri Balan, Chien-Hung Chou, Christopher T. Clark, Jeromy J. Cottell, Musong Kim, Thorsten A. Kirschberg, John O. Link, Gary Phillips, Scott D. Schroeder, Neil H. Squires, Kirk L. Stevens, James G.
Taylor, William J. Watkins, Nathan E. Wright, Sheila M. Zipfel
C07D 401/12, C07D 401/14, C07D 405/14, C07D 413/12, C07D 453/02, C07D 409/14, C07D 413/14, C07D 417/14, C07F 7/08
22 09809600 Antiviral compounds 2017/11/07 2016/07/11
Elizabeth M. Bacon, Jeromy J. Cottell, Ashley Anne Katana, Darryl Kato, Evan S. Krygowski, John O. Link, James G. Taylor, Chinh Viet Tran, Teresa Alejandra Trejo Martin, Zheng-Yu Yang, Sheila M. Zipfel
C07D 491/052, C07D 405/12
131
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23 09809559 (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)
pyrimidin-4-yl)benzamide 2017/11/07 2016/08/08
Brandon H. Brown, Ernest A. Carra, Jeffrey N. Hemenway, Henry Morrison, Troy Reynolds, Bing Shi, Dimitrios Stefanidis, Fang Wang, Matthew Robert Warr, James Andrew Whitney, Yan Xin
A61K 31/535, A61K 31/5377, C07D 239/42, C07D 265/30
24 09802941 Compounds and methods for inhibiting histone demethylases 2017/10/31 2015/08/26
Thomas Boesen, Marc Labelle, Ying Yang, Neerja Saraswat, Dastagiri Dudekula, Cyril John Cook, Ramkrishna Reddy Vakiti, Rui Zhang, Farman Ullah
C07D 487/04, A61K 31/5355, C07D 413/12, C07D 409/14, A61K 31/506, C07D 213/79, C07D 413/14, C07D 401/14, A61K 31/501, A61K 31/4985, A61K 31/444, A61K 31/4439, A61K 31/4412, C07D 213/38, C07D 213/48, C07D 213/56, C07D 401/04, C07D 413/04, C07D 401/12
25 09796718 6-(benzo[d]thiazol-5-yl)-n-(3,4-dimethoxyphenyl)imidazo
[1,2-a]pyrazin-8-amine 2017/10/24 2015/10/13
Scott A. Mitchell, Kevin S. Currie, Peter A. Blomgren, Jeffrey E. Kropf, Seung H. Lee, Jianjun Xu, Douglas G. Stafford, James P. Harding, Antonio J. M. Barbosa, Jr., Zhongdong Zhao, David M. Armistead, Soumya Mitra
A61K 31/4985, C07D 487/04, A61K 31/495, C07D 519/00, C07D 498/04, C12Q 1/48, C07D 471/04, C07D 491/107, G01N 33/573
26 09795602 Polycyclic-carbamoylpyridone compounds and their pharmaceutical
use 2017/10/24 2016/11/11
Elizabeth M. Bacon, Zhenhong R. Cai, Jeromy J. Cottell, Mingzhe Ji, Haolun Jin, Scott E. Lazerwith, Philip Anthony Morganelli, Hyung-Jung Pyun
A61K 31/4985, C07D 491/147, A61K 45/06
27 09789089 Therapeutic compounds 2017/10/17 2015/11/17 Steven S. Bondy, Carina E. Cannizzaro, Chien-Hung Chou, John O. Link, Qi Liu, Scott D. Schroeder, Winston C. Tse, Jennifer R. Zhang
A61K 31/4178, C07D 403/12, C07D 413/12, C07D 417/12, C07D 471/04, A61K 31/4192, A61K 31/4196, A61K 31/4245, A61K 31/427, A61K 31/437, A61K 45/06, A61K 31/422
28 09783568 Salts of HIV inhibitor compounds 2017/10/10 2016/06/01 Benjamin R. Graetz, Richard Polniaszek A61K 31/7076, A61K 45/06, C07H 19/20, A61K 9/20
29 09783567 Processes and intermediates for preparing anti-HIV agents 2017/10/10 2016/02/17
Richard Hung Chiu Yu, Brandon Heath Brown, Richard P. Polniaszek, Benjamin R. Graetz, Keiko Sujino, Duong Tran, Alan Scott Triman, Kenneth M. Kent, Steven Pfeiffer
C07H 19/00, C07H 19/22, C07H 19/20, C07H 19/02, C07H 19/04, C07H 19/173, C07D 473/34, C07F 9/40, C07F 9/44, C07F 9/6561, C07H 19/16, C07H 23/00
30 09777028 Co-crystals, salts and solid forms of tenofovir alafenamide 2017/10/03 2016/06/13 Bing Shi, Zhuoyi Su, Fang Wang C07F 9/6561, C07C 57/15
31 09771328 Processes for preparing ASK1 inhibitors 2017/09/26 2017/01/23 Joshua R. Dunetz C07D 233/64
32 09765089 ACC inhibitors and uses thereof 2017/09/19 2014/05/08 Jeremy Robert Greenwood, Geraldine C. Harriman, George Borg, Craig E.
