根據實驗結果證實 ，大蒜精油處理下可顯著降低大鼠血漿中 atorvastatin 與 其代謝物 2-hydroxy atorvastatin 的藥物濃度，主要經由調節藥物代謝酵素與膜轉運 蛋白之酵素、蛋白質與 mRNA 的表現。因此推論，大蒜精油如與 ATV 共同服用下，
可能與 ATV 的代謝產生交互作用，進而降低 ATV 降血膽固醇之藥效。
參考文獻
Abdelmegeed, M.A., Carruthers, N.J., Woodcroft, K.J., Kim, S.K., and Novak, R.F.
(2005). Acetoacetate induces CYP2E1 protein and suppresses CYP2E1 mRNA in primary cultured rat hepatocytes. The Journal of pharmacology and
experimental therapeutics 315, 203-213.
Abe, T., Kakyo, M., Tokui, T., Nakagomi, R., Nishio, T., Nakai, D., Nomura, H., Unno, M., Suzuki, M., Naitoh, T., et al. (1999). Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1. The Journal of biological chemistry 274, 17159-17163.
Ackermann, R.T., Mulrow, C.D., Ramirez, G., Gardner, C.D., Morbidoni, L., and Lawrence, V.A. (2001). Garlic shows promise for improving some
cardiovascular risk factors. Archives of internal medicine 161, 813-824.
Amagase, H. (2006). Clarifying the real bioactive constituents of garlic. The Journal of nutrition 136, 716S-725S.
Asdaq, S.M., and Inamdar, M.N. (2009). The potential for interaction of
hydrochlorothiazide with garlic in rats. Chemico-biological interactions 181, 472-479.
Banerjee, S.K., Mukherjee, P.K., and Maulik, S.K. (2003). Garlic as an antioxidant:
the good, the bad and the ugly. Phytotherapy Research 17, 97-106.
Berginc, K., Zakelj, S., and Kristl, A. (2010). In vitro interactions between aged garlic extract and drugs used for the treatment of cardiovascular and diabetic patients. European journal of nutrition 49, 373-384.
Berlett, B.S., and Stadtman, E.R. (1997). Protein oxidation in aging, disease, and oxidative stress. The Journal of biological chemistry 272, 20313-20316.
Bertilsson, G., Heidrich, J., Svensson, K., Asman, M., Jendeberg, L.,
Sydow-Backman, M., Ohlsson, R., Postlind, H., Blomquist, P., and Berkenstam, A. (1998). Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction. Proceedings of the National Academy of Sciences of the United States of America 95, 12208-12213.
Bertz, R.J., and Granneman, G.R. (1997). Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions. Clinical
pharmacokinetics 32, 210-258.
Bock, K.W. (2003). Vertebrate UDP-glucuronosyltransferases: functional and evolutionary aspects. Biochemical pharmacology 66, 691-696.
Borek, C. (2001). Antioxidant health effects of aged garlic extract. The Journal of nutrition 131, 1010S-1015S.
Burke, M.D., Thompson, S., Weaver, R.J., Wolf, C.R., and Mayer, R.T. (1994).
Cytochrome P450 specificities of alkoxyresorufin O-dealkylation in human and rat liver. Biochemical pharmacology 48, 923-936.
Chao, C.Y., Lii, C.K., Tsai, I.T., Li, C.C., Liu, K.L., Tsai, C.W., and Chen, H.W.
(2011). Andrographolide Inhibits ICAM-1 Expression and NF-kappaB
Activation in TNF-alpha-Treated EA.hy926 Cells. Journal of agricultural and food chemistry.
Chen, C.W., and Ho, C.T. (1998). Thermal Degradation of Allyl Isothiocyanate in Aqueous Solution. Journal of agricultural and food chemistry 46, 220-223.
Chen, Y., Shertzer, H.G., Schneider, S.N., Nebert, D.W., and Dalton, T.P. (2005).
Glutamate cysteine ligase catalysis: dependence on ATP and modifier subunit for regulation of tissue glutathione levels. The Journal of biological chemistry 280, 33766-33774.
