Chpater 4 Discussions
4.3 Conclusion
In conclusion, after working on the high-throughput functional genomics using DNA microarray technology, the most important thing is：Whatever gene that is discovered by the high-throughput screening or profiling methods should be carefully followed up with solid and thorough verification using conventional cell and molecular biological techniques.
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Appendix A
Cluster Human gene Mouse gene Score Chromosome Ensembl Gene ID Description
FZD2 Fzd2 2.35004 chr17q21.1 ENSG00000180340 frizzled homolog 2 (Drosophila) MB Mb 2.37105 chr22q13.1 ENSG00000198125 myoglobin FHL2 Fhl2 2.49196 chr2q12-q14 ENSG00000115641 four and a half LIM domains 2
CBX5 Cbx5 2.51184 chr12q13.13 ENSG00000094916 chromobox homolog 5 (HP1 alpha homolog, Drosophila)
CKMT2 Ckmt2 2.62403 chr5q13.3 ENSG00000131730 creatine kinase, mitochondrial 2 (sarcomeric)
LPL Lpl 2.64993 chr8p22 --- lipoprotein lipase
TGOLN2 Tgoln1 2.65776 chr2p11.2 ENSG00000152291 trans-golgi network protein 2
PAFAH1B3 Pafah1b3 2.73228 chr19q13.1 ENSG00000079462 platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDa
B2M B2m 2.75425 chr15q21-q22.2 ENSG00000166710 beta-2-microglobulin COL15A1 Col15a1 2.76479 chr9q21-q22 ENSG00000204291 collagen, type XV, alpha 1 1 (11 genes)
RHAG Rhag 2.77558 chr6p21.1-p11 ENSG00000112077 Rh-associated glycoprotein MAGED1 Maged1 2.78243 chrXp11.23 ENSG00000179222 melanoma antigen family D, 1 NIPSNAP1 Nipsnap1 2.89711 chr22q12.2 ENSG00000184117 nipsnap homolog 1 (C. elegans) JAM2 Jam2 2.92219 chr21q21.2 ENSG00000154721 junctional adhesion molecule 2 SMTN Smtn 2.95343 chr22q12.2 ENSG00000183963 smoothelin
HLA-DRA H2-Ea 3.03231 chr6p21.3 ENSG00000204287 ///
ENSG00000206243 ///
ENSG00000206308 major histocompatibility complex, class II, DR alpha SRM Srm 3.03747 chr1p36-p22 ENSG00000116649 spermidine synthase
CSRP2 Csrp2 3.11019 chr12q21.1 ENSG00000175183 cysteine and glycine-rich protein 2 2 (14 genes)
APRT Aprt 3.14577 chr16q24 ENSG00000198931 adenine phosphoribosyltransferase AHCY Ahcy 3.17586 chr20cen-q13.1 ENSG00000101444 S-adenosylhomocysteine hydrolase
CAV2 Cav2 3.17918 chr7q31.1 --- Caveolin 2
HBE1 Hbb-y 3.18354 chr11p15.5 ENSG00000196565 hemoglobin, epsilon 1 /// hemoglobin, epsilon 1 C6orf108 BC048355 3.20422 chr6p21.1 ENSG00000112667 chromosome 6 open reading frame 108
SYNE1 Syne1 3.21439 chr6q25 --- spectrin repeat containing, nuclear envelope 1 NR2F1 Nr2f1 3.23716 chr5q14 ENSG00000175745 nuclear receptor subfamily 2, group F, member 1 VSNL1 Vsnl1 3.23832 chr2p24.3 ENSG00000163032 visinin-like 1
KIF20A Kif20a 3.24549 chr5q31 ENSG00000112984 kinesin family member 20A DUSP1 Dusp1 3.25684 chr5q34 ENSG00000120129 dual specificity phosphatase 1
ELTD1 Eltd1 3.26212 chr1p33-p32 ENSG00000162618 EGF, latrophilin and seven transmembrane domain containing 1
ITPKB Itpkb 3.2697 chr1q42.13 ENSG00000143772 inositol 1,4,5-trisphosphate 3-kinase B RNF8 Rnf8 3.27455 chr6p21.3 ENSG00000112130 ring finger protein 8