Masse C07D 513/04, C07D 487/04, C07D 495/04, A01N 43/90
33 09765060 Phosphatidylinositol 3-kinase inhibitors 2017/09/19 2015/06/23
Jerry Evarts, Joshua Kaplan, Musong Kim, Devan Naduthambi, Leena Patel, Stephane Perreault, Gary Phillips, Lafe J. Purvis, II, Kirk L. Stevens, Jennifer A. Treiberg
C07D 403/12, C07D 403/14, C07D 409/14, C07D 491/107, C07D 413/14, C07D 401/14
34 09757406 Combination formulation of two antiviral compounds 2017/09/12 2016/09/30 Eric Gorman, Erik Mogalian, Reza Oliyai, Dimitrios Stefanidis, Lauren
Wiser, Vahid Zia A61K 31/7072, A61K 31/4188
35 09751874 Hydroxy containing FXR (NR1H4) modulating compounds 2017/09/05 2015/12/16 Christian Gege, Olaf Kinzel, Claus Kremoser, Aaron C. Schmitt C07D 417/12, C07D 417/14, C07D 413/12, C07D 261/08, C07D
36 09750730 Apoptosis signal-regulating kinase inhibitor 2017/09/05 2016/04/27 Gregory Notte A61K 31/44, C07D 213/56, A61K 31/4439, C07D 401/14, C07D
233/56, C07D 401/04, A61K 9/00, A61K 9/20, A61K 45/06 37 09744181 Compositions and methods for combination antiviral therapy 2017/08/29 2014/10/24 Terrence C. Dahl, Mark M. Menning, Reza Oliyai A61K 9/20, A61K 31/675, A61K 31/513, A61K 31/7076, A61K
45/06, A61K 31/683
38 09738646 Solid forms of a toll-like receptor modulator 2017/08/22 2015/09/14 Brandon Heath Brown, Paul Roethle C07D 401/10, C07D 475/06, A61K 31/519, C07D 487/04, A61K 39 9732156 Methods of treating rheumatoid arthritis using antibodies to matrix
metalloproteinase 9 2017/08/15 2013/02/28 Joanne I. Adamkewicz, Victoria Smith, Zung Thai, Michael J. Hawkins C07K 16/40, A61K 39/395, A61K 45/06, A61K 31/513, A61K 39/00
40 09730936 Quinazoline compounds 2017/08/15 2015/12/23
Ond{hacek over (r)}ej Baszczy{hacek over (n)}ski, Milan Dejmek, Yunfeng Eric Hu, Petr Jansa, Eric Lansdon, Richard L. Mackman, Petr {hacek over (S)}imon
A01N 43/54, A61K 31/517, C07D 401/00, C07D 403/00, C07D 413/00, C07D 417/00, C07D 419/00, C07D 401/12, C07D 239/94, A61K 45/06, C07D 239/84, C07D 239/95, C07D 403/12
41 9732092
Substituted 2,3,4,5,7,9,13,13a-octahydropyrido[1',2':4,5]
pyrazino[2,1-b][1,3]OXAZEPINES and methods for treating viral infections
2017/08/15 2016/11/11 Haolun Jin, Scott E. Lazerwith, Hyung-Jung Pyun, Elizabeth M. Bacon, Philip Anthony Morganelli, Mingzhe Ji
A61K 31/5365, C07D 413/14, C07D 498/14, A61K 45/06, A61K 31/537, A61K 31/553
42 9724360 Methods for treating Filoviridae virus infections 2017/08/08 2015/10/29
Byoung Kwon Chun, Michael O' Neil Hanrahan Clarke, Edward Doerffler, Hon Chung Hui, Robert Jordan, Richard L. Mackman, Jay P. Parrish, Adrian S. Ray, Dustin Siegel
C07H 15/18, C07H 7/06, A61K 31/685, C07D 487/04, C07D 519/00, C07F 9/24, C07F 9/6561, A61K 31/675, A61K 45/06, A61K 31/00, A61K 31/53, C07H 1/00, C07H 1/02, C07H 11/00
43 09718807 Synthesis of antiviral compound 2017/08/01 2016/08/04 Robert William Scott, Justin Philip Vitale, Kenneth Stanley Matthews, Martin
Gerald Teresk, Alexandra Formella, Jared Wayne Evans C07D 403/14, C07D 403/04 44 09708326 Inhibitors of bruton's tyrosine kinase 2017/07/18 2014/02/20 Wei Chen, Shunqi Yan, David J. Loury, Leah Lynn Frye, Jeremy Robert
Greenwood, Mee Yoo Shelley, Longcheng Wang C07D 473/32, C07D 487/04
132
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2017/07/18 2015/06/19 Ernest A. Carra, Irene Chen, Vahid Zia C07D 498/18, A61K 31/553, A61K 31/675, A61K 31/513, C07D 498/14
46 09708327 Polymorphic forms of a hydrochloride salt of
(S)-2-(1-(9H-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one 2017/07/18 2014/12/18 Suzanne Buttar, Ernest Carra, Tracy Ehiwe, Duong Tran, Fang Wang,
Christopher Worrall, Jerry Evarts C07D 473/34
47 9701682 Pyrrolo[1,2-f ][1,2,4]triazines useful for treating respiratory syncitial
virus infections 2017/07/11 2016/06/14 Michael O'Neil Hanrahan Clarke, Edward Doerffler, Richard L. Mackman,
Dustin Siegel C07H 7/06, C07D 405/04, C07D 405/14, C07D 487/04, C07F 9/6561
48 09700554 Polycyclic-carbamoylpyridone compounds and their pharmaceutical
use 2017/07/11 2016/07/12 Mingzhe Ji, Scott E. Lazerwith, Hyung-jung Pyun C07D 221/18, A61K 31/4985, A61K 31/537, A61K 45/06
49 09701677 Fused pyrimidine compounds 2017/07/11 2015/12/23 Petr Jansa, Miroslav Kvasnica, Richard L. Mackman C07D 471/04, C07D 487/04, A61K 31/519, A61P 31/18, A61K 45/06
50 09695192 Fused heterocyclic compounds as ion channel modulators 2017/07/04 2015/02/24
Britton Kenneth Corkey, Elfatih Elzein, Robert H. Jiang, Rao V. Kalla, Dmitry Koltun, Xiaofen Li, Ruben Martinez, Eric Q. Parkhill, Thao Perry, Jeff Zablocki, Chandrasekar Venkataramani, Michael Graupe, Juan Guerrero
A61K 31/553, C07D 267/14, C07D 401/04, C07D 401/12, C07D 401/14, C07D 403/04, C07D 403/12, C07D 403/14, C07D 413/04, C07D 413/14, C07D 471/12, C07D 487/04, C07D 498/04, C07D 413/12
51 09687492 Methods for treating cancers 2017/06/27 2014/12/03 Julie Di Paolo, Michael J. Hawkins, Jing Hu, Feng Jin, Flordeliza
Melchor-Khan, Anita Reddy A61K 31/5377
52 09682998 Fused heterocyclic compounds as ion channel modulators 2017/06/20 2016/06/21
Britton Kenneth Corkey, Elfatih Elzein, Michael Graupe, Juan Guerrero, Robert H. Jiang, Rao V. Kalla, Tetsuya Kobayashi, Dmitry Koltun, Xiaofen Li, Ruben Martinez, Gregory Notte, Eric Q. Parkhill, Thao Perry, Chandrasekar Venkataramani, Jeff Zablocki
C07D 255/04, C07D 403/04, C07D 403/06, C07D 403/08, C07D 403/14, C07D 401/14, A61K 31/53, A61P 25/08, C07D 498/10, C07D 498/04, C07D 263/58, C07D 237/32, C07D 239/88, C07D 239/90, C07D 253/08, C07D 265/22, C07D 401/04, C07D 401/06, C07D 401/12, C07D 403/12, C07D 405/12, C07D 413/06, C07D 413/14, C07D 417/06, C07D 417/14, C07D 217/26, C07D 413/12, C07D 279/08, C07D 417/12
53 09682989 Antiviral compounds 2017/06/20 2015/10/28 Elizabeth M. Bacon, Jeromy J. Cottell, John O. Link, Teresa Alejandra Trejo Martin
C07D 491/052, A61K 31/4188, A61K 31/7056, A61K 38/21, A61K 31/7072, A61K 45/06, A61K 31/7068, C07D 491/04
