• 沒有找到結果。

Chem Soc 64(3), 353-315.

8. 童慧珊 (2008). 不同食材萃出物和類黃酮對大鼠初代肝細胞中 pi 屬麩胱甘 肽硫轉移酶表現之探討. (台中,台灣:中山醫學大學營養科學研究所碩士論 文).

9. Abraham, N.G., Asija, A., Drummond, G., and Peterson, S. (2007). Heme

oxygenase -1 gene therapy: recent advances and therapeutic applications. Current gene therapy 7, 89-108.

10. Abraham, N.G., and Kappas, A. (2008). Pharmacological and clinical aspects of heme oxygenase. Pharmacological reviews 60, 79-127.

11. Afanas'ev, I.B., Dorozhko, A.I., Brodskii, A.V., Kostyuk, V.A., and Potapovitch, A.I. (1989). Chelating and free radical scavenging mechanisms of inhibitory action of rutin and quercetin in lipid peroxidation. Biochemical pharmacology 38, 1763-1769.

12. Alam, J., and Cook, J.L. (2007). How many transcription factors does it take to turn on the heme oxygenase-1 gene? American journal of respiratory cell and molecular biology 36, 166-174.

13. Alam, J., Stewart, D., Touchard, C., Boinapally, S., Choi, A.M., and Cook, J.L.

(1999). Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene. The Journal of biological chemistry 274, 26071-26078.

14. Alexandrakis, M.G., Kyriakou, D.S., Kempuraj, D., Huang, M., Boucher, W., Seretakis, D., and Theoharides, T.C. (2003). The isoflavone genistein inhibits proliferation and increases histamine content in human leukemic mast cells.

Allergy Asthma Proc 24, 373-377.

15. Bae, Y.S., Kang, S.W., Seo, M.S., Baines, I.C., Tekle, E., Chock, P.B., and Rhee, S.G. (1997). Epidermal growth factor (EGF)-induced generation of hydrogen peroxide. Role in EGF receptor-mediated tyrosine phosphorylation. In J Biol Chem, pp. 217-221.

16. Balla, J., Vercellotti, G.M., Jeney, V., Yachie, A., Varga, Z., Eaton, J.W., and Balla,

G. (2005). Heme, heme oxygenase and ferritin in vascular endothelial cell injury.

Molecular nutrition & food research 49, 1030-1043.

17. Ballatori, N., Krance, S.M., Notenboom, S., Shi, S., Tieu, K., and Hammond, C.L. (2009). Glutathione dysregulation and the etiology and progression of human diseases. Biological chemistry 390, 191-214.

18. Ballatori, N., and Rebbeor, J.F. (1998). Roles of MRP2 and oatp1 in hepatocellular export of reduced glutathione. Seminars in liver disease 18, 377-387.

19. Baranano, D.E., Rao, M., Ferris, C.D., and Snyder, S.H. (2002). Biliverdin reductase: a major physiologic cytoprotectant. Proceedings of the National Academy of Sciences of the United States of America 99, 16093-16098.

20. Berlett, B.S., and Stadtman, E.R. (1997). Protein oxidation in aging, disease, and oxidative stress. The Journal of biological chemistry 272, 20313-20316.

21. Bonnesen, C., Eggleston, I.M., and Hayes, J.D. (2001). Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines.

Cancer research 61, 6120-6130.

22. Bravo, L. (1998). Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. Nutrition reviews 56, 317-333.

23. Brouard, S., Otterbein, L.E., Anrather, J., Tobiasch, E., Bach, F.H., Choi, A.M., and Soares, M.P. (2000). Carbon monoxide generated by heme oxygenase 1 suppresses endothelial cell apoptosis. The Journal of experimental medicine 192, 1015-1026.

24. Brune, B., and Ullrich, V. (1987). Inhibition of platelet aggregation by carbon monoxide is mediated by activation of guanylate cyclase. Molecular

pharmacology 32, 497-504.