AKAP1 Akap1 3.28084 chr17q21-q23 ENSG00000121057 A kinase (PRKA) anchor protein 1
CHCHD3 Chchd3 3.2875 chr7q32.3-q33 ENSG00000106554 coiled-coil-helix-coiled-coil-helix domain containing 3
CDKN1C Cdkn1c 3.31253 chr11p15.5 ENSG00000129757 cyclin-dependent kinase inhibitor 1C (p57, Kip2) TCF4 Tcf4 3.32639 chr18q21.1 ENSG00000196628 transcription factor 4
PEG3 Peg3 3.32742 chr19q13.4 ENSG00000198300 paternally expressed 3 EFNA1 Efna1 3.33508 chr1q21-q22 ENSG00000169242 ephrin-A1
IL7R Il7r 3.34235 chr5p13 ENSG00000168685 interleukin 7 receptor /// interleukin 7 receptor LMOD1 Lmod1 3.3425 chr1q32 ENSG00000163431 leiomodin 1 (smooth muscle)
3 (16 genes)
PIP5K1B Pip5k1a 3.34681 chr9q13 --- phosphatidylinositol-4-phosphate 5-kinase, type I, beta
CA5B Car5b 3.34887 chrXp21.1 --- carbonic anhydrase VB, mitochondrial BAG2 Bag2 3.37544 chr6p12.3-p11.2 ENSG00000112208 BCL2-associated athanogene 2
EBI2 Ebi2 3.37733 chr13q32.3 ENSG00000169508 Epstein-Barr virus induced gene 2 (lymphocyte-specific G protein-coupled receptor)
NUP93 Nup93 3.38446 chr16q13 ENSG00000102900 nucleoporin 93kDa CCNF Ccnf 3.39695 chr16p13.3 ENSG00000162063 cyclin F
TMEM59 Tmem59 3.40408 chr1p36-p31 ENSG00000116209 transmembrane protein 59 PTHR1 Pthr1 3.40624 chr3p22-p21.1 ENSG00000160801 parathyroid hormone receptor 1
TACC3 Tacc3 3.40738 chr4p16.3 ENSG00000013810 transforming, acidic coiled-coil containing protein 3 SH3GL3 Sh3gl3 3.40802 chr15q24 --- SH3-domain GRB2-like 3
EPAS1 Epas1 3.41156 chr2p21-p16 ENSG00000116016 endothelial PAS domain protein 1 REC8L1 Rec8L1 3.41256 chr14q11.2-q12 ENSG00000100918 REC8-like 1 (yeast)
KCNJ8 Kcnj8 3.41825 chr12p11.23 ENSG00000121361 potassium inwardly-rectifying channel, subfamily J, member 8
FABP4 Fabp4 3.42139 chr8q21 ENSG00000170323 fatty acid binding protein 4, adipocyte GPM6B Gpm6b 3.42442 chrXp22.2 ENSG00000046653 glycoprotein M6B
HBZ Hba-x 3.45424 chr16p13.3 ENSG00000101442 Hemoglobin, zeta
CD36 Cd36 3.45645 chr7q11.2 --- CD36 molecule (thrombospondin receptor)
NR3C1 Nr3c1 3.46739 chr5q31.3 ENSG00000113580 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PPP1R14B Ppp1r14b 3.48588 chr11q13 ENSG00000173457 protein phosphatase 1, regulatory (inhibitor) subunit 14B
4 (37 genes)
PDE4B Pde4b 3.50097 chr1p31 --- Phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)
KIAA0141 0610009O20Rik 3.51167 chr5q31.3 ENSG00000081791 KIAA0141
PACSIN3 Pacsin3 3.52113 chr11p12-p11.12 ENSG00000165912 protein kinase C and casein kinase substrate in neurons 3
PPARGC1A Ppargc1a 3.52844 chr4p15.1 ENSG00000109819 peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
DHCR24 Dhcr24 3.53595 chr1p33-p31.1 ENSG00000116133 24-dehydrocholesterol reductase CYSLTR2 Cysltr2 3.54782 chr13q14.12-q21.1 ENSG00000152207 cysteinyl leukotriene receptor 2
BZRPL1 Bzrpl1 3.56339 chr6p21.1 ENSG00000112212 benzodiazapine receptor (peripheral)-like 1 ZWINT Zwint 3.5696 chr10q21-q22 ENSG00000122952 ZW10 interactor
