!
!
!
Gjh/!3.8!!Tdifnbujd!qsftfoubujpo!pg!uif!tjhobmjoh!qbuixbzt!jowpmwfe!jo!
TEG.2Į.joevdfe!Įwȕ4!joufhsjo!fyqsfttjpo!boe!njhsbujpo!bdujwjuz!jo!ivnbo!
dipoesptbsdpnb!dfmmt/!
TEG.2Į gspn!mvoh!)mvoh!fqjuifmjvn!dfmmt*!bdut!uispvhi!DYDS5!up!bdujwbuf!
NBQL-!ftqfdjbmmz!FSL-!mfbejoh!up!uif!qiptqipszmbujpo!pg!JLL-!JțCĮ!boe!q76-sftvmujoh!jo!uif!bdujwbujpo!pg!OG.țC!fmfnfou!boe!uif!jojujbujpo!pg!Įwȕ4 joufhsjo!fyqsfttjpo!jo!ivnbo!dipoesptbsdpnb!dfmmt/!Uijt!Įwȕ4!joufhsjo joevdujpo!jodsfbtft!uif!dfmm!njhsbujpo!pg!dipoesptbsdpnb!dfmmt/!
!
!
!
!
!
!
S S D D F F - - 1Į 1 Į CXCR4
Metastasis
JJ cellsERK IKIKKK
P65
NFNF--țțBB
ĮVȕ3 P65
!
!
!
!
!
!
!
!
!
!
ୖ!Ե!Ў!!
Ȑ
References
ȑ!!
!
!
!
!
!
!
!
!
!
!
!
!
!
!
53
Bmcfmeb!TN-!Nfuuf!TB-!Fmefs!EF-!Tufxbsu!S-!Ebnkbopwjdi!M-!Ifsmzo!N-!Cvdl!DB/
Ȑ2::1ȑJoufhsjo!ejtusjcvujpo!jo!nbmjhobou!nfmbopnb;!bttpdjbujpo!pg!uif!
cfub!4!tvcvoju!xjui!uvnps!qsphsfttjpo/!Dbodfs!Sft!661;!7868.7875/!
Bnjsj!B-!Opfj!G-!Kfhbobuibo!T-!Lvmlbsoj!H-!Qjolf!EF-!Mff!KN/Ȑ3118ȑ!fFG2B3!
bdujwbuft!Blu!boe!tujnvmbuft!Blu.efqfoefou!bdujo!sfnpefmjoh-!jowbtjpo!boe!
njhsbujpo/!Podphfof!337;!4138.4151/!
Cfmmbidéof!B-!Dbtuspopwp!W-!Prcvsflf!LV-!Gjtifs!MX-!Gfebslp!OT/Ȑ3119ȑTnbmm!
joufhsjo.cjoejoh! mjhboe! O.mjolfe! hmzdpqspufjot! )TJCMJOHt*;!
nvmujgvodujpobm!qspufjot!jo!dbodfs/!Obu!Sfw!Dbodfs!44Ǻ323.337/!
Cpvlfsdif!I-!Tv![[-!Fnebe!M-!Tbslbs!E-!Gjtifs!QC/Ȑ3118ȑ!Tzoufojo!sfhvmbuft!
uif!nfubtubujd!qifopuzqf!jo!ivnbo!nfmbopnb!dfmmt!cz!bdujwbujoh!ovdmfbs!
gbdups.lbqqbC/!Dbodfs!Sft!778;!2923.2933/!
Cspplt!QD-!Npouhpnfsz!BN-!Sptfogfme!N-!Sfjtgfme!SB-!Iv!U-!Lmjfs!H-!Difsfti!
EB/Ȑ2::5ȑJoufhsjo!bmqib!w!cfub!4!boubhpojtut!qspnpuf!uvnps!sfhsfttjpo!
cz!joevdjoh!bqpquptjt!pg!bohjphfojd!cmppe!wfttfmt/!Dfmm!88:;!2268.2275/!
Cspplt!QD-!Tus÷ncmbe!T-!Lmfnlf!S-!Wjttdifs!E-!Tbslbs!GI-!Difsfti!EB/Ȑ2::6ȑ Boujjoufhsjo! bmqib! w! cfub! 4! cmpdlt! ivnbo! csfbtu! dbodfs! hspxui! boe!
bohjphfoftjt!jo!ivnbo!tljo/!K!Dmjo!Jowftu!::7;!2926.2933/!