25. Chen, C., and Kong, A.N. (2005). Dietary cancer-chemopreventive compounds:

from signaling and gene expression to pharmacological effects. Trends in pharmacological sciences 26, 318-326.

26. Chen, Y., Shertzer, H.G., Schneider, S.N., Nebert, D.W., and Dalton, T.P. (2005).

Glutamate cysteine ligase catalysis: dependence on ATP and modifier subunit for regulation of tissue glutathione levels. The Journal of biological chemistry 280, 33766-33774.

27. Cholbi, M.R., Paya, M., and Alcaraz, M.J. (1991). Inhibitory effects of phenolic compounds on CCl4-induced microsomal lipid peroxidation. Experientia 47, 195-199.

28. Clark, J.E., Foresti, R., Sarathchandra, P., Kaur, H., Green, C.J., and Motterlini, R. (2000). Heme oxygenase-1-derived bilirubin ameliorates postischemic

myocardial dysfunction. American journal of physiology 278, H643-651.

29. Cook, N.C., and Samman, S. (1996). Flavonoids-Chemistry, metabolism, cardioprotective effects, and dietary sources. . The Journal of nutritional biochemistry 7, 66-76.

30. Dahl, E.L., and Mulcahy, R.T. (2001). Cell-type specific differences in glutamate cysteine ligase transcriptional regulation demonstrate independent subunit control. Toxicol Sci 61, 265-272.

31. Dalton, T.P., Chen, Y., Schneider, S.N., Nebert, D.W., and Shertzer, H.G. (2004).

Genetically altered mice to evaluate glutathione homeostasis in health and disease. Free radical biology & medicine 37, 1511-1526.

32. Dalton, T.P., Dieter, M.Z., Yang, Y., Shertzer, H.G., and Nebert, D.W. (2000).

Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene:

embryonic lethal when homozygous, and proposed model for moderate

glutathione deficiency when heterozygous. Biochemical and biophysical research communications 279, 324-329.

33. Di Carlo, G., Mascolo, N., Izzo, A.A., and Capasso, F. (1999). Flavonoids: old and new aspects of a class of natural therapeutic drugs. Life sciences 65, 337-353.

34. Eisenstein, R.S., Garcia-Mayol, D., Pettingell, W., and Munro, H.N. (1991).

Regulation of ferritin and heme oxygenase synthesis in rat fibroblasts by

different forms of iron. Proceedings of the National Academy of Sciences of the United States of America 88, 688-692.

35. Fang, Y.Z., Yang, S., and Wu, G. (2002). Free radicals, antioxidants, and nutrition.

Nutrition (Burbank, Los Angeles County, Calif 18, 872-879.

36. Farghali, H., Cerny, D., Kamenikova, L., Martinek, J., Horinek, A., Kmonickova, E., and Zidek, Z. (2009). Resveratrol attenuates lipopolysaccharide-induced hepatitis in D-galactosamine sensitized rats: role of nitric oxide synthase 2 and heme oxygenase-1. Nitric Oxide 21, 216-225.

37. Farombi, E.O., and Surh, Y.J. (2006). Heme oxygenase-1 as a potential

therapeutic target for hepatoprotection. Journal of biochemistry and molecular biology 39, 479-491.

38. Foresti, R., Hoque, M., Monti, D., Green, C.J., and Motterlini, R. (2005).

Differential activation of heme oxygenase-1 by chalcones and rosolic acid in endothelial cells. The Journal of pharmacology and experimental therapeutics

312, 686-693.

39. Franklin, C.C., Backos, D.S., Mohar, I., White, C.C., Forman, H.J., and Kavanagh, T.J. (2009). Structure, function, and post-translational regulation of the catalytic and modifier subunits of glutamate cysteine ligase. Molecular

aspects of medicine 30, 86-98.

40. Galecka, E., Jacewicz, R., Mrowicka, M., Florkowski, A., and Galecki, P. (2008).

[Antioxidative enzymes--structure, properties, functions]. Pol Merkur Lekarski

25, 266-268.