54 09682084
Crystalline forms of (2R,5S,13AR)-8-hydroxy-7,9,-dioxo-N-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13, 13a-octahydro-2,5-methanopyrido [1',2':4,5] pyrazino[2,1-b][1,3]oxazepine-10-carboxamide
2017/06/20 2015/06/19 Ernest A. Carra, Irene Chen, Katie Ann Keaton, Scott E. Lazerwith, Vahid Zia
A61K 31/5365, C07D 498/18, A61K 45/06, A61K 9/20, C07D 498/14, A61K 31/537
55 09682987 Solid forms of an antiviral compound 2017/06/20 2015/08/13 Erik Mogalian, Robert William Scott, Bing Shi, Fang Wang C07D 403/14, C07D 487/08, A61K 31/4184, A61K 31/7056, A61K 31/381, C07D 471/08
56 09676808 2',4'-substituted nucleosides as antiviral agents 2017/06/13 2016/01/27 Jinfa Du, Michael Joseph Sofia C07H 19/06, C07H 19/16, C07H 19/073, C07H 19/173, A61K 31/7064, A61K 31/7068, A61K 31/7072, A61K 31/7076, C07H 19/14 57 09676804 Methods for preparing anti-viral nucleotide analogs 2017/06/13 2016/04/21 Denise A. Colby, Andrew Anthony Martins, Benjamin James Roberts,
Robert William Scott, Nicole S. White C07F 9/6561
58 09676760 Fused heterocyclic compounds as ion channel modulators 2017/06/13 2016/05/11
Britton Kenneth Corkey, Elfatih Elzein, Michael Graupe, Juan Guerrero, Robert H. Jiang, Rao V. Kalla, Dmitry Koltun, Xiaofen Li, Ruben Martinez, Eric Q. Parkhill, Thao Perry, Chandrasekar Venkataramani, Jeff Zablocki
C07D 413/06, A61K 31/553, A61K 31/5513, C07D 267/08, C07D 243/24, C07D 267/14, C07D 291/08, C07D 403/06, C07D 413/12, C07D 413/14, C07D 419/06, C07D 471/04, C07D 487/04, C07D 498/04, C07D 243/14, C07B 59/00, C07D 413/04, C07D 417/14 59 09670205 Toll like receptor modulator compounds 2017/06/06 2016/03/02 Evangelos Aktoudianakis, Gregory Chin, Richard L. Mackman, Samuel E.
Metobo, Michael R. Mish, Hyung-jung Pyun, Jeff Zablocki C07D 471/04
60 09670187 Processes for preparing antiviral compounds 2017/06/06 2015/06/08
Kevin M. Allan, Shinji Fujimori, Lars V. Heumann, Grace May Huynh, Katie Ann Keaton, Christopher M. Levins, Ganapati Reddy Pamulapati, Benjamin James Roberts, Keshab Sarma, Martin Gerald Teresk, Xiang Wang, Scott Alan Wolckenhauer
C07D 491/052, C07D 405/14, C07D 405/12
61 09663528 Substituted
1,2,3,4,6,8,12,12a-octahydro-1,4-methanodipyrido[1,2-a:1',2'-d]pyrazines and methods for treating viral infections 2017/05/30 2015/07/31 Manoj C. Desai, Haolun Jin, Scott E. Lazerwith, Hyung-Jung Pyun, James
G. Taylor A61K 31/4985, C07D 241/38, C07D 487/14
133
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62 09655944 Inhibitors of hepatitis C virus 2017/05/23 2016/06/17
Kyla Bjornson, Eda Canales, Jeromy J. Cottell, Kapil K. Karki, Ashley A.
Katana, Darryl Kato, Tetsuya Kobayashi, John O. Link, Ruben Martinez, Barton W. Phillips, Hyung-jung Pyun, Michael Sangi, Adam J. Schrier, Dustin Siegel, James G. Taylor, Chinh V. Tran, Teresa A. Trejo Martin, Randall W. Vivian, Zheng-Yu Yang, Jeff Zablocki, Sheila Zipfel
A61K 38/21, A61K 38/06, C07D 498/16, A61K 31/4985, C07D 498/22, A61K 31/4745, A61K 31/506, A61K 31/519, A61K 45/06, C07K 5/087, C07K 5/08, C07K 5/083, A61K 38/00
63 09657023 Polymorph of Syk inhibitors 2017/05/23 2014/07/29 Tim G. Elford, Peter Chee-Chu Fung, Michael Laird Hurrey, Dimitrios
Stefanidis, Dragos Vizitiu C07D 487/04, C07C 309/04
64 09650339 Inhibitors of histone demethylases 2017/05/16 2014/02/26
Marc Labelle, Thomas Boesen, Qasim Khan, Ramkrishna Reddy Vakiti, Utpal Sharma, Ying Yang, Mukund Mehrotra, Neerja Saraswat, Farman Ullah
C07D 413/04, C07D 213/40, C07D 401/04, C07D 401/12, C07D 213/38, C07D 213/48, C07C 55/06, C07C 309/30, C07D 213/56, A61K 31/435, A61K 31/4427, A61K 31/4439, A61K 31/454, A61K 31/4545, A61K 31/496, A61K 31/506, A61K 31/5355, A61K 31/537, C07C 55/07, C07C 57/15, C07C 59/265, C07D 307/62
65 09643956 Solid forms of an ASK1 inhibitor 2017/05/09 2015/12/22
Mark Andres, Brenda J. Burke Chan, Ernest A. Carra, Anna Chiu, Olga Viktorovna Lapina, Stephen P. Lathrop, Gregory Notte, Valeriya Smolenskaya, Lok Him Yu
C07D 249/08, C07D 401/14, C07D 413/12, A61K 31/422, A61K 31/4439, A61K 31/541, C07C 55/07, C07C 57/145, C07C 57/15, C07C 59/06, C07C 309/04
66 09642889 Macrocyclic inhibitors of Flaviviridae viruses 2017/05/09 2015/05/21
Caroline Aciro, Jean Yves Chiva, David Kenneth Dean, Adrian John Highton, Petr Jansa, Andrew John Keats, Linos Lazarides, Richard Mackman, Karine G. Poullennec, Adam James Schrier, Dustin Scott Siegel, Victoria Alexandra Steadman, Greg Watt
A61K 38/21, A61K 38/12, C07D 487/08, C07D 498/08, C07D 498/18, C07D 498/22, A61K 39/29, A61K 45/06, C07K 5/02, A61K 39/05, A61K 38/15, A61K 38/00
67 09637512 Nucleoside phosphoramidates 2017/05/02 2014/01/10 Byoung-Kwon Chun, Ganapati Reddy Pamulapati, Suguna Rachakonda, Bruce Ross, Michael Joseph Sofia, Peiyuan Wang, Hai-Ren Zhang
C07H 19/10, A61K 31/7072, A61K 45/00, C07F 9/24, A61K 31/716, C07H 17/02, C07F 9/6558, C07H 1/00
68 09630978 Polycyclic-carbamoylpyridone compounds and their pharmaceutical
use 2017/04/25 2016/04/01 Zhenhong R. Cai, Haolun Jin, Scott E. Lazerwith, Hyung-Jung Pyun
C07D 513/22, A61K 31/4985, A61K 31/5365, A61K 45/06, C07D 491/22, C07D 498/16, C07D 498/22, A61K 31/4375, C07D 491/14, C07D 498/14
69 09630972 Solid forms of an antiviral compound 2017/04/25 2015/06/08 Olga Viktorovna Lapina, Bing Shi, Fang Wang, Scott Alan Wolckenhauer C07D 491/052
70 09624183 Process for the preparation of a fluorolacton derivative 2017/04/18 2015/07/14 Rongmin Chen, Yuanqiang Li, Jianqiang Zhao, Jianbing Zheng, Guoliang C07D 307/33, C07D 413/06, C07D 263/26
71 09624195 Isoquinoline compounds 2017/04/18 2015/12/23 Yunfeng Eric Hu, Petr Jansa, Eric Lansdon, Richard L. Mackman C07D 401/12, C07D 217/22, A61K 31/472, A61K 31/4725, A61K 31/497, A61K 31/501, A61K 31/506, A61K 45/06
72 09617310 Inhibitors of hepatitis C virus 2017/04/11 2014/03/14
Kyla L. Bjornson, Kapil K. Karki, John O. Link, Hyung-jung Pyun, Adam J.