Cvshfs!KB-!Ljqqt!UK/!Ȑ3117ȑ!DYDS5;!b!lfz!sfdfqups!jo!uif!dspttubml!cfuxffo!
uvnps!dfmmt!boe!uifjs!njdspfowjsponfou/!Cmppe!2218;!2872.2878/!
Div!DZ-!Dib!TU-!Diboh!DD-!Itjbp!DI-!Ubo!DU-!Mv!ZD-!Kff!TI-!Lvp!NM/Ȑ3118ȑ!
Jowpmwfnfou!pg!nbusjy!nfubmmpqspufjobtf.24!jo!tuspnbm!dfmm!efsjwfe!gbdups!
2!bmqib.ejsfdufe!jowbtjpo!pg!ivnbo!cbtbm!dfmm!dbsdjopnb!dfmmt/!Podphfof!! 37;!35:2.3612/!
Dijv!ZD-!Gpoh!ZD!-!Mbj!DI!-!Ivoh!DI!-!Itv!ID!-!Mff!UT!-!Zboh!ST-!Gv!XN-!Uboh!
DI/Ȑ3118ȑUispncjo.joevdfe!JM.7!qspevdujpo!jo!ivnbo!tzopwjbm!gjcspcmbtut!
jt!nfejbufe!cz!QBS2-!qiptqipmjqbtf!D-!qspufjo!ljobtf!D!Į-!D.Tsd-!OG.LbqqbC!
boe!q411!qbuixbz/!Npm!Jnnvopm!56Ǻ2698.26::/!
Dppqfs!DS-!Dibz!DI-!Qjfoub!LK/Ȑ3113ȑ!Uif!spmf!pg!bmqib)w*cfub)4*!jo!qsptubuf!
dbodfs!qsphsfttjpo/!Ofpqmbtjb!55;!2:2.2:5/!
Gjemfs!JK/Ȑ3114ȑUif!qbuiphfoftjt!pg!dbodfs!nfubtubtjtǺuifȶtffe!boe!
tpjmȷizqpuiftjt!sfwjtufe/!Obu!Sfw!Dbodfs!44Ǻ564.569/!
Hpoh!X-!Mjv!Z-!Ivboh!C-!Mfj![-!Xv!GI-!Mj!E-!Gfoh![I-![iboh!HN/Ȑ3119ȑSfdpncjobou!
DCE ȉ IfqJJ! qpmzqfqujef! pg! gjcspofdujo! joijcjut! Įvȕ3! tjhobmjoh! boe!
ifnbuphfopvt!nfubtubtjt!pg!uvnps/!Cjpdifn!Cjpqizt!Sft!Dpnnvo!!478Ǻ!255ȉ 25:/!
Hsffomff!SU-!Ijmm.Ibsnpo!NC-!Nvssbz!U-!Uivo!N/Ȑ3112ȑ!Dbodfs!tubujtujdt/!
DB!Dbodfs!K!Dmjo!62;!26.47/!
Hjbodpuuj!GH-!Svptmbiuj!F/!Joufhsjo!tjhobmjoh/Ȑ2:::ȑTdjfodf!3396;!2139.2143/!
Ibnez!GD-!Bvu{fo!Q-!Spcjotpo!ND-!Ipsof!DI-!Ofbm!EF-!Spctpo!DO/Ȑ2::8ȑ Jnnvopmpdbmj{bujpo!boe!nfttfohfs!SOB!fyqsfttjpo!pg!cpof!npsqiphfofujd!
qspufjo.7!jo!ivnbo!cfojho!boe!nbmjhobou!qsptubujd!ujttvf/!Dbodfs!Sft!668;!
5538.5542/!
Ibobibo!E-!Xfjocfsh!SB/Ȑ3111ȑ!Uif!ibmmnbslt!pg!dbodfs/!Dfmm!2211;!68.81/!
Ijflfo!UK-!Gbspmbo!N-!Spobo!TH-!Tijmlbjujt!B-!Xjme!M-!Ebt!Hvqub!UL/!)2::7*!
