HP-dependence
Among 20 freshly frozen tissue samples of high-grade gastric MALToma, of which the HP-dependence or –independence state have already been verified by previous prospective clinical study, 16 samples containing microdissectable HG and LG are identified. Microarray approaches to identify expression profiles of the co-existing LG and HG counterpart of the same gastric MALToma patient are ongoing. The results will be interpreted on a background of their individual response to HP eradication. This will help clarify if the genetic changes responsible for HG transformation and HP-independence are different.
計畫成果自評部份
In the first year of this 3-year project, we have successfully identified 2 molecular markers and 2 immunologic cellular markers that highly useful in predicitng HP-independence state of HG gastric MALToma. Since HG gastric MALToma may progress rapidly if unresponsive to HP eradication therapy, thes lines of information are invaluable adjunct for the clinicians to select the right modality of first-line treatment. Manuscripts of these findings have been submitted for publication. We have accomplished what we had proposed for the first year of study. We have also prepared all necessary materials for the second and third year of studies.
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