Clark, J.E., Foresti, R., Sarathchandra, P., Kaur, H., Green, C.J., and Motterlini, R.
(2000). Heme oxygenase-1-derived bilirubin ameliorates postischemic myocardial dysfunction. American journal of physiology 278, H643-651.
Congiu, M., Mashford, M.L., Slavin, J.L., and Desmond, P.V. (2002). UDP
glucuronosyltransferase mRNA levels in human liver disease. Drug metabolism and disposition: the biological fate of chemicals 30, 129-134.
Cox, M.C., Low, J., Lee, J., Walshe, J., Denduluri, N., Berman, A., Permenter, M.G., Petros, W.P., Price, D.K., Figg, W.D., et al. (2006). Influence of garlic (Allium sativum) on the pharmacokinetics of docetaxel. clinical cancer research 12, 4636-4640.
Dahan, A., Sabit, H., and Amidon, G.L. (2009). Multiple efflux pumps are involved in the transepithelial transport of colchicine: combined effect of p-glycoprotein and multidrug resistance-associated protein 2 leads to decreased intestinal absorption throughout the entire small intestine. Drug metabolism and disposition: the biological fate of chemicals 37, 2028-2036.
Dalton, T.P., Dieter, M.Z., Yang, Y., Shertzer, H.G., and Nebert, D.W. (2000).
Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene:
embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygous. Biochemical and biophysical research communications 279, 324-329.
Davenport, D.M., and Wargovich, M.J. (2005). Modulation of cytochrome P450 enzymes by organosulfur compounds from garlic. Food and Chemical Toxicology 43, 1753-1762.
Emoto, C., Yamazaki, H., Yamasaki, S., Shimada, N., Nakajima, M., and Yokoi, T.
(2000). Characterization of cytochrome P450 enzymes involved in drug oxidations in mouse intestinal microsomes. Xenobiotica; the fate of foreign compounds in biological systems 30, 943-953.
Evans, V. (2000). Herbs and the brain: friend or foe? The effects of ginkgo and garlic on warfarin use. Journal of Neuroscience Nursing 32, 229-232.
Evans, W.E., and Relling, M.V. (1999). Pharmacogenomics: translating functional genomics into rational therapeutics. Science (New York, NY 286, 487-491.
Fang, Y.Z., Yang, S., and Wu, G. (2002). Free radicals, antioxidants, and nutrition.
Nutrition (Burbank, Los Angeles County, Calif 18, 872-879.
Farghali, H., Cerny, D., Kamenikova, L., Martinek, J., Horinek, A., Kmonickova, E., and Zidek, Z. (2009). Resveratrol attenuates lipopolysaccharide-induced
hepatitis in D-galactosamine sensitized rats: role of nitric oxide synthase 2 and heme oxygenase-1. Nitric Oxide 21, 216-225.
Farombi, E.O., and Surh, Y.J. (2006). Heme oxygenase-1 as a potential therapeutic target for hepatoprotection. Journal of biochemistry and molecular biology 39, 479-491.
Fisher, C.D., Augustine, L.M., Maher, J.M., Nelson, D.M., Slitt, A.L., Klaassen, C.D., Lehman-McKeeman, L.D., and Cherrington, N.J. (2007). Induction of
drug-metabolizing enzymes by garlic and allyl sulfide compounds via activation of constitutive androstane receptor and nuclear factor E2-related factor 2. Drug metabolism and disposition: the biological fate of chemicals 35, 995-1000.
Franke, R.M., Gardner, E.R., and Sparreboom, A. (2010). Pharmacogenetics of drug transporters. Current pharmaceutical design 16, 220-230.
Franklin, C.C., Backos, D.S., Mohar, I., White, C.C., Forman, H.J., and Kavanagh, T.J. (2009). Structure, function, and post-translational regulation of the catalytic and modifier subunits of glutamate cysteine ligase. Molecular Aspects of
Medicine 30, 86-98.
