regulates membrane Type 1-matrix metalloproteinase (MMP) and MMP-2 activity during melanoma cell

vasculogenic mimicry. Cancer Res 63: 4757-62.

Hoult, J. R. & Paya, M. 1996. Pharmacological and biochemical actions of simple coumarins: natural products with therapeutic potential. Gen Pharmacol 27: 713-22.

Hsu, S. L., Hsieh, Y. C., Hsieh, W. C. & Chou, C. J. 2001. Baicalein induces a dual growth arrest by modulating multiple cell cycle regulatory molecules. Eur J Pharmacol 425: 165-71.

Huang, H. C., Wang, H. R. & Hsieh, L. M. 1994. Antiproliferative effect of baicalein, a flavonoid from a Chinese herb, on vascular smooth muscle cell. Eur J Pharmacol 251: 91-3.

Ichihashi, M., Ueda, M., Budiyanto, A., Bito, T., Oka, M., Fukunaga, M., Tsuru, K. & Horikawa, T. 2003. UV-induced skin damage. Toxicology

51

189: 21-39.

Ito, C., Itoigawa, M., Mishina, Y., Filho, V. C., Enjo, F., Tokuda, H., Nishino, H. & Furukawa, H. 2003. Chemical constituents of Calophyllum brasiliense. 2. Structure of three new coumarins and cancer chemopreventive activity of 4-substituted coumarins. J Nat Prod 66:

368-71.

Jeong, T. S., Kim, K. S., Kim, J. R., Cho, K. H., Lee, S. & Lee, W. S. 2004.

Novel 3,5-diaryl pyrazolines and pyrazole as low-density lipoprotein (LDL) oxidation inhibitor. Bioorg Med Chem Lett 14: 2719-23.

Jezek, P. & Hlavata, L. 2005. Mitochondria in homeostasis of reactive oxygen species in cell, tissues, and organism. Int J Biochem Cell Biol 37: 2478-503.

Justino, G. C., Santos, M. R., Canario, S., Borges, C., Florencio, M. H. &

Mira, L. 2004. Plasma quercetin metabolites: structure-antioxidant activity relationships. Arch Biochem Biophys 432: 109-21.

Kade, I. J., Paixao, M. W., Rodrigues, O. E., Barbosa, N. B., Braga, A. L., Avila, D. S., Nogueira, C. W. & Rocha, J. B. 2008. Comparative studies on dicholesteroyl diselenide and diphenyl diselenide as antioxidant agents and their effect on the activities of Na+/K+

ATPase and delta-aminolevulinic acid dehydratase in the rat brain.

Neurochem Res 33: 167-78.

Kakiuchi, Y., Sasaki, N., Satoh-Masuoka, M., Murofushi, H. &

Murakami-Murofushi, K. 2004. A novel pyrazolone, 4,4-dichloro-1-(2,4-dichlorophenyl)-3-methyl-5-pyrazolone, as a potent catalytic inhibitor of human telomerase. Biochem Biophys Res Commun 320: 1351-1358.

52

Kanayasu-Toyoda, T., Morita, I. & Murota, S. 1998. Arachidonic acid pretreatment enhances smooth muscle cell migration via increased Ca2+ influx. Prostaglandins Leukot Essent Fatty Acids 58: 25-31.

Karihtala, P. & Soini, Y. 2007. Reactive oxygen species and antioxidant mechanisms in human tissues and their relation to malignancies.

APMIS 115: 81-103.

Khan, I. A., Kulkarni, M. V., Gopal, M., Shahabuddin, M. S. & Sun, C. M.

2005. Synthesis and biological evaluation of novel angularly fused polycyclic coumarins. Bioorg Med Chem Lett 15: 3584-7.

Khan, K. M., Saify, Z. S., Khan, M. Z., Zia, U., Choudhary, I. M., Atta Ur, R., Perveen, S., Chohan, Z. H. & Supuran, C. T. 2004. Synthesis of coumarin derivatives with cytotoxic, antibacterial and antifungal activity. J Enzyme Inhib Med Chem 19: 373-9.

Kidane, A. G., Salacinski, H., Tiwari, A., Bruckdorfer, K. R. & Seifalian, A.

M. 2004. Anticoagulant and antiplatelet agents: their clinical and device application(s) together with usages to engineer surfaces.

Biomacromolecules 5: 798-813.

Kimura, Y., Matsushita, N. & Okuda, H. 1997. Effects of baicalein isolated from Scutellaria baicalensis on interleukin 1 beta- and tumor necrosis factor alpha-induced adhesion molecule expression in cultured human umbilical vein endothelial cells. J Ethnopharmacol 57: 63-7.