ZBTB20 Zbtb20 3.57055 chr3q13.2 --- zinc finger and BTB domain containing 20 S100B S100b 3.57258 chr21q22.3 ENSG00000160307 S100 calcium binding protein B
DYSF Dysf 3.57496 chr2p13.3-p13.1 ENSG00000135636 dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)
SDC1 Sdc1 3.5805 chr2p24.1 ENSG00000115884 syndecan 1 HIST1H2BD Hist1h2bp 3.58233 chr6p21.3 ENSG00000158373 histone cluster 1, H2bd
CYP1B1 Cyp1b1 3.58453 chr2p21 ENSG00000138061 cytochrome P450, family 1, subfamily B, polypeptide 1
TAPBP Tapbp 3.5885 chr6p21.3 ENSG00000112493 TAP binding protein (tapasin)
MYL1 Myl1 3.59016 chr2q33-q34 ENSG00000168530 myosin, light chain 1, alkali; skeletal, fast MELK Melk 3.59676 chr9p13.2 ENSG00000165304 maternal embryonic leucine zipper kinase ORMDL2 Ormdl2 3.60337 chr12q13.2 ENSG00000123353 ORM1-like 2 (S. cerevisiae)
ITGB2 Itgb2 3.60614 chr21q22.3 ENSG00000160255 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
5 (3 genes)
RASL11B Rasl11b 3.61041 chr4q12 ENSG00000128045 RAS-like, family 11, member B
ROBO1 Robo1 3.61483 chr3p12 ENSG00000169855 roundabout, axon guidance receptor, homolog 1 (Drosophila)
FYN Fyn 3.61523 chr6q21 --- FYN oncogene related to SRC, FGR, YES MDK Mdk 3.61841 chr11p11.2 ENSG00000110492 midkine (neurite growth-promoting factor 2) FZD7 Fzd7 3.62471 chr2q33 ENSG00000155760 frizzled homolog 7 (Drosophila)
DARS Dars 3.62581 chr2q21.3 ENSG00000115866 aspartyl-tRNA synthetase
ATP6V1D Atp6v1d 3.63456 chr14q23-q24.2 --- ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
H2AFX H2afx 3.6369 chr11q23.2-q23.3 --- H2A histone family, member X SASH1 Sash1 3.63903 chr6q24.3 ENSG00000111961 SAM and SH3 domain containing 1 ACVR2B Acvr2b 3.65439 chr3p22 ENSG00000114739 activin A receptor, type IIB HSPB8 Hspb8 3.65606 chr12q24.23 ENSG00000152137 heat shock 22kDa protein 8
FXYD6 Fxyd6 3.6581 chr11q23.3 ENSG00000137726 FXYD domain containing ion transport regulator 6 FADS2 Fads2 3.66594 chr11q12-q13.1 ENSG00000134824 fatty acid desaturase 2
CD47 Cd47 3.66923 chr3q13.1-q13.2 ENSG00000196776 CD47 molecule HIGD1A Higd1a 3.66961 chr3p22.1 ENSG00000181061 HIG1 domain family, member 1A DIP BC021523 3.68572 chr22q13.31 ENSG00000075240 death-inducing-protein
SNRPE Snrpe 3.68966 chr1q32 ENSG00000182004 small nuclear ribonucleoprotein polypeptide E AHNAK Ahnak 3.70083 chr11q12.2 --- AHNAK nucleoprotein (desmoyokin)
CLEC3B Clec3b 3.70897 chr3p22-p21.3 ENSG00000163815 C-type lectin domain family 3, member B UNC84A Unc84a 3.71529 chr7p22.3 ENSG00000164828 unc-84 homolog A (C. elegans)
TNIP2 Tnip2 3.71928 chr4p16.3 ENSG00000168884 TNFAIP3 interacting protein 2 6 (22 genes)
FOXC2 Foxc2 3.72093 chr16q22-16q24 ENSG00000176692 forkhead box C2 (MFH-1, mesenchyme forkhead 1)
BRP44L Brp44l 3.72977 chr6q27 ENSG00000060762 brain protein 44-like COL9A3 Col9a3 3.73265 chr20q13.3 ENSG00000092758 collagen, type IX, alpha 3
POLR2H Polr2h 3.7444 chr3q28 ENSG00000163882 polymerase (RNA) II (DNA directed) polypeptide H
PIK3CA Pik3ca 3.74511 chr3q26.3 --- Phosphoinositide-3-kinase, catalytic, alpha polypeptide