Schrier, Kirk L. Stevens, James G. Taylor, Randall W. Vivian, Jeff Zablocki, Sheila Zipfel
C07D 498/22, A61K 31/437, A61K 31/519, A61K 31/4985, A61P 31/14, C07K 7/64, C07D 487/00, C07D 487/02, C07D 203/02 73 09617295 2'-chloro aminopyrimidinone and pyrimidine dione nucleosides 2017/04/11 2015/08/19 Michael O'Neil Hanrahan Clarke, Richard L. Mackman, Dustin Siegel C07H 19/073, C07H 19/10, C07H 19/06
74 09611268 Modulators of toll-like receptor 7 2017/04/04 2015/02/19 Michael Graupe, Randall L. Halcomb C07D 473/18, A61K 31/522, A61K 31/5377, A61K 31/55, A61K 31/551, A61K 45/06
75 09610299 Compounds for the treatment of addiction 2017/04/04 2015/03/16 Carina E. Cannizzaro, Michael Graupe, Juan A. Guerrero, Yafan Lu, Robert
G. Strickley, Chandrasekar Venkataramani, Jeff Zablocki A61K 31/675, C07D 213/64, C07F 9/58, A61K 31/4418
76 09598435 Fused heterocyclic compounds as ion channel modulators 2017/03/21 2015/10/01
Britton Kenneth Corkey, Elfatih Elzein, Michael Graupe, Juan Guerrero, Robert H. Jiang, Rao V. Kalla, Dmitry Koltun, Xiaofen Li, Ruben Martinez, Eric Q. Parkhill, Thao Perry, Chandrasekar Venkataramani, Jeff Zablocki
C07D 267/08, C07D 498/04, A61K 31/553, A61K 31/5513, C07D 243/24, C07D 267/14, C07D 291/08, C07D 403/06, C07D 413/06, C07D 413/12, C07D 413/14, C07D 419/06, C07D 471/04, C07D 487/04, C07D 243/14, C07B 59/00, C07D 413/04, C07D 417/14 77 09586932 Apoptosis signal-regulating kinase inhibitors 2017/03/07 2015/05/19 Michael Graupe, Keith Koch, Britton K. Corkey, Gregory Notte, Lawrence
S. Melvin, Jr.
C07D 401/14, C07D 401/12, C07D 471/04, C07D 491/048, C07D 417/14, C07D 405/14, C07D 413/12, C07D 413/14
78 09586933 Processes for preparing ASK1 inhibitors 2017/03/07 2015/12/22 Gregory Notte C07D 233/64, C07D 401/14, C07D 233/56
79 09585906 Nucleoside phosphoramidate prodrugs 2017/03/07 2015/03/12 Jinfa Du, Dhanapalan Nagarathnam, Michael J. Sofia, Peiyuan Wang
A01N 43/04, A61K 31/70, A61K 31/7072, C07H 19/06, A61K 45/06, C07H 19/073, A61K 31/7064, A61K 31/706, A61K 31/7068, C07H 19/04
80 09579332 Phosphonate analogs of HIV inhibitor compounds 2017/02/28 2012/10/17 Constantine G. Boojamra, Kuei-Ying Lin, Richard L. Mackman, David Y.
Markevitch, Oleg V. Petrakovsky, Adrian S. Ray, Lijun Zhang
C07F 9/02, A61K 31/675, A61K 31/662, C07F 9/6561, C07H 19/00, A61K 45/06, C07H 19/20
134
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81 09573952 Methods of preparing toll-like receptor modulators 2017/02/21 2015/09/14
Darin Allen, Brandon Heath Brown, Jessica Jade Chao, Randall L. Halcomb, Paul Hrvatin, Ryan McFadden, Paul Roethle, Erwina Rudio, Hong Yang, Richard Hung Chiu Yu
C07D 247/02, C07D 475/06, C07D 207/09, C07D 239/47, C07D 239/46, C07D 239/48, C07D 239/545, C07D 487/04, C07D 207/06
82 09567348 Substituted pyrazolo[1,5-a]pyrimidines as Syk inhibitors 2017/02/14 2015/02/23 Scott A. Mitchell, Kevin S. Currie, Peter A. Blomgren, Jeffrey E. Kropf, Seung H. Lee, Jianjun Xu, Douglas G. Stafford
A61K 31/437, C07D 239/70, C07D 519/00, C07D 487/04, C07D 471/04
83 09567337 Process methods for phosphatidylinositol 3-kinase inhibitors 2017/02/14 2014/12/18 Stacy Bremner, Jerry Evarts, Keiko Sujino, Duong Tran, Dragos Vizitiu C07D 473/34, C07D 263/58, C07D 239/91, C07D 487/04, C07D 265/10, C07C 233/90
84 09562056 Imidazopyridines Syk inhibitors 2017/02/07 2011/03/11 Peter A. Blomgren, Kevin S. Currie, Jeffrey E. Kropf, Seung H. Lee, Scott
A. Mitchell, Aaron C. Schmitt, Jianjun Xu, Zhongdong Zhao C07D 471/04, C07D 519/00, C07D 498/04, C07D 487/04, C12Q 1/48 85 09562058 Crystalline forms of an antiviral compound 2017/02/07 2014/12/18 Dustin Bringley, Johann Chan, Peter Fung, Katie Keaton, Olga Lapina,
Henry Morrison, Dominika Pcion A61K 31/4985, C07D 498/16, A61K 45/06, C07K 5/083
86 09549941 Compositions and methods for treating hepatitis C virus 2017/01/24 2014/11/11
Darryl G. Cleary, Charles J. Reynolds, Miriam Michelle Berrey, Robert G.