41. Gopalakrishnan, A., and Tony Kong, A.N. (2008). Anticarcinogenesis by dietary phytochemicals: cytoprotection by Nrf2 in normal cells and cytotoxicity by modulation of transcription factors NF-kappa B and AP-1 in abnormal cancer cells. Food Chem Toxicol 46, 1257-1270.

42. Griffith, O.W. (1999). Biologic and pharmacologic regulation of mammalian glutathione synthesis. Free radical biology & medicine 27, 922-935.

43. Griffith, O.W., and Mulcahy, R.T. (1999). The enzymes of glutathione synthesis:

gamma-glutamylcysteine synthetase. Advances in enzymology and related areas of molecular biology 73, 209-267, xii.

44. Gruber, F., Mayer, H., Lengauer, B., Mlitz, V., Sanders, J.M., Kadl, A., Bilban, M., de Martin, R., Wagner, O., Kensler, T.W., et al. (2010). NF-E2-related factor 2 regulates the stress response to UVA-1-oxidized phospholipids in skin cells.

Faseb J 24, 39-48.

45. Halliwell, B., and Cross, C.E. (1994). Oxygen-derived species: their relation to human disease and environmental stress. Environmental health perspectives 102

Suppl 10, 5-12.

46. Han, D., Sen, C.K., Roy, S., Kobayashi, M.S., Tritschler, H.J., and Packer, L.

(1997). Protection against glutamate-induced cytotoxicity in C6 glial cells by thiol antioxidants. The American journal of physiology 273, R1771-1778.

47. Hanneken, A., Lin, F.F., Johnson, J., and Maher, P. (2006). Flavonoids protect human retinal pigment epithelial cells from oxidative-stress-induced death.

Investigative ophthalmology & visual science 47, 3164-3177.

48. Hertog, M.G., Feskens, E.J., Hollman, P.C., Katan, M.B., and Kromhout, D.

(1994). Dietary flavonoids and cancer risk in the Zutphen Elderly Study.

Nutrition and cancer 22, 175-184.

49. Hodek, P., Trefil, P., and Stiborova, M. (2002). Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450.

Chemico-biological interactions 139, 1-21.

50. Hollenberg, P.F., Kent, U.M., and Bumpus, N.N. (2008). Mechanism-based inactivation of human cytochromes p450s: experimental characterization,

reactive intermediates, and clinical implications. Chemical research in toxicology

21, 189-205.

51. Idriss, N.K., Blann, A.D., and Lip, G.Y. (2008). Hemoxygenase-1 in cardiovascular disease. Journal of the American College of Cardiology 52,

971-978.

52. Ioannides, C., Lewis, D.F., and Parke, D.V. (1994). The use of computers in the safety evaluation of drugs and other chemicals. European journal of drug metabolism and pharmacokinetics 19, 225-233.

53. Itoh, K., Chiba, T., Takahashi, S., Ishii, T., Igarashi, K., Katoh, Y., Oyake, T., Hayashi, N., Satoh, K., Hatayama, I., et al. (1997). An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochemical and biophysical research communications 236, 313-322.

54. Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., O'Connor, T., and Yamamoto, M.

(2003). Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles. Genes Cells 8, 379-391.

55. Jaganathan, S.K., and Mandal, M. (2009). Antiproliferative effects of honey and of its polyphenols: a review. Journal of biomedicine & biotechnology 2009, 830616.

56. Jaiswal, A.K. (2004). Nrf2 signaling in coordinated activation of antioxidant gene expression. Free radical biology & medicine 36, 1199-1207.

57. Johnson, J., Maher, P., and Hanneken, A. (2009). The flavonoid, eriodictyol, induces long-term protection in ARPE-19 cells through its effects on Nrf2 activation and phase 2 gene expression. Investigative ophthalmology & visual science 50, 2398-2406.