AP2S1 Ap2s1 3.74648 chr19q13.2-q13.3 ENSG00000042753 adaptor-related protein complex 2, sigma 1 subunit ///
adaptor-related protein complex 2, sigma 1 subunit
UBE2C Ube2c 3.74671
TRIP13 Trip13 3.74956 chr5p15.33 ENSG00000071539 thyroid hormone receptor interactor 13 MRLC2 Mylc2b 3.75306 chr18p11.31 --- myosin regulatory light chain MRLC2 SKP2 Skp2 3.75813 chr5p13 ENSG00000145604 S-phase kinase-associated protein 2 (p45) CDC20 Cdc20 3.75973 chr1p34.1 ENSG00000117399 cell division cycle 20 homolog (S. cerevisiae) FLJ20152 1810015C04Rik 3.76006 chr5p15.1 ENSG00000154153 hypothetical protein FLJ20152
PERP Perp 3.76096 chr6q24 ENSG00000112378 PERP, TP53 apoptosis effector
PSMB8 Psmb8 3.76747 chr6p21.3
ENSG00000204264 ///
ENSG00000206234 ///
ENSG00000206298
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
RASL12 Rasl12 3.77026 chr15q11.2-q22.33 ENSG00000103710 RAS-like, family 12
SSB Ssb 3.77204 chr2q31.1 ENSG00000138385 Sjogren syndrome antigen B (autoantigen La) ALDOC Aldoc 3.7721 chr17cen-q12 ENSG00000109107 aldolase C, fructose-bisphosphate
PALMD Palmd 3.77349 chr1p22-p21 ENSG00000099260 palmdelphin
SQLE Sqle 3.78196 chr8q24.1 ENSG00000104549 squalene epoxidase RAG2 Rag2 3.78734 chr11p13 ENSG00000175097 recombination activating gene 2 AQP1 Aqp1 3.79434 chr7p14 ENSG00000106125 aquaporin 1 (Colton blood group)
SMARCA2 Smarca2 3.79632 chr9p22.3 ENSG00000080503 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 PSAT1 Psat1 3.79808 chr9q21.2 ENSG00000135069 phosphoserine aminotransferase 1 PTPRK Ptprk 3.7984 chr6q22.2-23.1 ENSG00000152894 protein tyrosine phosphatase, receptor type, K TXN2 Txn2 3.80206 chr22q13.1 ENSG00000100348 thioredoxin 2
TCF7 Tcf7 3.80427 chr5q31.1 ENSG00000081059 transcription factor 7 (T-cell specific, HMG-box) NCKAP1L Nckap1l 3.80457 chr12q13.1 ENSG00000123338 NCK-associated protein 1-like
XRCC1 Xrcc1 3.81405 chr19q13.2 ENSG00000073050 X-ray repair complementing defective repair in Chinese hamster cells 1
NDUFA5 Ndufa5 3.81644 chr7q32 --- NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13kDa
CDKN2B Cdkn2b 3.82074 chr9p21 ENSG00000147883 cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
TXNIP Txnip 3.82367 chr1q21.1 ENSG00000117289 thioredoxin interacting protein
PPP6C Ppp6c 3.82451 chr9q33.3 ENSG00000119414 protein phosphatase 6, catalytic subunit PLXDC1 Plxdc1 3.82481 chr17q21.1 ENSG00000161381 plexin domain containing 1
EHD4 Ehd4 3.82888 chr15q11.1 ENSG00000103966 EH-domain containing 4 TCAP Tcap 3.83883 chr17q12 ENSG00000173991 titin-cap (telethonin)
SGK Sgk 3.84073 chr6q23 ENSG00000118515 serum/glucocorticoid regulated kinase BLM Blm 3.84131 chr15q26.1 ENSG00000197299 Bloom syndrome
ZNF423 Zfp423 3.84204 chr16q12 --- Zinc finger protein 423
NBL1 Nbl1 3.84563 chr1p36.13-p36.11 ENSG00000158747 neuroblastoma, suppression of tumorigenicity 1 ITGA7 Itga7 3.85159 chr12q13 ENSG00000135424 integrin, alpha 7
8 (49 genes)