Goard, C.A., Mather, R.G., Vinepal, B., Clendening, J.W., Martirosyan, A., Boutros,
P.C., Sharom, F.J., and Penn, L.Z. (2010). Differential interactions between statins and P-glycoprotein: implications for exploiting statins as anticancer agents. International journal of cancer 127, 2936-2948.
Gottesman, M.M., and Pastan, I. (1993). Biochemistry of multidrug resistance mediated by the multidrug transporter. Annual review of biochemistry 62, 385-427.
Griffith, O.W., and Mulcahy, R.T. (1999). The enzymes of glutathione synthesis:
gamma-glutamylcysteine synthetase. Adv Enzymol Relat Areas Mol Biol 73, 209-267, xii.
Gruber, F., Mayer, H., Lengauer, B., Mlitz, V., Sanders, J.M., Kadl, A., Bilban, M., de Martin, R., Wagner, O., Kensler, T.W., et al. (2010). NF-E2-related factor 2 regulates the stress response to UVA-1-oxidized phospholipids in skin cells.
Journal of the Federation of American Societies for Experimental Biology 24, 39-48.
Gu, Y.Z., Hogenesch, J.B., and Bradfield, C.A. (2000). The PAS superfamily: sensors of environmental and developmental signals. Annual review of pharmacology and toxicology 40, 519-561.
Guengerich, F.P. (2004). Cytochrome P450: what have we learned and what are the future issues? Drug metabolism reviews 36, 159-197.
Gurley, B.J., Gardner, S.F., Hubbard, M.A., Williams, D.K., Gentry, W.B., Cui, Y., and Ang, C.Y. (2002). Cytochrome P450 phenotypic ratios for predicting herb-drug interactions in humans. Clinical pharmacology and therapeutics 72, 276-287.
Gurley, B.J., Gardner, S.F., Hubbard, M.A., Williams, D.K., Gentry, W.B., Cui, Y., and Ang, C.Y. (2005). Clinical assessment of effects of botanical
supplementation on cytochrome P450 phenotypes in the elderly: St John's wort, garlic oil, Panax ginseng and Ginkgo biloba. Drugs & aging 22, 525-539.
Hagenbuch, B., and Meier, P.J. (2003). The superfamily of organic anion transporting polypeptides. Biochimica et biophysica acta 1609, 1-18.
Hajda, J., Rentsch, K.M., Gubler, C., Steinert, H., Stieger, B., and Fattinger, K.
(2010). Garlic extract induces intestinal P-glycoprotein, but exhibits no effect on intestinal and hepatic CYP3A4 in humans. European Journal of
Pharmaceutical Sciences 41, 729-735.
Halliwell, B., and Cross, C.E. (1994). Oxygen-derived species: their relation to human disease and environmental stress. Environ Health Perspect 102 Suppl 10, 5-12.
Han, D., Sen, C.K., Roy, S., Kobayashi, M.S., Tritschler, H.J., and Packer, L. (1997a).
Protection against glutamate-induced cytotoxicity in C6 glial cells by thiol antioxidants. Am J Physiol 273, R1771-1778.
Han, D., Sen, C.K., Roy, S., Kobayashi, M.S., Tritschler, H.J., and Packer, L. (1997b).
Protection against glutamate-induced cytotoxicity in C6 glial cells by thiol antioxidants. American journal of physiology 273, R1771-1778.
Hanioka, N., Jinno, H., Tanaka-Kagawa, T., Nishimura, T., and Ando, M. (2001).
Determination of UDP-glucuronosyltransferase UGT1A6 activity in human and rat liver microsomes by HPLC with UV detection. Journal of pharmaceutical and biomedical analysis 25, 65-75.
Hankinson, O. (1994). The role of the aryl hydrocarbon receptor nuclear translocator protein in aryl hydrocarbon receptor action. Trends in endocrinology and metabolism: TEM 5, 240-244.
Hayes, J.D., Flanagan, J.U., and Jowsey, I.R. (2005). Glutathione transferases.
Annual review of pharmacology and toxicology 45, 51-88.