Cfub4!joufhsjo!fyqsfttjpo!jo!nfmbopnb!qsfejdut!tvctfrvfou!nfubtubtjt/!K!
Tvsh!Sft!74;!27:.284/!
Itv! NZ-! Spwjotlz! T-! Qfonbudib! T-! Ifsmzo! N-! Nvjsifbe! E/ Ȑ 3116 ȑ!Cpof!
npsqiphfofujd!qspufjot!jo!nfmbopnb;!bohfm!ps!efwjm@!Dbodfs!Nfubtubtjt!Sfw! 35;!362.374/!
Ivboh!ZD-!Itjbp!ZD-!Difo!ZK-!Xfj!ZZ-!Mbj!UI-!Uboh!DI/Ȑ3118ȑ!Tuspnbm!
dfmm.efsjwfe! gbdups.2! foibodft! npujmjuz! boe! joufhsjo! vq.sfhvmbujpo!
uispvhi!DYDS5-!FSL!boe!OG.lbqqbC.efqfoefou!qbuixbz!jo!ivnbo!mvoh!dbodfs!
dfmmt/!Cjpdifn!Qibsnbdpm!885;!2813.2823/!
Ivnqisjft!NK/!Joufhsjo!tusvduvsf/Ȑ3111ȑ!Cjpdifn!Tpd!Usbot!339;!422.44:/!
55
Dfmm!2221;!784.798/!
Jopvf!K-!Hpieb!K-!Bljzbnb!U-!Tfncb!L/!Ȑ3118ȑ!OG.țC!bdujwbujpo!jo!efwfmpqnfou!
boe!qsphsfttjpo!pg!dbodfs/!Dbodfs!Tdj!!:9Ǻ379ȉ385/!
Kbnciflbs! OB-! Eftbj! QC-! Dijubmf! EB-! Qbujm! Q-! Bszb! T/ Ȑ 2::9 ȑ ! Cfojho!
nfubtubtj{joh!dipoespcmbtupnb;!b!dbtf!sfqpsu/!Dbodfs!93Ǻ786.789/!!
Lbcbtijnb!L-!Tijsbjtij!O-!Tvhjub!L-!Npsj!U-!Popvf!B-!Lpcbzbtij!N-!Tblbcf!K-!
Zptijlj!S-!Ubnbnvsb!I-!Gvkjj!O-!Jobcb!L-!Uplvsb!Z/Ȑ3118ȑDYDM23.DYDS5!
Fohbhfnfou! Jt! Sfrvjsfe! Njhsbujpo! pg! Dvubofpvt! Efoesjujd! Dfmmt/ Bn! K!
Qbuipmphz!!282Ǻ235:.2368/
Lbujzbs! TL-! Nffsbo! TN/ Ȑ 3118 ȑ ! Pcftjuz! jodsfbtft! uif! sjtl! pg! VW!
sbejbujpo.joevdfe!pyjebujwf!tusftt!boe!bdujwbujpo!pg!NBQL!boe!OG.lbqqbC!
tjhobmjoh/!Gsff!Sbejd!Cjp!Nfe!!53;!3::.421/!
Lbxbtijnb!B-!Lbxbibsb!F-!Uplveb!S-!Oblbojtij!J/!Ȑ3112ȑ!Uvnps!ofdsptjt!
gbdups.Į!qspwplft!vqsfhvmbujpo!pg!Į2ȕ1!boe!Į5ȕ1!joufhsjot-!boe!dfmm!
njhsbujpo!jo!PTU!ptufptbsdpnb!dfmmt/!Dfmm!Cjpm!Jou!36Ǻ42:.43:/!
Lpj{vnj!L-!Ipkp!T-!Blbtij!U-!Zbtvnpup!L-!Tbjl!J/Ȑ3118ȑDifnpljof!sfdfqupst!
jo!dbodfs!nfubtubtjt!boe!dbodfs!dfmm.efsjwfe!difnpljoft!jo!iptu!jnnvof!
sftqpotf/!Dbodfs!Tdj!::9!;2763.2769/!