PACSIN2 Pacsin2 3.86178 chr22q13.2-13.33 ENSG00000100266 protein kinase C and casein kinase substrate in neurons 2
CENTD2 Centd2 3.86738 chr11q13.4 ENSG00000186635 centaurin, delta 2
MGAT1 Mgat1 3.87863 chr5q35 ENSG00000131446 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
SDHB Sdhb 3.88122 chr1p36.1-p35 ENSG00000117118 succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SRPX Srpx 3.88385 chrXp21.1 ENSG00000101955 sushi-repeat-containing protein, X-linked EGLN3 Egln3 3.88671 chr14q13.1 ENSG00000129521 egl nine homolog 3 (C. elegans)
POLR2L Polr2l 3.89059 chr11p15 ENSG00000177700
polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa /// polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PMP22 Pmp22 3.89087 chr17p12-p11.2 ENSG00000109099 peripheral myelin protein 22
LTBP4 Ltbp4 3.89479 chr19q13.1-q13.2 ENSG00000090006 latent transforming growth factor beta binding protein 4
ITK Itk 3.89795 chr5q31-q32 ENSG00000113263 IL2-inducible T-cell kinase
LSM3 Lsm3 3.89848 chr3p25.1 ENSG00000170860 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
CD38 Cd38 3.90328 chr4p15 ENSG00000004468 CD38 molecule
CKAP4 Ckap4 3.90394 chr12q23.3 ENSG00000136026 cytoskeleton-associated protein 4 PHGDH Phgdh 3.91476 chr1p12 ENSG00000092621 phosphoglycerate dehydrogenase DLG7 Dlg7 3.9183 chr14q22.3 ENSG00000126787 discs, large homolog 7 (Drosophila) EFHD1 Efhd1 3.93142 chr2q37.1 ENSG00000115468 EF-hand domain family, member D1
PCK2 Pck2 3.93339 chr14q12 ENSG00000100889 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
HADHA Hadha 3.93926 chr2p23 ENSG00000084754
hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A
thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit
LOC387680 D6Wsu116e 3.94456
SCARB2 Scarb2 3.95368 chr4q21.1 --- scavenger receptor class B, member 2
ACAT1 Acat1 3.95369 chr11q22.3-q23.1 ENSG00000075239 acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase)
TXN Txn1 3.95531 chr9q31 --- Thioredoxin
VRK1 Vrk1 3.95618 chr14q32 ENSG00000100749 vaccinia related kinase 1
MX1 Mx2 3.96311 chr21q22.3 ENSG00000157601
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) ///
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
OGDH Ogdh 3.97278 chr7p14-p13 ENSG00000105953 oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
SYPL1 Sypl 3.98562 chr7q22.2 ENSG00000008282 synaptophysin-like 1 SR140 2610101N10Rik 3.99061 chr3q23 --- U2-associated SR140 protein
APEX1 Apex1 3.99157 chr14q11.2-q12 ENSG00000100823 APEX nuclease (multifunctional DNA repair enzyme) 1
RABGAP1L Rabgap1l 3.99435 chr1q24 ENSG00000152061 RAB GTPase activating protein 1-like LAMB2 Lamb2 4.00081 chr3p21 ENSG00000172037 laminin, beta 2 (laminin S)
POLD2 Pold2 4.00496 chr7p13 --- Polymerase (DNA directed), delta 2, regulatory subunit 50kDa
RCN1 Rcn1 4.00714 chr11p13 --- reticulocalbin 1, EF-hand calcium binding domain PDC Pdc 4.00998 chr1q25.2 ENSG00000116703 phosducin
VARS Vars2 4.01065 chr6p21.3 ENSG00000204394 ///
ENSG00000096171 valyl-tRNA synthetase GPC3 Gpc3 4.01352 chrXq26.1 ENSG00000147257 glypican 3