58. Johnson, J.A., Johnson, D.A., Kraft, A.D., Calkins, M.J., Jakel, R.J., Vargas, M.R., and Chen, P.C. (2008). The Nrf2-ARE pathway: an indicator and modulator of oxidative stress in neurodegeneration. Annals of the New York Academy of Sciences 1147, 61-69.

59. Joyeux, M., Lobstein, A., Anton, R., and Mortier, F. (1995). Comparative antilipoperoxidant, antinecrotic and scavenging properties of terpenes and biflavones from Ginkgo and some flavonoids. Planta medica 61, 126-129.

60. Kandaswami, C., Lee, L.T., Lee, P.P., Hwang, J.J., Ke, F.C., Huang, Y.T., and Lee, M.T. (2005). The antitumor activities of flavonoids. In vivo (Athens, Greece) 19, 895-909.

61. Kang, D.G., Lee, A.S., Mun, Y.J., Woo, W.H., Kim, Y.C., Sohn, E.J., Moon, M.K., and Lee, H.S. (2004). Butein ameliorates renal concentrating ability in

cisplatin-induced acute renal failure in rats. Biological & pharmaceutical bulletin

27, 366-370.

62. Kaspar, J.W., Niture, S.K., and Jaiswal, A.K. (2009). Nrf2:INrf2 (Keap1) signaling in oxidative stress. Free radical biology & medicine 47, 1304-1309.

63. Khor, T.O., Huang, M.T., Kwon, K.H., Chan, J.Y., Reddy, B.S., and Kong, A.N.

(2006). Nrf2-deficient mice have an increased susceptibility to dextran sulfate sodium-induced colitis. Cancer research 66, 11580-11584.

64. Klaassen, C.D., and Reisman, S.A. Nrf2 the rescue: effects of the antioxidative/electrophilic response on the liver. Toxicology and applied pharmacology 244, 57-65.

65. Knapen, M.F., Peters, W.H., Mulder, T.P., Merkus, H.M., Jansen, J.B., and Steegers, E.A. (1999). Glutathione and glutathione-related enzymes in decidua and placenta of controls and women with pre-eclampsia. Placenta 20, 541-546.

66. Kobayashi, M., and Yamamoto, M. (2005). Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation. Antioxidants & redox signaling 7, 385-394.

67. Kode, A., Rajendrasozhan, S., Caito, S., Yang, S.R., Megson, I.L., and Rahman, I.

(2008). Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells. American journal of physiology 294, L478-488.

68. Kong, A.N., Owuor, E., Yu, R., Hebbar, V., Chen, C., Hu, R., and Mandlekar, S.

(2001). Induction of xenobiotic enzymes by the MAP kinase pathway and the antioxidant or electrophile response element (ARE/EpRE). Drug metabolism reviews 33, 255-271.

69. Lee-Hilz, Y.Y., Boerboom, A.M., Westphal, A.H., Berkel, W.J., Aarts, J.M., and Rietjens, I.M. (2006). Pro-oxidant activity of flavonoids induces EpRE-mediated gene expression. Chemical research in toxicology 19, 1499-1505.

70. Lee, J.C., Lim, K.T., and Jang, Y.S. (2002). Identification of Rhus verniciflua Stokes compounds that exhibit free radical scavenging and anti-apoptotic properties. Biochimica et biophysica acta 1570, 181-191.

71. Lee, S.H., Nan, J.X., Zhao, Y.Z., Woo, S.W., Park, E.J., Kang, T.H., Seo, G.S., Kim, Y.C., and Sohn, D.H. (2003). The chalcone butein from Rhus verniciflua shows antifibrogenic activity. Planta medica 69, 990-994.

72. Lee, S.H., Seo, G.S., Jin, X.Y., Ko, G., and Sohn, D.H. (2007). Butein blocks tumor necrosis factor alpha-induced interleukin 8 and matrix metalloproteinase 7 production by inhibiting p38 kinase and osteopontin mediated signaling events in HT-29 cells. Life sciences 81, 1535-1543.