Hediger, M.A., Romero, M.F., Peng, J.B., Rolfs, A., Takanaga, H., and Bruford, E.A.
(2004). The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteinsIntroduction. Pflugers Arch 447, 465-468.
Hoffman, E.C., Reyes, H., Chu, F.F., Sander, F., Conley, L.H., Brooks, B.A., and Hankinson, O. (1991). Cloning of a factor required for activity of the Ah (dioxin) receptor. Science (New York, NY 252, 954-958.
Hoshino, T., Kashimoto, N., and Kasuga, S. (2001). Effects of garlic preparations on the gastrointestinal mucosa. The Journal of nutrition 131, 1109S-1113S.
Hukkanen, J. (2000). Xenobiotic-metabolizing cytochrome p450 enzymes in human lung.Department of Pharmacology and Toxicology, University of Oulu.
Idriss, N.K., Blann, A.D., and Lip, G.Y. (2008). Hemoxygenase-1 in cardiovascular disease. Journal of the American College of Cardiology 52, 971-978.
Imada, O. (1990). Toxicity aspects of garlic. First World Congress on the Health Significance of Garlic and Garlic Constituents. Nutrition International Irvine, CA 47.
IMS Health. (2010)
http://www.imshealth.com/portal/site/imshealth/menuitem.a46c6d4df3db4b3d88 f611019418c22a/?vgnextoid=3a4d5e0108d88210VgnVCM100000ed152ca2RCR D&vgnextfmt=default. MIDAS.
Ingelman-Sundberg, M. (2004). Human drug metabolising cytochrome P450
enzymes: properties and polymorphisms. Naunyn-Schmiedeberg's archives of pharmacology 369, 89-104.
IPI-193. (2001) http://www.ktgh.com.tw/Public/tbDrug/200812188367055.pdf Irene Lelekis, P.D.c. (2008). Alternative medicines update: a focus on the most
common products your patients are using. PharmaNote 23, 1-7.
Jancova, P., Anzenbacher, P., and Anzenbacherova, E. (2010). Phase II drug metabolizing enzymes. Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia 154, 103-116.
Jin, L., and Baillie, T.A. (1997). Metabolism of the chemoprotective agent diallyl sulfide to glutathione conjugates in rats. Chemical research in toxicology 10, 318-327.
Jonker, J.W., Buitelaar, M., Wagenaar, E., Van Der Valk, M.A., Scheffer, G.L.,
Scheper, R.J., Plosch, T., Kuipers, F., Elferink, R.P., Rosing, H., et al. (2002). The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria. Proceedings of the National Academy of Sciences of the United States of America 99, 15649-15654.
Kanazawa, H., Okada, A., Igarashi, E., Higaki, M., Miyabe, T., Sano, T., and
Nishimura, R. (2004). Determination of midazolam and its metabolite as a probe for cytochrome P450 3A4 phenotype by liquid chromatography-mass
spectrometry. Journal of chromatography 1031, 213-218.
Klein, T.E., Chang, J.T., Cho, M.K., Easton, K.L., Fergerson, R., Hewett, M., Lin, Z., Liu, Y., Liu, S., Oliver, D.E., et al. (2001). Integrating genotype and phenotype information: an overview of the PharmGKB project. Pharmacogenetics Research Network and Knowledge Base. The pharmacogenomics journal 1, 167-170.
Knapen, M.F., Zusterzeel, P.L., Peters, W.H., and Steegers, E.A. (1999). Glutathione and glutathione-related enzymes in reproduction. A review. European journal of obstetrics, gynecology, and reproductive biology 82, 171-184.
Kobayashi, K., Urashima, K., Shimada, N., and Chiba, K. (2002). Substrate specificity for rat cytochrome P450 (CYP) isoforms: screening with
cDNA-expressed systems of the rat. Biochemical pharmacology 63, 889-896.
Lachmann, G., Lorenz, D., Radeck, W., and Steiper, M. (1994). The
pharmacokinetics of the S35 labeled labeled garlic constituents alliin, allicin and vinyldithiine. Arzneimittel-Forschung 44, 734-743.