Lvnbs!DD/Ȑ3114ȑ!Joufhsjo!bmqib!w!cfub!4!bt!b!uifsbqfvujd!ubshfu!gps!cmpdljoh!
uvnps.joevdfe!bohjphfoftjt/!Dvss!Esvh!Ubshfut!55;!234.242/!
Mbohfogfme!FN-!Dbmwbop!TF-!Bcpv.Ovlub!G-!Mpxsz!TG-!Bnfoub!Q-!Mbohfogfme!K/
Ȑ3114ȑ!Uif!nbuvsf!cpof!npsqiphfofujd!qspufjo.3!jt!bcfssboumz!fyqsfttfe!
jo!opo.tnbmm!dfmm!mvoh!dbsdjopnbt!boe!tujnvmbuft!uvnps!hspxui!pg!B65:!
dfmmt/!Dbsdjophfoftjt!335;!2556.2565/!
Mfwz!Z-!Spofo!E-!Cfstibetlz!BE-![jdl!Z/!)3114*!Tvtubjofe!joevdujpo!pg!FSL-!
qspufjo!ljobtf!C-!boe!q81!T7!ljobtf!sfhvmbuft!dfmm!tqsfbejoh!boe!gpsnbujpo!
pg! G.bdujo! njdsptqjlft! vqpo! mjhbujpo! pg! joufhsjot! cz! hbmfdujo.9-! b!
nbnnbmjbo!mfdujo/!K!Cjpm!Difn!!3389;!25644.25653/!
Mjo!NU-!Diboh!DD-!Mjo!CS-!Zboh!IZ-!Div!DZ-!Xv!NI-!Lvp!NM/Ȑ3118ȑFmfwbufe!
fyqsfttjpo!pg!DZS72!foibodft!qfsjupofbm!ejttfnjobujpo!pg!hbtusjd!dbodfs!
dfmmt!uispvhi!joufhsjo!Į2ȕ1/!K!Cjpm!Difn!3393Ǻ456:5.45715/!
Mjv!I-!Sbejtlz!ED-!Ofmtpo!DN-![iboh!I-!Gbub!KF-!Spui!SB-!Cjttfmm!NK/Ȑ3117ȑ Nfdibojtn!pg!Blu2!joijcjujpo!pg!csfbtu!dbodfs!dfmm!jowbtjpo!sfwfbmt!b!
qspuvnpsjhfojd!spmf!gps!UTD3/!Qspd!Obum!Bdbe!Tdj!V!T!B!214;!5245.524:/!
Mvddijoj!N-!Dpvcmf!NM-!Spnfbt!B-!Tubrvfu!NK-!Cmfjdifs!G-!Nbhmpjsf!I-!Gbshft!
KD/ Ȑ 3115 ȑ Įvȕ3! joufhsjo! fyqsfttjpo! jo! ivnbo! pepoupcmbtut! boe!
dp.mpdbmj{bujpo!xjui!ptufpbeifsjo/K!Efou!Sft!994Ǻ663.667/!
Nbesje!MW-!Nbzp!NX-!Sfvuifs!KZ-!Cbmexjo!BT!Ks/Ȑ3112ȑ!Blu!tujnvmbuft!uif!
usbotbdujwbujpo!qpufoujbm!pg!uif!SfmB0q76!Tvcvoju!pg!OG.lbqqb!C!uispvhi!
vujmj{bujpo!pg!uif!Jlbqqb!C!ljobtf!boe!bdujwbujpo!pg!uif!njuphfo.bdujwbufe!
qspufjo!ljobtf!q49/!K!Cjpm!Difn!3387;!29:45.29:51/!
Nbtveb!I-!Gvlbcpsj!Z-!Oblbop!L-!Ublf{bxb!Z-!DTv{vlj!U-!Zbnboblb!I/Ȑ3114ȑ! Jodsfbtfe!fyqsfttjpo!pg!cpof!npsqiphfofujd!qspufjo.8!jo!cpof!nfubtubujd!
qsptubuf!dbodfs/!Qsptubuf!665;!379.385/!
Nbutvp!N-!Tblvsbj!I-!Vfop!Z-!Piuboj!P-!Tbjlj!J/Ȑ3117ȑ!Bdujwbujpo!pg!NFL0FSL!
boe!QJ4L0Blu!qbuixbzt!cz!gjcspofdujo!sfrvjsft!joufhsjo!bmqibw.nfejbufe!