73. Li, M.H., Jang, J.H., Na, H.K., Cha, Y.N., and Surh, Y.J. (2007). Carbon monoxide produced by heme oxygenase-1 in response to nitrosative stress induces expression of glutamate-cysteine ligase in PC12 cells via activation of phosphatidylinositol 3-kinase and Nrf2 signaling. The Journal of biological chemistry 282, 28577-28586.

74. Liska, D.J. (1998). The detoxification enzyme systems. Altern Med Rev 3,

187-198.

75. Lu, S.C. (2009). Regulation of glutathione synthesis. Molecular aspects of medicine 30, 42-59.

76. Lu, S.C., Bao, Y., Huang, Z.Z., Sarthy, V.P., and Kannan, R. (1999). Regulation of gamma-glutamylcysteine synthetase subunit gene expression in retinal Muller cells by oxidative stress. Investigative ophthalmology & visual science 40, 1776-1782.

77. Ma, S.C., Du, J., But, P.P., Deng, X.L., Zhang, Y.W., Ooi, V.E., Xu, H.X., Lee, S.H., and Lee, S.F. (2002). Antiviral Chinese medicinal herbs against respiratory syncytial virus. Journal of ethnopharmacology 79, 205-211.

78. Martens, S., Forkmann, G., Matern, U., and Lukacin, R. (2001). Cloning of parsley flavone synthase I. Phytochemistry 58, 43-46.

79. Masella, R., Di Benedetto, R., Vari, R., Filesi, C., and Giovannini, C. (2005).

Novel mechanisms of natural antioxidant compounds in biological systems:

involvement of glutathione and glutathione-related enzymes. The Journal of nutritional biochemistry 16, 577-586.

80. Mates, J.M., Segura, J.M., Perez-Gomez, C., Rosado, R., Olalla, L., Blanca, M., and Sanchez-Jimenez, F.M. (1999). Antioxidant enzymatic activities in human blood cells after an allergic reaction to pollen or house dust mite. Blood cells, molecules & diseases 25, 103-109.

81. McCoubrey, W.K., Jr., Huang, T.J., and Maines, M.D. (1997). Isolation and characterization of a cDNA from the rat brain that encodes hemoprotein heme oxygenase-3. European journal of biochemistry / FEBS 247, 725-732.

82. McMahon, M., Itoh, K., Yamamoto, M., Chanas, S.A., Henderson, C.J.,

McLellan, L.I., Wolf, C.R., Cavin, C., and Hayes, J.D. (2001). The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes. Cancer research 61, 3299-3307.

83. Meister, A. (1995). Glutathione metabolism. Methods in enzymology 251, 3-7.

84. Middleton, E., Jr., Kandaswami, C., and Theoharides, T.C. (2000). The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacological reviews 52, 673-751.

85. Minamino, T., Christou, H., Hsieh, C.M., Liu, Y., Dhawan, V., Abraham, N.G., Perrella, M.A., Mitsialis, S.A., and Kourembanas, S. (2001). Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular

responses to hypoxia. Proceedings of the National Academy of Sciences of the United States of America 98, 8798-8803.

86. Moon, Y.J., Wang, X., and Morris, M.E. (2006). Dietary flavonoids: effects on

xenobiotic and carcinogen metabolism. Toxicol In Vitro 20, 187-210.

87. Motohashi, H., O'Connor, T., Katsuoka, F., Engel, J.D., and Yamamoto, M.

(2002). Integration and diversity of the regulatory network composed of Maf and CNC families of transcription factors. Gene 294, 1-12.

88. Myhrstad, M.C., Carlsen, H., Nordstrom, O., Blomhoff, R., and Moskaug, J.O.

(2002). Flavonoids increase the intracellular glutathione level by transactivation of the gamma-glutamylcysteine synthetase catalytical subunit promoter. Free radical biology & medicine 32, 386-393.

89. Myhrstad, M.C., Husberg, C., Murphy, P., Nordstrom, O., Blomhoff, R., Moskaug, J.O., and Kolsto, A.B. (2001). TCF11/Nrf1 overexpression increases the intracellular glutathione level and can transactivate the

gamma-glutamylcysteine synthetase (GCS) heavy subunit promoter. Biochimica et biophysica acta 1517, 212-219.