Lawson, L.D. (1996). The composition and chemistry of garlic cloves and processed garlic. In:Koch, H.P., Lawson, L.D.(Eds.), Garlic The Science and Therapeutic
Application of Allium sativum L. and related species. Williams and Wilkins Press, USA, pp.37-107.
Lin, J.H., and Yamazaki, M. (2003). Role of P-glycoprotein in pharmacokinetics:
clinical implications. Clinical pharmacokinetics 42, 59-98.
Lin, M.C., Wang, E.J., Patten, C., Lee, M.J., Xiao, F., Reuhl, K.R., and Yang, C.S.
(1996). Protective effect of diallyl sulfone against acetaminophen-induced hepatotoxicity in mice. Journal of biochemical toxicology 11, 11-20.
Lu, S.C. (2009). Regulation of glutathione synthesis. Molecular aspects of medcine 30, 42-59.
Lu, S.C., Bao, Y., Huang, Z.Z., Sarthy, V.P., and Kannan, R. (1999). Regulation of gamma-glutamylcysteine synthetase subunit gene expression in retinal Muller cells by oxidative stress. Investigative ophthalmology & visual science 40, 1776-1782.
Mackenzie, P.I., Owens, I.S., Burchell, B., Bock, K.W., Bairoch, A., Belanger, A., Fournel-Gigleux, S., Green, M., Hum, D.W., Iyanagi, T., et al. (1997). The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence. Pharmacogenetics 7, 255-269.
Manson, M.M., Ball, H.W., Barrett, M.C., Clark, H.L., Judah, D.J., Williamson, G., and Neal, G.E. (1997). Mechanism of action of dietary chemoprotective agents in rat liver: induction of phase I and II drug metabolizing enzymes and aflatoxin B1 metabolism. Carcinogenesis 18, 1729-1738.
Markowitz, J.S., Devane, C.L., Chavin, K.D., Taylor, R.M., Ruan, Y., and Donovan, J.L. (2003). Effects of garlic (Allium sativum L.) supplementation on
cytochrome P450 2D6 and 3A4 activity in healthy volunteers. Clinical pharmacology and therapeutics 74, 170-177.
MedlinePlus. http://www.nlm.nlh.gov/medlineplus/druginfo/natural/300.html.
Meech, R., and Mackenzie, P.I. (1997). Structure and function of uridine
diphosphate glucuronosyltransferases. Clinical and experimental pharmacology
& physiology 24, 907-915.
Minamino, T., Christou, H., Hsieh, C.M., Liu, Y., Dhawan, V., Abraham, N.G.,
Perrella, M.A., Mitsialis, S.A., and Kourembanas, S. (2001). Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular
responses to hypoxia. Proceedings of the National Academy of Sciences of the United States of America 98, 8798-8803.
Mohammed Abdul, M.I., Jiang, X., Williams, K.M., Day, R.O., Roufogalis, B.D., Liauw, W.S., Xu, H., and McLachlan, A.J. (2008). Pharmacodynamic interaction
of warfarin with cranberry but not with garlic in healthy subjects. British journal of pharmacology 154, 1691-1700.
Mojarrabi, B., and Mackenzie, P.I. (1998). Characterization of two UDP
glucuronosyltransferases that are predominantly expressed in human colon.
Biochemical and biophysical research communications 247, 704-709.
Moore, L.B., Parks, D.J., Jones, S.A., Bledsoe, R.K., Consler, T.G., Stimmel, J.B., Goodwin, B., Liddle, C., Blanchard, S.G., Willson, T.M., et al. (2000). Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands. The Journal of biological chemistry 275, 15122-15127.
Omura, T., and Sato, R. (1964). The Carbon Monoxide-Binding Pigment of Liver Microsomes. I. Evidence for Its Hemoprotein Nature. The Journal of biological chemistry 239, 2370-2378.
Paine, M.F., Hart, H.L., Ludington, S.S., Haining, R.L., Rettie, A.E., and Zeldin, D.C. (2006). The human intestinal cytochrome P450 "pie". Drug metabolism and disposition: the biological fate of chemicals 34, 880-886.