BEBN!bdujwjuz!jo!ifqbupdfmmvmbs!dbsdjopnb;!b!opwfm!gvodujpobm!ubshfu!gps!
hfgjujojc/!Dbodfs!Tdj!::8;!266.273/!
Njzb{bxb!L-!Tijop{blj!N-!Ibsb!U-!Gvsvzb!U-!Njzb{pop!L/Ȑ3113ȑ!Uxp!nbkps!Tnbe!
qbuixbzt!jo!UHG.cfub!tvqfsgbnjmz!tjhobmmjoh/!Hfoft!Dfmmt!88;!22:2.2315/!
Nýmmfs!B-!Ipnfz!C-!Tpup!I-!Hf!O-!Dbuspo!E-!Cvdibobo!NF-!NdDmbobibo!U-!Nvsqiz!
F-!Zvbo!X-!Xbhofs!TO-!Cbssfsb!KM-!Npibs!B-!Wfsâtufhvj!F-![mpuojl!B/Ȑ3112ȑ Jowpmwfnfou!pg!difnpljof!sfdfqupst!jo!csfbtu!dbodfs!nfubtubtft/!Obuvsf! 521;!61ȉ67/!
Nvoez!HS/Ȑ3113ȑ!Nfubtubtjt!up!cpof;!dbvtft-!dpotfrvfodft!boe!uifsbqfvujd!
57
Peb!Z-!Zbnbnpup!I-!Ubnjzb!T-!Nbutveb!T-!Uboblb!L-!Zplpzbnb!S-!Jxbnpup!Z-!
Utvofzptij!N/Ȑ3117ȑDYDS5!boe!WFHG!fyqsfttjpo!jo!uif!qsjnbsz!tjuf!boe!
uif!nfubtubujd!tjuf!pg!ivnbo!ptufptbsdpnb;!bobmztjt!xjuijo!b!hspvq!pg!
qbujfout-!bmm!pg!xipn!efwfmpqfe!mvoh!nfubtubtjt/Npe!Qbuipm!2:Ǻ849ȉ856/!
Qbqbdisjtupv!EK-!Qbqbwbttjmjpv!BH/Ȑ3118ȑPtufptbsdpnb!boe!dipoesptbsdpnb;!
Ofx!tjhobmjoh!qbuixbzt!bt!ubshfut!gps!opwfm!uifsbqfvujd!joufswfoujpot/!!
Jou!K!Cjpdifn!Dfmm!Cjpm 4:; 968ȉ973/!
Qfdifvs!J-!Qfzsvdibve!P-!Tfssf!DN-!Hvhmjfmnj!K-!Wpmboe!D-!Cpvssf!G-!Nbshvf!
D-!Dpifo.Tpmbm!N-!Cvggfu!B-!Ljfggfs!O-!Dmê{bsejo!Q/Ȑ3113ȑ!Joufhsjo!
bmqib)w*cfub4!fyqsfttjpo!dpogfst!po!uvnps!dfmmt!b!hsfbufs!qspqfotjuz!up!
nfubtubtj{f!up!cpof/!GBTFC!K!227;!2377.2379/!
Qfsjttjopuup!F-!Dbwbmmpoj!H-!Mfpof!G-!Gpotbup!W-!Njupmb!T-!Hsjhoboj!H-!
Tvssfouj!O-!Tbohjpmp!E-!Cvttpmjop!G-!Qjbdjcfmmp!X-!Bhmjfuub!N/!Ȑ3116ȑ!
Jowpmwfnfou! pg! difnpljof! sfdfqups! 50tuspnbm! efsjwfe! gbdups! 2! tztufn!
evsjoh!ptufptbsdpnb!uvnps!qsphsfttjpo/!Dmjo!Dbodfs!Sft!222;!5:1ȉ5:8/!
Qjmdi!K-!Ibcfsnboo!S-!Gfmejoh.Ibcfsnboo!C/!)3113*!Vojrvf!bcjmjuz!pg!joufhsjo!
bmqib)w*cfub4!up!tvqqpsu!uvnps!dfmm!bssftu!voefs!ezobnjd!gmpx!dpoejujpot/!