Hindes, William T. Symonds, Adrian S. Ray, Hongmei Mo, Christy M.
Hebner, Reza Oliyai, Vahid Zia, Dimitrios Stefanidis, Rowchanak Pakdaman, Melissa Jean Casteel
A61K 31/685, A61K 31/7056, A61K 31/7068, A61K 31/4196, A61K 31/7072, A61K 9/20, A61K 31/513, A61K 31/664, A61K 31/675
87 09550836 Method of detecting human matrix metalloproteinase 9 using
antibodies 2017/01/24 2012/02/29 Victoria Smith, Scott McCauley G01N 33/53, C07K 16/40, C12N 9/64, G01N 33/573, A61K 39/00
88 09549926 Compositions and methods of treating pulmonary hypertension 2017/01/24 2013/11/13 Luiz Belardinelli, Hunter Campbell Gillies, Faquan Liang, John Shryock, Suya Yang
A61K 31/505, A61K 31/422, A61K 31/4985, A61K 31/519, A61K 31/53, A61K 45/06
89 09545414 Unitary pharmaceutical dosage form 2017/01/17 2015/03/06 Terrence C. Dahl, Munir A. Hussain, Robert A. Lipper, Robert L. Jerzewski, Mark M. Menning, Reza Oliyai, Taiyin Yang
A61K 31/683, A61K 31/536, A61K 31/513, A61K 9/24, A61K 9/20, A61K 31/522, A61K 31/535, A61K 31/551, A61K 31/675
90 09540343 Compounds for the treatment of HIV 2017/01/10 2012/07/05
Steven S. Bondy, Carina E. Cannizzaro, Chien-hung Chou, Randall L.
Halcomb, Yunfeng Eric Hu, John O. Link, Qi Liu, Scott D. Schroeder, Winston C. Tse, Jennifer R. Zhang
A01N 43/00, A61K 31/00, C07D 401/12, C07D 213/40, C07D 401/14, C07D 403/12, C07D 403/14, C07D 405/12, C07D 471/04, C07D 471/06, C07D 487/04, C07D 491/04, C07D 495/04, A61K 31/4439, A61K 31/444, A61K 31/4545, A61K 31/4709, A61K 31/4985, A61K 31/50, A61K 31/506, A61K 31/5377, A61K 45/06, C07D 409/14, C07D 413/14, C07D 491/052
91 09539244 FXR (NR1H4) binding and activity modulating compounds 2017/01/10 2015/08/12 Olaf Kinzel, Christoph Steeneck, Claus Kremoser A61K 31/42, A61K 31/422, A61K 31/4439, C07D 261/08, C07D 413/12, C07D 413/14
92 09533000 Inhalable aztreonam for treatment and prevention of pulmonary
bacterial infections 2017/01/03 2013/10/04 Alan Bruce Montgomery A61K 9/00, A61K 9/12, A61K 31/15, A61K 31/426, A61K 31/7036,
A61K 31/397, A61K 31/427
93 09522912 Polycyclic-carbamoylpyridone compounds and their pharmaceutical
use 2016/12/20 2015/12/21
Elizabeth M. Bacon, Zhenhong R. Cai, Jeromy J. Cottell, Mingzhe Ji, Haolun Jin, Scott E. Lazerwith, Philip Anthony Morganelli, Hyung-jung Pyun
A61K 31/4985, C07D 471/04, C07D 491/147, C07D 491/20, A61K 45/06
94 09511056 Antiviral compounds 2016/12/06 2014/05/16
Elizabeth M. Bacon, Eda Canales, Aesop Cho, Jeromy J. Cottell, Manoj C.
Desai, Michael Graupe, Hongyan Guo, Randall L. Halcomb, Darryl Kato, Choung U. Kim, Thorsten A. Kirschberg, Evan S. Krygowski, Scott E.
Lazerwith, John O. Link, Hongtao Liu, Qi Liu, Richard L. Mackman, Michael L. Mitchell, Jay P. Parrish, Hyung-Jung Pyun, Joseph H. Saugier, Scott D. Schroeder, Jianyu Sun, James G. Taylor, James D. Trenkle, Winston C. Tse, Randall W. Vivian, William J. Watkins, Lianhong Xu
C07D 403/04, C07D 403/14, C07D 471/08, A61K 45/06, A61K 31/4184, C07F 5/02
95 09512175 Macrocyclic inhibitors of flaviviridae viruses 2016/12/06 2015/08/07
Caroline Aciro, Jean Yves Chiva, David Kenneth Dean, Neil Andrew Dunbar, Adrian John Highton, Petr Jansa, Kapil Kumar Karki, Andrew John Keats, Linos Lazarides, Richard Mackman, Simon Neil Pettit, Karine G.
Poullennec, Adam James Schrier, Dustin Scott Siegel, Victoria Alexandra Steadman
A61K 38/21, C07K 5/062, C07K 5/068, C07K 5/078, C07K 5/06, C07D 487/18, C07D 498/18, A61K 38/12, A61K 45/06
96 09504684 Syk inhibitors 2016/11/29 2015/07/09
Peter A. Blomgren, Astrid Clarke, Kevin S. Currie, Julie Di Paolo, Jeffrey E.