Paine, M.F., Khalighi, M., Fisher, J.M., Shen, D.D., Kunze, K.L., Marsh, C.L., Perkins, J.D., and Thummel, K.E. (1997). Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism. The Journal of pharmacology and experimental therapeutics 283, 1552-1562.
Papageorgiou, C., Corbet, J.P., Menezes-Brandao, F., Pecegueiro, M., and Benezra, C. (1983). Allergic contact dermatitis to garlic (Allium sativum L.).
Identification of the allergens: the role of mono-, di-, and trisulfides present in garlic. A comparative study in man and animal (guinea-pig). Archives of dermatological research 275, 229-234.
Pfizer, Inc. http://www.lipitor.com/aboutLipitor.aspx.
Phillips, A.H., and Langdon, R.G. (1962). Hepatic triphosphopyridine
nucleotide-cytochrome c reductase: isolation, characterization, and kinetic studies. The Journal of biological chemistry 237, 2652-2660.
Pichard-Garcia L, P.J.-M.M.P. (2000). Carotenoids activate PXR and are inducers of CYP2B6 and CYP3A4 in human hepatocytes in primary culture (abstract).
13th International Symposium on Microsomes and Drug Oxidations, 195.
Piscitelli, S.C., Burstein, A.H., Welden, N., Gallicano, K.D., and Falloon, J. (2002).
The effect of garlic supplements on the pharmacokinetics of saquinavir. Clinical Infectious Diseases 34, 234-238.
Plosker, G.L., and Scott, L.J. (2003). Saquinavir: a review of its use in boosted
regimens for treating HIV infection. Drugs 63, 1299-1324.
Pompella, A., Visvikis, A., Paolicchi, A., De Tata, V., and Casini, A.F. (2003). The changing faces of glutathione, a cellular protagonist. Biochem Pharmacol 66, 1499-1503.
Pool-Zobel, B., Veeriah, S., and Bohmer, F.D. (2005). Modulation of xenobiotic metabolising enzymes by anticarcinogens -- focus on glutathione S-transferases and their role as targets of dietary chemoprevention in colorectal carcinogenesis.
Mutation research 591, 74-92.
Quattrochi, L.C., Vu, T., and Tukey, R.H. (1994). The human CYP1A2 gene and induction by 3-methylcholanthrene. A region of DNA that supports AH-receptor binding and promoter-specific induction. The Journal of biological chemistry 269, 6949-6954.
Reichel, C., Gao, B., Van Montfoort, J., Cattori, V., Rahner, C., Hagenbuch, B., Stieger, B., Kamisako, T., and Meier, P.J. (1999). Localization and function of the organic anion-transporting polypeptide Oatp2 in rat liver. Gastroenterology 117, 688-695.
Rushmore, T.H., and Kong, A.N. (2002). Pharmacogenomics, regulation and
signaling pathways of phase I and II drug metabolizing enzymes. Current drug metabolism 3, 481-490.
Schinkel, A.H., Mayer, U., Wagenaar, E., Mol, C.A., van Deemter, L., Smit, J.J., van der Valk, M.A., Voordouw, A.C., Spits, H., van Tellingen, O., et al. (1997).
Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins. Proceedings of the National Academy of Sciences of the United States of America 94, 4028-4033.
Schinkel, A.H., Smit, J.J., van Tellingen, O., Beijnen, J.H., Wagenaar, E., van Deemter, L., Mol, C.A., van der Valk, M.A., Robanus-Maandag, E.C., te Riele, H.P., et al. (1994). Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell 77, 491-502.
Schmidt, J.V., and Bradfield, C.A. (1996). Ah receptor signaling pathways. Annual review of cell and developmental biology 12, 55-89.
Seelig, G.F., Simondsen, R.P., and Meister, A. (1984). Reversible dissociation of gamma-glutamylcysteine synthetase into two subunits. The Journal of biological chemistry 259, 9345-9347.