90. Nardini, M., Natella, F., and Scaccini, C. (2007). Role of dietary polyphenols in platelet aggregation. A review of the supplementation studies. Platelets 18, 224-243.

91. Nguyen, T., Sherratt, P.J., and Pickett, C.B. (2003). Regulatory mechanisms controlling gene expression mediated by the antioxidant response element.

Annual review of pharmacology and toxicology 43, 233-260.

92. Nijveldt, R.J., van Nood, E., van Hoorn, D.E., Boelens, P.G., van Norren, K., and van Leeuwen, P.A. (2001). Flavonoids: a review of probable mechanisms of action and potential applications. The American journal of clinical nutrition 74, 418-425.

93. Ohnuma, T., Komatsu, T., Nakayama, S., Nishiyama, T., Ogura, K., and Hiratsuka, A. (2009). Induction of antioxidant and phase 2 drug-metabolizing enzymes by falcarindiol isolated from Notopterygium incisum extract, which activates the Nrf2/ARE pathway, leads to cytoprotection against oxidative and electrophilic stress. Archives of biochemistry and biophysics 488, 34-41.

94. Otterbein, L.E., Otterbein, S.L., Ifedigbo, E., Liu, F., Morse, D.E., Fearns, C., Ulevitch, R.J., Knickelbein, R., Flavell, R.A., and Choi, A.M. (2003). MKK3 mitogen-activated protein kinase pathway mediates carbon monoxide-induced protection against oxidant-induced lung injury. The American journal of pathology 163, 2555-2563.

95. Packer, L. (1991). Protective role of vitamin E in biological systems. The American journal of clinical nutrition 53, 1050S-1055S.

96. Piantadosi, C.A. (2008). Carbon monoxide, reactive oxygen signaling, and oxidative stress. Free radical biology & medicine 45, 562-569.

97. Pompella, A., Visvikis, A., Paolicchi, A., De Tata, V., and Casini, A.F. (2003).

The changing faces of glutathione, a cellular protagonist. Biochemical pharmacology 66, 1499-1503.

98. Pushpavalli, G., Kalaiarasi, P., Veeramani, C., and Pugalendi, K.V. (2010). Effect of chrysin on hepatoprotective and antioxidant status in

D-galactosamine-induced hepatitis in rats. European journal of pharmacology

631, 36-41.

99. Ramos-Gomez, M., Kwak, M.K., Dolan, P.M., Itoh, K., Yamamoto, M., Talalay, P., and Kensler, T.W. (2001). Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice. Proceedings of the National Academy of Sciences of the United States of America 98, 3410-3415.

100. Reisman, S.A., Yeager, R.L., Yamamoto, M., and Klaassen, C.D. (2009).

Increased Nrf2 activation in livers from Keap1-knockdown mice increases expression of cytoprotective genes that detoxify electrophiles more than those that detoxify reactive oxygen species. Toxicol Sci 108, 35-47.

101. Rezk, B.M., Haenen, G.R., van der Vijgh, W.J., and Bast, A. (2002). The antioxidant activity of phloretin: the disclosure of a new antioxidant pharmacophore in flavonoids. Biochemical and biophysical research communications 295, 9-13.

102. Rice-Evans, C. (2001). Flavonoid antioxidants. Current medicinal chemistry 8, 797-807.

103. Rice-Evans, C.A., Miller, N.J., and Paganga, G. (1996). Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free radical biology &

medicine 20, 933-956.

104. Rushmore, T.H., and Kong, A.N. (2002). Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes. Current drug metabolism 3, 481-490.

105. Rushmore, T.H., Morton, M.R., and Pickett, C.B. (1991). The antioxidant

responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity. The Journal of biological chemistry 266, 11632-11639.

