未來研究

1. 對於人類間質幹細胞接受體外震波治療後是否促進分化增生擬 再研究探討。

2. 對於人類間質幹細胞接受體外震波治療後是否會朝向骨頭分化 擬再研究探討。

七、參考文獻及附錄：

1. Coleman AJ, Saunders JE. A review of the physical properties and biological effects of the high amplitude acoustic field used in extracorporeal lithotripsy. Ultrasonics. 1993;31(2):75-89.

2. Ogden JA, Alvarez R, Levitt R, Cross GL, Marlow M. Shock wave therapy for chronic proximal plantar fasciitis. Clin Orthop. 2001 Jun;(387):47-59.

3. Wang CJ. An overview of shock wave therapy in musculoskeletal disorders. Chang Gung Med J. 2003 Apr;26(4):220-32.

4. Delius M, Draenert K, Al Diek Y, Draenert Y. Biological effects of shock waves: in vivo effect of high energy pulses on rabbit bone.

Ultrasound Med Biol 1995;21:1219-25.

5. Rompe JD, Rumler F, Hopf C, Nafe B, Heine J. Extracorporal shock wave therapy for calcifying tendinitis of the shoulder. Clin Orthop. 1995 Dec;(321):196-201

6. Loew M, Jurgowsky W, Mau H, Thomson M: "Treatment of Calcifying Tendonitis of Rotator Cuff by Extracorporeal Shock Waves: A Preliminary Report" Journal of Shoulder and Elbow Surgery, Vol.

4, No. 2, pp. 101-06 (1995).

7. Spindler A, Berman A, Lucero E, Braier M: Extracorporeal shock wave treatment for chronic calcific tendinitis of the shoulder. J Rheumatol 1998 Jun;25(6):1161-3

8. Wang CJ, Yang KD, Wang FS, Chen HH, Wang JW. Shock wave therapy for calcific tendinitis of the shoulder: a prospective clinical study with two-year follow-up. Am J Sports Med. 2003 May-Jun;31(3):425-30.

9. Wang CJ, Ko JY, Chen HS. Treatment of calcifying tendinitis of the shoulder with shock wave therapy. Clin Orthop. 2001 Jun;(387):83-9.

10. Rompe JD, Hopf C, Nafe B, Burger R: Low-energy extracorporeal shock wave therapy for painful heel: a prospective controlled single-blind study. Arch Orthop Trauma Surg 1996;115(2):75-9 11. Wang CJ, Chen HS, Huang TW. Shockwave therapy for patients with plantar fasciitis: a one-year follow-up study. Foot Ankle Int.

2002 Mar;23(3):204-7.

12. Ogden JA, Alvarez R, Levitt R, Cross GL, Marlow M. Shock wave therapy for chronic proximal plantar fasciitis. Clin Orthop. 2001 Jun;(387):47-59.

13. Chen HS, Chen LM, Huang TW. Treatment of painful heel syndrome with shock waves. Clin Orthop. 2001 Jun;(387):41-6.

14. Wang CJ, Chen HS. Shock wave therapy for patients with lateral epicondylitis of the elbow: a one- to two-year follow-up study.

Am J Sports Med. 2002 May-Jun;30(3):422-5.

15. Ko JY, Chen HS, Chen LM. Treatment of lateral epicondylitis of the elbow with shock waves. Clin Orthop. 2001 Jun;(387):60-7.

16. Rompe JD, Hope C, Kullmer K, Heine J, Burger R: Analgesic effect of extracorporeal shock-wave therapy on chronic tennis elbow. J Bone Joint Surg Br 1996 March, than in 78(2):233-7

17. Wang CJ, Chen HS, Chen CE, Yang KD. Treatment of nonunions of long bone fractures with shock waves. Clin Orthop. 2001 Jun;(387):95-101.

18. Rompe JD, Rosendahl T, Schollner C, Theis C. High-energy extracorporeal shock wave treatment of nonunions. Clin Orthop.

2001 Jun;(387):102-11.

19. Schaden W, Fischer A, Sailler A. Extracorporeal shock wave therapy of nonunion or delayed osseous union. Clin Orthop. 2001 Jun;(387):90-4.