Sheen, L.Y., Lii, C.K., Sheu, S.F., Meng, R.H., and Tsai, S.J. (1996). Effect of the active principle of garlic--diallyl sulfide--on cell viability, detoxification
capability and the antioxidation system of primary rat hepatocytes. Food and Chemical Toxicology 34, 971-978.
Shimada, T., Yamazaki, H., Mimura, M., Inui, Y., and Guengerich, F.P. (1994).
Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. The Journal of pharmacology and experimental therapeutics 270, 414-423.
Simi, A., and Ingelman-Sundberg, M. (1999). Post-translational inhibition of
cytochrome P-450 2E1 expression by chlomethiazole in Fao hepatoma cells. The Journal of pharmacology and experimental therapeutics 289, 847-852.
Siow, R.C., Sato, H., and Mann, G.E. (1999). Heme oxygenase-carbon monoxide signalling pathway in atherosclerosis: anti-atherogenic actions of bilirubin and carbon monoxide? Cardiovascular research 41, 385-394.
Smit, J.W., Huisman, M.T., van Tellingen, O., Wiltshire, H.R., and Schinkel, A.H.
(1999). Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure. The Journal of clinical investigation 104, 1441-1447.
Sole, M., and Livingstone, D.R. (2005). Components of the cytochrome P450-dependent monooxygenase system and 'NADPH-independent
benzo[a]pyrene hydroxylase' activity in a wide range of marine invertebrate species. Comp Biochem Physiol C Toxicol Pharmacol 141, 20-31.
Soltaninassab, S.R., Sekhar, K.R., Meredith, M.J., and Freeman, M.L. (2000).
Multi-faceted regulation of gamma-glutamylcysteine synthetase. Journal of Cellular Physiology 182, 163-170.
Sparreboom, A., van Asperen, J., Mayer, U., Schinkel, A.H., Smit, J.W., Meijer, D.K., Borst, P., Nooijen, W.J., Beijnen, J.H., and van Tellingen, O. (1997). Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine. Proceedings of the National Academy of Sciences of the United States of America 94, 2031-2035.
Sugiyama, T., Kubota, Y., Shinozuka, K., Yamada, S., Wu, J., and Umegaki, K.
(2004). Ginkgo biloba extract modifies hypoglycemic action of tolbutamide via hepatic cytochrome P450 mediated mechanism in aged rats. Life sciences 75, 1113-1122.
Szaefer, H., Jodynis-Liebert, J., Cichocki, M., Matuszewska, A., and
Baer-Dubowska, W. (2003). Effect of naturally occurring plant phenolics on the induction of drug metabolizing enzymes by o-toluidine. Toxicology 186, 67-77.
Tang, Y.M., Wo, Y.Y., Stewart, J., Hawkins, A.L., Griffin, C.A., Sutter, T.R., and Greenlee, W.F. (1996). Isolation and characterization of the human cytochrome P450 CYP1B1 gene. The Journal of biological chemistry 271, 28324-28330.
Tsai, C.W., Chen, H.W., Yang, J.J., Sheen, L.Y., and Lii, C.K. (2007). Diallyl disulfide and diallyl trisulfide up-regulate the expression of the pi class of glutathione S-transferase via an AP-1-dependent pathway. Journal of agricultural and food chemistry 55, 1019-1026.
Tukey, R.H., and Strassburg, C.P. (2001). Genetic multiplicity of the human UDP-glucuronosyltransferases and regulation in the gastrointestinal tract.
Molecular pharmacology 59, 405-414.
Vachharajani, T.J., Work, J., Issekutz, A.C., and Granger, D.N. (2000). Heme oxygenase modulates selectin expression in different regional vascular beds.
American journal of physiology 278, H1613-1617.
Vaes, L.P., and Chyka, P.A. (2000). Interactions of warfarin with garlic, ginger, ginkgo, or ginseng: nature of the evidence. The Annals of pharmacotherapy 34, 1478-1482.
van Iersel, M.L., Verhagen, H., and van Bladeren, P.J. (1999). The role of biotransformation in dietary (anti)carcinogenesis. Mutation research 443, 259-270.
van Tellingen, O. (2001). The importance of drug-transporting P-glycoproteins in toxicology. Toxicology letters 120, 31-41.