106. Sabzevari, O., Galati, G., Moridani, M.Y., Siraki, A., and O'Brien, P.J. (2004).

Molecular cytotoxic mechanisms of anticancer hydroxychalcones.

Chemico-biological interactions 148, 57-67.

107. Seelig, G.F., Simondsen, R.P., and Meister, A. (1984). Reversible dissociation of gamma-glutamylcysteine synthetase into two subunits. The Journal of biological chemistry 259, 9345-9347.

108. Shen, G., Xu, C., Hu, R., Jain, M.R., Nair, S., Lin, W., Yang, C.S., Chan, J.Y., and

Kong, A.N. (2005). Comparison of (-)-epigallocatechin-3-gallate elicited liver and small intestine gene expression profiles between C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice. Pharmaceutical research 22, 1805-1820.

109. Siow, R.C., Sato, H., and Mann, G.E. (1999). Heme oxygenase-carbon monoxide signalling pathway in atherosclerosis: anti-atherogenic actions of bilirubin and carbon monoxide? Cardiovascular research 41, 385-394.

110. Soltaninassab, S.R., Sekhar, K.R., Meredith, M.J., and Freeman, M.L. (2000).

Multi-faceted regulation of gamma-glutamylcysteine synthetase. Journal of cellular physiology 182, 163-170.

111. Stangl, V., Lorenz, M., Ludwig, A., Grimbo, N., Guether, C., Sanad, W., Ziemer, S., Martus, P., Baumann, G., and Stangl, K. (2005). The flavonoid phloretin suppresses stimulated expression of endothelial adhesion molecules and reduces activation of human platelets. The Journal of nutrition 135, 172-178.

112. Stocker, R., and Ames, B.N. (1987). Potential role of conjugated bilirubin and copper in the metabolism of lipid peroxides in bile. Proceedings of the National Academy of Sciences of the United States of America 84, 8130-8134.

113. Surh, Y.J., Kundu, J.K., Na, H.K., and Lee, J.S. (2005). Redox-sensitive transcription factors as prime targets for chemoprevention with

anti-inflammatory and antioxidative phytochemicals. The Journal of nutrition

135, 2993S-3001S.

114. Tenhunen, R., Marver, H.S., and Schmid, R. (1968). The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase. Proceedings of the National Academy of Sciences of the United States of America 61, 748-755.

115. Vachharajani, T.J., Work, J., Issekutz, A.C., and Granger, D.N. (2000). Heme oxygenase modulates selectin expression in different regional vascular beds.

American journal of physiology 278, H1613-1617.

116. Valko, M., Leibfritz, D., Moncol, J., Cronin, M.T., Mazur, M., and Telser, J.

(2007). Free radicals and antioxidants in normal physiological functions and human disease. The international journal of biochemistry & cell biology 39, 44-84.

117. Valko, M., Rhodes, C.J., Moncol, J., Izakovic, M., and Mazur, M. (2006). Free radicals, metals and antioxidants in oxidative stress-induced cancer.

Chemico-biological interactions 160, 1-40.

118. van Iersel, M.L., Verhagen, H., and van Bladeren, P.J. (1999). The role of biotransformation in dietary (anti)carcinogenesis. Mutation research 443, 259-270.

119. Venugopal, R., and Jaiswal, A.K. (1996). Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated

expression of NAD(P)H:quinone oxidoreductase1 gene. Proceedings of the National Academy of Sciences of the United States of America 93, 14960-14965.

120. Venugopal, R., and Jaiswal, A.K. (1998). Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and

coordinated induction of genes encoding detoxifying enzymes. Oncogene 17, 3145-3156.

121. Wang, J., and Mazza, G. (2002). Inhibitory effects of anthocyanins and other phenolic compounds on nitric oxide production in LPS/IFN-gamma-activated RAW 264.7 macrophages. Journal of agricultural and food chemistry 50, 850-857.