CHPT1 Chpt1 4.01748 chr12q ENSG00000111666 choline phosphotransferase 1
GATA1 Gata1 4.01886 chrXp11.23 ENSG00000102145 GATA binding protein 1 (globin transcription factor 1)
NOTCH3 Notch3 4.01929 chr19p13.2-p13.1 ENSG00000074181 Notch homolog 3 (Drosophila)
NONO Nono 4.01981 chrXq13.1 ENSG00000147140 non-POU domain containing, octamer-binding RTN1 Rtn1 4.02291 chr14q23.1 ENSG00000139970 reticulon 1
ALOX5AP Alox5ap 4.0268 chr13q12 ENSG00000132965 arachidonate 5-lipoxygenase-activating protein MEN1 Men1 4.02722 chr11q13 ENSG00000133895 multiple endocrine neoplasia I
PRKAR1A Prkar1a 4.03187 chr17q23-q24 ENSG00000108946 protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)
SPTA1 Spna1 4.03272 chr1q21 ENSG00000163554 spectrin, alpha, erythrocytic 1 (elliptocytosis 2) PDE1A Pde1a 4.03709 chr2q32.1 --- phosphodiesterase 1A, calmodulin-dependent
SLC4A1 Slc4a1 4.04481
PIGQ Pigq 4.04696 chr16p13.3 ENSG00000007541 phosphatidylinositol glycan anchor biosynthesis, class Q
MYOZ2 Myoz2 4.0483 chr4q26-q27 ENSG00000172399 myozenin 2 SEC14L1 Sec14l1 4.05721 chr17q25.1-17q25.2 --- SEC14-like 1 (S. cerevisiae)
MMD Mmd 4.05742 chr17q ENSG00000108960 monocyte to macrophage differentiation-associated ZNF160 Zfp26 4.05756 chr19q13.41 --- zinc finger protein 160
9 (9 genes)
CD3D Cd3d 4.05909 chr11q23 ENSG00000167286 CD3d molecule, delta (CD3-TCR complex) GAP43 Gap43 4.06687 chr3q13.1-q13.2 --- growth associated protein 43
10 (38 genes)
ODC1 Odc1 4.06765 chr2p25 ENSG00000115758 ornithine decarboxylase 1
STAT3 Stat3 4.07063 chr17q21.31 ENSG00000168610 signal transducer and activator of transcription 3 (acute-phase response factor)
COL5A3 Col5a3 4.07122 chr19p13.2 ENSG00000080573 collagen, type V, alpha 3 KTN1 Ktn1 4.07466 chr14q22.1 ENSG00000126777 kinectin 1 (kinesin receptor) PRKCD Prkcd 4.0789 chr3p21.31 ENSG00000163932 protein kinase C, delta
PHLDA1 Phlda1 4.081 chr12q15 ENSG00000139289 pleckstrin homology-like domain, family A, member 1
UCHL1 Uchl1 4.08355 chr4p14 ENSG00000154277 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
GALK1 Galk1 4.08428 chr17q24 ENSG00000108479 galactokinase 1
MDH1 Mdh1 4.0903 chr2p13.3 ENSG00000014641 malate dehydrogenase 1, NAD (soluble)
SUCLA2 Sucla2 4.09384 chr13q12.2-q13.3 ENSG00000136143 succinate-CoA ligase, ADP-forming, beta subunit MLYCD Mlycd 4.09803 chr16q24 ENSG00000103150 malonyl-CoA decarboxylase
SLC4A4 Slc4a4 4.10084 chr4q21 ENSG00000080493 solute carrier family 4, sodium bicarbonate cotransporter, member 4
RUFY2 Rufy2 4.10278 chr10q21.3 --- RUN and FYVE domain containing 2 HRC Hrc 4.10447 chr19q13.3 ENSG00000130528 histidine rich calcium binding protein
ORC6L Orc6l 4.10543 chr16q12 ENSG00000091651 origin recognition complex, subunit 6 like (yeast) CAV1 Cav1 4.10718 chr7q31.1 ENSG00000105974 caveolin 1, caveolae protein, 22kDa
DNMT1 Dnmt1 4.10873 chr19p13.2 ENSG00000130816 DNA (cytosine-5-)-methyltransferase 1
NASP Nasp 4.11372 chr1p34.1 ENSG00000132780 nuclear autoantigenic sperm protein (histone-binding)