Walsky, R.L., and Obach, R.S. (2004). Validated assays for human cytochrome P450 activities. Drug metabolism and disposition: the biological fate of chemicals 32, 647-660.
Watkins, P.B., Wrighton, S.A., Schuetz, E.G., Molowa, D.T., and Guzelian, P.S.
(1987). Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man. The Journal of clinical investigation 80, 1029-1036.
Waxman, D.J. (1999). P450 gene induction by structurally diverse xenochemicals:
central role of nuclear receptors CAR, PXR, and PPAR. Archives of biochemistry and biophysics 369, 11-23.
Whitlock, J.P., Jr. (1999). Induction of cytochrome P4501A1. Annual review of pharmacology and toxicology 39, 103-125.
Wijnholds, J., deLange, E.C., Scheffer, G.L., van den Berg, D.J., Mol, C.A., van der Valk, M., Schinkel, A.H., Scheper, R.J., Breimer, D.D., and Borst, P. (2000).
Multidrug resistance protein 1 protects the choroid plexus epithelium and
contributes to the blood-cerebrospinal fluid barrier. The Journal of clinical investigation 105, 279-285.
Wu, C.Y., and Benet, L.Z. (2005). Predicting drug disposition via application of BCS:
transport/absorption/ elimination interplay and development of a
biopharmaceutics drug disposition classification system. Pharmaceutical research 22, 11-23.
Wu, D., Meydani, S.N., Sastre, J., Hayek, M., and Meydani, M. (1994). In vitro glutathione supplementation enhances interleukin-2 production and mitogenic response of peripheral blood mononuclear cells from young and old subjects.
The Journal of nutrition 124, 655-663.
Xu, C., Li, C.Y., and Kong, A.N. (2005). Induction of phase I, II and III drug metabolism/transport by xenobiotics. Archives of pharmacal research 28, 249-268.
Yang, Y.M., Noh, K., Han, C.Y., and Kim, S.G. (2010). Transactivation of genes encoding for phase II enzymes and phase III transporters by phytochemical antioxidants. Molecules (Basel, Switzerland) 15, 6332-6348.
Yao, H.T., Chang, Y.W., Lan, S.J., and Yeh, T.K. (2008). The inhibitory effect of tannic acid on cytochrome P450 enzymes and NADPH-CYP reductase in rat and human liver microsomes. Food Chem Toxicol 46, 645-653.
Yet, S.F., Tian, R., Layne, M.D., Wang, Z.Y., Maemura, K., Solovyeva, M., Ith, B., Melo, L.G., Zhang, L., Ingwall, J.S., et al. (2001). Cardiac-specific expression of heme oxygenase-1 protects against ischemia and reperfusion injury in
transgenic mice. Circulation research 89, 168-173.
Zhang, P., Noordine, M.L., Cherbuy, C., Vaugelade, P., Pascussi, J.M., Duee, P.H., and Thomas, M. (2006). Different activation patterns of rat xenobiotic
metabolism genes by two constituents of garlic. Carcinogenesis 27, 2090-2095.
Zhao, C., and Shichi, H. (1998). Prevention of acetaminophen-induced cataract by a combination of diallyl disulfide and N-acetylcysteine. Journal of Ocular
Pharmacology and Therapeutics 14, 345-355.
Zuckerbraun, B.S., McCloskey, C.A., Mahidhara, R.S., Kim, P.K., Taylor, B.S., and Tzeng, E. (2003). Overexpression of mutated IkappaBalpha inhibits vascular smooth muscle cell proliferation and intimal hyperplasia formation. Journal of Vascular Surgery 38, 812-819.
附錄
圖一、大蒜精油對大鼠肝臟(A)與小腸(B)GCLC 與 GCLM 蛋白質表現之影響
圖一、大蒜精油對大鼠肝臟(A)與小腸(B)GCLC 與 GCLM 蛋白質表現之影響