Kontogiorgis, C. & Hadjipavlou-Litina, D. 2003. Biological evaluation of several coumarin derivatives designed as possible anti-inflammatory/antioxidant agents. J Enzyme Inhib Med Chem 18:

63-9.

53

Kontogiorgis, C. A. & Hadjipavlou-Litina, D. J. 2004. Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage. Bioorg Med Chem Lett 14: 611-4.

Kontogiorgis, C. A. & Hadjipavlou-Litina, D. J. 2005. Synthesis and antiinflammatory activity of coumarin derivatives. J Med Chem 48:

6400-8.

Kostova, I. 2005. Synthetic and natural coumarins as cytotoxic agents. Curr Med Chem Anticancer Agents 5: 29-46.

Lee, B. H., Clothier, M. F., Dutton, F. E., Conder, G. A. & Johnson, S. S. 1998.

Anthelmintic beta-hydroxyketoamides (BKAs). Bioorg Med Chem Lett 8: 3317-20.

Lee, K. H. 2004. Current developments in the discovery and design of new drug candidates from plant natural product leads. J Nat Prod 67:

273-83.

Lin, H. C., Tsai, S. H., Chen, C. S., Chang, Y. C., Lee, C. M., Lai, Z. Y. & Lin, C. M. 2008. Structure-activity relationship of coumarin derivatives on xanthine oxidase-inhibiting and free radical-scavenging activities.

Biochem Pharmacol 75: 1416-25.

Lin, R., Chiu, G., Yu, Y., Connolly, P. J., Li, S., Lu, Y., Adams, M., Fuentes-Pesquera, A. R., Emanuel, S. L. & Greenberger, L. M. 2007a.

Design, synthesis, and evaluation of 3,4-disubstituted pyrazole analogues as anti-tumor CDK inhibitors. Bioorg Med Chem Lett 17:

4557-61.

Lin, Y. T., Yang, J. S., Lin, H. J., Tan, T. W., Tang, N. Y., Chaing, J. H., Chang, Y. H., Lu, H. F. & Chung, J. G. 2007b. Baicalein induces apoptosis in SCC-4 human tongue cancer cells via a Ca2+-dependent

54

mitochondrial pathway. In Vivo 21: 1053-8.

Liu, H., Colavitti, R., Rovira, II & Finkel, T. 2005. Redox-dependent transcriptional regulation. Circ Res 97: 967-74.

Liu, J. J., Huang, T. S., Cheng, W. F. & Lu, F. J. 2003. Baicalein and baicalin are potent inhibitors of angiogenesis: Inhibition of endothelial cell proliferation, migration and differentiation. Int J Cancer 106: 559-65.

Liu, Z. Q., Yu, W. & Liu, Z. L. 1999. Antioxidative and prooxidative effects of coumarin derivatives on free radical initiated and photosensitized peroxidation of human low-density lipoprotein. Chem Phys Lipids 103:

125-35.

Lloyd, R. V., Hanna, P. M. & Mason, R. P. 1997. The origin of the hydroxyl radical oxygen in the Fenton reaction. Free Radic Biol Med 22: 885-8.

Maltese, A., Maugeri, F., Ward, K. W. & Bucolo, C. 2007. Development and validation of an RP-HPLC-UV method for the determination of BOL-303225-A, a new coumarin-based anti-inflammatory drug, in rat plasma. Biomed Chromatogr 21: 351-5.

Martins, H. F., Leal, J. P., Fernandez, M. T., Lopes, V. H. & Cordeiro, M. N.

2004. Toward the prediction of the activity of antioxidants:

experimental and theoretical study of the gas-phase acidities of flavonoids. J Am Soc Mass Spectrom 15: 848-61.

Mates, J. M. & Sanchez-Jimenez, F. M. 2000. Role of reactive oxygen species in apoptosis: implications for cancer therapy. Int J Biochem Cell Biol 32: 157-70.

Natarajan, R., Stern, N., Hsueh, W., Do, Y. & Nadler, J. 1988. Role of the lipoxygenase pathway in angiotensin II-mediated aldosterone biosynthesis in human adrenal glomerulosa cells. J Clin Endocrinol

55

Metab 67: 584-91.

Nie, D., Krishnamoorthy, S., Jin, R., Tang, K., Chen, Y., Qiao, Y., Zacharek, A., Guo, Y., Milanini, J., Pages, G. & Honn, K. V. 2006. Mechanisms regulating tumor angiogenesis by 12-lipoxygenase in prostate cancer cells. J Biol Chem 281: 18601-9.