20. Vogel J, Hopf C, Eysel P, Rompe JD. Application of extracorporeal shock-waves in the treatment of pseudarthrosis of the lower extremity. Preliminary results. Arch Orthop Trauma Surg.

1997;116(8):480-3.

21. Valchanou VD, Michailov P. High energy shock waves in the treatment of delayed and nonunion of fractures. Int Orthop.

1991;15(3):181-4.

22. Evan AP, Willis LR, Lingeman JE, McAteer JA. Renal trauma and the risk of long-term complications in shock wave lithotripsy. Nephron 1998;78(1):1-8

23. Howard D, Sturtevant B. In vitro study of the mechanical effects of shock-wave lithotripsy. Ultrasound Med Biol 1997;23(7):1107-22 24. Suhr D, Brummer F, Irmer U, Hulser DF. Disturbance of cellular calcium homeostasis by in vitro application of shock waves.

Ultrasound Med Biol 1996;22(5):671-9

25. Graff J, Pastor J, Richter K.D. Effect of high-energy shock-waves on bony tissue. Urol Res 1998;16:252

26. Wang CJ, Huang HY, Pai CH. Shock wave-enhanced neovascularization at the tendon-bone junction: an experiment in dogs. J Foot Ankle

Surg. 2002 Jan-Feb;41(1):16-22.

27. Wang FS, Wang CJ, Sheen-Chen SM, Kuo YR, Chen RF, Yang KD.

Superoxide mediates shock wave induction of ERK-dependent osteogenic transcription factor (CBFA1) and mesenchymal cell differentiation toward osteoprogenitors. J Biol Chem. 2002 Mar 29;277(13):10931-7. Epub 2002 Jan 09.

28. Wang FS, Yang KD, Kuo YR, Wang CJ, Sheen-Chen SM, Huang HC, Chen YJ. Temporal and spatial expression of bone morphogenetic proteins in extracorporeal shock wave-promoted healing of segmental defect.

Bone. 2003 Apr;32(4):387-96.

29. Wang FS, Wang CJ, Huang HJ, Chung H, Chen RF, Yang KD. Physical shock wave mediates membrane hyperpolarization and Ras activation for osteogenesis in human bone marrow stromal cells. Biochem Biophys Res Commun. 2001 Sep 28;287(3):648-55.

30. Wang FS, Yang KD, Chen RF, Wang CJ, Sheen-Chen SM. Extracorporeal shock wave promotes growth and differentiation of bone-marrow stromal cells towards osteoprogenitors associated with induction of TGF-beta1. J Bone Joint Surg Br. 2002 Apr;84(3):457-61.

31. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca

JD, Moorman MA, Simonetti DW, Craig S, Marshak DR. Multilineage potential of adult human mesenchymal stem cells. Science 1999 Apr 2;284(5411):143-7

32. Rickard DJ, Kassem M, Hefferan TE, Sarkar G, Spelsberg TC, Riggs BL. Isolation and characterization of osteoblast precursor cells from human bone marrow. J Bone Miner Res 1996 Mar;11(3):312-24 33. Bruder SP, Kraus KH, Goldberg VM, Kadiyala S. The effect of implants loaded with autologous mesenchymal stem cells on the healing of canine segmental bone defects J Bone Joint Surg Am 1998 Jul;80(7):985-96

34. Beresford JN. Osteogenic stem cells and the stromal system of bone and marrow. Clin Orthop 1989 Mar;(240):270-80

35. Caplan AI. The mesengenic process. Clin Plast Surg 1994 Jul;21(3):429-35

36. Indrawattana N, Chen G, Tadokoro M, Shann LH, Ohgushi H, Tateishi T, Tanaka J, Bunyaratvej A. Growth factor combination for chondrogenic induction from human mesenchymal stem cell. Biochem Biophys Res Commun. 2004 Jul 30;320(3):914-9.

37. Roelen BA, Dijke P. Controlling mesenchymal stem cell

differentiation by TGFBeta family members. J Orthop Sci.

2003;8(5):740-8.

38. Brittberg M, Lindahl A, Nilsson A, Ohlsson C, Isaksson O, Peterson L, “Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation.” N. Engl. J. Med., 332:889-895, 1994.