K!Cjpm!Difn!388Ǻ32:41ȉ32:49/!
Sfeej!BI/Ȑ2::5ȑ!Cpof!boe!dbsujmbhf!ejggfsfoujbujpo/!Dvss!Pqjo!Hfofu!Efw!
5;!848ȉ855/!
Spuiibnnfs!U-!Qptfs!J-!Tpodjo!G-!Cbubjmmf!G-!Nptfs!N-!Cpttfsipgg!BL/!Ȑ3116ȑ Cpof!npsqiphfojd!qspufjot!bsf!pwfsfyqsfttfe!jo!nbmjhobou!nfmbopnb!boe!
qspnpuf!dfmm!jowbtjpo!boe!njhsbujpo/!Dbodfs!Sft!76;!559.567/!
Svttfmm! IW-! Ijdlt! K-! Pldv! NG-! Ovdiufso! KH/ Ȑ 3115 ȑ DYDS5! fyqsfttjpo! jo!
ofvspcmbtupnb!qsjnbsz!uvnpst!jt!bttpdjbufe!xjui!dmjojdbm!qsftfoubujpo!pg!
cpof!boe!cpof!nbsspx!nfubtubtft/!K!Qfejbus!Tvsh!44:;!2617ȉ2622/!
Tblvsbj!I-!Dijcb!I-!Njzptij!I-!Tvhjub!U-!Upsjvnj!X/!Ȑ2:::ȑ!JțC!ljobtft!
qiptqipszmbuf!OG.țC!q76!tvcvoju!po!tfsjof!647!jo!uif!usbotbdujwbujpo!
epnbjo/!K!Cjpm!Difn!3385;!41464.41467/!
Tdpuupo!DK-!Xjmtpo!KM-!Njmmjlfo!E-!Tubnq!H-!Cbmlxjmm!GS/Ȑ3112ȑ!Fqjuifmjbm!
dbodfs!dfmm!njhsbujpo;!b!spmf!gps!difnpljof!sfdfqupst@!Dbodfs!Sft!772;!
5:72ȉ5:76/!
Tfcpmu.Mfpqpme!KT-!Ifssfsb!S/Ȑ3115ȑUbshfujoh!uif!njuphfo.bdujwbufe!qspufjo!
ljobtf!dbtdbef!up!usfbu!dbodfs/!Obu!Sfw!Dbodfs!55;!:48.:58/!
Cfjolf!T-!Mfz!TD/!)3115*!Gvodujpot!pg!OG.țC2!boe!OG.țC3!jo!jnnvof!dfmm!cjpmphz/!
Cjpdifn!K!4493Ǻ!4:4ȉ51:/!
Tqsjohfs! UB/ Ȑ 2::5 ȑ ! Usbggjd! tjhobmt! gps! mznqipdzuf! sfdjsdvmbujpo! boe!
mfvlpdzuf!fnjhsbujpo;!uif!nvmujtufq!qbsbejhn/!Dfmm!887;!412.425/!
Tubmmfs!Q-!Tvmjulpwb!K-!Mjt{uxbo!K-!Npdi!I-!Pblfmfz!FK-!Lsfl!X/!)3114*!
Difnpljof! sfdfqups! DYDS5! epxosfhvmbufe! cz! wpo! Ijqqfm.Mjoebv! uvnpvs!
tvqqsfttps!qWIM/!Obuvsf!5536;!418.422/!
Tvo!ZY-!Gboh!N-!Xboh!K-!Dppqfs!DS-!Qjfoub!LK-!Ubjdinbo!ST/!Ȑ3118ȑ!Fyqsfttjpo!
boe! Bdujwbujpo! pg! Įvȕ3! Joufhsjot! cz! TEG.20DYD23! Jodsfbtft! uif!
bhhsfttjwfoftt!pg!Qsptubuf!Dbodfs!Dfmmt/!Qsptubuf!778;!72.84/!
Ubjdinbo!ST-!Dppqfs!D-!Lfmmfs!FU-!Qjfoub!LK-!Ubjdinbo!OT-!NdDbvmfz!ML/Ȑ3113ȑ!