Nishio, E. & Watanabe, Y. 1997. Role of the lipoxygenase pathway in phenylephrine-induced vascular smooth muscle cell proliferation and migration. Eur J Pharmacol 336: 267-73.

Okuda, S., Saito, H. & Katsuki, H. 1994. Arachidonic acid: toxic and trophic effects on cultured hippocampal neurons. Neuroscience 63: 691-9.

Postovit, L. M., Seftor, E. A., Seftor, R. E. & Hendrix, M. J. 2006. Influence of the microenvironment on melanoma cell fate determination and phenotype. Cancer Res 66: 7833-6.

Raj, H. G., Parmar, V. S., Jain, S. C., Goel, S., Poonam, Himanshu, Malhotra, S., Singh, A., Olsen, C. E. & Wengel, J. 1998. Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part I:

Dioxygenated 4-methyl coumarins as superb antioxidant and radical scavenging agents. Bioorg Med Chem 6: 833-9.

Rashba-Step, J., Turro, N. J. & Cederbaum, A. I. 1993. Increased NADPH- and NADH-dependent production of superoxide and hydroxyl radical by microsomes after chronic ethanol treatment. Arch Biochem Biophys 300: 401-8.

Rice-Evans, C. A., Miller, N. J. & Paganga, G. 1996. Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radic Biol Med 20: 933-56.

Saibara, T., Toda, K., Wakatsuki, A., Ogawa, Y., Ono, M. & Onishi, S. 2003.

56

Protective effect of 3-methyl-1-phenyl-2-pyrazolin-5-one, a free radical scavenger, on acute toxicity of paraquat in mice. Toxicol Lett 143: 51-4.

Schuppan, D. & Popov, Y. 2002. Hepatic fibrosis: from bench to bedside. J Gastroenterol Hepatol 17 Suppl 3: S300-5.

Sekiya, K. & Okuda, H. 1982. Selective inhibition of platelet lipoxygenase by baicalein. Biochem Biophys Res Commun 105: 1090-5.

Sharma, S. D., Rajor, H. K., Chopra, S. & Sharma, R. K. 2005. Studies on structure activity relationship of some dihydroxy-4-methylcoumarin antioxidants based on their interaction with Fe(III) and ADP.

Biometals 18: 143-54.

Stohs, S. J. & Bagchi, D. 1995. Oxidative mechanisms in the toxicity of metal ions. Free Radic Biol Med 18: 321-36.

Tao, J., Hu, S., Pacholec, M. & Walsh, C. T. 2003. Synthesis of proposed oxidation-cyclization-methylation intermediates of the coumarin antibiotic biosynthetic pathway. Org Lett 5: 3233-6.

Verhaegen, M., Bauer, J. A., Martin de la Vega, C., Wang, G., Wolter, K. G., Brenner, J. C., Nikolovska-Coleska, Z., Bengtson, A., Nair, R., Elder, J. T., Van Brocklin, M., Carey, T. E., Bradford, C. R., Wang, S. &

Soengas, M. S. 2006. A novel BH3 mimetic reveals a mitogen-activated protein kinase-dependent mechanism of melanoma cell death controlled by p53 and reactive oxygen species.

Cancer Res 66: 11348-59.

Wang, J., Yu, Y., Hashimoto, F., Sakata, Y., Fujii, M. & Hou, D. X. 2004.

Baicalein induces apoptosis through ROS-mediated mitochondrial dysfunction pathway in HL-60 cells. Int J Mol Med 14: 627-32.

57

Winer, I., Normolle, D. P., Shureiqi, I., Sondak, V. K., Johnson, T., Su, L. &

Brenner, D. E. 2002. Expression of 12-lipoxygenase as a biomarker for melanoma carcinogenesis. Melanoma Res 12: 429-34.

Wu, C., Chen, F., Wang, X., Wu, Y., Dong, M., He, G., Galyean, R. D., He, L.

& Huang, G. 2007. Identification of antioxidant phenolic compounds in feverfew (Tanacetum parthenium) by HPLC-ESI-MS/MS and NMR. Phytochem Anal 18: 401-10.

Wu, W. S. 2006. The signaling mechanism of ROS in tumor progression.

Cancer Metastasis Rev 25: 695-705.

Xanthoudakis, S., Miao, G., Wang, F., Pan, Y. C. & Curran, T. 1992. Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme. EMBO J 11: 3323-35.