39. Barry FP. Mesenchymal stem cell therapy in joint disease.

Novartis Found Symp. 2003;249:86-96

40. Barnard, J.A., Lyons, R.M. and Moses, H.L. The cell biology of transforming growth factor beta. Biochim Biophys Acta. 1990 Jun 1;1032(1):79-87.

41. Sporn MB, Roberts AB, Wakefield LM, de Crombrugghe B. Some recent advances in the chemistry and biology of transforming growth factor-beta. J Cell Biol. 1987 Sep;105(3):1039-45.

42. Moses, H.L., Yang, E.Y. and Pietenpol, J.A. TGF-beta stimulation and inhibition of cell proliferation: new mechanistic insights.

Cell. 1990 Oct 19;63(2):245-7.

43. Sporn, M.B. and Roberts, A.B. Transforming growth factor-beta:

recent progress and new challenges. J Cell Biol. 1992

Dec;119(5):1017-21.

44. Lindholm D, Castren E, Kiefer R, Zafra F, Thoenen H. Transforming growth factor-beta 1 in the rat brain: increase after injury and inhibition of astrocyte proliferation. J Cell Biol. 1992 Apr;117(2):395-400.

45. Prehn JH, Peruche B, Unsicker K, Krieglstein J. Isoform-specific effects of transforming growth factors-beta on degeneration of primary neuronal cultures induced by cytotoxic hypoxia or glutamate. J Neurochem. 1993 May;60(5):1665-72.

46. Roberts AB, Sporn MB. Physiological actions and clinical applications of transforming growth factor-beta (TGF-beta).

Growth Factors. 1993;8(1):1-9.

47. Beck LS, Deguzman L, Lee WP, Xu Y, McFatridge LA, Gillett NA, Amento EP. Rapid publication. TGF-beta 1 induces bone closure of skull defects. J Bone Miner Res. 1991 Nov;6(11):1257-65.

48. Einhorn TA. The cell and molecular biology of fracture healing.

Clin Orthop 1988;Suppl 355:7-21.

49. Lind M, Schumacker B, Soballe K, et al. Transforming growth factor enhances fracture healing in rabbit tibiae. Acta Orthop Scand

1993;64:533-6.

50. Long MW, Robinson JA, Ashcraft EA, Mann KG. Regulation of human bone marrow-derived osteoprogenitor cells by osteogenic growth factors. J Clin Invest 1995;95:881-87.

51. Wang FS, Yang KD, Chen RF, Wang CJ, Sheen-Chen SM. Extracorporeal shock wave promotes growth and differentiation of bone-marrow stromal cells towards osteoprogenitors associated with induction of TGF-beta1. J Bone Joint Surg Br 2002 Apr;84(3):457-61 52. Neufeld G, Cohen T, Gengrinovitch S, et al. Vascular endothelial

growth factor (VEGF) and its receptors. FASEB J 1999;13:9-22.

53. Ferrara N, Henzel WJ. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cell. Biochem Biophys Res Commun 1989;161:851-8.

54. Gospodarowicz D, Abraham J, Schlling J, et al. Isolation and characterization of a vascular endothelial cell mitogen produced by pituitary-derived follicular stellate cell. Proc Natl Acad Sci USA 1989;86:7311-5.

55. Senger DR, Galli SJ, Dvorak AM, et al. Tumor cells secrete a vascular permeability factor that promotes accumulaton of ascites

fluid. Science 1983;219:983-5.

56. Leung DW, Cachianes G, Kuang WJ, et al. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 1989;246:1306-9.

57. Shweiki D, Itin DA, Soffer D, et al. Vascular endothelial growth factor induced by hypoxia may mediated hypoxia-initiated angiogenesis. Nature 1992;359:843-5.

58. Xiong M, Elson G, Legarda D, et al. Production of vascular endothelial growth factor by murine macrophages: regulation by hypoxia, lactate, and the inducible nitric oxide synthase pathway.

Am J Pathol 1998;153:587-98.

59. Harmey JH, Demitriandis E, Kay E, et al. Regulation of macrophage production of vascular endothelial growth factor (VEGF) by hypoxia and transforming growth factor beta-1. Ann Surg Oncol 1998;5:271-8.

60. Aiello L, Avery RL, Arrigg PG, et al. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Eng J Med 1994;331:1480-7.

61. Admis AP, Miller JW, Bernal MT, et al. Increased vascular

endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy. Am J Ophthalmol 1994;118:445-50.