Kropf, Seung H. Lee, Jennifer R. Lo, Scott A. Mitchell, Aaron C. Schmitt, Sundaramoorthi Swaminathan, Jin-Ming Xiong, Jianjun Xu, Zhongdong Zhao
A61K 31/4985, A61K 31/5377, A61K 31/475, A61K 31/519
135
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97 09504689 Compounds and methods for antiviral treatment 2016/11/29 2015/03/02 Dustin Siegel, David Sperandio, Hai Yang, Michael Sangi, Jay P. Parrish, Hon Chung Hui
A61K 31/519, A61K 31/5377, C07D 487/04, C07D 519/00, C07D 471/04, A61K 45/06, A61K 31/4545, A61K 31/5025, A61K 31/53
98 09505785 Pyridone and aza-pyridone compounds and methods of use 2016/11/29 2013/10/22
Antonio J. M. Barbosa, Peter A. Blomgren, Kevin S. Currie, Ravi Krishnamoorthy, Jeffrey E. Kropf, Seung H. Lee, Scott A. Mitchell, Daniel Ortwine, Aaron C. Schmitt, Xiaojing Wang, Jianjun Xu, Wendy Young, Honglu Zhang, Zhongdong Zhao, Pavel E. Zhichkin
C07D 519/00, C07D 487/04, C07D 495/04, C07D 498/04, A61K 31/497, A61K 31/4985, A61K 31/501, A61K 31/5025, A61K 31/506, A61K 31/5377, A61K 31/5383, A61K 31/5386, A61K 31/551, A61K 45/06, C07D 471/14
99 09504685 Method for treating a pulmonary hypertension condition 2016/11/29 2015/04/24 Michael J. Gerber, Christopher Dufton A61K 31/53, A61K 31/505, A61K 31/4985, A61K 31/519 100 09499523 Phosphatidylinositol 3-kinase inhibitors 2016/11/22 2015/06/10 Musong Kim, Stephane Perreault, Suet Chung Yeung C07D 403/14, C07D 471/04, C07D 491/048, C07D 487/04 101 09492449 Therapies for hematologic malignancies 2016/11/15 2012/03/09 W. Michael Gallatin, Roger G. Ulrich, Neill A. Giese, Brian Lannutti,
Langdon Miller, Thomas M. Jahn A61K 31/517, A61K 31/395, A61K 31/519, A61K 39/00 102 09487546 Solid forms of tenofovir 2016/11/08 2015/01/09 Paul Bernard Hurley, Olga Viktorovna Lapina, Bing Shi, Fang Wang, Zhi
Xian Wang, Jacqueline Ching-See Woo C07F 9/6561
103 09487544 Methods for the preparation of diasteromerically pure
phosphoramidate prodrugs 2016/11/08 2015/06/22 Aesop Cho, Michael O'Neil Hanrahan Clarke, Scott Alan Wolckenhauer C07H 21/00, C07F 9/24, A61K 31/7052, A61K 31/7042, C07H 1/00, C07H 19/02, C07H 19/10, C07H 19/20, C07F 9/6558, C07F 9/6561 104 09481704 2'-substituted carba-nucleoside analogs for antiviral treatment 2016/11/01 2013/03/11 Michael O'Neil Hanrahan Clarke C07H 19/12, A61K 31/706, A61K 45/06, C07H 19/23
105 09474752 Method for treating a pulmonary hypertension condition 2016/10/25 2014/02/17 Michael J. Gerber, Christopher Dufton A61K 31/5377, A61K 31/505, A61K 31/4985, A61K 31/519, A61K 106 09469643 Polymorphic forms of
(S)-2-(1-(9H-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one 2016/10/18 2014/09/22 Ernest Carra, Michael Gerber, Bing Shi, Keiko Sujino, Duong Tran, Fang
Wang, Jerry B. Evarts C07D 473/34
107 09469613 (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino
)pyrimidin-4-yl)benzamide 2016/10/18 2015/06/11
Brandon H. Brown, Ernest A. Carra, Jeffrey N. Hemenway, Henry Morrison, Troy Reynolds, Bing Shi, Dimitrios Stefanidis, Fang Wang, Matthew Robert Warr, James Andrew Whitney, Yan Xin
A61K 31/535, C07D 265/30, C07D 239/42, A61K 31/5377
108 09463194 Methods of treating patients co-infected with HIV and tuberculosis 2016/10/11 2015/02/04 Rebecca Restituto Begley, Joseph Marcello Custodio, Brian P. Kearney
A61K 31/47, A61K 31/44, A61K 31/535, A61K 31/5377, A61K 45/06, A61K 31/427, A61K 31/438, A61K 31/506, A61K 31/683, A61K 31/675, A61K 31/426, A61K 31/454, A61K 31/473, A61K 31/52, A61K 31/435
109 09464096 Therapeutic compounds 2016/10/11 2015/02/26 Kerim Babaoglu, Michael L. Mitchell, Ryan McFadden, Paul A. Roethle, Lianhong Xu, Hong Yang
C07D 491/052, A61K 31/4741, A61K 45/06, C07D 277/62, C07D 277/64, C07D 277/82, C07D 417/04, C07D 491/06, A61K 31/428 110 09457035 Antiviral compounds 2016/10/04 2014/02/11 Constantine G. Boojamra, Kuei-Ying Lin, Richard L. Mackman, David Y.
Markevitch, Oleg V. Petrakovsky, Adrian S. Ray, Lijun Zhang
C07H 19/04, A61K 31/675, A61K 31/662, C07F 9/6561, C07H 19/00, A61K 45/06, C07H 19/20
111 09457036 Compositions and methods for combination antiviral therapy 2016/10/04 2014/10/24 Terrence C. Dahl, Mark M. Menning, Reza Oliyai A01N 43/54, A61K 31/505, A61K 31/675, A61K 31/513, A61K 31/7076, A61K 45/06, A61K 31/683, A61K 9/20
112 09458145 Benzimidazole derivatives as bromodomain inhibitors 2016/10/04 2014/05/08
Evangelos Aktoudianakis, Gregory Chin, Britton Kenneth Corkey, Jinfa Du, Kristyna Elbel, Robert H. Jiang, Tetsuya Kobayashi, Rick Lee, Ruben Martinez, Samuel E. Metobo, Michael Mish, Manuel Munoz, Sophie Shevick, David Sperandio, Hai Yang, Jeff Zablocki
C07D 471/04, C07D 417/14, C07D 413/14, C07D 413/04
113 09458159 Substituted pyrido[1',2':4,5]pyrazino[1,2-a]azepines for treating viral
infections 2016/10/04 2014/07/11 Manoj C. Desai, Mingzhe Ji, Haolun Jin, Teresa Alejandra Trejo Martin,
Hyung-Jung Pyun A61K 31/498, C07D 241/38, C07D 471/18, C07D 471/14
114 09452166 Modulators of toll-like receptors 2016/09/27 2015/07/20 Manoj C. Desai, Randall L. Halcomb, Paul Hrvatin, Hon Chung Hui, Ryan McFadden, Paul A. Roethle, Hong Yang
C07D 475/06, C07D 475/08, C07D 475/12, C07D 487/04, A61K 31/519, A61K 31/5377, A61K 31/573, A61K 31/683, A61K 31/7056, A61K 31/7072, A61K 31/708, A61K 38/16, A61K 38/21, C07D 475/10, C07D 403/12, A61K 31/527, A61K 31/551, A61K 45/06
115 09452154 Methods for treating HCV 2016/09/27 2014/10/14 William E. Delaney, IV, John O. Link, Hongmei Mo, David W. Oldach, Adrian S. Ray, William J. Watkins, Cheng Yong Yang, Weidong Zhong
A61K 31/675, A61K 31/4184, A61K 31/381, A61K 31/40, A61K 31/401, A61K 31/4025, A61K 31/407, A61K 31/4178, A61K 31/4188, A61K 31/4353, A61K 31/4436, A61K 31/662, A61K 31/7056, A61K 45/06, A61K 31/501, A61K 31/5377, A61K 38/21, A61K 31/706
116 09453026 ACC inhibitors and uses thereof 2016/09/27 2015/01/23 Geraldine C. Harriman, Craig E. Masse, James Harwood, Sathesh Bhat,
Jeremy Robert Greenwood C07D 495/04, A61K 31/519
136
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117 09440991 Synthesis of an antiviral compound 2016/09/13 2014/12/18
Amy Cagulada, Johann Chan, Lina Chan, Denise A. Colby, Kapil Kumar Karki, Darryl Kato, Katie Ann Keaton, Sudha Kondapally, Chris Levins, Adam Littke, Ruben Martinez, Dominika Pcion, Troy Reynolds, Bruce Ross, Michael Sangi, Adam J. Schrier, Pamela Seng, Dustin Siegel, Nathan Shapiro, Donald Tang, James G. Taylor, Jonathan Tripp, Andrew W.