122. Wang, L., Gaziano, J.M., Norkus, E.P., Buring, J.E., and Sesso, H.D. (2008).

Associations of plasma carotenoids with risk factors and biomarkers related to cardiovascular disease in middle-aged and older women. The American journal of clinical nutrition 88, 747-754.

123. Wild, A.C., and Mulcahy, R.T. (2000). Regulation of gamma-glutamylcysteine synthetase subunit gene expression: insights into transcriptional control of antioxidant defenses. Free radical research 32, 281-301.

124. Williams, R.J., Spencer, J.P., and Rice-Evans, C. (2004). Flavonoids:

antioxidants or signalling molecules? Free radical biology & medicine 36, 838-849.

125. Wise, C.D., and Drabkin., D.L. (1964). Degradation of haneoglobin and hemin to biliverdin by a new cell-free system obtained from the hemophagous organ of dog placenta. Fed Proc 23:323.

126. Wu, C.C., Hsu, M.C., Hsieh, C.W., Lin, J.B., Lai, P.H., and Wung, B.S. (2006).

Upregulation of heme oxygenase-1 by Epigallocatechin-3-gallate via the phosphatidylinositol 3-kinase/Akt and ERK pathways. Life sciences 78, 2889-2897.

127. Wu, D., Meydani, S.N., Sastre, J., Hayek, M., and Meydani, M. (1994). In vitro glutathione supplementation enhances interleukin-2 production and mitogenic response of peripheral blood mononuclear cells from young and old subjects.

The Journal of nutrition 124, 655-663.

128. Xu, C., Li, C.Y., and Kong, A.N. (2005). Induction of phase I, II and III drug metabolism/transport by xenobiotics. Archives of pharmacal research 28, 249-268.

129. Yang, E.B., Guo, Y.J., Zhang, K., Chen, Y.Z., and Mack, P. (2001). Inhibition of epidermal growth factor receptor tyrosine kinase by chalcone derivatives.

Biochimica et biophysica acta 1550, 144-152.

130. Yang, Y., Chen, Y., Johansson, E., Schneider, S.N., Shertzer, H.G., Nebert, D.W.,

and Dalton, T.P. (2007). Interaction between the catalytic and modifier subunits of glutamate-cysteine ligase. Biochemical pharmacology 74, 372-381.

131. Yang, Y., Dieter, M.Z., Chen, Y., Shertzer, H.G., Nebert, D.W., and Dalton, T.P.

(2002). Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse. Novel model system for a severely compromised oxidative stress response. The Journal of biological chemistry 277, 49446-49452.

132. Yao, M., Zhang, H., Chong, S., Zhu, M., and Morrison, R.A. (2003). A rapid and sensitive LC/MS/MS assay for quantitative determination of digoxin in rat plasma. Journal of pharmaceutical and biomedical analysis 32, 1189-1197.

133. Yet, S.F., Tian, R., Layne, M.D., Wang, Z.Y., Maemura, K., Solovyeva, M., Ith, B., Melo, L.G., Zhang, L., Ingwall, J.S., et al. (2001). Cardiac-specific

expression of heme oxygenase-1 protects against ischemia and reperfusion injury in transgenic mice. Circulation research 89, 168-173.

134. Young, I.S., and Woodside, J.V. (2001). Antioxidants in health and disease.

Journal of clinical pathology 54, 176-186.

135. Zand, R.S., Jenkins, D.J., and Diamandis, E.P. (2000). Steroid hormone activity of flavonoids and related compounds. Breast cancer research and treatment 62, 35-49.

136. Zipper, L.M., and Mulcahy, R.T. (2000). Inhibition of ERK and p38 MAP kinases inhibits binding of Nrf2 and induction of GCS genes. Biochemical and biophysical research communications 278, 484-492.

137. Zuckerbraun, B.S., McCloskey, C.A., Mahidhara, R.S., Kim, P.K., Taylor, B.S., and Tzeng, E. (2003). Overexpression of mutated IkappaBalpha inhibits vascular smooth muscle cell proliferation and intimal hyperplasia formation. J Vasc Surg

38, 812-819.

相關文件