綜合以上結果與討論，我們發現糖尿病前期者於有氧運動前攝取咖啡因會引發血糖 與胰島素濃度顯著上升反應，但不會造成 C-Peptide 濃度的改變，而咖啡因不利血糖調 控之現象，並不受中強度有氧運動介入的影響。據研究所得，本研究僅觀察血液葡萄糖、
胰島素與 C-Peptide 濃度等生化指標的變化，其中的調節機制尚有所不足，建議未來研 究可結合觀察 GLUT4、AMPK 活性等相關機轉做更深入的探討；而本研究僅針對沒有 運動習慣的糖尿病前期者，觀察有氧運動前攝取咖啡因對運動後血糖調控的影響，建議 未來可針對不同咖啡內容物或其他族群進行探討。
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附錄
附錄一 研究參與者身體活動調查問卷
附錄二 研究參與者知情同意書
粉) 的自製膠囊。於製備補充膠囊時將依據「食品安全衛生管理法」、「食品良好衛生
30-55歲男性研究參與者皆頇符合以下條件：(一) 符合糖尿病前期、(二) 無規律
B. 保存人員為：■計畫主持人 □其他：___________________
C. 保存地點為：■計畫主持人研究室櫃子 ■計畫主持人研究電腻 □其他：
理由，且不會引起任何不愉快或影響您的權益。若您決定撤回同意，可與計畫聯
附錄三 最大攝氧量紀錄表
NO.______________ 測驗日期：_____/____/____
姓名： _______________
安靜心跳：________ (bpm/min)
室內溫度 (℃)：____________ 相對溼度 (%)：___________
階
時間 (min)
總時間 (min)
速度 (km/h)
坡度 (%)
HR RPE 備註
0 3 min 0-3 min 2.7 0 0.5 3 min 3-6 min 2.7 5 1 3 min 6-9 min 2.7 10 2 3 min 9-12 min 4.0 12 3 3 min 12-15 min 5.4 14 4 3 min 15-18 min 6.7 16 5 3 min 18-21 min 8.0 18 6 3 min 21-24 min 8.8 20 7 3 min 24-27 min 9.6 22
最大攝氧量 (V ‧
O
2max)：__________(ml/kg/min)
附錄四 飲食紀錄表
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研究倫理審查核可證明書
Certificate of REC Approval
國立臺灣師範大學
National Taiwan Normal University
臺北市大安區和平東路一段162號 162, Section 1, Heping E. Rd., Taipei City 106, Taiwan.
Tel：886-2-77341395
Proposal Title:Effect of pre-exercise caffeine supplement on post-exercise glycemia regulation in prediabetes REC Number:202011HM020
University/Dept./Principal Investigator: National Taiwan Normal University/ College of Sports and
Recreation/ Department of Physical Education/ Professor Ho-Seng Wang
University/Dept./Co-Principal Investigator:National Taiwan Normal University/ College of Sports and
Recreation/ Department of Physical Education/ PhD Student Chun-Chin HuangProject Version/Date:2020/12/21/Version2
Informed Consent Document Version/Date:2020/12/21/Version2 Full Board Review Approved Meeting No.:80th Board Meeting
NTNUREC retains the right to revoke the approval before the final endorsement by board.
Approval Date: February 05, 2021
Effective Period:February 05, 2021 to July 31, 2021
※Amendments should be submitted to REC before implementation if there are any changes to the approved protocol, including increasing participant enrollment.
※Continuing Review Applications should be submitted to REC before the current approval expires. The final report should be submitted within 3 months after expiration.
Shu-Man Pan
附錄五 研究倫理審查核可證明書
66
Chairperson
Research Ethics Committee, National Taiwan Normal University February 05, 2021
附錄六
不同處理與不同時間點之血糖變異數分析摘要表
變異來源
SS df MS F
處理 (A) 1961.167 1 1961.167 15.690*
誤差 (S/A) 1374.976 11 124.998
時間 (B) 142642.286 6 23773.714 37.821*
交互作用 (A×B) 1567.833 6 261.306 1.774 殘差 (B×S/A) 9723.024 66 147.319
*代表 p＜.05。
附錄七
不同處理與不同時間點之胰島素變異數分析摘要表
變異來源
SS df MS F
處理 (A) 9897.680 1 9897.680 13.233*
誤差 (S/A) 8227.465 11 747.951
時間 (B) 515933.092 6 85988.849 27.033*
交互作用 (A×B) 12209.548 6 2034.925 3.077*
殘差 (B×S/A) 43651.213 66 661.382
*代表 p＜.05。
附錄八
不同處理與不同時間點之 C-peptide 變異數分析摘要表
變異來源
SS df MS F
處理 (A) 1.166 1 1.166 1.039
誤差 (S/A) 12.347 11 1.122
時間 (B) 1280.369 3 426.790 70.909*
交互作用 (A×B) 4.945 3 1.648 3.188*
殘差 (B×S/A) 17.066 33 .517
*代表 p＜.05。
附錄九
不同處理與不同時間點在 OGTT 中對血糖影響之變異數分析摘要表
變異來源
SS df MS F
處理 (A) 673.365 1 673.365 11.148*
誤差 (S/A) 664.424 11 60.402
時間 (B) 4960.820 3 1653.607 17.488*
交互作用 (A×B) 70.929 3 23.643 1.099 殘差 (B×S/A) 709.751 33 21.508
*代表 p＜.05。
附錄十
不同處理與不同時間點在 OGTT 中對胰島素影響之變異數分析摘要表
變異來源
SS df MS F
處理 (A) 3222.484 1 3222.484 9.876*
誤差 (S/A) 3589.204 11 326.291
時間 (B) 13580.949 3 4526.983 9.484*
交互作用 (A×B) 355.335 3 118.445 1.192 殘差 (B×S/A) 3278.068 33 99.335
*代表 p＜.05。
附錄十一
不同處理與不同時間點之 HOMA-IR 變異數分析摘要表
變異來源
SS df MS F
處理 (A) 224.512 1 224.512 0.67
誤差 (S/A) 596.027 11 54.184
時間 (B) 10274.398 3 3424.799 14.893*
交互作用 (A×B) 633.681 3 211.227 4.413*
殘差 (B×S/A) 1579.417 33 47.861
附錄十二
不同處理與不同時間點之 HOMA-β 變異數分析摘要表
變異來源
SS df MS F
處理 (A) 16018.475 1 16018.475 1.999 誤差 (S/A) 88136.947 11 8012.450
時間 (B) 1536306 3 512102.286 54.473*
交互作用 (A×B) 65628.686 3 21876.229 5.138*
殘差 (B×S/A) 140493.566 33 4257.381