Waltman, Lawrence Yu
C07D 403/12, C07D 413/14, C07D 498/16, C07C 227/02, C07D 453/02, C07C 209/00, C07C 51/09, C07K 5/083
118 09428473 Methods and intermediates for preparing pharmaceutical agents 2016/08/30 2015/07/14
Richard Polniaszek, Steven Pfeiffer, Richard Yu, Aaron Cullen, Eric Dowdy, Duong Tran, Kenneth Kent, Zhongxin Zhou, Douglas Cordeau, Leah Easton-Scott
C07D 413/12, C07D 277/30, C07D 413/14, C07D 417/14, C07C 307/02, C07C 209/62, C07C 209/70, C07C 307/06, C07D 277/28, C07D 417/12, C07C 303/34
119 09421214 Polycyclic-carbamoylpyridone compounds and their pharmaceutical
use 2016/08/23 2014/07/11 Mingzhe Ji, Scott E. Lazerwith, Hyung-Jung Pyun C07D 221/18, A61K 31/553, C07D 498/18, A61K 31/537, C07D
471/18, A61K 31/4985, A61K 45/06, C07D 471/14, C07D 498/14 120 09416115 Fused heterocyclic compounds as ion channel modulators 2016/08/16 2014/12/03 Michael Graupe, Yafan Lu, Jeff A. Zablocki C07D 261/20, C07D 498/04, C07D 471/04, C07D 417/12, C07D
413/12, C07D 413/14 121 09416128 Fused heterocyclic compounds as ion channel modulators 2016/08/16 2014/12/17 Rao Kalla, Thao Perry, Jeff Zablocki C07D 413/06, C07D 417/06
122 09409891 Solid forms of an antiviral compound 2016/08/09 2014/06/24 Ahmad Hashash, Scott Wolckenhauer, Bing Shi A61K 31/381, A61K 31/4184, A61K 31/7056, A61K 31/7072, A61K 45/06, C07D 407/04, C07D 409/12, C07D 471/08
123 09403782 Fused heterocyclic compounds as ion channel modulators 2016/08/02 2015/07/24
Britton Kenneth Corkey, Elfatih Elzein, Michael Graupe, Juan Guerrero, Robert H. Jiang, Rao V. Kalla, Tetsuya Kobayashi, Dmitry Koltun, Xiaofen Li, Ruben Martinez, Gregory Notte, Eric Q. Parkhill, Thao Perry, Chandrasekar Venkataramani, Jeff Zablocki
C07D 237/30, C07D 401/06, C07D 401/14, C07D 403/06, C07D 413/06, C07D 413/14, A61K 31/502, A61K 31/506, A61K 31/5377, A61K 31/4427, A61P 25/08, C07D 253/08, C07D 498/04, C07D 263/58, C07D 237/32, C07D 239/88, C07D 239/90, C07D 265/22, C07D 401/04, C07D 401/12, C07D 403/04, C07D 403/08, C07D 403/12, C07D 403/14, C07D 405/12, C07D 417/06, C07D 417/14, C07D 217/26, C07D 413/12, C07D 498/10
124 09393256 Methods for treating HCV 2016/07/19 2013/05/01 Adrian S. Ray, John O. Link, David W. Oldach, William E. Delaney, IV, Hongmei Mo, Cheng Yong Yang
A61K 31/505, A61K 31/415, A61K 31/40, A61K 31/34, A61K 31/7072, A61K 31/381, A61K 31/4184, A61K 31/4196, A61K 31/513, A61K 45/06, A61K 31/7056, A61K 38/21
125 09394331 2'-spiro-nucleosides and derivatives thereof useful for treating
hepatitis C virus and dengue virus infections 2016/07/19 2014/07/15 Jinfa Du, Michael Joseph Sofia
A01N 43/04, A61K 31/70, C07H 19/207, A61K 31/706, A61K 31/7052, A61K 31/7064, A61K 31/708, C07H 19/06, C07H 19/10, C07H 19/16, C07H 19/20, C07H 23/00, A61K 31/7076, A61K 45/06 126 09388208 Pyrrolo[1,2-f][1,2,4]triazines useful for treating respiratory syncitial
virus infections 2016/07/12 2014/11/06 Michael O'Neil Hanrahan Clarke, Edward Doerffler, Richard L Mackman,
Dustin Siegel C07H 7/06, C07D 405/04, C07D 405/14, C07D 487/04
127 09381206 Salts of HIV inhibitor compounds 2016/07/05 2014/12/29 Benjamin R. Graetz, Richard Polniaszek A61K 31/7076, A61K 45/06, C07H 19/20, A61K 9/20 128 09382256 Formulation of Syk inhibitors 2016/07/05 2014/07/29 Melissa Jean Casteel, Bei Li, Rowchanak Pakdaman, Diana Sperger,
Dimitrios Stefanidis
A61K 31/495, C07D 487/04, A61K 9/20, C07C 309/66, A61K 31/5377, A61K 9/28
129 09376392 2-(tert-butoxy)-2-(7-methylquinolin-6-yl) acetic acid derivatives for
treating AIDS 2016/06/28 2013/01/03
Kerim Babaoglu, Kyla L. Bjornson, Paul Hrvatin, Eric Lansdon, John O.
Link, Hongtao Liu, Ryan McFadden, Michael L. Mitchell, Yingmei Qi, Paul A. Roethle, Lianhong Xu
C07D 215/227, A61K 31/4704, C07D 519/00, A61K 31/4745, C07D 491/06, A61K 45/06, A61K 31/4741, A61K 31/497, A61K 31/506
130 09376441 Substituted pyrrolidines as SYK inhibitors 2016/06/28 2014/07/31
Kevin S. Currie, Zhimin Du, Julie Farand, Juan A. Guerrero, Ashley A.