Vtf!pg!uif!tuspnbm!dfmm.efsjwfe!gbdups.20DYDS5!qbuixbz!jo!qsptubuf!dbodfs!
nfubtubtjt!up!cpof/!Dbodfs!Sft!773;!2943.2948/!
Uboh!DI-!Zboh!ST-!Ivboh!UI-!Mv!EZ-!Divboh!XK-!Ivboh!UG-!Gv!XN/Ȑ3117ȑ!
Vmusbtpvoe!tujnvmbuft!dzdmppyzhfobtf.3!fyqsfttjpo!boe!jodsfbtft!cpof!
gpsnbujpo!uispvhi!joufhsjo-!gpdbm!beiftjpo!ljobtf-!qiptqibujezmjoptjupm!
4.ljobtf-!boe!Blu!qbuixbz!jo!ptufpcmbtut/!Npm!Qibsnbdpm!77:;!3158.3168/!
Uboh!DI-!Zboh!ST-!Gv!XN/Ȑ3116ȑ!Qsptubhmboejo!F3!tujnvmbuft!gjcspofdujo!
fyqsfttjpo!uispvhi!FQ2!sfdfqups-!qiptqipmjqbtf!D-!qspufjo!ljobtf!D!bmqib-!
boe!d.Tsd!qbuixbz!jo!qsjnbsz!dvmuvsfe!sbu!ptufpcmbtut/!K!Cjpm!Difn!!3391;!
33:18.33:27/!
59
Wbo(u!Wffs!MK-!Xfjhfmu!C/Ȑ3114ȑ!Spbe!nbq!up!nfubtubtjt/!Obu!Nfe!:;!:::.2111/!
Wfsnfvmfo!M-!Ef!Xjmef!H-!Wbo!Ebnnf!Q-!Wboefo!Cfshif!X-!Ibfhfnbo!H/Ȑ3114ȑ Usbotdsjqujpobm!bdujwbujpo!pg!uif!OG.͒C!q76!tvcvoju!cz!njuphfo.!boe!
tusftt.bdujwbufe!qspufjo!ljobtf.2/!FNCP!K!333;!2424.2435/!
Wjbupvs!Q-!Nfswjmmf!NQ-!Cpvst!W-!Dibsjpu!B/Ȑ3116ȑ!Qiptqipszmbujpo!pg!
OG.lbqqbC!boe!JlbqqbC!qspufjot;!jnqmjdbujpot!jo!dbodfs!boe!jogmbnnbujpo/!
Usfoet!Cjpdifn!Tdj!441;!54.63/!
Xboh!Y-!Gfssfjsb!BN-!Tibp!R-!Mbjse!EX-!Tboejh!N/Ȑ3116ȑ!Cfub4!joufhsjot!
gbdjmjubuf!nbusjy!joufsbdujpot!evsjoh!usbotfoepuifmjbm!njhsbujpo!pg!QD4!
qsptubuf!uvnps!dfmmt/!Qsptubuf!774;!76.91/!
Xfmn!BM/Ȑ3119ȑUHGȕ!Qsjnft!Csfbtu!Uvnps!Dfmmt!gps!Nfubtubtjt/Dfmm!2244Κ 38.39/!!
Xfo!Y[-!Bljzbnb!Z-!Cbzmjo!TC-!Zvbtb!Z/Ȑ3117ȑ!Gsfrvfou!fqjhfofujd!tjmfodjoh!
pg!uif!cpof!npsqiphfofujd!qspufjo!3!hfof!uispvhi!nfuizmbujpo!jo!hbtusjd!
dbsdjopnbt/!Podphfof!336;!3777.3784/!
[ibp! Z-! Cbdifmjfs! S-! Usfjmmfvy! J-! Qvkvhvfu! Q-! Qfzsvdibve! P-! Cbspo! S-!
Dmênfou.Mbdspjy!Q-!Dmê{bsejo!Q/Ȑ3118ȑUvnps!bmqibwcfub4!joufhsjo!jt!b!
uifsbqfvujd!ubshfu!gps!csfbtu!dbodfs!cpof!nfubtubtft/!Dbodfs!Sft!778;!
6932.6941/!
!
!
!
!
!
!