RASSF3 Rassf3 4.11601 chr12q14.2 --- Ras association (RalGDS/AF-6) domain family 3
SEC61B Sec61b 4.12347 chr9q22.32-q31.3 ENSG00000106803 Sec61 beta subunit TBX5 Tbx5 4.12454 chr12q24.1 ENSG00000089225 T-box 5
THBS1 Thbs1 4.12753 chr15q15 --- Thrombospondin 1
NGFRAP1 Ngfrap1 4.13084 chrXq22.2 ENSG00000166681 nerve growth factor receptor (TNFRSF16) associated protein 1
ARHGEF12 Arhgef12 4.1316 chr11q23.3 ENSG00000196914 Rho guanine nucleotide exchange factor (GEF) 12 KLF9 Klf9 4.13334 chr9q13 ENSG00000119138 Kruppel-like factor 9
WNT11 Wnt11 4.13515 chr11q13.5 ENSG00000085741 wingless-type MMTV integration site family, member 11
RAP1A Rap1a 4.13695 chr1p13.3 --- RAP1A, member of RAS oncogene family
ILKAP Ilkap 4.13996 chr2q37.3 ENSG00000132323 integrin-linked kinase-associated serine/threonine phosphatase 2C
BSDC1 Bsdc1 4.13999 chr1p35.1 ENSG00000160058 BSD domain containing 1
NPR3 Npr3 4.14203 chr5p14-p13 ENSG00000113389 natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
ABLIM1 Ablim1 4.14207 chr10q25 ENSG00000099204 actin binding LIM protein 1 RPL14 Rpl14 4.14492 chr3p22-p21.2 --- ribosomal protein L14 KLHL7 Klhl7 4.1459 chr7p15.3 ENSG00000122550 kelch-like 7 (Drosophila)
CITED1 Cited1 4.14591 chrXq13.1 ENSG00000125931 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
SP100 Sp100 4.14747 chr2q37.1 --- SP100 nuclear antigen
CDC25A Cdc25a 4.15595 chr3p21 ENSG00000164045 cell division cycle 25 homolog A (S. cerevisiae)
11 (9 genes) CDIPT Cdipt 4.15666 chr16p11.2 ENSG00000103502
CDP-diacylglycerol--inositol
3-phosphatidyltransferase (phosphatidylinositol synthase)
PRKD2 Prkd2 4.15827 chr19q13.3 ENSG00000105287 protein kinase D2 TALDO1 Taldo1 4.15958 chr11p15.5-p15.4 ENSG00000177156 transaldolase 1 GENX-3414 D5Ertd593e 4.16432 chr4q24-q25 --- genethonin 1 LMNB2 Lmnb2 4.16501 chr19p13.3 ENSG00000176619 lamin B2 SYN1 Syn1 4.16552 chrXp11.23 ENSG00000008056 synapsin I
ESRRG Esrrg 4.16678 chr1q41 ENSG00000196482 estrogen-related receptor gamma
CDC6 Cdc6 4.16971 chr17q21.3 ENSG00000094804 cell division cycle 6 homolog (S. cerevisiae)
TNFRSF4 Tnfrsf4 4.17453 chr1p36 ENSG00000186827 tumor necrosis factor receptor superfamily, member 4 PDE2A Pde2a 4.1751 chr11q13.4 ENSG00000186642 phosphodiesterase 2A, cGMP-stimulated
PPOX Ppox 4.17989 chr1q22 ENSG00000143224 protoporphyrinogen oxidase
HSPA5 Hspa5 4.19148 chr9q33-q34.1 ENSG00000044574 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
CYFIP2 Cyfip2 4.19543 chr5q33.3 ENSG00000055163 cytoplasmic FMR1 interacting protein 2 ///
cytoplasmic FMR1 interacting protein 2 HIST1H2BG Hist1h2bm 4.19658 chr6p21.3 ENSG00000187990 histone cluster 1, H2bg
AP1B1 Ap1b1 4.19898 chr22q12|22q12.2 ENSG00000100280 adaptor-related protein complex 1, beta 1 subunit 12 (7 genes)
HNRPM Hnrpm 4.19951 chr19p13.3-p13.2 --- heterogeneous nuclear ribonucleoprotein M
Appendix B
Cluster 1
Cluster 2
Cluster 3
Cluster 4
Cluster 5
Cluster 6
Cluster 7
Cluster 8
Cluster 9
Cluster 10
Cluster 11
Cluster 12