Katana, Darryl Kato, Scott E. Lazerwith, Jiayao Li, John O. Link, Nicholas Mai, Gregory Notte, Hyung-jung Pyun, Michael Sangi, Aaron C. Schmitt, Adam J. Schrier, Kirk L. Stevens, Chandrasekar Venkataramani, William J.
Watkins, Zheng-Yu Yang, Jeff Zablocki, Sheila Zipfel, Jennifer R. Lo, Seung H. Lee, Zhongdong Zhao, Jeffrey Kropf, Jianjun Xu, Peter Blomgren, Scott A. Mitchell, JinMing Xiong, Jayaraman Chandrasekhar
A61K 31/4015, C07D 207/12, C07D 487/04, C07D 401/14, C07D 403/12, C07D 417/04, C07D 417/12, C07D 471/04, C07D 407/14, C07D 417/14
131 09371329 Fused heterocyclic compounds as ion channel modulators 2016/06/21 2014/05/09
Britton Corkey, Elfatih Elzein, Robert Jiang, Rao Kalla, Tetsuya Kobayashi, Dmitry Koltun, Xiaofen Li, Gregory Notte, Eric Parkhill, Thao Perry, Jeff Zablocki
C07D 487/04, C07D 471/04
132 09372272 Earthquake warning system 2016/06/21 2011/12/19 Michael John Price, Gilead Wurman G08B 21/00, G01V 1/00, G08B 21/10
133 09353423 HCV genotype 6 replicons 2016/05/31 2013/11/06 Guofeng Cheng, William E. Delaney, IV, Betty Peng, Mei Yu C12Q 1/70, C07K 16/00, C07K 14/005, C07K 16/10, C12N 7/00
137
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134 09346796 Methods and intermediates for preparing pharmaceutical agents 2016/05/24 2013/02/01 Aaron J. Cullen, Richard Hung Chiu Yu
C07D 417/12, C07C 271/12, C07C 271/16, C07C 271/20, C07D 233/60, C07C 309/73, C07C 329/16, C07D 203/20, C07D 277/24, C07D 277/28
135 09346841 Methods for preparing anti-viral nucleotide analogs 2016/05/24 2015/04/08 Denise A. Colby, Andrew Anthony Martins, Benjamin James Roberts,
Robert William Scott, Nicole S. White C07F 9/6512, C07F 9/6561, C07F 9/6558 136 09345663 Inhalable aztreonam lysinate formulation for treatment and prevention
of pulmonary bacterial infections 2016/05/24 2014/04/30 Alan B. Montgomery A61K 31/427, A61K 9/00, A61K 31/397, A61K 31/198
137 09340568 Solid forms of an antiviral compound 2016/05/17 2014/12/08 Melissa Jean Casteel, Kathleen Dashner, Hyuk-Jun Jung, Mun Sik Seo, Bing Shi, Fang Wang, Vahid Zia
A01N 43/04, A61K 31/70, C07H 19/10, A61K 31/7052, A61K 31/7064, A61K 31/706, A61K 31/7068, A61K 31/7072, C07F 9/6558, C07H 19/06
138 09333197 Apoptosis signal-regulating kinase inhibitor 2016/05/10 2014/04/16 Gregory Notte A61K 31/44, C07D 213/56, A61K 31/4439, C07D 401/14, C07D
233/56, C07D 401/04 139 09321753 Inhibitors of Flaviviridae viruses 2016/04/26 2013/07/11 Eda Canales, Michael O'Neil Hanrahan Clarke, Scott E. Lazerwith, Willard
Lew, Philip Anthony Morganelli, William J. Watkins A61K 31/4436, A61K 31/381, A61K 45/06, C07D 409/12 140 09321800 7-deazapurine nucleosides for therapeutic uses 2016/04/26 2010/04/19 Aurelie Bourderioux, Michal Hocek, Petr Naus C07H 19/14, A61K 31/7064, A61K 45/06
141 09296782 Inhibitors of hepatitis C virus 2016/03/29 2013/07/02
Kyla Bjornson, Eda Canales, Jeromy J. Cottell, Kapil Kumar Karki, Ashley Anne Katana, Darryl Kato, Tetsuya Kobayashi, John O. Link, Ruben Martinez, Barton W. Phillips, Hyung-Jung Pyun, Michael Sangi, Adam James Schrier, Dustin Siegel, James G. Taylor, Chinh Viet Tran, Teresa Alejandra Trejo Martin, Randall W. Vivian, Zheng-Yu Yang, Jeff Zablocki, Sheila Zipfel
A61K 6/00, C07K 1/00, C07K 5/08, C07D 498/16, A61K 31/4985, C07D 498/22, A61K 31/4745, A61K 31/506, A61K 31/519, A61K 45/06, C07K 5/087, C07K 5/083, A61K 38/21, A61K 38/06, A61K 38/00
142 09296777 2',4'-substituted nucleosides as antiviral agents 2016/03/29 2014/04/30 Michael Joseph Sofia, Jinfa Du C07H 19/06, C07H 19/14, C07H 19/16, A61K 31/7064, A61K 31/7068, A61K 31/7072, A61K 31/7076
143 09296758 2-quinolinyl-acetic acid derivatives as HIV antiviral compounds 2016/03/29 2011/07/01
Kerim Babaoglu, Kyla Bjornson, Hongyan Guo, Randall L. Halcomb, John O. Link, Hongtao Liu, Michael L. Mitchell, Jianyu Sun, James Taylor, Randall W. Vivian, Lianhong Xu
C07D 498/04, C07D 215/06, C07D 215/14, C07D 215/18, C07D 215/227, C07D 215/38, C07D 215/48, C07D 401/04, C07D 401/12, C07D 405/04, C07D 413/04, C07D 417/04, C07D 487/04, C07D 519/00, C07D 491/052, C07D 215/20
144 09296779 Processes and intermediates for preparing anti-HIV agents 2016/03/29 2015/02/05
Richard Hung Chiu Yu, Brandon Heath Brown, Richard P. Polniaszek, Benjamin R. Graetz, Keiko Sujino, Duong Duc-Phi Tran, Alan Scott Triman, Kenneth M. Kent, Steven Pfeiffer
C07H 19/00, C07H 19/22, C07H 23/00, C07H 19/02, C07H 19/04, C07H 19/173, C07D 473/34, C07F 9/40, C07F 9/44, C07F 9/6561, C07H 19/20, C07H 19/16
145 09296769 Tenofovir alafenamide hemifumarate 2016/03/29 2014/03/05 Dazhan Liu, Bing Shi, Fang Wang, Richard Hung Chiu Yu A61K 31/685, C07F 9/6561, A61K 31/52, C07D 473/34
145 09296769 Tenofovir alafenamide hemifumarate 2016/03/29 2014/03/05 Dazhan Liu, Bing Shi, Fang Wang, Richard Hung Chiu Yu A61K 31/685, C07F 9/6561, A61K 31/52, C07D 473/34