62. Brown LF, Yeo KT, Berse B, et al. Expression of vascular permeability factor (vascular endothelial growth factor) by epidermal keratinocytes during wound healing. J Exp Med 1992;176:1375-9.

63. M.M.L. Deckers, M. Karperien, C. van der Bent, T. Yamshita, S.E.

Papapoulos and C.W.G.M. Lowik, Expression of vascular endothelial growth factors and their receptors during osteoblasts differentiation. Endocrinology 141 (2000), pp. 1667–1674.

64. K.A. Thomas, Vascular endothelial growth factor, a potent and selective angiogenic agent. J. Biol. Chem. 271 (1996), pp.

603–606.

65. J. Street, M. Bao, L. deGuzman, S. Bunting, F.V. Peale, Jr., N.

Ferrara et al., Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover. Proc. Natl.

Acad. Sci. U. S. A. 99 (2002), pp. 9656–9661.

66. C. Maes, P. Carmeliet, K. Moermans, I. Stockmans, N. Smets, D.

Collen et al., Impaired angiogenesis and endochondral bone formation in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188. Mech. Dev. 111 (2002), pp. 61–73.

67. C. Ferguson, E. Alpern, T. Miclau and J.A. Helms, Does adult fracture repair recapitulate embryonic skeletal formation? Mech.

Dev. 87 (1999), pp. 57–66.

68. Burgess WH, Maciag T. The heparin-binding (fibroblast) growth factor family of proteins. Annu Rev Biochem. 1989;58:575-606.

69. Gonzalez AM, Buscaglia M, Ong M, Baird A. Distribution of basic fibroblast growth factor in the 18-day rat fetus: localization in the basement membranes of diverse tissues. J Cell Biol. 1990 Mar;110(3):753-65.

70. Baird A, Klagsbrun M. The fibroblast growth factor family. Cancer Cells. 1991 Jun;3(6):239-43.

71. Hanada K, Dennis JE, Caplan AI. Stimulatory effects of basic fibroblast growth factor and bone morphogenetic protein-2 on osteogenic differentiation of rat bone marrow-derived mesenchymal

stem cells. J Bone Miner Res 1997 Oct;12(10):1606-14

72. Kotev-Emeth S, Savion N, Pri-chen S, Pitaru S. Effect of maturation on the osteogenic response of cultured stromal bone marrow cells to basic fibroblast growth factor. Bone 2000 Dec;27(6):777-83.

73. Einhorn TA, Majeska RJ, Rush EB, Levine PM, Horowitz MC. The expression of cytokine activity by fracture callus. J Bone Miner Res. 1995 Aug;10(8):1272-81.

74. Zuo J, Jiang J, Dolce C, Holliday LS. Effects of basic fibroblast growth factor on osteoclasts and osteoclast-like cells. Biochem Biophys Res Commun. 2004 May 21;318(1):162-7.

75. Collin-Osdoby P, Rothe L, Bekker S, Anderson F, Huang Y, Osdoby P. Basic fibroblast growth factor stimulates osteoclast recruitment, development, and bone pit resorption in association with angiogenesis in vivo on the chick chorioallantoic membrane

and activates isolated avian osteoclast resorption in vitro. J Bone Miner Res. 2002 Oct;17(10):1859-71.

76. Montero A, Okada Y, Tomita M, Ito M, Tsurukami H, Nakamura T, Doetschman T, Coffin JD, Hurley MM. Disruption of the fibroblast growth factor-2 gene results in decreased bone mass and bone formation. J Clin Invest. 2000 Apr;105(8):1085-93.

77. Chen YJ, Kuo YR, Yang KD, Wang CJ, Huang HC, Wang FS. Shock wave application enhances pertussis toxin protein-sensitive bone formation of segmental femoral defect in rats. J Bone Miner Res.

2003 Dec;18(12):2169-79.

八、簡單自述 姓 名: 許晉榮

出生日期: 民國 59 年 9 月 1 日 籍 貫: 台灣屏東

通訊方式:

電話：（04）22052121 ext. 2073

通訊地址：406 台中市北區育德路 2 號

現 職

民國 92 年迄今 中國醫藥學院附設醫院骨科部主治醫師